# Size of variable arrays: sizeAlgebraic = 55 sizeStates = 19 sizeConstants = 59 from math import * from numpy import * def createLegends(): legend_states = [""] * sizeStates legend_rates = [""] * sizeStates legend_algebraic = [""] * sizeAlgebraic legend_voi = "" legend_constants = [""] * sizeConstants legend_voi = "time in component environment (second)" legend_constants[0] = "q_RB1_inactive_init in component environment (fmol)" legend_constants[1] = "q_L_RB1_inactive_init in component environment (fmol)" legend_algebraic[0] = "q_LB1_init in component environment (fmol)" legend_constants[2] = "q_RB1_init in component environment (fmol)" legend_constants[3] = "q_Gs_init in component environment (fmol)" legend_constants[4] = "q_RB1_Gs_init in component environment (fmol)" legend_constants[5] = "q_L_RB1_init in component environment (fmol)" legend_constants[6] = "q_L_RB1_Gs_init in component environment (fmol)" legend_constants[7] = "q_Gsa_GTP_init in component environment (fmol)" legend_constants[8] = "q_Gsbetagamma_init in component environment (fmol)" legend_constants[9] = "q_Gsa_GDP_init in component environment (fmol)" legend_constants[10] = "q_GTP_init in component environment (fmol)" legend_constants[11] = "q_GDP_init in component environment (fmol)" legend_constants[12] = "q_Pi_init in component environment (fmol)" legend_constants[13] = "q_RB1_tag_init in component environment (fmol)" legend_constants[14] = "q_L_RB1_tag_init in component environment (fmol)" legend_constants[15] = "q_RB1_GRKArr_init in component environment (fmol)" legend_constants[16] = "q_L_RB1_GRKArr_init in component environment (fmol)" legend_constants[17] = "q_GRKArr_init in component environment (fmol)" legend_constants[18] = "stimSt in component environment (second)" legend_constants[19] = "stimDur in component environment (second)" legend_constants[20] = "tR in component environment (second)" legend_constants[21] = "stimMag in component environment (fmol)" legend_constants[22] = "stimHolding in component environment (fmol)" legend_constants[57] = "m in component environment (fmol_per_sec)" legend_algebraic[1] = "q_RB1_inactive in component environment (fmol)" legend_algebraic[2] = "q_L_RB1_inactive in component environment (fmol)" legend_algebraic[3] = "q_LB1 in component environment (fmol)" legend_algebraic[4] = "q_RB1 in component environment (fmol)" legend_algebraic[5] = "q_Gs in component environment (fmol)" legend_algebraic[6] = "q_RB1_Gs in component environment (fmol)" legend_algebraic[7] = "q_L_RB1 in component environment (fmol)" legend_algebraic[8] = "q_L_RB1_Gs in component environment (fmol)" legend_algebraic[9] = "q_Gsa_GTP in component environment (fmol)" legend_algebraic[10] = "q_Gsbetagamma in component environment (fmol)" legend_algebraic[11] = "q_Gsa_GDP in component environment (fmol)" legend_algebraic[13] = "q_GTP in component environment (fmol)" legend_algebraic[14] = "q_GDP in component environment (fmol)" legend_algebraic[15] = "q_Pi in component environment (fmol)" legend_algebraic[16] = "q_RB1_tag in component environment (fmol)" legend_algebraic[17] = "q_L_RB1_tag in component environment (fmol)" legend_algebraic[18] = "q_RB1_GRKArr in component environment (fmol)" legend_algebraic[19] = "q_L_RB1_GRKArr in component environment (fmol)" legend_algebraic[22] = "q_GRKArr in component environment (fmol)" legend_states[0] = "q_RB1_inactive in component GPCR_B1AR_reduced (fmol)" legend_states[1] = "q_L_RB1_inactive in component GPCR_B1AR_reduced (fmol)" legend_states[2] = "q_LB1 in component GPCR_B1AR_reduced (fmol)" legend_states[3] = "q_RB1 in component GPCR_B1AR_reduced (fmol)" legend_states[4] = "q_Gs in component GPCR_B1AR_reduced (fmol)" legend_states[5] = "q_RB1_Gs in component GPCR_B1AR_reduced (fmol)" legend_states[6] = "q_L_RB1 in component GPCR_B1AR_reduced (fmol)" legend_states[7] = "q_L_RB1_Gs in component GPCR_B1AR_reduced (fmol)" legend_states[8] = "q_Gsa_GTP in component GPCR_B1AR_reduced (fmol)" legend_states[9] = "q_Gsbetagamma in component GPCR_B1AR_reduced (fmol)" legend_states[10] = "q_Gsa_GDP in component GPCR_B1AR_reduced (fmol)" legend_states[11] = "q_GTP in component GPCR_B1AR_reduced (fmol)" legend_states[12] = "q_GDP in component GPCR_B1AR_reduced (fmol)" legend_states[13] = "q_Pi in component GPCR_B1AR_reduced (fmol)" legend_states[14] = "q_RB1_tag in component GPCR_B1AR_reduced (fmol)" legend_states[15] = "q_L_RB1_tag in component GPCR_B1AR_reduced (fmol)" legend_states[16] = "q_RB1_GRKArr in component GPCR_B1AR_reduced (fmol)" legend_states[17] = "q_L_RB1_GRKArr in component GPCR_B1AR_reduced (fmol)" legend_states[18] = "q_GRKArr in component GPCR_B1AR_reduced (fmol)" legend_algebraic[20] = "conserv_R_T in component environment (fmol)" legend_algebraic[21] = "conserv_L_T in component environment (fmol)" legend_algebraic[12] = "conserv_G_T in component environment (fmol)" legend_constants[58] = "total_R_init in component environment (fmol)" legend_constants[23] = "kappa_Rswitch_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[24] = "kappa_LRswitch_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[25] = "kappa_C_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[26] = "kappa_R_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[27] = "kappa_L_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[28] = "kappa_L_actR in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[29] = "kappa_Act1_Gs in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[30] = "kappa_Act2_Gs in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[31] = "kappa_Hyd_Gs in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[32] = "kappa_Reassoc_Gs in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[33] = "kappa_InternR_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[34] = "kappa_InternLR_B1 in component GPCR_B1AR_reduced_parameters (fmol_per_sec)" legend_constants[35] = "K_RB1_inactive in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[36] = "K_L_RB1_inactive in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[37] = "K_LB1 in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[38] = "K_RB1 in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[39] = "K_Gs in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[40] = "K_RB1_Gs in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[41] = "K_L_RB1 in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[42] = "K_L_RB1_Gs in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[43] = "K_Gsa_GTP in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[44] = "K_Gsbetagamma in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[45] = "K_Gsa_GDP in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[46] = "K_GTP in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[47] = "K_GDP in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[48] = "K_Pi in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[49] = "K_RB1_tag in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[50] = "K_L_RB1_tag in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[51] = "K_RB1_GRKArr in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[52] = "K_L_RB1_GRKArr