Generated Code
The following is python code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
# Size of variable arrays:
sizeAlgebraic = 31
sizeStates = 12
sizeConstants = 32
from math import *
from numpy import *
def createLegends():
legend_states = [""] * sizeStates
legend_rates = [""] * sizeStates
legend_algebraic = [""] * sizeAlgebraic
legend_voi = ""
legend_constants = [""] * sizeConstants
legend_voi = "time in component environment (second)"
legend_algebraic[0] = "q_L_B1_init in component environment (fmol)"
legend_constants[0] = "q_R_B1_init in component environment (fmol)"
legend_constants[1] = "q_Gs_init in component environment (fmol)"
legend_constants[2] = "q_LR_B1_init in component environment (fmol)"
legend_constants[3] = "q_LR_B1Gs_init in component environment (fmol)"
legend_constants[4] = "q_B1d_init in component environment (fmol)"
legend_constants[5] = "q_BARK_init in component environment (fmol)"
legend_constants[6] = "q_LR_B1_BARK_init in component environment (fmol)"
legend_constants[7] = "q_LR_B1Gs_BARK_init in component environment (fmol)"
legend_constants[8] = "q_B1p_init in component environment (fmol)"
legend_constants[9] = "q_PKACI_init in component environment (fmol)"
legend_constants[10] = "q_R_PKACI_init in component environment (fmol)"
legend_algebraic[2] = "q_L_B1 in component environment (fmol)"
legend_algebraic[1] = "q_R_B1 in component environment (fmol)"
legend_algebraic[4] = "q_Gs in component environment (fmol)"
legend_algebraic[6] = "q_LR_B1 in component environment (fmol)"
legend_algebraic[8] = "q_LR_B1Gs in component environment (fmol)"
legend_algebraic[10] = "q_B1d in component environment (fmol)"
legend_algebraic[12] = "q_BARK in component environment (fmol)"
legend_algebraic[14] = "q_LR_B1_BARK in component environment (fmol)"
legend_algebraic[17] = "q_LR_B1Gs_BARK in component environment (fmol)"
legend_algebraic[3] = "q_B1p in component environment (fmol)"
legend_algebraic[5] = "q_PKACI in component environment (fmol)"
legend_algebraic[7] = "q_R_PKACI in component environment (fmol)"
legend_states[0] = "q_L_B1 in component B1AR (fmol)"
legend_states[1] = "q_R_B1 in component B1AR (fmol)"
legend_states[2] = "q_Gs in component B1AR (fmol)"
legend_states[3] = "q_LR_B1 in component B1AR (fmol)"
legend_states[4] = "q_LR_B1Gs in component B1AR (fmol)"
legend_states[5] = "q_B1d in component B1AR (fmol)"
legend_states[6] = "q_BARK in component B1AR (fmol)"
legend_states[7] = "q_LR_B1_BARK in component B1AR (fmol)"
legend_states[8] = "q_LR_B1Gs_BARK in component B1AR (fmol)"
legend_states[9] = "q_B1p in component B1AR (fmol)"
legend_states[10] = "q_PKACI in component B1AR (fmol)"
legend_states[11] = "q_R_PKACI in component B1AR (fmol)"
legend_constants[11] = "kappa_B11 in component B1AR_parameters (fmol_per_sec)"
legend_constants[12] = "kappa_B12 in component B1AR_parameters (fmol_per_sec)"
legend_constants[13] = "kappa_B21 in component B1AR_parameters (fmol_per_sec)"
legend_constants[14] = "kappa_B22 in component B1AR_parameters (fmol_per_sec)"
legend_constants[15] = "kappa_P1 in component B1AR_parameters (fmol_per_sec)"
legend_constants[16] = "kappa_P2 in component B1AR_parameters (fmol_per_sec)"
legend_constants[17] = "K_L_B1 in component B1AR_parameters (per_fmol)"
legend_constants[18] = "K_R_B1 in component B1AR_parameters (per_fmol)"
legend_constants[19] = "K_Gs in component B1AR_parameters (per_fmol)"
legend_constants[20] = "K_LR_B1 in component B1AR_parameters (per_fmol)"
