C C There are a total of 39 entries in the algebraic variable array. C There are a total of 11 entries in each of the rate and state variable arrays. C There are a total of 48 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is q_Cai_init in component environment (fmol). C CONSTS(2) is q_TRPN_init in component environment (fmol). C CONSTS(3) is q_Ca_TRPN_init in component environment (fmol). C CONSTS(4) is q_B_init in component environment (fmol). C CONSTS(5) is q_U_init in component environment (fmol). C CONSTS(6) is q_W_init in component environment (fmol). C CONSTS(7) is q_S_init in component environment (fmol). C ALGBRC(3) is q_TRPN in component environment (fmol). C ALGBRC(6) is q_Cai in component environment (fmol). C ALGBRC(9) is q_Ca_TRPN in component environment (fmol). C ALGBRC(10) is q_B in component environment (fmol). C ALGBRC(11) is q_U in component environment (fmol). C ALGBRC(12) is q_W in component environment (fmol). C ALGBRC(13) is q_S in component environment (fmol). C STATES(1) is q_TRPN in component crossbridge_TRPN (fmol). C STATES(2) is q_Cai in component crossbridge_TRPN (fmol). C STATES(3) is q_Ca_TRPN in component crossbridge_TRPN (fmol). C STATES(4) is q_B in component crossbridge_TRPN (fmol). C STATES(5) is q_U in component crossbridge_TRPN (fmol). C STATES(6) is q_W in component crossbridge_TRPN (fmol). C STATES(7) is q_S in component crossbridge_TRPN (fmol). C ALGBRC(36) is T_total in component crossbridge_TRPN (kPa). C STATES(8) is SL in component crossbridge_TRPN (metre). C CONSTS(8) is kappa_R_TRPNCa in component crossbridge_TRPN_parameters (fmol_per_sec). C CONSTS(9) is kappa_R_BU in component crossbridge_TRPN_parameters (fmol_per_sec). C CONSTS(10) is kappa_R_UW in component crossbridge_TRPN_parameters (fmol_per_sec). C CONSTS(11) is kappa_R_WS in component crossbridge_TRPN_parameters (fmol_per_sec). C CONSTS(12) is kappa_R_SU in component crossbridge_TRPN_parameters (fmol_per_sec). C CONSTS(13) is K_TRPN in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(14) is K_Cai in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(15) is K_Ca_TRPN in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(16) is K_B in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(17) is K_U in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(18) is K_W in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(19) is K_S in component crossbridge_TRPN_parameters (per_fmol). C CONSTS(20) is R in component constants (J_per_K_per_mol). C CONSTS(21) is T in component constants (kelvin). C CONSTS(22) is n_Tm in component crossbridge_TRPN (dimensionless). C ALGBRC(14) is mu_TRPN in component crossbridge_TRPN (J_per_mol). C ALGBRC(15) is mu_Cai in component crossbridge_TRPN (J_per_mol). C ALGBRC(16) is mu_Ca_TRPN in component crossbridge_TRPN (J_per_mol). C ALGBRC(17) is mu_B in component crossbridge_TRPN (J_per_mol). C ALGBRC(19) is mu_U in component crossbridge_TRPN (J_per_mol). C ALGBRC(21) is mu_W in component crossbridge_TRPN (J_per_mol). C ALGBRC(23) is mu_S in component crossbridge_TRPN (J_per_mol). C ALGBRC(39) is v_R_TRPNCa in component crossbridge_TRPN (fmol_per_sec). C ALGBRC(25) is v_R_BU in component crossbridge_TRPN (fmol_per_sec). C ALGBRC(31) is v_R_UW in component crossbridge_TRPN (fmol_per_sec). C ALGBRC(33) is v_R_WS in component crossbridge_TRPN (fmol_per_sec). C ALGBRC(35) is v_R_SU in component crossbridge_TRPN (fmol_per_sec). C ALGBRC(37) is tension in component crossbridge_TRPN (N_per_mm2). C ALGBRC(38) is mu_tension in component crossbridge_TRPN (J_per_mol). C CONSTS(23) is kf_coeff in component crossbridge_TRPN (dimensionless). C CONSTS(44) is n in component crossbridge_TRPN (J_per_mol). C CONSTS(24) is hh in component crossbridge_TRPN (mm2_per_N). C CONSTS(25) is SL_0 in component crossbridge_TRPN (metre). C CONSTS(26) is q_MS in component crossbridge_TRPN (fmol). C CONSTS(27) is r_s in component crossbridge_TRPN (dimensionless). C CONSTS(28) is r_w in component crossbridge_TRPN (dimensionless). C CONSTS(29) is A_eff in component crossbridge_TRPN (dimensionless). C CONSTS(30) is phi in component crossbridge_TRPN (dimensionless). C CONSTS(31) is k_uw in component crossbridge_TRPN (per_sec). C CONSTS(32) is k_ws in component crossbridge_TRPN (per_sec). C STATES(9) is G_w in component crossbridge_TRPN (metre). C STATES(10) is G_s in component crossbridge_TRPN (metre). C CONSTS(41) is c_w in component crossbridge_TRPN (per_sec). C CONSTS(42) is c_s in component crossbridge_TRPN (per_sec). C CONSTS(43) is A_w in component crossbridge_TRPN (dimensionless). C CONSTS(45) is A_s in component crossbridge_TRPN (dimensionless). C ALGBRC(4) is mu_1 in component crossbridge_TRPN (J_per_m). C CONSTS(46) is mu_2 in component crossbridge_TRPN (J_per_m). C ALGBRC(1) is mu_3 in component crossbridge_TRPN (J_per_m). C ALGBRC(5) is mu_4 in component crossbridge_TRPN (J_per_m). C CONSTS(47) is mu_5 in component crossbridge_TRPN (J_per_m). C ALGBRC(2) is mu_6 in component crossbridge_TRPN (J_per_m). C ALGBRC(7) is v_1 in component crossbridge_TRPN (m_per_s). C CONSTS(33) is v_2 in component crossbridge_TRPN (m_per_s). C ALGBRC(8) is v_4 in component crossbridge_TRPN (m_per_s). C CONSTS(34) is v_to_mu in component crossbridge_TRPN (Js_per_m2). C ALGBRC(24) is T_active in component crossbridge_TRPN (kPa). C CONSTS(35) is T_ref in