in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[53] = "K_GRKArr in component GPCR_B1AR_reduced_parameters (per_fmol)" legend_constants[54] = "R in component constants (J_per_K_per_mol)" legend_constants[55] = "T in component constants (kelvin)" legend_algebraic[23] = "mu_RB1_inactive in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[24] = "mu_L_RB1_inactive in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[25] = "mu_LB1 in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[26] = "mu_RB1 in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[27] = "mu_Gs in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[28] = "mu_RB1_Gs in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[29] = "mu_L_RB1 in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[30] = "mu_L_RB1_Gs in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[31] = "mu_Gsa_GTP in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[32] = "mu_Gsbetagamma in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[33] = "mu_Gsa_GDP in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[34] = "mu_GTP in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[35] = "mu_GDP in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[36] = "mu_Pi in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[37] = "mu_RB1_tag in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[38] = "mu_L_RB1_tag in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[39] = "mu_RB1_GRKArr in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[40] = "mu_L_RB1_GRKArr in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[41] = "mu_GRKArr in component GPCR_B1AR_reduced (J_per_mol)" legend_algebraic[42] = "v_Rswitch_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[43] = "v_LRswitch_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[44] = "v_C_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[45] = "v_R_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[46] = "v_L_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[48] = "v_L_actR in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[47] = "v_Act1_Gs in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[49] = "v_Act2_Gs in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[50] = "v_Hyd_Gs in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[53] = "v_Reassoc_Gs in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[51] = "v_InternR_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[54] = "v_InternLR_B1 in component GPCR_B1AR_reduced (fmol_per_sec)" legend_algebraic[52] = "v_Rsynthesis in component GPCR_B1AR_reduced (fmol_per_sec)" legend_constants[56] = "F in component constants (C_per_mol)" legend_rates[0] = "d/dt q_RB1_inactive in component GPCR_B1AR_reduced (fmol)" legend_rates[1] = "d/dt q_L_RB1_inactive in component GPCR_B1AR_reduced (fmol)" legend_rates[2] = "d/dt q_LB1 in component GPCR_B1AR_reduced (fmol)" legend_rates[3] = "d/dt q_RB1 in component GPCR_B1AR_reduced (fmol)" legend_rates[4] = "d/dt q_Gs in component GPCR_B1AR_reduced (fmol)" legend_rates[5] = "d/dt q_RB1_Gs in component GPCR_B1AR_reduced (fmol)" legend_rates[6] = "d/dt q_L_RB1 in component GPCR_B1AR_reduced (fmol)" legend_rates[7] = "d/dt q_L_RB1_Gs in component GPCR_B1AR_reduced (fmol)" legend_rates[8] = "d/dt q_Gsa_GTP in component GPCR_B1AR_reduced (fmol)" legend_rates[9] = "d/dt q_Gsbetagamma in component GPCR_B1AR_reduced (fmol)" legend_rates[10] = "d/dt q_Gsa_GDP in component GPCR_B1AR_reduced (fmol)" legend_rates[11] = "d/dt q_GTP in component GPCR_B1AR_reduced (fmol)" legend_rates[12] = "d/dt q_GDP in