MEKi-P
c75
c60
phosphatase3
c10
EGF-EGFRi
jlim063@aucklanduni.ac.nz
c5
(EGF-EGFR*)2
phosphorylated EGF-EGFR complex dimer
c62
ERK-P-phosphatase3
MEK-P-phosphatase2
c54
c39
Shc*-Grb2
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP
c27
c76
MEK-P-Rafi*
c31
Shc
c14
GAP
Grb2-Sos
c30
Ras-GTP*
c43
Prot
c12
c3
EGF-EGFR
EGF-EGFR complex
c6
EGFRi
Muller
c11
(EGF-EGFRi)2
ERKi-P-MEKi-PP
c82
60
Ras-GTP
c28
c65
(EGF-EGFRi*)2-GAP-SHC*-Grb2
c35
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos
c25
(EGF-EGFR*)2-GAP-Grb2-Sos
c36
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
MEKi-PP-phosphatase2
c78
375
20
370
Computational Modeling of the Dynamics of the MAP Kinase Cascade Activated by Surface and Internalized EGF Receptors.
E
Gilles
Eichler-Jonsson
11923843
c91
(EGF-EGFR*)2-GAP-SHC*-Grb2-Prot
ERK-PP
c59
(EGF-EGFRi*)2-GAP-Grb2
c18
c17
(EGF-EGFRi*)2-GAP
(EGF-EGFRi*)2-GAP-SHC
c63
c61
ERK-PP-phosphatase3
Proti
c9
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP
c29
epidermal growth factor
EGF
c1
epidermal growth factor receptor
c2
EGFR
Jeelean Lim
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GDP
c67
Rafi*
c72
c4
(EGF-EGFR)2
EGF-EGFR complex dimer
ERKi-P-phosphatase3
c85
c81
ERKi-P
Ras-GTPi
c69
The Schoeberl et al.'s Model of the Dynamics of the MAP Kinase Cascade Activated by Surface and Internalized EGF Receptors
c80
ERKi-MEKi-PP
ERK
c55
c93
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GDP-Prot
c56
ERK-MEK-PP
c42
Ras-Raf-GTP
c74
MEK-Rafi*
C
c73
Rafi*-phosphatase1
ERK-P-MEK-PP
c58
c45
Raf*
c64
(EGF-EGFRi*)2-GAP-SHC*
ERK-P
c57
c49
MEK-P
phosphatase2
c53
c47
MEK
(EGF-EGFR*)2-GAP-Grb2
c23
c32
(EGF-EGFR*)2-GAP-SHC
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
c68
keyword
EGFRideg
c86
c52
MEK-PP-phosphatase2
2002-04
G
(EGF-EGFRi*)2deg
c87
c90
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GTP-Prot
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GDP
c20
c40
Shc*
c21
(EGF-EGFRi*)2-GAP-Grb2-Sos-Ras-GTP
c83
ERKi-PP
c15
(EGF-EGFR*)2-GAP
(EGF-EGFRi*)2-GAP-SHC*-Grb2-Sos
c66
c16
EGFi
ERKi-PP-phosphatase3
c84
c26
Ras-GDP
c8
(EGF-EGFRi*)2
c70
Raf-Ras-GTPi
c94
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP-Prot
c92
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Prot
c33
(EGF-EGFR*)2-GAP-SHC*
signal transduction
Epidermal Growth Factor
c88
(EGF-EGFR*)2-GAP-Grb2-Sos-Prot
The University of Auckland
Auckland Bioengineering Institute
Mitogen-activated protein kinase
c44
Phosphatase1
MEK-P-Raf*
c50
c48
MEK-Raf*
Jeelean
Ras-GTPi*
c71
c51
MEK-PP
(EGF-EGFR*)2-GAP-Grb20-Prot
c7
(EGF-EGFR*)2-GAP-SHC*-Grb2-Sos-Ras-GTP
c37
Raf*-phosphatase1
c46
c79
MEKi-P-phosphatase2
c77
MEKi-PP
c24
Sos
Grb2
c22
c13
EGFideg
Lim
c19
(EGF-EGFRi*)2-GAP-Grb2-Sos
(EGF-EGFR*)2-GAP-SHC*-Grb2
c34
D
2001-09-10
c38
Shc*-Grb2-Sos
c89
(EGF-EGFR*)2-GAP-Grb2-Sos-Ras-GDP-Prot
c41
Raf
B
Schoeberl
Nature Biotechnology
This is the CellML description of Schoeberl et al.'s model of the dynamics of the MAP kinase cascade activated by surface and internalized EGF receptors