component crossbridge_TRPN (kPa). C ALGBRC(22) is mu_T_a in component crossbridge_TRPN (kPa). C ALGBRC(18) is mu_T_S in component crossbridge_TRPN (kPa). C ALGBRC(20) is mu_T_W in component crossbridge_TRPN (kPa). C STATES(11) is Cdd in component crossbridge_TRPN (metre). C ALGBRC(26) is eta in component crossbridge_TRPN (per_sec). C CONSTS(36) is eta_l in component crossbridge_TRPN (per_sec). C CONSTS(37) is eta_s in component crossbridge_TRPN (per_sec). C CONSTS(38) is k in component crossbridge_TRPN (dimensionless). C CONSTS(39) is alpha in component crossbridge_TRPN (kPa). C ALGBRC(30) is v_Cdd in component crossbridge_TRPN (m_per_s). C ALGBRC(27) is mu_d in component crossbridge_TRPN (J_per_m). C ALGBRC(28) is mu_k in component crossbridge_TRPN (J_per_m). C ALGBRC(29) is mu_f in component crossbridge_TRPN (J_per_m). C ALGBRC(32) is mu_T_passive in component crossbridge_TRPN (kPa). C ALGBRC(34) is T_passive in component crossbridge_TRPN (kPa). C CONSTS(40) is F in component constants (C_per_mol). C RATES(2) is d/dt q_Cai in component crossbridge_TRPN (fmol). C RATES(1) is d/dt q_TRPN in component crossbridge_TRPN (fmol). C RATES(3) is d/dt q_Ca_TRPN in component crossbridge_TRPN (fmol). C RATES(4) is d/dt q_B in component crossbridge_TRPN (fmol). C RATES(5) is d/dt q_U in component crossbridge_TRPN (fmol). C RATES(6) is d/dt q_W in component crossbridge_TRPN (fmol). C RATES(7) is d/dt q_S in component crossbridge_TRPN (fmol). C RATES(9) is d/dt G_w in component crossbridge_TRPN (metre). C RATES(8) is d/dt SL in component crossbridge_TRPN (metre). C RATES(10) is d/dt G_s in component crossbridge_TRPN (metre). C RATES(11) is d/dt Cdd in component crossbridge_TRPN (metre). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 6.82e-1 CONSTS(2) = 2.57 CONSTS(3) = 1e-6 CONSTS(4) = 1 CONSTS(5) = 0 CONSTS(6) = 0 CONSTS(7) = 0 STATES(1) = 1e-16 STATES(2) = 1e-16 STATES(3) = 1e-16 STATES(4) = 1e-16 STATES(5) = 1e-16 STATES(6) = 1e-16 STATES(7) = 1e-16 STATES(8) = 1e-6 CONSTS(8) = 52.0453 CONSTS(9) = 2.90875 CONSTS(10) = 0.332501 CONSTS(11) = 0.00782356 CONSTS(12) = 140824 CONSTS(13) = 1.27424 CONSTS(14) = 1.27424 CONSTS(15) = 0.11171 CONSTS(16) = 6.06164 CONSTS(17) = 2.27312 CONSTS(18) = 14.8627 CONSTS(19) = 3.71567e-06 CONSTS(20) = 8.31 CONSTS(21) = 310 CONSTS(22) = 1.1 CONSTS(23) = -0.0118 CONSTS(24) = 1 CONSTS(25) = 2e-6 CONSTS(26) = 1e-6 CONSTS(27) = 0.25 CONSTS(28) = 0.5 CONSTS(29) = 25 CONSTS(30) = 2.23 CONSTS(31) = 26 CONSTS(32) = 4 STATES(9) = 1e-6 STATES(10) = 1e-6 CONSTS(33) = 0 CONSTS(34) = 1 CONSTS(35) = 40.5 STATES(11) = 0 CONSTS(36) = 200e3 CONSTS(37) = 200e3 CONSTS(38) = 7 CONSTS(39) = 2.1 CONSTS(40) = 96485 