/* There are a total of 69 entries in the algebraic variable array. There are a total of 17 entries in each of the rate and state variable arrays. There are a total of 46 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is R in component membrane (joule_per_mole_kelvin). * CONSTANTS[1] is T in component membrane (kelvin). * CONSTANTS[2] is F in component membrane (coulomb_per_millimole). * CONSTANTS[3] is Cm in component membrane (picoF). * CONSTANTS[4] is V_c in component membrane (micrometre3). * ALGEBRAIC[50] is i_K1 in component inward_rectifier_potassium_current (picoA_per_picoF). * ALGEBRAIC[57] is i_to in component transient_outward_current (picoA_per_picoF). * ALGEBRAIC[51] is i_Kr in component rapid_time_dependent_potassium_current (picoA_per_picoF). * ALGEBRAIC[52] is i_Ks in component slow_time_dependent_potassium_current (picoA_per_picoF). * ALGEBRAIC[55] is i_CaL in component L_type_Ca_current (picoA_per_picoF). * ALGEBRAIC[58] is i_NaK in component sodium_potassium_pump_current (picoA_per_picoF). * ALGEBRAIC[53] is i_Na in component fast_sodium_current (picoA_per_picoF). * ALGEBRAIC[54] is i_b_Na in component sodium_background_current (picoA_per_picoF). * ALGEBRAIC[59] is i_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF). * ALGEBRAIC[56] is i_b_Ca in component calcium_background_current (picoA_per_picoF). * ALGEBRAIC[61] is i_p_K in component potassium_pump_current (picoA_per_picoF). * ALGEBRAIC[60] is i_p_Ca in component calcium_pump_current (picoA_per_picoF). * ALGEBRAIC[0] is i_Stim in component membrane (picoA_per_picoF). * CONSTANTS[5] is stim_start in component membrane (millisecond). * CONSTANTS[6] is stim_period in component membrane (millisecond). * CONSTANTS[7] is stim_duration in component membrane (millisecond). * CONSTANTS[8] is stim_amplitude in component membrane (picoA_per_picoF). * ALGEBRAIC[13] is E_Na in component reversal_potentials (millivolt). * ALGEBRAIC[26] is E_K in component reversal_potentials (millivolt). * ALGEBRAIC[35] is E_Ks in component reversal_potentials (millivolt). * ALGEBRAIC[44] is E_Ca in component reversal_potentials (millivolt). * CONSTANTS[9] is P_kna in component reversal_potentials (dimensionless). * CONSTANTS[10] is K_o in component potassium_dynamics (millimolar). * CONSTANTS[11] is Na_o in component sodium_dynamics (millimolar). * STATES[1] is K_i in component potassium_dynamics (millimolar). * STATES[2] is Na_i in component sodium_dynamics (millimolar). * CONSTANTS[12] is Ca_o in component calcium_dynamics (millimolar). * STATES[3] is Ca_i in component calcium_dynamics (millimolar). * CONSTANTS[13] is g_K1 in component inward_rectifier_potassium_current (nanoS_per_picoF). * ALGEBRAIC[49] is xK1_inf in component inward_rectifier_potassium_current (dimensionless). * ALGEBRAIC[47] is alpha_K1 in component inward_rectifier_potassium_current (per_millisecond). * ALGEBRAIC[48] is beta_K1 in component inward_rectifier_potassium_current (per_millisecond). * CONSTANTS[14] is g_Kr in component rapid_time_dependent_potassium_current (nanoS_per_picoF). * STATES[4] is Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * STATES[5] is Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[1] is xr1_inf in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * ALGEBRAIC[14] is alpha_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * ALGEBRAIC[27] is beta_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * ALGEBRAIC[36] is tau_xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (millisecond). * ALGEBRAIC[2] is xr2_inf in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[15] is alpha_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[28] is beta_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * ALGEBRAIC[37] is