component GPCR_B1AR_reduced (fmol)" legend_rates[13] = "d/dt q_Pi in component GPCR_B1AR_reduced (fmol)" legend_rates[14] = "d/dt q_RB1_tag in component GPCR_B1AR_reduced (fmol)" legend_rates[15] = "d/dt q_L_RB1_tag in component GPCR_B1AR_reduced (fmol)" legend_rates[16] = "d/dt q_RB1_GRKArr in component GPCR_B1AR_reduced (fmol)" legend_rates[17] = "d/dt q_L_RB1_GRKArr in component GPCR_B1AR_reduced (fmol)" legend_rates[18] = "d/dt q_GRKArr in component GPCR_B1AR_reduced (fmol)" return (legend_states, legend_algebraic, legend_voi, legend_constants) def initConsts(): constants = [0.0] * sizeConstants; states = [0.0] * sizeStates; constants[0] = 0.0004579000e0 constants[1] = 1e-18 constants[2] = 1e-18 constants[3] = 0.1455400000 constants[4] = 1e-18 constants[5] = 1e-18 constants[6] = 1e-18 constants[7] = 0.01 constants[8] = 0.02 constants[9] = 0.01 constants[10] = 2.2 constants[11] = 1.1 constants[12] = 570 constants[13] = 1e-18 constants[14] = 1e-18 constants[15] = 1e-18 constants[16] = 1e-18 constants[17] = 1e-3 constants[18] = 2.5 constants[19] = 5e-1 constants[20] = 5e0 constants[21] = 1e1 constants[22] = 1e-8 states[0] = 1e-16 states[1] = 1e-16 states[2] = 1e-16 states[3] = 1e-16 states[4] = 1e-16 states[5] = 1e-16 states[6] = 1e-16 states[7] = 1e-16 states[8] = 1e-16 states[9] = 1e-16 states[10] = 1e-16 states[11] = 1e-16 states[12] = 1e-16 states[13] = 1e-16 states[14] = 1e-16 states[15] = 1e-16 states[16] = 1e-16 states[17] = 1e-16 states[18] = 1e-16 constants[23] = 1036.38 constants[24] = 1.83921e-07 constants[25] = 891573 constants[26] = 1.58222e+06 constants[27] = 0 constants[28] = 52417.5 constants[29] = 0.000610519 constants[30] = 0.576677 constants[31] = 0.0661821 constants[32] = 8.60273e-06 constants[33] = 0.00230556 constants[34] = 2.17775 constants[35] = 28.0492 constants[36] = 1.58056e+11 constants[37] = 0.0574759 constants[38] = 0.280492 constants[39] = 0.00337913 constants[40] = 1.07597 constants[41] = 0.158056 constants[42] = 0.00113911 constants[43] = 0.00878478 constants[44] = 736.699 constants[45] = 161.34 constants[46] = 823.314 constants[47] = 3.61368e-10 constants[48] = 7.91408e-11 constants[49] = 0.500146 constants[50] = 0.000529497 constants[51] = 1.26086e-05 constants[52] = 1.33485e-08 constants[53] = 732843 constants[54] = 8.31 constants[55] = 310 constants[56] = 96485 constants[57] = constants[21]/constants[20] constants[58] = constants[0]+constants[1]+constants[2]+constants[4]+constants[5]+constants[6] return (states, constants) def computeRates(voi, states, constants): rates = [0.0] * sizeStates; algebraic = [0.0] * sizeAlgebraic algebraic[2] = states[1]+constants[1] algebraic[24] = constants[54]*constants[55]*log(constants[36]*algebraic[2]) algebraic[7] = states[6]+constants[5] algebraic[29] = constants[54]*constants[55]*log(constants[41]*algebraic[7]) algebraic[43] = constants[24]*(exp(algebraic[24]/(constants[54]*constants[55]))-exp(algebraic[29]/(constants[54]*constants[55]))) algebraic[1] = states[0]+constants[0] algebraic[23] = constants[54]*constants[55]*log(constants[35]*algebraic[1]) algebraic[0] = custom_piecewise([less(voi , constants[18]) & greater(voi , constants[18]-constants[20]), constants[22]+constants[57]*((voi-constants[18])+constants[20]) , greater_equal(voi , constants[18]) & less(voi , constants[18]+constants[19]), constants[21]+constants[22] , less_equal(voi , constants[18]+constants[20]+constants[19]) & greater_equal(voi , constants[18]+constants[19]), constants[22]+-constants[57]*(((voi-constants[18])-constants[20])-constants[19]) , True, constants[22]]) algebraic[3] = states[2]+algebraic[0] algebraic[25] = constants[54]*constants[55]*log(constants[37]*algebraic[3]) algebraic[46] = constants[27]*(exp((algebraic[23]+algebraic[25])/(constants[54]*constants[55]))-exp(algebraic[24]/(constants[54]*constants[55]))) rates[1] = -algebraic[43]+algebraic[46] algebraic[4] = states[3]+constants[2] algebraic[26] = constants[54]*constants[55]*log(constants[38]*algebraic[4]) algebraic[5] = states[4]+constants[3] algebraic[27] = constants[54]*constants[55]*log(constants[39]*algebraic[5]) algebraic[6] = states[5]+constants[4] algebraic[28] = constants[54]*constants[55]*log(constants[40]*algebraic[6]) algebraic[44] = constants[25]*(exp((algebraic[26]+algebraic[27])/(constants[54]*constants[55]))-exp(algebraic[28]/(constants[54]*constants[55]))) algebraic[9] = states[8]+constants[7] algebraic[31] = constants[54]*constants[55]*log(constants[43]*algebraic[9]) algebraic[10] = states[9]+constants[8] algebraic[32] = constants[54]*constants[55]*log(constants[44]*algebraic[10]) algebraic[13] = states[11]+constants[10] algebraic[34] = constants[54]*constants[55]*log(constants[46]*algebraic[13]) algebraic[14] = states[12]+constants[11] algebraic[35] = constants[54]*constants[55]*log(constants[47]*algebraic[14]) algebraic[16] = states[14]+constants[13] algebraic[37] = constants[54]*constants[55]*log(constants[49]*algebraic[16]) algebraic[47] = constants[29]*(exp((algebraic[28]+algebraic[34])/(constants[54]*constants[55]))-exp((algebraic[31]+algebraic[32]+algebraic[37]+algebraic[35])/(constants[54]*constants[55]))) rates[5] = algebraic[44]-algebraic[47] algebraic[48] = constants[28]*(exp((algebraic[26]+algebraic[25])/(constants[54]*constants[55]))-exp(algebraic[29]/(constants[54]*constants[55]))) rates[2] = -algebraic[46]-algebraic[48] algebraic[42] = constants[23]*(exp(algebraic[23]/(constants[54]*constants[55]))-exp(algebraic[26]/(constants[54]*constants[55]))) rates[3] = (algebraic[42]-algebraic[44])-algebraic[48] algebraic[8] = states[7]+constants[6] algebraic[30] = constants[54]*constants[55]*log(constants[42]*algebraic[8]) algebraic[45] = constants[26]*(exp((algebraic[29]+algebraic[27])/(constants[54]*constants[55]))-exp(algebraic[30]/(constants[54]*constants[55]))) rates[6] = (algebraic[43]-algebraic[45])+algebraic[48] algebraic[17] = states[15]+constants[14] algebraic[38] = constants[54]*constants[55]*log(constants[50]*algebraic[17]) algebraic[49] = constants[30]*(exp((algebraic[30]+algebraic[34])/(constants[54]*constants[55]))-exp((algebraic[31]+algebraic[32]+algebraic[38]+algebraic[35])/(constants[54]*constants[55]))) rates[7] = algebraic[45]-algebraic[49] rates[11] = -algebraic[47]-algebraic[49] rates[12] = algebraic[47]+algebraic[49] algebraic[52] = algebraic[42]+algebraic[48] rates[0] = (-algebraic[42]-algebraic[46])+0.00000*algebraic[52] algebraic[11] = states[10]+constants[9] algebraic[33] = constants[54]*constants[55]*log(constants[45]*algebraic[11]) algebraic[15] = states[13]+constants[12] algebraic[36] = constants[54]*constants[55]*log(constants[48]*algebraic[15]) algebraic[50] = constants[31]*(exp(algebraic[31]/(constants[54]*constants[55]))-exp((algebraic[33]+algebraic[36])/(constants[54]*constants[55]))) rates[8] = (algebraic[47]+algebraic[49])-algebraic[50] rates[13] = algebraic[50] algebraic[18] = states[16]+constants[15] algebraic[39] = constants[54]*constants[55]*log(constants[51]*algebraic[18]) algebraic[22] = states[18]+constants[17] algebraic[41] = constants[54]*constants[55]*log(constants[53]*algebraic[22]) algebraic[51] = constants[33]*(exp((algebraic[37]+algebraic