CONSTS(41) = ( CONSTS(30)*CONSTS(31)*(1.00000 - CONSTS(28)))/CONSTS(28) CONSTS(42) = ( CONSTS(30)*CONSTS(32)*(1.00000 - CONSTS(27))*CONSTS(28))/CONSTS(27) CONSTS(43) = ( CONSTS(29)*CONSTS(27))/( (1.00000 - CONSTS(27))*CONSTS(28)+CONSTS(27)) CONSTS(44) = CONSTS(23)*CONSTS(20)*CONSTS(21) CONSTS(47) = CONSTS(33) CONSTS(45) = CONSTS(43) CONSTS(46) = - CONSTS(43)*CONSTS(33)*CONSTS(34) CONSTS(47) = - CONSTS(45)*CONSTS(33)*CONSTS(34) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(8) = CONSTS(47) ALGBRC(1) = CONSTS(41)*STATES(9)*CONSTS(34) ALGBRC(4) = - CONSTS(46) - ALGBRC(1) ALGBRC(7) = ALGBRC(4)/CONSTS(34) RATES(9) = ALGBRC(7) ALGBRC(2) = CONSTS(42)*STATES(10)*CONSTS(34) ALGBRC(5) = - CONSTS(47) - ALGBRC(2) ALGBRC(8) = ALGBRC(5)/CONSTS(34) RATES(10) = ALGBRC(8) ALGBRC(9) = STATES(3)+CONSTS(3) ALGBRC(16) = CONSTS(20)*CONSTS(21)*log( CONSTS(15)*ALGBRC(9)) ALGBRC(10) = STATES(4)+CONSTS(4) ALGBRC(17) = CONSTS(20)*CONSTS(21)*log( CONSTS(16)*ALGBRC(10)) ALGBRC(11) = STATES(5)+CONSTS(5) ALGBRC(19) = CONSTS(20)*CONSTS(21)*log( CONSTS(17)*ALGBRC(11)) ALGBRC(25) = CONSTS(9)*(EXP((ALGBRC(17)+ CONSTS(22)*ALGBRC(16))/( CONSTS(20)*CONSTS(21))) - EXP((ALGBRC(19)+ CONSTS(22)*ALGBRC(16))/( CONSTS(20)*CONSTS(21)))) RATES(4) = - ALGBRC(25) CALL minimize(minfunc_0, CONSTS, VARIABLES, ) ALGBRC(30) = ALGBRC(27)/CONSTS(34) RATES(11) = ALGBRC(30) ALGBRC(12) = STATES(6)+CONSTS(6) ALGBRC(21) = CONSTS(20)*CONSTS(21)*log( CONSTS(18)*ALGBRC(12)) ALGBRC(31) = CONSTS(10)*(EXP(ALGBRC(19)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(21)/( CONSTS(20)*CONSTS(21)))) ALGBRC(13) = STATES(7)+CONSTS(7) ALGBRC(23) = CONSTS(20)*CONSTS(21)*log( CONSTS(19)*ALGBRC(13)) ALGBRC(33) = CONSTS(11)*(EXP(ALGBRC(21)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(23)/( CONSTS(20)*CONSTS(21)))) RATES(6) = ALGBRC(31) - ALGBRC(33) ALGBRC(35) = CONSTS(12)*(EXP(ALGBRC(23)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(19)/( CONSTS(20)*CONSTS(21)))) RATES(5) = (ALGBRC(25) - ALGBRC(31))+ALGBRC(35) RATES(7) = ALGBRC(33) - ALGBRC(35) ALGBRC(3) = STATES(1)+CONSTS(2) ALGBRC(14) = CONSTS(20)*CONSTS(21)*log( CONSTS(13)*ALGBRC(3)) ALGBRC(6) = STATES(2)+CONSTS(1) ALGBRC(15) = CONSTS(20)*CONSTS(21)*log( CONSTS(14)*ALGBRC(6)) ALGBRC(18) = (CONSTS(35)/( CONSTS(25)*CONSTS(26)*CONSTS(27)))*STATES(7)*(STATES(10)+CONSTS(25)) ALGBRC(20) = (CONSTS(35)/( CONSTS(25)*CONSTS(26)*CONSTS(27)))*STATES(6)*STATES(9) ALGBRC(22) = ALGBRC(18)+ALGBRC(20) ALGBRC(24) = ALGBRC(22) ALGBRC(32) = (( CONSTS(39)*ALGBRC(26))/CONSTS(25))*ALGBRC(30) ALGBRC(34) = ALGBRC(32) ALGBRC(36) = ALGBRC(24)+ALGBRC(34) ALGBRC(37) = ALGBRC(36)*1000.00 