/* There are a total of 28 entries in the algebraic variable array. There are a total of 22 entries in each of the rate and state variable arrays. There are a total of 48 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is q_Cai_init in component environment (fmol). * CONSTANTS[1] is q_TRPN_init in component environment (fmol). * CONSTANTS[2] is q_Ca_TRPN_init in component environment (fmol). * CONSTANTS[3] is q_B_init in component environment (fmol). * CONSTANTS[4] is q_U_init in component environment (fmol). * CONSTANTS[5] is q_W_init in component environment (fmol). * CONSTANTS[6] is q_S_init in component environment (fmol). * ALGEBRAIC[0] is q_TRPN in component environment (fmol). * ALGEBRAIC[1] is q_Cai in component environment (fmol). * ALGEBRAIC[2] is q_Ca_TRPN in component environment (fmol). * ALGEBRAIC[3] is q_B in component environment (fmol). * ALGEBRAIC[4] is q_U in component environment (fmol). * ALGEBRAIC[5] is q_W in component environment (fmol). * ALGEBRAIC[6] is q_S in component environment (fmol). * STATES[0] is q_TRPN in component crossbridge_TRPN (fmol). * STATES[1] is q_Cai in component crossbridge_TRPN (fmol). * STATES[2] is q_Ca_TRPN in component crossbridge_TRPN (fmol). * STATES[3] is q_B in component crossbridge_TRPN (fmol). * STATES[4] is q_U in component crossbridge_TRPN (fmol). * STATES[5] is q_W in component crossbridge_TRPN (fmol). * STATES[6] is q_S in component crossbridge_TRPN (fmol). * STATES[11] is T_total in component crossbridge_TRPN (kPa). * STATES[7] is SL in component crossbridge_TRPN (metre). * CONSTANTS[7] is kappa_R_TRPNCa in component crossbridge_TRPN_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_R_BU in component crossbridge_TRPN_parameters (fmol_per_sec). * CONSTANTS[9] is kappa_R_UW in component crossbridge_TRPN_parameters (fmol_per_sec). * CONSTANTS[10] is kappa_R_WS in component crossbridge_TRPN_parameters (fmol_per_sec). * CONSTANTS[11] is kappa_R_SU in component crossbridge_TRPN_parameters (fmol_per_sec). * CONSTANTS[12] is K_TRPN in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[13] is K_Cai in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[14] is K_Ca_TRPN in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[15] is K_B in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[16] is K_U in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[17] is K_W in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[18] is K_S in component crossbridge_TRPN_parameters (per_fmol). * CONSTANTS[19] is R in component constants (J_per_K_per_mol). * CONSTANTS[20] is T in component constants (kelvin). * CONSTANTS[21] is n_Tm in component crossbridge_TRPN (dimensionless). * ALGEBRAIC[7] is mu_TRPN in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[8] is mu_Cai in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[9] is mu_Ca_TRPN in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[10] is mu_B in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[11] is mu_U in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[12] is mu_W in component crossbridge_TRPN (J_per_mol). * ALGEBRAIC[13] is mu_S in component crossbridge_TRPN (J_per_mol). * STATES[12] is v_R_TRPNCa in component crossbridge_TRPN (fmol_per_sec). * ALGEBRAIC[14] is