C C There are a total of 16 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 37 entries in the constant variable array. C C C VOI is Time in component Environmental (second). C CONSTS(1) is S in component Parameters (hertz). C CONSTS(2) is Zeta in component Parameters (dimensionless). C CONSTS(3) is R0 in component Parameters (mm). C CONSTS(4) is Cwall in component Parameters (mm_per_mmHg). C CONSTS(5) is Kne in component Parameters (mmHg_per_mm). C CONSTS(6) is K1 in component Parameters (mmHg_per_mm). C CONSTS(7) is K2 in component Parameters (mmHg_per_mm). C CONSTS(8) is K3 in component Parameters (mmHg_per_mm). C CONSTS(9) is Bwall in component Parameters (mmHg_s_per_sq_mm). C CONSTS(10) is B1 in component Parameters (mmHg_s_per_mm). C CONSTS(11) is B2 in component Parameters (mmHg_s_per_mm). C CONSTS(12) is B3 in component Parameters (mmHg_s_per_mm). C CONSTS(13) is Tsmax in component Parameters (AU). C CONSTS(14) is Tpmax in component Parameters (AU). C CONSTS(15) is Tsmin in component Parameters (AU). C CONSTS(16) is Tpmin in component Parameters (AU). C CONSTS(17) is Gcns in component Parameters (dimensionless). C CONSTS(18) is Gs in component Parameters (per_Hertz). C CONSTS(19) is Gp in component Parameters (per_Hertz). C CONSTS(20) is tau_nor in component Parameters (second). C CONSTS(21) is tau_ach in component Parameters (second). C CONSTS(22) is tau_HR_nor in component Parameters (second). C CONSTS(23) is tau_HR_ach in component Parameters (second). C CONSTS(24) is HRo in component Parameters (Beats_per_min). C CONSTS(25) is HRmax in component Parameters (Beats_per_min). C CONSTS(26) is HRmin in component Parameters (Beats_per_min). C CONSTS(27) is Beta in component Parameters (dimensionless). C CONSTS(28) is delta_th in component Parameters (dimensionless). C CONSTS(29) is q_nor in component Parameters (per_s). C CONSTS(30) is q_ach in component Parameters (per_s). C CONSTS(31) is K_nor in component Parameters (AU). C CONSTS(32) is K_ach in component Parameters (AU). C CONSTS(33) is Gamma in component Parameters (dimensionless). C ALGBRC(11) is alpha_cns in component Nervous_System (hertz). C ALGBRC(9) is n in component Nervous_System (hertz). C ALGBRC(7) is Delta in component Coupling_Dynamics (dimensionless). C CONSTS(34) is alpha_s0 in component Nervous_System (hertz). C CONSTS(35) is alpha_p0 in component Nervous_System (hertz). C STATES(1) is A in component Aortic_Wall (mm_sq). C ALGBRC(1) is P in component Aortic_Wall (mmHg). C ALGBRC(2) is R in component Aortic_Wall (mm). C STATES(2) is Eps_1 in component Coupling_Dynamics (dimensionless). C STATES(3) is Eps_2 in component Coupling_Dynamics (dimensionless). C STATES(4) is Eps_3 in component Coupling_Dynamics (dimensionless). C ALGBRC(5) is Eps_wall in component Coupling_Dynamics (dimensionless). C ALGBRC(13) is Ts in component PNS_tones (AU). C ALGBRC(14) is Tp in component PNS_tones (AU). C STATES(5) is c_nor in component Norepinephrine (AU). C STATES(6) is C_ach in component Acetylcholine (AU). C ALGBRC(3) is delta_HR_ss in component Heart_Response_Nor (Beats_per_min). C CONSTS(36) is delta_HR_smax in component Heart_Response_Nor (Beats_per_min). C STATES(7) is delta_HR_s in component Heart_Response_Nor (Beats_per_min). C ALGBRC(4) is delta_HR_ps in component HR_ach (Beats_per_min). C CONSTS(37) is delta_HR_pmax in component HR_ach (Beats_per_min). C ALGBRC(6) is delta_HR_pfast in component HR_ach (Beats_per_min). C STATES(8) is delta_HR_pslow in component HR_ach (Beats_per_min). C ALGBRC(8) is delta_HR_p in component HR_ach (Beats_per_min). C ALGBRC(15) is HR in component HR_Combined (Beats_per_min). C ALGBRC(12) is HR_p in component HR_Combined (Beats_per_min). C ALGBRC(10) is HR_s in component HR_Combined (Beats_per_min). C ALGBRC(16) is Period in component HR_Combined (Sec_per_Beat). C RATES(1) is d/dt A in component Aortic_Wall (mm_sq). C RATES(2) is d/dt Eps_1 in component Coupling_Dynamics (dimensionless). C RATES(3) is d/dt Eps_2 in component Coupling_Dynamics (dimensionless). C RATES(4) is d/dt Eps_3 in component Coupling_Dynamics (dimensionless). C RATES(5) is d/dt c_nor in component Norepinephrine (AU). C RATES(6) is d/dt C_ach in component Acetylcholine (AU). C RATES(7) is d/dt delta_HR_s in component Heart_Response_Nor (Beats_per_min). C RATES(8) is d/dt delta_HR_pslow in component HR_ach (Beats_per_min). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 480 CONSTS(2) = 1 CONSTS(3) = 1.6 CONSTS(4) = 0.006 CONSTS(5) = 1 CONSTS(6) = 1.5 CONSTS(7) = 3.75 CONSTS(8) = 1.05 CONSTS(9) = 1 CONSTS(10) = 1 CONSTS(11) = 10 CONSTS(12) = 206.973 CONSTS(13) = 4.12 CONSTS(14) = 4.994 CONSTS(15) = 0.5 CONSTS(16) = 1.6 CONSTS(17) = 1 CONSTS(18) = 0.178 CONSTS(19) = 0.492 CONSTS(20) = 9.1 CONSTS(21) = 0.2 CONSTS(22) = 2.1 CONSTS(23) = 2.5 CONSTS(24) = 282.648 CONSTS(25) = 483.218 CONSTS(26) = 226.238 CONSTS(27) = 0.175 CONSTS(28) = 0 CONSTS(29) = 0.1099 CONSTS(30) = 5 CONSTS(31) = 1.12 CONSTS(32) = 0.65 CONSTS(33) = 0.75 CONSTS(34) = 58.6 CONSTS(35) = 76.019 STATES(1) = 15.20531 STATES(2) = 0.2042 STATES(3) = 0.183 STATES(4) = 0.161 STATES(5) = 1.441 STATES(6) = 1.0 STATES(7) = 0 STATES(8) = 0 CONSTS(36) = CONSTS(25) - CONSTS(24) CONSTS(37) = CONSTS(24) - CONSTS(26) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = 100.000+ 10.0000* sin( 5.00000*VOI) RATES(1) = (- ( (STATES(1)/ 3.14159265358979) ** (1.0 / 2) - CONSTS(3))/CONSTS(4)+ALGBRC(1))/CONSTS(9) ALGBRC(3) = ( CONSTS(36)*STATES(5) ** 2.00000)/(CONSTS(31) ** 2.00000+STATES(5) ** 2.00000) RATES(7) = (- STATES(7)+ALGBRC(3))/CONSTS(22) ALGBRC(4) = ( CONSTS(37)*STATES(6) ** 2.00000)/(CONSTS(32) ** 2.00000+STATES(6) ** 2.00000) RATES(8) = (- STATES(8)+ (1.00000 - CONSTS(33))*ALGBRC(4))/CONSTS(23) ALGBRC(2) = STATES(1)/ 3.14159265358979 ** 0.500000 ALGBRC(5) = (ALGBRC(2) - CONSTS(3))/CONSTS(3) CALL minimize(minfunc_0, CONSTS, VARIABLES, ) ALGBRC(7) = ALGBRC(5) - STATES(2) ALGBRC(9) = CONSTS(1)*(ALGBRC(7) - CONSTS(2)*CONSTS(28)) ALGBRC(11) = CONSTS(17)*ALGBRC(9) ALGBRC(13) = CONSTS(15)+(CONSTS(13) - CONSTS(15))/(EXP( CONSTS(18)*(ALGBRC(11) - CONSTS(34)))+1.00000) RATES(5) = - (STATES(5)/CONSTS(20))+ CONSTS(29)*ALGBRC(13) ALGBRC(14) = CONSTS(16)+(CONSTS(14) - CONSTS(16))/(EXP( - CONSTS(19)*(ALGBRC(11) - CONSTS(35)))+1.00000) RATES(6) = - (STATES(6)/CONSTS(21))+ CONSTS(30)*ALGBRC(14) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = 100.000+ 10.0000* sin( 5.00000*VOI) ALGBRC(3) = ( CONSTS(36)*STATES(5) ** 2.00000)/(CONSTS(31) ** 2.00000+STATES(5) ** 2.00000) ALGBRC(4) = ( CONSTS(37)*STATES(6) ** 2.00000)/(CONSTS(32) ** 2.00000+STATES(6) ** 2.00000) ALGBRC(2) = STATES(1)/ 3.14159265358979 ** 0.500000 ALGBRC(5) = (ALGBRC(2) - CONSTS(3))/CONSTS(3) ALGBRC(7) = ALGBRC(5) - STATES(2) ALGBRC(9) = CONSTS(1)*(ALGBRC(7) - CONSTS(2)*CONSTS(28)) ALGBRC(11) = CONSTS(17)*ALGBRC(9) ALGBRC(13) = CONSTS(15)+(CONSTS(13) - CONSTS(15))/(EXP( CONSTS(18)*(ALGBRC(11) - CONSTS(34)))+1.00000) ALGBRC(14) = CONSTS(16)+(CONSTS(14) - CONSTS(16))/(EXP( - CONSTS(19)*(ALGBRC(11) - CONSTS(35)))+1.00000) ALGBRC(6) = CONSTS(33)*ALGBRC(4) ALGBRC(8) = ALGBRC(6)+STATES(8) ALGBRC(10) = CONSTS(24)+STATES(7) ALGBRC(12) = CONSTS(24) - ALGBRC(8) ALGBRC(15) = ALGBRC(12)+( (ALGBRC(10) - CONSTS(24))*(ALGBRC(12) - CONSTS(27)*CONSTS(26)))/(CONSTS(24) - CONSTS(27)*CONSTS(26)) ALGBRC(16) = 60.0000/ALGBRC(15) RETURN END REAL FUNCTION minfunc_0(CONSTS, VARIABLES) REAL CONSTS(*), VARIABLES(*) minfunc_0[1] = abs(RATES(2) - (( CONSTS(5)*(ALGBRC(5) - STATES(2)) - CONSTS(6)*(STATES(2) - STATES(3)))/CONSTS(10)+RATES(3))) minfunc_0[2] = abs(RATES(3) - (( CONSTS(6)*(STATES(2) - STATES(3)) - CONSTS(7)*(STATES(3) - STATES(4)))+ CONSTS(10)*RATES(2)+ CONSTS(11)*RATES(4))/(CONSTS(10)+CONSTS(11))) minfunc_0[3] = abs(RATES(4) - (( CONSTS(7)*(STATES(3) - STATES(4)) - CONSTS(8)*STATES(4))+ CONSTS(11)*RATES(3))/(CONSTS(11)+CONSTS(12))) RETURN END