[41])/(constants[54]*constants[55]))-exp(algebraic[39]/(constants[54]*constants[55]))) rates[14] = algebraic[47]-algebraic[51] rates[16] = algebraic[51] algebraic[53] = constants[32]*(exp((algebraic[33]+algebraic[32])/(constants[54]*constants[55]))-exp(algebraic[27]/(constants[54]*constants[55]))) rates[4] = (-algebraic[44]-algebraic[45])+algebraic[53] rates[9] = (algebraic[47]+algebraic[49])-algebraic[53] rates[10] = algebraic[50]-algebraic[53] algebraic[19] = states[17]+constants[16] algebraic[40] = constants[54]*constants[55]*log(constants[52]*algebraic[19]) algebraic[54] = constants[34]*(exp((algebraic[38]+algebraic[41])/(constants[54]*constants[55]))-exp(algebraic[40]/(constants[54]*constants[55]))) rates[15] = algebraic[49]-algebraic[54] rates[17] = algebraic[54] rates[18] = -algebraic[51]-algebraic[54] return(rates) def computeAlgebraic(constants, states, voi): algebraic = array([[0.0] * len(voi)] * sizeAlgebraic) states = array(states) voi = array(voi) algebraic[2] = states[1]+constants[1] algebraic[24] = constants[54]*constants[55]*log(constants[36]*algebraic[2]) algebraic[7] = states[6]+constants[5] algebraic[29] = constants[54]*constants[55]*log(constants[41]*algebraic[7]) algebraic[43] = constants[24]*(exp(algebraic[24]/(constants[54]*constants[55]))-exp(algebraic[29]/(constants[54]*constants[55]))) algebraic[1] = states[0]+constants[0] algebraic[23] = constants[54]*constants[55]*log(constants[35]*algebraic[1]) algebraic[0] = custom_piecewise([less(voi , constants[18]) & greater(voi , constants[18]-constants[20]), constants[22]+constants[57]*((voi-constants[18])+constants[20]) , greater_equal(voi , constants[18]) & less(voi , constants[18]+constants[19]), constants[21]+constants[22] , less_equal(voi , constants[18]+constants[20]+constants[19]) & greater_equal(voi , constants[18]+constants[19]), constants[22]+-constants[57]*(((voi-constants[18])-constants[20])-constants[19]) , True, constants[22]]) algebraic[3] = states[2]+algebraic[0] algebraic[25] = constants[54]*constants[55]*log(constants[37]*algebraic[3]) algebraic[46] = constants[27]*(exp((algebraic[23]+algebraic[25])/(constants[54]*constants[55]))-exp(algebraic[24]/(constants[54]*constants[55]))) algebraic[4] = states[3]+constants[2] algebraic[26] = constants[54]*constants[55]*log(constants[38]*algebraic[4]) algebraic[5] = states[4]+constants[3] algebraic[27] = constants[54]*constants[55]*log(constants[39]*algebraic[5]) algebraic[6] = states[5]+constants[4] algebraic[28] = constants[54]*constants[55]*log(constants[40]*algebraic[6]) algebraic[44] = constants[25]*(exp((algebraic[26]+algebraic[27])/(constants[54]*constants[55]))-exp(algebraic[28]/(constants[54]*constants[55]))) algebraic[9] = states[8]+constants[7] algebraic[31] = constants[54]*constants[55]*log(constants[43]*algebraic[9]) algebraic[10] = states[9]+constants[8] algebraic[32] = constants[54]*constants[55]*log(constants[44]*algebraic[10]) algebraic[13] = states[11]+constants[10] algebraic[34] = constants[54]*constants[55]*log(constants[46]*algebraic[13]) algebraic[14] = states[12]+constants[11] algebraic[35] = constants[54]*constants[55]*log(constants[47]*algebraic[14]) algebraic[16] = states[14]+constants[13] algebraic[37] = constants[54]*constants[55]*log(constants[49]*algebraic[16]) algebraic[47] = constants[29]*(exp((algebraic[28]+algebraic[34])/(constants[54]*constants[55]))-exp((algebraic[31]+algebraic[32]+algebraic[37]+algebraic[35])/(constants[54]*constants[55]))) algebraic[48] = constants[28]*(exp((algebraic[26]+algebraic[25])/(constants[54]*constants[55]))-exp(algebraic[29