legend_constants[21] = "K_LR_B1Gs in component B1AR_parameters (per_fmol)"
legend_constants[22] = "K_B1d in component B1AR_parameters (per_fmol)"
legend_constants[23] = "K_BARK in component B1AR_parameters (per_fmol)"
legend_constants[24] = "K_LR_B1_BARK in component B1AR_parameters (per_fmol)"
legend_constants[25] = "K_LR_B1Gs_BARK in component B1AR_parameters (per_fmol)"
legend_constants[26] = "K_B1p in component B1AR_parameters (per_fmol)"
legend_constants[27] = "K_PKACI in component B1AR_parameters (per_fmol)"
legend_constants[28] = "K_R_PKACI in component B1AR_parameters (per_fmol)"
legend_constants[29] = "R in component constants (J_per_K_per_mol)"
legend_constants[30] = "T in component constants (kelvin)"
legend_algebraic[27] = "vB11 in component B1AR (fmol_per_sec)"
legend_algebraic[28] = "vB12 in component B1AR (fmol_per_sec)"
legend_algebraic[29] = "vB21 in component B1AR (fmol_per_sec)"
legend_algebraic[30] = "vB22 in component B1AR (fmol_per_sec)"
legend_algebraic[16] = "vP1 in component B1AR (fmol_per_sec)"
legend_algebraic[18] = "vP2 in component B1AR (fmol_per_sec)"
legend_algebraic[19] = "mu_L_B1 in component B1AR (J_per_mol)"
legend_algebraic[9] = "mu_R_B1 in component B1AR (J_per_mol)"
legend_algebraic[20] = "mu_Gs in component B1AR (J_per_mol)"
legend_algebraic[21] = "mu_LR_B1 in component B1AR (J_per_mol)"
legend_algebraic[22] = "mu_LR_B1Gs in component B1AR (J_per_mol)"
legend_algebraic[23] = "mu_B1d in component B1AR (J_per_mol)"
legend_algebraic[24] = "mu_BARK in component B1AR (J_per_mol)"
legend_algebraic[25] = "mu_LR_B1_BARK in component B1AR (J_per_mol)"
legend_algebraic[26] = "mu_LR_B1Gs_BARK in component B1AR (J_per_mol)"
legend_algebraic[11] = "mu_B1p in component B1AR (J_per_mol)"
legend_algebraic[13] = "mu_PKACI in component B1AR (J_per_mol)"
legend_algebraic[15] = "mu_R_PKACI in component B1AR (J_per_mol)"
legend_constants[31] = "F in component constants (C_per_mol)"
legend_rates[0] = "d/dt q_L_B1 in component B1AR (fmol)"
legend_rates[1] = "d/dt q_R_B1 in component B1AR (fmol)"
legend_rates[2] = "d/dt q_Gs in component B1AR (fmol)"
legend_rates[3] = "d/dt q_LR_B1 in component B1AR (fmol)"
legend_rates[5] = "d/dt q_B1d in component B1AR (fmol)"
legend_rates[6] = "d/dt q_BARK in component B1AR (fmol)"
legend_rates[7] = "d/dt q_LR_B1_BARK in component B1AR (fmol)"
legend_rates[4] = "d/dt q_LR_B1Gs in component B1AR (fmol)"
legend_rates[8] = "d/dt q_LR_B1Gs_BARK in component B1AR (fmol)"
legend_rates[9] = "d/dt q_B1p in component B1AR (fmol)"
legend_rates[10] = "d/dt q_PKACI in component B1AR (fmol)"
legend_rates[11] = "d/dt q_R_PKACI in component B1AR (fmol)"
return (legend_states, legend_algebraic, legend_voi, legend_constants)
def initConsts():
constants = [0.0] * sizeConstants; states = [0.0] * sizeStates;
constants[0] = 0.00005
constants[1] = 0.00015
constants[2] = 0
constants[3] = 0.0000508778
constants[4] = 0
constants[5] = 0.0228
constants[6] = 0.0000508778
constants[7] = 0.0000508778
constants[8] = 0
constants[9] = 0.000221209
constants[10] = 0.008778
states[0] = 1e-16
states[1] = 1e-16
states[2] = 1e-16
states[3] = 1e-16
states[4] = 1e-16
states[5] = 1e-16
states[6] = 1e-16
states[7] = 1e-16
states[8] = 1e-16
states[9] = 1e-16
states[10] = 1e-16
states[11] = 1e-16
constants[11] = 0.000282928
constants[12] = 128604
constants[13] = 0.000200356
constants[14] = 91071.1
constants[15] = 2.28764e-05
constants[16] = 10398.4
constants[17] = 2.90698e-08
constants[18] = 1849.44
constants[19] = 0.0410501
constants[20] = 0.0242248
constants[21] = 0.0342084