tau_xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (millisecond). * CONSTANTS[15] is g_Ks in component slow_time_dependent_potassium_current (nanoS_per_picoF). * STATES[6] is Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[3] is xs_inf in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[16] is alpha_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[29] is beta_xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * ALGEBRAIC[38] is tau_xs in component slow_time_dependent_potassium_current_Xs_gate (millisecond). * CONSTANTS[16] is g_Na in component fast_sodium_current (nanoS_per_picoF). * STATES[7] is m in component fast_sodium_current_m_gate (dimensionless). * STATES[8] is h in component fast_sodium_current_h_gate (dimensionless). * STATES[9] is j in component fast_sodium_current_j_gate (dimensionless). * ALGEBRAIC[4] is m_inf in component fast_sodium_current_m_gate (dimensionless). * ALGEBRAIC[17] is alpha_m in component fast_sodium_current_m_gate (dimensionless). * ALGEBRAIC[30] is beta_m in component fast_sodium_current_m_gate (dimensionless). * ALGEBRAIC[39] is tau_m in component fast_sodium_current_m_gate (millisecond). * ALGEBRAIC[5] is h_inf in component fast_sodium_current_h_gate (dimensionless). * ALGEBRAIC[18] is alpha_h in component fast_sodium_current_h_gate (per_millisecond). * ALGEBRAIC[31] is beta_h in component fast_sodium_current_h_gate (per_millisecond). * ALGEBRAIC[40] is tau_h in component fast_sodium_current_h_gate (millisecond). * ALGEBRAIC[6] is j_inf in component fast_sodium_current_j_gate (dimensionless). * ALGEBRAIC[19] is alpha_j in component fast_sodium_current_j_gate (per_millisecond). * ALGEBRAIC[32] is beta_j in component fast_sodium_current_j_gate (per_millisecond). * ALGEBRAIC[41] is tau_j in component fast_sodium_current_j_gate (millisecond). * CONSTANTS[17] is g_bna in component sodium_background_current (nanoS_per_picoF). * CONSTANTS[18] is g_CaL in component L_type_Ca_current (litre_per_farad_second). * STATES[10] is d in component L_type_Ca_current_d_gate (dimensionless). * STATES[11] is f in component L_type_Ca_current_f_gate (dimensionless). * STATES[12] is fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[7] is d_inf in component L_type_Ca_current_d_gate (dimensionless). * ALGEBRAIC[20] is alpha_d in component L_type_Ca_current_d_gate (dimensionless). * ALGEBRAIC[33] is beta_d in component L_type_Ca_current_d_gate (dimensionless). * ALGEBRAIC[42] is gamma_d in component L_type_Ca_current_d_gate (millisecond). * ALGEBRAIC[45] is tau_d in component L_type_Ca_current_d_gate (millisecond). * ALGEBRAIC[8] is f_inf in component L_type_Ca_current_f_gate (dimensionless). * ALGEBRAIC[21] is tau_f in component L_type_Ca_current_f_gate (millisecond). * ALGEBRAIC[9] is alpha_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[22] is beta_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[34] is gama_fCa in component L_type_Ca_current_fCa_gate (dimensionless). * ALGEBRAIC[43] is fCa_inf in component L_type_Ca_current_fCa_gate (dimensionless). * CONSTANTS[45] is tau_fCa in component L_type_Ca_current_fCa_gate (millisecond). * ALGEBRAIC[46] is d_fCa in component L_type_Ca_current_fCa_gate (per_millisecond). * CONSTANTS[19] is g_bca in component calcium_background_current (nanoS_per_picoF). * CONSTANTS[20] is g_to in component transient_outward_current (nanoS_per_picoF). * STATES[13] is s in component transient_outward_current_s_gate (dimensionless). * STATES[14] is r in component transient_outward_current_r_gate (dimensionless). * ALGEBRAIC[10] is s_inf in component transient_outward_current_s_gate (dimensionless). * ALGEBRAIC[23] is tau_s in component transient_outward_current_s_gate (millisecond). * ALGEBRAIC[11] is r_inf in component transient_outward_current_r_gate (dimensionless). * ALGEBRAIC[24] is tau_r in component transient_outward_current_r_gate (millisecond). * CONSTANTS[21] is P_NaK in component sodium_potassium_pump_current (picoA_per_picoF). * CONSTANTS[22] is K_mk in component sodium_potassium_pump_current (millimolar). * CONSTANTS[23] is K_mNa in component sodium_potassium_pump_current (millimolar). * CONSTANTS[24] is K_NaCa in component sodium_calcium_exchanger_current (picoA_per_picoF). * CONSTANTS[25] is K_sat in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[26] is alpha in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[27] is gamma in component sodium_calcium_exchanger_current (dimensionless). * CONSTANTS[28] is Km_Ca in component sodium_calcium_exchanger_current (millimolar). * CONSTANTS[29] is Km_Nai in component sodium_calcium_exchanger_current (millimolar). * CONSTANTS[30] is g_pCa in component calcium_pump_current (picoA_per_picoF). * CONSTANTS[31] is K_pCa in component calcium_pump_current (millimolar). * CONSTANTS[32] is g_pK in component potassium_pump_current (nanoS_per_picoF). * STATES[15] is Ca_SR in component calcium_dynamics (millimolar). * ALGEBRAIC[62] is i_rel in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[63] is i_up in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[64] is i_leak in component calcium_dynamics (millimolar_per_millisecond). * STATES[16] is g in component calcium_dynamics (dimensionless). * CONSTANTS[33] is tau_g in component calcium_dynamics (millisecond). * ALGEBRAIC[12] is g_inf in component calcium_dynamics (dimensionless). * CONSTANTS[34] is a_rel in component calcium_dynamics (millimolar_per_millisecond). * CONSTANTS[35] is b_rel in component calcium_dynamics (millimolar). * CONSTANTS[36] is c_rel in component calcium_dynamics (millimolar_per_millisecond). * CONSTANTS[37] is K_up in component calcium_dynamics (millimolar). * CONSTANTS[38] is V_leak in component calcium_dynamics (per_millisecond). * CONSTANTS[39] is Vmax_up in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[65] is ddt_Ca_i_total in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[66] is ddt_Ca_sr_total in component calcium_dynamics (millimolar_per_millisecond). * ALGEBRAIC[67] is f_JCa_i_free in component calcium_dynamics (dimensionless). * ALGEBRAIC[68] is f_JCa_sr_free in component calcium_dynamics (dimensionless). * CONSTANTS[40] is Buf_c in component calcium_dynamics (millimolar). * CONSTANTS[41] is K_buf_c in component calcium_dynamics (millimolar). * CONSTANTS[42] is Buf_sr in component calcium_dynamics (millimolar). * CONSTANTS[43] is K_buf_sr in component calcium_dynamics (millimolar). * CONSTANTS[44] is V_sr in component calcium_dynamics (micrometre3). * ALGEBRAIC[25] is d_g in component calcium_dynamics (per_millisecond). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[4] is d/dt Xr1 in component rapid_time_dependent_potassium_current_Xr1_gate (dimensionless). * RATES[5] is d/dt Xr2 in component rapid_time_dependent_potassium_current_Xr2_gate (dimensionless). * RATES[6] is d/dt Xs in component slow_time_dependent_potassium_current_Xs_gate (dimensionless). * RATES[7] is d/dt m in component fast_sodium_current_m_gate (dimensionless). * RATES[8] is d/dt h in component fast_sodium_current_h_gate (dimensionless). * RATES[9] is d/dt j in component fast_sodium_current_j_gate (dimensionless). * RATES[10] is d/dt d in component L_type_Ca_current_d_gate (dimensionless). * RATES[11] is d/dt f in component L_type_Ca_current_f_gate (dimensionless). * RATES[12] is d/dt fCa in component L_type_Ca_current_fCa_gate (dimensionless). * RATES[13] is d/dt s in component