]/(constants[54]*constants[55]))) algebraic[42] = constants[23]*(exp(algebraic[23]/(constants[54]*constants[55]))-exp(algebraic[26]/(constants[54]*constants[55]))) algebraic[8] = states[7]+constants[6] algebraic[30] = constants[54]*constants[55]*log(constants[42]*algebraic[8]) algebraic[45] = constants[26]*(exp((algebraic[29]+algebraic[27])/(constants[54]*constants[55]))-exp(algebraic[30]/(constants[54]*constants[55]))) algebraic[17] = states[15]+constants[14] algebraic[38] = constants[54]*constants[55]*log(constants[50]*algebraic[17]) algebraic[49] = constants[30]*(exp((algebraic[30]+algebraic[34])/(constants[54]*constants[55]))-exp((algebraic[31]+algebraic[32]+algebraic[38]+algebraic[35])/(constants[54]*constants[55]))) algebraic[52] = algebraic[42]+algebraic[48] algebraic[11] = states[10]+constants[9] algebraic[33] = constants[54]*constants[55]*log(constants[45]*algebraic[11]) algebraic[15] = states[13]+constants[12] algebraic[36] = constants[54]*constants[55]*log(constants[48]*algebraic[15]) algebraic[50] = constants[31]*(exp(algebraic[31]/(constants[54]*constants[55]))-exp((algebraic[33]+algebraic[36])/(constants[54]*constants[55]))) algebraic[18] = states[16]+constants[15] algebraic[39] = constants[54]*constants[55]*log(constants[51]*algebraic[18]) algebraic[22] = states[18]+constants[17] algebraic[41] = constants[54]*constants[55]*log(constants[53]*algebraic[22]) algebraic[51] = constants[33]*(exp((algebraic[37]+algebraic[41])/(constants[54]*constants[55]))-exp(algebraic[39]/(constants[54]*constants[55]))) algebraic[53] = constants[32]*(exp((algebraic[33]+algebraic[32])/(constants[54]*constants[55]))-exp(algebraic[27]/(constants[54]*constants[55]))) algebraic[19] = states[17]+constants[16] algebraic[40] = constants[54]*constants[55]*log(constants[52]*algebraic[19]) algebraic[54] = constants[34]*(exp((algebraic[38]+algebraic[41])/(constants[54]*constants[55]))-exp(algebraic[40]/(constants[54]*constants[55]))) algebraic[12] = algebraic[5]+algebraic[6]+algebraic[8]+algebraic[9]+algebraic[11] algebraic[20] = algebraic[1]+algebraic[2]+algebraic[4]+algebraic[6]+algebraic[7]+algebraic[8]+algebraic[16]+algebraic[17]+algebraic[18]+algebraic[19] algebraic[21] = algebraic[2]+algebraic[3]+algebraic[7]+algebraic[8]+algebraic[17]+algebraic[19] return algebraic def custom_piecewise(cases): """Compute result of a piecewise function""" return select(cases[0::2],cases[1::2]) def solve_model(): """Solve model with ODE solver""" from scipy.integrate import ode # Initialise constants and state variables (init_states, constants) = initConsts() # Set timespan to solve over voi = linspace(0, 10, 500) # Construct ODE object to solve r = ode(computeRates) r.set_integrator('vode', method='bdf', atol=1e-06, rtol=1e-06, max_step=1) r.set_initial_value(init_states, voi[0]) r.set_f_params(constants) # Solve model states = array([[0.0] * len(voi)] * sizeStates) states[:,0] = init_states for (i,t) in enumerate(voi[1:]): if r.successful(): r.integrate(t) states[:,i+1] = r.y else: break # Compute algebraic variables algebraic = computeAlgebraic(constants, states, voi) return (voi, states, algebraic) def plot_model(voi, states, algebraic): """Plot variables against variable of integration""" import pylab (legend_states, legend_algebraic, legend_voi, legend_constants) = createLegends() pylab.figure(1) pylab.plot(voi,vstack((states,algebraic)).T) pylab.xlabel(legend_voi) pylab.legend(legend_states + legend_algebraic, loc='best') pylab.show() if __name__ == "__main__": (voi, states, algebraic) = solve_model() plot_model(voi, states, algebraic)