constants[22] = 2.90698e-08
constants[23] = 0.226042
constants[24] = 0.226042
constants[25] = 0.319199
constants[26] = 1.13021e-09
constants[27] = 7.19049e-05
constants[28] = 2.79561
constants[29] = 8.31
constants[30] = 310
constants[31] = 96485
return (states, constants)
def computeRates(voi, states, constants):
rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic
algebraic[1] = states[1]+constants[0]
algebraic[9] = constants[29]*constants[30]*log(constants[18]*algebraic[1])
algebraic[5] = states[10]+constants[9]
algebraic[13] = constants[29]*constants[30]*log(constants[27]*algebraic[5])
algebraic[7] = states[11]+constants[10]
algebraic[15] = constants[29]*constants[30]*log(constants[28]*algebraic[7])
algebraic[16] = constants[15]*(exp((algebraic[9]+algebraic[13])/(constants[29]*constants[30]))-exp(algebraic[15]/(constants[29]*constants[30])))
rates[1] = -algebraic[16]
rates[9] = -algebraic[16]
algebraic[3] = states[9]+constants[8]
algebraic[11] = constants[29]*constants[30]*log(constants[26]*algebraic[3])
algebraic[18] = constants[16]*(exp(algebraic[15]/(constants[29]*constants[30]))-exp((algebraic[13]+algebraic[11])/(constants[29]*constants[30])))
rates[10] = algebraic[18]-algebraic[16]
rates[11] = algebraic[16]-algebraic[18]
algebraic[6] = states[3]+constants[2]
algebraic[21] = constants[29]*constants[30]*log(constants[20]*algebraic[6])
algebraic[12] = states[6]+constants[5]
algebraic[24] = constants[29]*constants[30]*log(constants[23]*algebraic[12])
algebraic[14] = states[7]+constants[6]
algebraic[25] = constants[29]*constants[30]*log(constants[24]*algebraic[14])
algebraic[27] = constants[11]*(exp((algebraic[21]+algebraic[24])/(constants[29]*constants[30]))-exp(algebraic[25]/(constants[29]*constants[30])))
rates[3] = -algebraic[27]
algebraic[0] = custom_piecewise([greater(sin(2.00000* pi*voi) , 0.100000), 0.000100000 , True, 1.00000e-06])
algebraic[2] = states[0]+algebraic[0]
algebraic[19] = constants[29]*constants[30]*log(constants[17]*algebraic[2])
algebraic[10] = states[5]+constants[4]
algebraic[23] = constants[29]*constants[30]*log(constants[22]*algebraic[10])
algebraic[28] = constants[12]*(exp(algebraic[25]/(constants[29]*constants[30]))-exp((algebraic[24]+algebraic[23]+algebraic[19])/(constants[29]*constants[30])))
rates[7] = algebraic[27]-algebraic[28]
algebraic[8] = states[4]+constants[3]
algebraic[22] = constants[29]*constants[30]*log(constants[21]*algebraic[8])
algebraic[17] = states[8]+constants[7]
algebraic[26] = constants[29]*constants[30]*log(constants[25]*algebraic[17])
algebraic[29] = constants[13]*(exp((algebraic[22]+algebraic[24])/(constants[29]*constants[30]))-exp(algebraic[26]/(constants[29]*constants[30])))
rates[4] = -algebraic[29]
algebraic[4] = states[2]+constants[1]
algebraic[20] = constants[29]*constants[30]*log(constants[19]*algebraic[4])
algebraic[30] = constants[14]*(exp(algebraic[26]/(constants[29]*constants[30]))-exp((algebraic[24]+algebraic[23]+algebraic[19]+algebraic[20])/(constants[29]*constants[30])))
rates[0] = algebraic[28]+algebraic[30]
rates[2] = algebraic[30]
rates[5] = algebraic[28]+algebraic[30]
rates[6] = ((algebraic[28]+algebraic[30])-algebraic[27])-algebraic[29]
rates[8] = algebraic[29]-algebraic[30]
return(rates)
def computeAlgebraic(constants, states, voi):
algebraic = array([[0.0] * len(voi)] * sizeAlgebraic)
states = array(states)
voi = array(voi)
algebraic[1] = states[1]+constants[0]
algebraic[9] = constants[29]*constants[30]*log(constants[18]*algebraic[1])
algebraic[5] = states[10]+constants[9]
