C C There are a total of 1 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 18 entries in the constant variable array. C C C VOI is time in component environment (hour). C STATES(1) is M in component M (micromolar). C CONSTS(1) is Km in component M (micromolar). C CONSTS(2) is vs in component M (flux). C CONSTS(3) is vm in component M (flux). C CONSTS(4) is n in component M (dimensionless). C CONSTS(5) is KI in component M (micromolar). C STATES(2) is PN in component PN (micromolar). C STATES(3) is P0 in component P0 (micromolar). C CONSTS(6) is ks in component P0 (first_order_rate_constant). C STATES(4) is P1 in component P1 (micromolar). C CONSTS(7) is K1 in component parameters (micromolar). C CONSTS(8) is V1 in component parameters (flux). C CONSTS(9) is K2 in component parameters (micromolar). C CONSTS(10) is V2 in component parameters (flux). C STATES(5) is P2 in component P2 (micromolar). C CONSTS(11) is K3 in component parameters (micromolar). C CONSTS(12) is V3 in component parameters (flux). C CONSTS(13) is K4 in component parameters (micromolar). C CONSTS(14) is V4 in component parameters (flux). C CONSTS(15) is Kd in component P2 (micromolar). C CONSTS(16) is vd in component P2 (flux). C CONSTS(17) is k1 in component parameters (first_order_rate_constant). C CONSTS(18) is k2 in component parameters (first_order_rate_constant). C ALGBRC(1) is Pt in component Pt (micromolar). C RATES(1) is d/dt M in component M (micromolar). C RATES(3) is d/dt P0 in component P0 (micromolar). C RATES(4) is d/dt P1 in component P1 (micromolar). C RATES(5) is d/dt P2 in component P2 (micromolar). C RATES(2) is d/dt PN in component PN (micromolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.6 CONSTS(1) = 0.5 CONSTS(2) = 0.76 CONSTS(3) = 0.65 CONSTS(4) = 4.0 CONSTS(5) = 1.0 STATES(2) = 1.1 STATES(3) = 0.5 CONSTS(6) = 0.38 STATES(4) = 0.6 CONSTS(7) = 2.0 CONSTS(8) = 3.2 CONSTS(9) = 2.0 CONSTS(10) = 1.58 STATES(5) = 0.6 CONSTS(11) = 2.0 CONSTS(12) = 5.0 CONSTS(13) = 2.0 CONSTS(14) = 2.5 CONSTS(15) = 0.2 CONSTS(16) = 0.95 CONSTS(17) = 1.9 CONSTS(18) = 1.3 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = CONSTS(2)*(CONSTS(5) ** CONSTS(4)/(CONSTS(5) ** CONSTS(4)+STATES(2) ** CONSTS(4))) - CONSTS(3)*(STATES(1)/(CONSTS(1)+STATES(1))) RATES(3) = ( CONSTS(6)*STATES(1) - CONSTS(8)*(STATES(3)/(CONSTS(7)+STATES(3))))+ CONSTS(10)*(STATES(4)/(CONSTS(9)+STATES(4))) RATES(4) = ( CONSTS(8)*(STATES(3)/(CONSTS(7)+STATES(3))) - ( CONSTS(10)*(STATES(4)/(CONSTS(9)+STATES(4)))+ CONSTS(12)*(STATES(4)/(CONSTS(11)+STATES(4)))))+ CONSTS(14)*(STATES(5)/(CONSTS(13)+STATES(5))) RATES(5) = (( CONSTS(12)*(STATES(4)/(CONSTS(11)+STATES(4))) - ( CONSTS(14)*(STATES(5)/(CONSTS(13)+STATES(5)))+ CONSTS(17)*STATES(5)))+ CONSTS(18)*STATES(2)) - CONSTS(16)*(STATES(5)/(CONSTS(15)+STATES(5))) RATES(2) = CONSTS(17)*STATES(5) - CONSTS(18)*STATES(2) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(3)+STATES(4)+STATES(5)+STATES(2) RETURN END