transient_outward_current_s_gate (dimensionless). * RATES[14] is d/dt r in component transient_outward_current_r_gate (dimensionless). * RATES[16] is d/dt g in component calcium_dynamics (dimensionless). * RATES[3] is d/dt Ca_i in component calcium_dynamics (millimolar). * RATES[15] is d/dt Ca_SR in component calcium_dynamics (millimolar). * RATES[2] is d/dt Na_i in component sodium_dynamics (millimolar). * RATES[1] is d/dt K_i in component potassium_dynamics (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -86.2; CONSTANTS[0] = 8.314; CONSTANTS[1] = 310; CONSTANTS[2] = 96.485; CONSTANTS[3] = 185; CONSTANTS[4] = 16404; CONSTANTS[5] = 10; CONSTANTS[6] = 1000; CONSTANTS[7] = 1; CONSTANTS[8] = -52; CONSTANTS[9] = 0.03; CONSTANTS[10] = 5.4; CONSTANTS[11] = 140; STATES[1] = 138.3; STATES[2] = 11.6; CONSTANTS[12] = 2; STATES[3] = 0.0002; CONSTANTS[13] = 5.405; CONSTANTS[14] = 0.096; STATES[4] = 0; STATES[5] = 1; CONSTANTS[15] = 0.245; STATES[6] = 0; CONSTANTS[16] = 14.838; STATES[7] = 0; STATES[8] = 0.75; STATES[9] = 0.75; CONSTANTS[17] = 0.00029; CONSTANTS[18] = 0.175; STATES[10] = 0; STATES[11] = 1; STATES[12] = 1; CONSTANTS[19] = 0.000592; CONSTANTS[20] = 0.294; STATES[13] = 1; STATES[14] = 0; CONSTANTS[21] = 1.362; CONSTANTS[22] = 1; CONSTANTS[23] = 40; CONSTANTS[24] = 1000; CONSTANTS[25] = 0.1; CONSTANTS[26] = 2.5; CONSTANTS[27] = 0.35; CONSTANTS[28] = 1.38; CONSTANTS[29] = 87.5; CONSTANTS[30] = 0.825; CONSTANTS[31] = 0.0005; CONSTANTS[32] = 0.0146; STATES[15] = 0.2; STATES[16] = 1; CONSTANTS[33] = 2; CONSTANTS[34] = 0.016464; CONSTANTS[35] = 0.25; CONSTANTS[36] = 0.008232; CONSTANTS[37] = 0.00025; CONSTANTS[38] = 8e-5; CONSTANTS[39] = 0.000425; CONSTANTS[40] = 0.15; CONSTANTS[41] = 0.001; CONSTANTS[42] = 10; CONSTANTS[43] = 0.3; CONSTANTS[44] = 1094; CONSTANTS[45] = 2.00000; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000)); ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000)); RATES[11] = (ALGEBRAIC[8] - STATES[11])/ALGEBRAIC[21]; ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/5.00000)); ALGEBRAIC[23] = 85.0000*exp(- pow(STATES[0]+45.0000, 2.00000)/320.000)+5.00000/(1.00000+exp((STATES[0] - 20.0000)/5.00000))+3.00000; RATES[13] = (ALGEBRAIC[10] - STATES[13])/ALGEBRAIC[23]; ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000)); ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000; RATES[14] = (ALGEBRAIC[11] - STATES[14])/ALGEBRAIC[24]; ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000))); ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[33]; RATES[16] = (ALGEBRAIC[12]>STATES[16]&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[25]); ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000)); ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000)); ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000)); ALGEBRAIC[36] = 1.00000*ALGEBRAIC[14]*ALGEBRAIC[27]; RATES[4] = (ALGEBRAIC[1] - STATES[4])/ALGEBRAIC[36]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000)); ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000)); ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[37] = 1.00000*ALGEBRAIC[15]*ALGEBRAIC[28]; RATES[5] = (ALGEBRAIC[2] - STATES[5])/ALGEBRAIC[37]; ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000)); ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2); ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[38] = 1.00000*ALGEBRAIC[16]*ALGEBRAIC[29]; RATES[6] = (ALGEBRAIC[3] - STATES[6])/ALGEBRAIC[38]; ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000); ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000)); ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000)); ALGEBRAIC[39] = 1.00000*ALGEBRAIC[17]*ALGEBRAIC[30]; RATES[7] = (ALGEBRAIC[4] - STATES[7])/ALGEBRAIC[39]; ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000); ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000)))); ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]); RATES[8] = (ALGEBRAIC[5] - STATES[8])/ALGEBRAIC[40]; ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? (( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/1.00000)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000); ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000)))); ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]); RATES[9] = (ALGEBRAIC[6] - STATES[9])/ALGEBRAIC[41]; ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000)); ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000; ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000)); ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000)); ALGEBRAIC[45] = 1.00000*ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42]; RATES[10] = (ALGEBRAIC[7] - STATES[10])/ALGEBRAIC[45]; ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000)); ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000)); ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000)); ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000; ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[45]; RATES[12] = (ALGEBRAIC[43]>STATES[12]&&STATES[0]>- 60.0000 ? 0.00000 : ALGEBRAIC[46]); ALGEBRAIC[58] = (( (( CONSTANTS[21]*CONSTANTS[10])/(CONSTANTS[10]+CONSTANTS[22]))*STATES[2])/(STATES[2]+CONSTANTS[23]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[11]/STATES[2]); ALGEBRAIC[53] = CONSTANTS[16]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[54] = CONSTANTS[17]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[59] = ( CONSTANTS[24]*( exp(( CONSTANTS[27]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[12] - exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[11], 3.00000)*STATES[3]*CONSTANTS[26]))/( (pow(CONSTANTS[29], 3.00000)+pow(CONSTANTS[11], 3.00000))*(CONSTANTS[28]+CONSTANTS[12])*(1.00000+ CONSTANTS[25]*exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))); RATES[2] = ( - (ALGEBRAIC[53]+ALGEBRAIC[54]+ 3.00000*ALGEBRAIC[58]+ 3.00000*ALGEBRAIC[59])*CONSTANTS[3])/( CONSTANTS[4]*CONSTANTS[2]); ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[10]/STATES[1]); ALGEBRAIC[47] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[26]) - 200.000))); ALGEBRAIC[48] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[26])+100.000))+ 1.00000*exp( 0.100000*((STATES[0] - ALGEBRAIC[26]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[26]))); ALGEBRAIC[49] = ALGEBRAIC[47]/(ALGEBRAIC[47]+ALGEBRAIC[48]); ALGEBRAIC[50] = CONSTANTS[13]*ALGEBRAIC[49]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[57] = CONSTANTS[20]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[51] = CONSTANTS[14]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[35] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[10]+ CONSTANTS[9]*CONSTANTS[11])/(STATES[1]+ CONSTANTS[9]*STATES[2])); ALGEBRAIC[52] = CONSTANTS[15]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[55] = ( (( CONSTANTS[18]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[12]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000); ALGEBRAIC[44] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[12]/STATES[3]); ALGEBRAIC[56] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[44]); ALGEBRAIC[61] = ( CONSTANTS[32]*(STATES[0] - ALGEBRAIC[26]))/(1.00000+exp((25.0000 - STATES[0])/5.98000)); ALGEBRAIC[60] = ( CONSTANTS[30]*STATES[3])/(STATES[3]+CONSTANTS[31]); ALGEBRAIC[0] = (VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]>=CONSTANTS[5]&&VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[5]+CONSTANTS[7] ? CONSTANTS[8] : 