Generated Code

function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction()
    % This is the "main function".  In Matlab, things work best if you rename this function to match the filename.
   [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel();
end

function [algebraicVariableCount] = getAlgebraicVariableCount() 
    % Used later when setting a global variable with the number of algebraic variables.
    % Note: This is not the "main method".  
    algebraicVariableCount =0;
end
% There are a total of 2 entries in each of the rate and state variable arrays.
% There are a total of 16 entries in the constant variable array.
%

function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel()
    % Create ALGEBRAIC of correct size
    global algebraicVariableCount;  algebraicVariableCount = getAlgebraicVariableCount();
    % Initialise constants and state variables
    [INIT_STATES, CONSTANTS] = initConsts;

    % Set timespan to solve over 
    tspan = [0, 10];

    % Set numerical accuracy options for ODE solver
    options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1);

    % Solve model with ODE solver
    [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options);

    % Compute algebraic variables
    [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS);
    ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI);

    % Plot state variables against variable of integration
    [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends();
    figure();
    plot(VOI, STATES);
    xlabel(LEGEND_VOI);
    l = legend(LEGEND_STATES);
    set(l,'Interpreter','none');
end

function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends()
    LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = '';
    LEGEND_VOI = strpad('time in component environment (minute)');
    LEGEND_STATES(:,1) = strpad('Pha in component Pha (millimolar)');
    LEGEND_CONSTANTS(:,1) = strpad('V_1 in component Pha (per_minute)');
    LEGEND_CONSTANTS(:,2) = strpad('K_1 in component Pha (dimensionless)');
    LEGEND_CONSTANTS(:,3) = strpad('K_2 in component Pha (dimensionless)');
    LEGEND_CONSTANTS(:,4) = strpad('V_M2 in component Pha (per_minute)');
    LEGEND_CONSTANTS(:,5) = strpad('alpha in component Pha (dimensionless)');
    LEGEND_CONSTANTS(:,6) = strpad('GLC in component Pha (millimolar)');
    LEGEND_CONSTANTS(:,7) = strpad('K_a1 in component Pha (millimolar)');
    LEGEND_CONSTANTS(:,8) = strpad('K_a2 in component Pha (millimolar)');
    LEGEND_STATES(:,2) = strpad('GSa in component GSa (millimolar)');
    LEGEND_CONSTANTS(:,9) = strpad('V_M3 in component GSa (per_minute)');
    LEGEND_CONSTANTS(:,10) = strpad('beta in component GSa (dimensionless)');
    LEGEND_CONSTANTS(:,11) = strpad('G6P in component GSa (millimolar)');
    LEGEND_CONSTANTS(:,12) = strpad('K_a3 in component GSa (millimolar)');
    LEGEND_CONSTANTS(:,13) = strpad('K_3 in component GSa (dimensionless)');
    LEGEND_CONSTANTS(:,14) = strpad('K_4 in component GSa (dimensionless)');
    LEGEND_CONSTANTS(:,15) = strpad('K_a4 in component GSa (millimolar)');
    LEGEND_CONSTANTS(:,16) = strpad('V_4 in component GSa (per_minute)');
    LEGEND_RATES(:,1) = strpad('d/dt Pha in component Pha (millimolar)');
    LEGEND_RATES(:,2) = strpad('d/dt GSa in component GSa (millimolar)');
    LEGEND_STATES  = LEGEND_STATES';
    LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC';
    LEGEND_RATES = LEGEND_RATES';
    LEGEND_CONSTANTS = LEGEND_CONSTANTS';
end

function [STATES, CONSTANTS] = initConsts()
    VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = [];
    STATES(:,1) = 0.845;
    CONSTANTS(:,1) = 1.25;
    CONSTANTS(:,2) = 0.1;
    CONSTANTS(:,3) = 0.2;
    CONSTANTS(:,4) = 0.22;
    CONSTANTS(:,5) = 9;
    CONSTANTS(:,6) = 32.5;
    CONSTANTS(:,7) = 10;
    CONSTANTS(:,8) = 10;
    STATES(:,2) = 0.02;
    CONSTANTS(:,9) = 0.05;
    CONSTANTS(:,10) = 9;
    CONSTANTS(:,11) = 0.4;
    CONSTANTS(:,12) = 0.5;
    CONSTANTS(:,13) = 0.4;
    CONSTANTS(:,14) = 0.4;
    CONSTANTS(:,15) = 0.5;
    CONSTANTS(:,16) = 0.2;
    if (isempty(STATES)), warning('Initial values for states not set');, end
end

function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS)
    global algebraicVariableCount;
    statesSize = size(STATES);
    statesColumnCount = statesSize(2);
    if ( statesColumnCount == 1)
        STATES = STATES';
        ALGEBRAIC = zeros(1, algebraicVariableCount);
        utilOnes = 1;
    else
        statesRowCount = statesSize(1);
        ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount);
        RATES = zeros(statesRowCount, statesColumnCount);
        utilOnes = ones(statesRowCount, 1);
    end
    RATES(:,1) = ( CONSTANTS(:,1).*(1.00000 - STATES(:,1)))./((CONSTANTS(:,2)+1.00000) - STATES(:,1)) - ( CONSTANTS(:,4).*STATES(:,1).*(1.00000+( CONSTANTS(:,5).*CONSTANTS(:,6))./(CONSTANTS(:,7)+CONSTANTS(:,6))))./(CONSTANTS(:,3)./(1.00000+CONSTANTS(:,6)./CONSTANTS(:,8))+STATES(:,1));
    RATES(:,2) = ( CONSTANTS(:,9).*(1.00000+( CONSTANTS(:,10).*CONSTANTS(:,11))./(CONSTANTS(:,12)+CONSTANTS(:,11))).*(CONSTANTS(:,2)./(CONSTANTS(:,2)+STATES(:,1))).*(1.00000 - STATES(:,2)))./((CONSTANTS(:,13)./(1.00000+CONSTANTS(:,11)./CONSTANTS(:,15))+1.00000) - STATES(:,2)) - ( CONSTANTS(:,16).*STATES(:,2))./(CONSTANTS(:,14)+ STATES(:,2).*1.00000);
   RATES = RATES';
end

% Calculate algebraic variables
function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI)
    statesSize = size(STATES);
    statesColumnCount = statesSize(2);
    if ( statesColumnCount == 1)
        STATES = STATES';
        utilOnes = 1;
    else
        statesRowCount = statesSize(1);
        utilOnes = ones(statesRowCount, 1);
    end
end

% Pad out or shorten strings to a set length
function strout = strpad(strin)
    req_length = 160;
    insize = size(strin,2);
    if insize > req_length
        strout = strin(1:req_length);
    else
        strout = [strin, blanks(req_length - insize)];
    end
end