Reaction R1 forward rate constant
Reaction R9 forward rate constant
Receptor not bound to G-alpha-GDP
Area density of noncoupled receptors
PLC-beta bound to calcium (2+)
Binding of calcium to PLC-beta
Reaction R8 flux
G-alpha-GTP density
Reaction R2 forward rate constant
PLC-beta bound to G-alpha-GTP
Binding of PLC-beta to G-alpha-GTP
Reaction R9 flux
Density of PLC-beta bound to calcium (2+)
Receptor bound to G-alpha-GDP
Density of receptors coupled with G-proteins
Ligand bound to phosphorylated receptor and G-alpha-GDP
Phosphorylated receptor density
PIP2 density
Ligand bound to receptor
Ligand bound to receptor and G-alpha-GDP
Dissociation of G-alpha-GTP from activated receptor
Reaction R6 flux
Time domain
Reverse rate constant for the binding of calcium to
PLC-beta
Degradation of G-alpha-GTP
Reaction R7 flux
Degradation of free IP3
Reaction R16 flux
Reaction R11 dissociation rate constant
Reaction R2 reverse rate constant
Factor for converting number of particles to a density on the cell�s plasma membrane
Reaction R15 Km value
Ligand-bound receptor density
Full-strength ligand concentration during stimulation
PLC-beta bound to calcium (2+) and G-alpha-GTP
Density of PLC-beta bound to calcium (2+) and G-alpha-GTP
Reaction R14 Km value
Hydrolysis of PIP2 by calcium-bound PLC-beta
Reaction R14 flux
Density of PLC-beta bound to G-alpha-GTP
Reaction R2 reverse rate constant
Cytosolic volume
IP3 concentration in cytosol
Hydrolysis of PIP2 by calcium-bound PLC-beta and G-alpha-GTP complex
Reaction R15 flux
Area density of free inactive G-protein. "...represents the densities of a species required to form that mobile messenger�the amount of free G-alpha-GDP."
Reaction R3 reverse rate constant
Dissociation of G-alpha-GTP from calcium-bound PLC-beta and degradation
Reaction R12 flux
Reaction R9 forward rate constant
Reaction R10 reverse rate constant
Dissociation constant for the binding of ligand to the receptor with attached G-protein
Rate constant for the nonstimulated IP3 production
reaction
Dissociation of G-alpha-GTP from PLC-beta and degradation
Reaction R13 flux
Active receptor density
Binding of ligand to receptor
Reaction R1 flux
Reaction R1 reverse rate constant
Reaction R13 forward rate constant
Binding of G-alpha-GTP to calcium-bound PLC-beta
Reaction R10 flux
Reaction R7 forward rate constant
Time of ligand stimulation
.1
10000
100
Signal Transduction
keyword
Cooling
Mike
m.cooling@auckland.ac.nz
Auckland Bioengineering Institute
University of Auckland
Hunter
Peter
p.hunter@auckland.ac.nz
Auckland Bioengineering Institute
University of Auckland
Crampin
Edmund
e.crampin@auckland.ac.nz
Auckland Bioengineering Institute
University of Auckland
93
Modeling hypertrophic IP3 transients in the cardiac myocyte
Biophysical Journal
2007-00-00 00:00
3421
3433
Cytosolic calcium (2+) concentration
Extracellular ligand concentration for unstimulated condition
Dissociation constant for the binding of unbound receptor to G-protein
Rate constant for the degradation of IP3
Factor for converting between density fluxes and concentration fluxes
Forward rate constant for the binding of calcium to
PLC-beta
Binding of calcium to G-alpha-GTP-bound PLC-beta
Reaction R11 flux
Reaction R11 reverse rate constant
Factor for converting from number of particles to cytosolic concentration
Reaction R15 forward rate constant
Rate constant for the phosphorylation of active receptor
Cooling
Mike
m.cooling@auckland.ac.nz
The University of Auckland
Auckland Bioengineering Institute
Reaction R10 forward rate constant
Binding of ligand to receptor and G-alpha-GDP
Reaction R4 flux
G-protein dissociation rate from the activated receptor
Phosphorylation of ligand-bound receptor
Reaction R5 flux
Dissociation constant for the binding of ligand to the receptor with no attached G-protein
Reaction R3 forward rate constant
Binding of G-alpha-GDP to receptor
Reaction R2 flux
PLC-beta density
Reaction R12 forward rate constant
Ratio of plasma membrane surface area to cytosolic
volume
Forward rate for the binding of ligand to precoupled receptor
Reaction R11 forward rate constant
Binding of ligand and receptor to G-alpha-GDP
Reaction R3 flux