v_R_BU in component crossbridge_TRPN (fmol_per_sec). * ALGEBRAIC[15] is v_R_UW in component crossbridge_TRPN (fmol_per_sec). * ALGEBRAIC[16] is v_R_WS in component crossbridge_TRPN (fmol_per_sec). * ALGEBRAIC[17] is v_R_SU in component crossbridge_TRPN (fmol_per_sec). * STATES[13] is tension in component crossbridge_TRPN (N_per_mm2). * STATES[14] is mu_tension in component crossbridge_TRPN (J_per_mol). * CONSTANTS[22] is kf_coeff in component crossbridge_TRPN (dimensionless). * CONSTANTS[43] is n in component crossbridge_TRPN (J_per_mol). * CONSTANTS[23] is hh in component crossbridge_TRPN (mm2_per_N). * CONSTANTS[24] is SL_0 in component crossbridge_TRPN (metre). * CONSTANTS[25] is q_MS in component crossbridge_TRPN (fmol). * CONSTANTS[26] is r_s in component crossbridge_TRPN (dimensionless). * CONSTANTS[27] is r_w in component crossbridge_TRPN (dimensionless). * CONSTANTS[28] is A_eff in component crossbridge_TRPN (dimensionless). * CONSTANTS[29] is phi in component crossbridge_TRPN (dimensionless). * CONSTANTS[30] is k_uw in component crossbridge_TRPN (per_sec). * CONSTANTS[31] is k_ws in component crossbridge_TRPN (per_sec). * STATES[8] is G_w in component crossbridge_TRPN (metre). * STATES[9] is G_s in component crossbridge_TRPN (metre). * CONSTANTS[40] is c_w in component crossbridge_TRPN (per_sec). * CONSTANTS[41] is c_s in component crossbridge_TRPN (per_sec). * CONSTANTS[42] is A_w in component crossbridge_TRPN (dimensionless). * CONSTANTS[44] is A_s in component crossbridge_TRPN (dimensionless). * ALGEBRAIC[20] is mu_1 in component crossbridge_TRPN (J_per_m). * CONSTANTS[45] is mu_2 in component crossbridge_TRPN (J_per_m). * ALGEBRAIC[18] is mu_3 in component crossbridge_TRPN (J_per_m). * ALGEBRAIC[21] is mu_4 in component crossbridge_TRPN (J_per_m). * CONSTANTS[46] is mu_5 in component crossbridge_TRPN (J_per_m). * ALGEBRAIC[19] is mu_6 in component crossbridge_TRPN (J_per_m). * ALGEBRAIC[25] is v_1 in component crossbridge_TRPN (m_per_s). * CONSTANTS[32] is v_2 in component crossbridge_TRPN (m_per_s). * ALGEBRAIC[26] is v_4 in component crossbridge_TRPN (m_per_s). * CONSTANTS[33] is v_to_mu in component crossbridge_TRPN (Js_per_m2). * ALGEBRAIC[27] is T_active in component crossbridge_TRPN (kPa). * CONSTANTS[34] is T_ref in component crossbridge_TRPN (kPa). * ALGEBRAIC[24] is mu_T_a in component crossbridge_TRPN (kPa). * ALGEBRAIC[22] is mu_T_S in component crossbridge_TRPN (kPa). * ALGEBRAIC[23] is mu_T_W in component crossbridge_TRPN (kPa). * STATES[10] is Cdd in component crossbridge_TRPN (metre). * STATES[15] is eta in component crossbridge_TRPN (per_sec). * CONSTANTS[35] is eta_l in component crossbridge_TRPN (per_sec). * CONSTANTS[36] is eta_s in component crossbridge_TRPN (per_sec). * CONSTANTS[37] is k in component crossbridge_TRPN (dimensionless). * CONSTANTS[38] is alpha in component crossbridge_TRPN (kPa). * STATES[16] is v_Cdd in component crossbridge_TRPN (m_per_s). * STATES[17] is mu_d in component crossbridge_TRPN (J_per_m). * STATES[18] is mu_k in component crossbridge_TRPN (J_per_m). * STATES[19] is mu_f in component crossbridge_TRPN (J_per_m). * STATES[20] is mu_T_passive in component crossbridge_TRPN (kPa). * STATES[21] is T_passive in component crossbridge_TRPN (kPa). * CONSTANTS[39] is F in component constants (C_per_mol). * RATES[1] is d/dt q_Cai in component crossbridge_TRPN (fmol). * RATES[0] is d/dt q_TRPN in component crossbridge_TRPN (fmol). * RATES[2] is d/dt q_Ca_TRPN in component crossbridge_TRPN (fmol). * RATES[3] is d/dt q_B in component crossbridge_TRPN (fmol). * RATES[4] is d/dt q_U in component crossbridge_TRPN (fmol). * RATES[5] is d/dt q_W in component crossbridge_TRPN (fmol). * RATES[6] is d/dt q_S in component crossbridge_TRPN (fmol). * RATES[8] is d/dt G_w in component crossbridge_TRPN (metre). * RATES[7] is d/dt SL in component crossbridge_TRPN (metre). * RATES[9] is d/dt G_s in component crossbridge_TRPN (metre). * RATES[10] is d/dt Cdd in component crossbridge_TRPN (metre). * There are a total of 1 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 6.82e-1; CONSTANTS[1] = 2.57; CONSTANTS[2] = 1e-6; CONSTANTS[3] = 1; CONSTANTS[4] = 0; CONSTANTS[5] = 0; CONSTANTS[6] = 0; STATES[0] = 1e-16; STATES[1] = 1e-16; STATES[2] = 1e-16; STATES[3] = 1e-16; STATES[4] = 1e-16; STATES[5] = 1e-16; STATES[6] = 1e-16; STATES[7] = 1e-6; CONSTANTS[7] = 52.0453; CONSTANTS[8] = 2.90875; CONSTANTS[9] = 0.332501; CONSTANTS[10] = 0.00782356; CONSTANTS[11] = 140824; CONSTANTS[12] = 1.27424; CONSTANTS[13] = 1.27424; CONSTANTS[14] = 0.11171; CONSTANTS[15] = 6.06164; CONSTANTS[16] = 2.27312; CONSTANTS[17] = 14.8627; CONSTANTS[18] = 3.71567e-06; CONSTANTS[19] = 8.31; CONSTANTS[20] = 310; CONSTANTS[21] = 1.1; CONSTANTS[22] = -0.0118; CONSTANTS[23] = 1; CONSTANTS[24] = 2e-6; CONSTANTS[25] = 1e-6; CONSTANTS[26] = 0.25; CONSTANTS[27] = 0.5; CONSTANTS[28] = 25; CONSTANTS[29] = 2.23; CONSTANTS[30] = 26; CONSTANTS[31] = 4; STATES[8] = 1e-6; STATES[9] = 1e-6; CONSTANTS[32] = 0; CONSTANTS[33] = 1; CONSTANTS[34] = 40.5; STATES[10] = 0; CONSTANTS[35] = 200e3; CONSTANTS[36] = 200e3; CONSTANTS[37] = 7; CONSTANTS[38] = 2.1; CONSTANTS[39] = 96485; CONSTANTS[40] = ( CONSTANTS[29]*CONSTANTS[30]*(1.00000 - CONSTANTS[27]))/CONSTANTS[27]; CONSTANTS[41] = ( CONSTANTS[29]*CONSTANTS[31]*(1.00000 - CONSTANTS[26])*CONSTANTS[27])/CONSTANTS[26]; CONSTANTS[42] = ( CONSTANTS[28]*CONSTANTS[26])/( (1.00000 - CONSTANTS[26])*CONSTANTS[27]+CONSTANTS[26]); CONSTANTS[43] = CONSTANTS[22]*CONSTANTS[19]*CONSTANTS[20]; CONSTANTS[47] = CONSTANTS[32]; CONSTANTS[44] = CONSTANTS[42]; CONSTANTS[45] = - CONSTANTS[42]*CONSTANTS[32]*CONSTANTS[33]; CONSTANTS[46] = - CONSTANTS[44]*CONSTANTS[32]*CONSTANTS[33]; STATES[11] = 0.1001; STATES[12] = 0.1001; STATES[13] = 0.1001; STATES[14] = 0.1001; STATES[15] = 0.1001; STATES[16] = 0.1001; STATES[17] = 0.1001; STATES[18] = 0.1001; STATES[19] = 0.1001; STATES[20] = 0.1001; STATES[21] = 0.1001; RATES[1] = 0.1001; RATES[0] = 0.1001; RATES[2] = 0.1001; RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; RATES[10] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = STATES[12] - CONSTANTS[7]*(exp((ALGEBRAIC[8]+ALGEBRAIC[7])/( CONSTANTS[19]*CONSTANTS[20])) - exp((ALGEBRAIC[9]+STATES[14])/( CONSTANTS[19]*CONSTANTS[20]))); resid[1] = RATES[1] - - STATES[12]; resid[2] = RATES[0] - - STATES[12]; resid[3] = RATES[2] - STATES[12]; resid[4] = RATES[3] - - ALGEBRAIC[14]; resid[5] = RATES[4] - (ALGEBRAIC[14] - ALGEBRAIC[15])+ALGEBRAIC[17]; resid[6] = RATES[5] - ALGEBRAIC[15] - ALGEBRAIC[16]; resid[7] = RATES[6] - ALGEBRAIC[16] - ALGEBRAIC[17]; resid[8] = STATES[13] - STATES[11]*1000.00; resid[9] = STATES[14] - CONSTANTS[23]*CONSTANTS[43]*STATES[13]; resid[10] = RATES[8] - ALGEBRAIC[25]; resid[11] = RATES[9] - ALGEBRAIC[26]; resid[12] = STATES[15] - (CONDVAR[0]>0.00000 ? CONSTANTS[35] : CONSTANTS[36]); resid[13] = RATES[10] - STATES[16]; resid[14] = STATES[16] - STATES[17]/CONSTANTS[33]; resid[15] = STATES[18] - (CONSTANTS[37]/STATES[15])*STATES[10]*CONSTANTS[33]; resid[16] = STATES[19] - (CONSTANTS[37]/STATES[15])*(STATES[7] - CONSTANTS[24])*CONSTANTS[33]; resid[17] = STATES[17] - - STATES[18]+STATES[19]; resid[18] = STATES[20] - (( CONSTANTS[38]*STATES[15])/CONSTANTS[24])*STATES[16]; resid[19] = STATES[21] - STATES[20]; resid[20] = STATES[11] - ALGEBRAIC[27]+STATES[21]; resid[21] = RATES[7] - CONSTANTS[47]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[0]+CONSTANTS[1]; ALGEBRAIC[7] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[12]*ALGEBRAIC[0]); ALGEBRAIC[1] = STATES[1]+CONSTANTS[0]; ALGEBRAIC[8] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[13]*ALGEBRAIC[1]); ALGEBRAIC[2] = STATES[2]+CONSTANTS[2]; ALGEBRAIC[9] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[14]*ALGEBRAIC[2]); ALGEBRAIC[3] = STATES[3]+CONSTANTS[3]; ALGEBRAIC[10] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[15]*ALGEBRAIC[3]); ALGEBRAIC[4] = STATES[4]+CONSTANTS[4]; ALGEBRAIC[11] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[16]*ALGEBRAIC[4]); ALGEBRAIC[14] = CONSTANTS[8]*(exp((ALGEBRAIC[10]+ CONSTANTS[21]*ALGEBRAIC[9])/( CONSTANTS[19]*CONSTANTS[20])) - exp((ALGEBRAIC[11]+ CONSTANTS[21]*ALGEBRAIC[9])/( CONSTANTS[19]*CONSTANTS[20]))); ALGEBRAIC[5] = STATES[5]+CONSTANTS[5]; ALGEBRAIC[12] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[17]*ALGEBRAIC[5]); ALGEBRAIC[15] = CONSTANTS[9]*(exp(ALGEBRAIC[11]/( CONSTANTS[19]*CONSTANTS[20])) - exp(ALGEBRAIC[12]/( CONSTANTS[19]*CONSTANTS[20]))); ALGEBRAIC[6] = STATES[6]+CONSTANTS[6]; ALGEBRAIC[13] = CONSTANTS[19]*CONSTANTS[20]*log( CONSTANTS[18]*ALGEBRAIC[6]); ALGEBRAIC[16] = CONSTANTS[10]*(exp(ALGEBRAIC[12]/( CONSTANTS[19]*CONSTANTS[20])) - exp(ALGEBRAIC[13]/( CONSTANTS[19]*CONSTANTS[20]))); ALGEBRAIC[17] = CONSTANTS[11]*(exp(ALGEBRAIC[13]/( CONSTANTS[19]*CONSTANTS[20])) - exp(ALGEBRAIC[11]/( CONSTANTS[19]*CONSTANTS[20]))); ALGEBRAIC[18] = CONSTANTS[40]*STATES[8]*CONSTANTS[33]; ALGEBRAIC[20] = - CONSTANTS[45] - ALGEBRAIC[18]; ALGEBRAIC[25] = ALGEBRAIC[20]/CONSTANTS[33]; ALGEBRAIC[19] = CONSTANTS[41]*STATES[9]*CONSTANTS[33]; ALGEBRAIC[21] = - CONSTANTS[46] - ALGEBRAIC[19]; ALGEBRAIC[26] = ALGEBRAIC[21]/CONSTANTS[33]; ALGEBRAIC[22] = (CONSTANTS[34]/( CONSTANTS[24]*CONSTANTS[25]*CONSTANTS[26]))*STATES[6]*(STATES[9]+CONSTANTS[24]); ALGEBRAIC[23] = (CONSTANTS[34]/( CONSTANTS[24]*CONSTANTS[25]*CONSTANTS[26]))*STATES[5]*STATES[8]; ALGEBRAIC[24] = ALGEBRAIC[22]+ALGEBRAIC[23]; ALGEBRAIC[27] = ALGEBRAIC[24]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[11] = 0.0; SI[7] = 1.0; SI[12] = 0.0; SI[13] = 0.0; SI[14] = 0.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[15] = 0.0; SI[16] = 0.0; SI[17] = 0.0; SI[18] = 0.0; SI[19] = 0.0; SI[20] = 0.0; SI[21] = 0.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = STATES[17] - 0.00000; }