algebraic[13] = constants[29]*constants[30]*log(constants[27]*algebraic[5])
algebraic[7] = states[11]+constants[10]
algebraic[15] = constants[29]*constants[30]*log(constants[28]*algebraic[7])
algebraic[16] = constants[15]*(exp((algebraic[9]+algebraic[13])/(constants[29]*constants[30]))-exp(algebraic[15]/(constants[29]*constants[30])))
algebraic[3] = states[9]+constants[8]
algebraic[11] = constants[29]*constants[30]*log(constants[26]*algebraic[3])
algebraic[18] = constants[16]*(exp(algebraic[15]/(constants[29]*constants[30]))-exp((algebraic[13]+algebraic[11])/(constants[29]*constants[30])))
algebraic[6] = states[3]+constants[2]
algebraic[21] = constants[29]*constants[30]*log(constants[20]*algebraic[6])
algebraic[12] = states[6]+constants[5]
algebraic[24] = constants[29]*constants[30]*log(constants[23]*algebraic[12])
algebraic[14] = states[7]+constants[6]
algebraic[25] = constants[29]*constants[30]*log(constants[24]*algebraic[14])
algebraic[27] = constants[11]*(exp((algebraic[21]+algebraic[24])/(constants[29]*constants[30]))-exp(algebraic[25]/(constants[29]*constants[30])))
algebraic[0] = custom_piecewise([greater(sin(2.00000* pi*voi) , 0.100000), 0.000100000 , True, 1.00000e-06])
algebraic[2] = states[0]+algebraic[0]
algebraic[19] = constants[29]*constants[30]*log(constants[17]*algebraic[2])
algebraic[10] = states[5]+constants[4]
algebraic[23] = constants[29]*constants[30]*log(constants[22]*algebraic[10])
algebraic[28] = constants[12]*(exp(algebraic[25]/(constants[29]*constants[30]))-exp((algebraic[24]+algebraic[23]+algebraic[19])/(constants[29]*constants[30])))
algebraic[8] = states[4]+constants[3]
algebraic[22] = constants[29]*constants[30]*log(constants[21]*algebraic[8])
algebraic[17] = states[8]+constants[7]
algebraic[26] = constants[29]*constants[30]*log(constants[25]*algebraic[17])
algebraic[29] = constants[13]*(exp((algebraic[22]+algebraic[24])/(constants[29]*constants[30]))-exp(algebraic[26]/(constants[29]*constants[30])))
algebraic[4] = states[2]+constants[1]
algebraic[20] = constants[29]*constants[30]*log(constants[19]*algebraic[4])
algebraic[30] = constants[14]*(exp(algebraic[26]/(constants[29]*constants[30]))-exp((algebraic[24]+algebraic[23]+algebraic[19]+algebraic[20])/(constants[29]*constants[30])))
return algebraic
def custom_piecewise(cases):
"""Compute result of a piecewise function"""
return select(cases[0::2],cases[1::2])
def solve_model():
"""Solve model with ODE solver"""
from scipy.integrate import ode
# Initialise constants and state variables
(init_states, constants) = initConsts()
# Set timespan to solve over
voi = linspace(0, 10, 500)
# Construct ODE object to solve
r = ode(computeRates)
r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1)
r.set_initial_value(init_states, voi[0])
r.set_f_params(constants)
# Solve model
states = array([[0.0] * len(voi)] * sizeStates)
states[:,0] = init_states
for (i,t) in enumerate(voi[1:]):
if r.successful():
r.integrate(t)
states[:,i+1] = r.y
else:
break
# Compute algebraic variables
algebraic = computeAlgebraic(constants, states, voi)
return (voi, states, algebraic)
def plot_model(voi, states, algebraic):
"""Plot variables against variable of integration"""
import pylab
(legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends()
pylab.figure(1)
pylab.plot(voi,vstack((states,algebraic)).T)
pylab.xlabel(legend_voi)
pylab.legend(legend_states + legend_algebraic, loc='best')
pylab.show()
if __name__ == "__main__":
(voi, states, algebraic) = solve_model()
plot_model(voi, states, algebraic)