ALGBRC(38) = CONSTS(24)*CONSTS(44)*ALGBRC(37) ALGBRC(39) = CONSTS(8)*(EXP((ALGBRC(15)+ALGBRC(14))/( CONSTS(20)*CONSTS(21))) - EXP((ALGBRC(16)+ALGBRC(38))/( CONSTS(20)*CONSTS(21)))) RATES(2) = - ALGBRC(39) RATES(1) = - ALGBRC(39) RATES(3) = ALGBRC(39) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(41)*STATES(9)*CONSTS(34) ALGBRC(4) = - CONSTS(46) - ALGBRC(1) ALGBRC(7) = ALGBRC(4)/CONSTS(34) ALGBRC(2) = CONSTS(42)*STATES(10)*CONSTS(34) ALGBRC(5) = - CONSTS(47) - ALGBRC(2) ALGBRC(8) = ALGBRC(5)/CONSTS(34) ALGBRC(9) = STATES(3)+CONSTS(3) ALGBRC(16) = CONSTS(20)*CONSTS(21)*log( CONSTS(15)*ALGBRC(9)) ALGBRC(10) = STATES(4)+CONSTS(4) ALGBRC(17) = CONSTS(20)*CONSTS(21)*log( CONSTS(16)*ALGBRC(10)) ALGBRC(11) = STATES(5)+CONSTS(5) ALGBRC(19) = CONSTS(20)*CONSTS(21)*log( CONSTS(17)*ALGBRC(11)) ALGBRC(25) = CONSTS(9)*(EXP((ALGBRC(17)+ CONSTS(22)*ALGBRC(16))/( CONSTS(20)*CONSTS(21))) - EXP((ALGBRC(19)+ CONSTS(22)*ALGBRC(16))/( CONSTS(20)*CONSTS(21)))) ALGBRC(30) = ALGBRC(27)/CONSTS(34) ALGBRC(12) = STATES(6)+CONSTS(6) ALGBRC(21) = CONSTS(20)*CONSTS(21)*log( CONSTS(18)*ALGBRC(12)) ALGBRC(31) = CONSTS(10)*(EXP(ALGBRC(19)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(21)/( CONSTS(20)*CONSTS(21)))) ALGBRC(13) = STATES(7)+CONSTS(7) ALGBRC(23) = CONSTS(20)*CONSTS(21)*log( CONSTS(19)*ALGBRC(13)) ALGBRC(33) = CONSTS(11)*(EXP(ALGBRC(21)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(23)/( CONSTS(20)*CONSTS(21)))) ALGBRC(35) = CONSTS(12)*(EXP(ALGBRC(23)/( CONSTS(20)*CONSTS(21))) - EXP(ALGBRC(19)/( CONSTS(20)*CONSTS(21)))) ALGBRC(3) = STATES(1)+CONSTS(2) ALGBRC(14) = CONSTS(20)*CONSTS(21)*log( CONSTS(13)*ALGBRC(3)) ALGBRC(6) = STATES(2)+CONSTS(1) ALGBRC(15) = CONSTS(20)*CONSTS(21)*log( CONSTS(14)*ALGBRC(6)) ALGBRC(18) = (CONSTS(35)/( CONSTS(25)*CONSTS(26)*CONSTS(27)))*STATES(7)*(STATES(10)+CONSTS(25)) ALGBRC(20) = (CONSTS(35)/( CONSTS(25)*CONSTS(26)*CONSTS(27)))*STATES(6)*STATES(9) ALGBRC(22) = ALGBRC(18)+ALGBRC(20) ALGBRC(24) = ALGBRC(22) ALGBRC(32) = (( CONSTS(39)*ALGBRC(26))/CONSTS(25))*ALGBRC(30) ALGBRC(34) = ALGBRC(32) ALGBRC(36) = ALGBRC(24)+ALGBRC(34) ALGBRC(37) = ALGBRC(36)*1000.00 ALGBRC(38) = CONSTS(24)*CONSTS(44)*ALGBRC(37) ALGBRC(39) = CONSTS(8)*(EXP((ALGBRC(15)+ALGBRC(14))/( CONSTS(20)*CONSTS(21))) - EXP((ALGBRC(16)+ALGBRC(38))/( CONSTS(20)*CONSTS(21)))) RETURN END REAL FUNCTION minfunc_0(CONSTS, VARIABLES) REAL CONSTS(*), VARIABLES(*) minfunc_0[1] = abs(ALGBRC(26) - (TERNRY(ALGBRC(27).GT.0.00000, CONSTS(36), CONSTS(37)))) minfunc_0[2] = abs(ALGBRC(28) - (CONSTS(38)/ALGBRC(26))*STATES(11)*CONSTS(34)) minfunc_0[3] = abs(ALGBRC(29) - (CONSTS(38)/ALGBRC(26))*(STATES(8) - CONSTS(25))*CONSTS(34)) minfunc_0[4] = abs(ALGBRC(27) - (- ALGBRC(28)+ALGBRC(29))) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END