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Renal Na+/H+ antiporter (NHE3) model
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Renal Na+/H+ antiporter (NHE3) model - figure 3
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Model Mathematics
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Component: environment
Component: Concentrations
d
d
time
C_ext_Na
=
100
Component: NHE3_Parameters
Component: NHE3
alpha_ext_Na
=
C_ext_Na
K_NHE3_Na
beta_ext_H
=
C_ext_H
K_NHE3_H
gamma_ext_NH4
=
C_ext_NH4
K_NHE3_NH4
alpha_int_Na
=
C_int_Na
K_NHE3_Na
beta_int_H
=
C_int_H
K_NHE3_H
gamma_int_NH4
=
C_int_NH4
K_NHE3_NH4
XTxP_NHE3_Na
=
XTxP0_NHE3_Na
2
C_int_H
C_int_H
+
1
e
-6
XTxP_NHE3_H
=
XTxP0_NHE3_H
2
C_int_H
C_int_H
+
1
e
-6
XTxP_NHE3_NH4
=
XTxP0_NHE3_NH4
2
C_int_H
C_int_H
+
1
e
-6
sum_NHE3
=
1
+
alpha_ext_Na
+
beta_ext_H
+
gamma_ext_NH4
XTxP_NHE3_Na
alpha_int_Na
+
XTxP_NHE3_H
beta_int_H
+
XTxP_NHE3_NH4
gamma_int_NH4
+
1
+
alpha_int_Na
+
beta_int_H
+
gamma_int_NH4
XTxP_NHE3_Na
alpha_ext_Na
+
XTxP_NHE3_H
beta_ext_H
+
XTxP_NHE3_NH4
gamma_ext_NH4
J_NHE3_Na
=
XTxP_NHE3_Na
XTxP_NHE3_H
sum_NHE3
alpha_ext_Na
beta_int_H
-
alpha_int_Na
beta_ext_H
+
XTxP_NHE3_Na
XTxP_NHE3_NH4
sum_NHE3
alpha_ext_Na
gamma_int_NH4
-
alpha_int_Na
gamma_ext_NH4
J_NHE3_H
=
XTxP_NHE3_Na
XTxP_NHE3_H
sum_NHE3
alpha_int_Na
beta_ext_H
-
alpha_ext_Na
beta_int_H
+
XTxP_NHE3_H
XTxP_NHE3_NH4
sum_NHE3
beta_ext_H
gamma_int_NH4
-
beta_int_H
gamma_ext_NH4
J_NHE3_NH4
=
XTxP_NHE3_Na
XTxP_NHE3_NH4
sum_NHE3
alpha_int_Na
gamma_ext_NH4
-
alpha_ext_Na
gamma_int_NH4
+
XTxP_NHE3_H
XTxP_NHE3_NH4
sum_NHE3
gamma_ext_NH4
beta_int_H
-
beta_ext_H
gamma_int_NH4
J_NHE3_Na_Max
=
XTxP_NHE3_Na
XTxP_NHE3_H
XTxP_NHE3_Na
+
XTxP_NHE3_H
plot
=
C_ext_Na
J_NHE3_Na
J_NHE3_Na_Max
K_Na
=
beta_int_H
+
2
beta_int_H
beta_ext_H
+
beta_ext_H
beta_int_H
+
1
+
beta_int_H
XTxP_NHE3_Na
XTxP_NHE3_H
Source
Derived from workspace
Weinstein, 1995
at changeset
66bb53476998
.
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.
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Renal Na+/H+ antiporter (NHE3) model
Renal Na+/H+ antiporter (NHE3) model - figure 2
Renal Na+/H+ antiporter (NHE3) model - figure 3
Weinstein_1995_NHE3_Fig3b.cellml
Renal Na+/H+ antiporter (NHE3) model - figure 4
Renal Na+/H+ antiporter (NHE3) model - figure 4b
Renal Na+/H+ antiporter (NHE3) model - figure 5