0.00000); RATES[0] = - (ALGEBRAIC[50]+ALGEBRAIC[57]+ALGEBRAIC[51]+ALGEBRAIC[52]+ALGEBRAIC[55]+ALGEBRAIC[58]+ALGEBRAIC[53]+ALGEBRAIC[54]+ALGEBRAIC[59]+ALGEBRAIC[56]+ALGEBRAIC[61]+ALGEBRAIC[60]+ALGEBRAIC[0]); RATES[1] = ( - ((ALGEBRAIC[50]+ALGEBRAIC[57]+ALGEBRAIC[51]+ALGEBRAIC[52]+ALGEBRAIC[61]+ALGEBRAIC[0]) - 2.00000*ALGEBRAIC[58])*CONSTANTS[3])/( CONSTANTS[4]*CONSTANTS[2]); ALGEBRAIC[62] = (( CONSTANTS[34]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[35], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[36])*STATES[10]*STATES[16]; ALGEBRAIC[63] = CONSTANTS[39]/(1.00000+pow(CONSTANTS[37], 2.00000)/pow(STATES[3], 2.00000)); ALGEBRAIC[64] = CONSTANTS[38]*(STATES[15] - STATES[3]); ALGEBRAIC[65] = (( (- ((ALGEBRAIC[55]+ALGEBRAIC[56]+ALGEBRAIC[60]) - 2.00000*ALGEBRAIC[59])/( 2.00000*CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]+ALGEBRAIC[64]) - ALGEBRAIC[63])+ALGEBRAIC[62]; ALGEBRAIC[67] = 1.00000/(1.00000+( CONSTANTS[40]*CONSTANTS[41])/pow(STATES[3]+CONSTANTS[41], 2.00000)); RATES[3] = ALGEBRAIC[65]*ALGEBRAIC[67]; ALGEBRAIC[66] = (CONSTANTS[4]/CONSTANTS[44])*(ALGEBRAIC[63] - (ALGEBRAIC[62]+ALGEBRAIC[64])); ALGEBRAIC[68] = 1.00000/(1.00000+( CONSTANTS[42]*CONSTANTS[43])/pow(STATES[15]+CONSTANTS[43], 2.00000)); RATES[15] = ALGEBRAIC[66]*ALGEBRAIC[68]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[8] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/7.00000)); ALGEBRAIC[21] = 1125.00*exp(- pow(STATES[0]+27.0000, 2.00000)/240.000)+80.0000+165.000/(1.00000+exp((25.0000 - STATES[0])/10.0000)); ALGEBRAIC[10] = 1.00000/(1.00000+exp((STATES[0]+20.0000)/5.00000)); ALGEBRAIC[23] = 85.0000*exp(- pow(STATES[0]+45.0000, 2.00000)/320.000)+5.00000/(1.00000+exp((STATES[0] - 20.0000)/5.00000))+3.00000; ALGEBRAIC[11] = 1.00000/(1.00000+exp((20.0000 - STATES[0])/6.00000)); ALGEBRAIC[24] = 9.50000*exp(- pow(STATES[0]+40.0000, 2.00000)/1800.00)+0.800000; ALGEBRAIC[12] = (STATES[3]<0.000350000 ? 1.00000/(1.00000+pow(STATES[3]/0.000350000, 6.00000)) : 1.00000/(1.00000+pow(STATES[3]/0.000350000, 16.0000))); ALGEBRAIC[25] = (ALGEBRAIC[12] - STATES[16])/CONSTANTS[33]; ALGEBRAIC[1] = 1.00000/(1.00000+exp((- 26.0000 - STATES[0])/7.00000)); ALGEBRAIC[14] = 450.000/(1.00000+exp((- 45.0000 - STATES[0])/10.0000)); ALGEBRAIC[27] = 6.00000/(1.00000+exp((STATES[0]+30.0000)/11.5000)); ALGEBRAIC[36] = 1.00000*ALGEBRAIC[14]*ALGEBRAIC[27]; ALGEBRAIC[2] = 1.00000/(1.00000+exp((STATES[0]+88.0000)/24.0000)); ALGEBRAIC[15] = 3.00000/(1.00000+exp((- 60.0000 - STATES[0])/20.0000)); ALGEBRAIC[28] = 1.12000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[37] = 1.00000*ALGEBRAIC[15]*ALGEBRAIC[28]; ALGEBRAIC[3] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/14.0000)); ALGEBRAIC[16] = 1100.00/ pow((1.00000+exp((- 10.0000 - STATES[0])/6.00000)), 1.0 / 2); ALGEBRAIC[29] = 1.00000/(1.00000+exp((STATES[0] - 60.0000)/20.0000)); ALGEBRAIC[38] = 1.00000*ALGEBRAIC[16]*ALGEBRAIC[29]; ALGEBRAIC[4] = 1.00000/pow(1.00000+exp((- 56.8600 - STATES[0])/9.03000), 2.00000); ALGEBRAIC[17] = 1.00000/(1.00000+exp((- 60.0000 - STATES[0])/5.00000)); ALGEBRAIC[30] = 0.100000/(1.00000+exp((STATES[0]+35.0000)/5.00000))+0.100000/(1.00000+exp((STATES[0] - 50.0000)/200.000)); ALGEBRAIC[39] = 1.00000*ALGEBRAIC[17]*ALGEBRAIC[30]; ALGEBRAIC[5] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[18] = (STATES[0]<- 40.0000 ? 0.0570000*exp(- (STATES[0]+80.0000)/6.80000) : 0.00000); ALGEBRAIC[31] = (STATES[0]<- 40.0000 ? 2.70000*exp( 0.0790000*STATES[0])+ 310000.*exp( 0.348500*STATES[0]) : 0.770000/( 0.130000*(1.00000+exp((STATES[0]+10.6600)/- 11.1000)))); ALGEBRAIC[40] = 1.00000/(ALGEBRAIC[18]+ALGEBRAIC[31]); ALGEBRAIC[6] = 1.00000/pow(1.00000+exp((STATES[0]+71.5500)/7.43000), 2.00000); ALGEBRAIC[19] = (STATES[0]<- 40.0000 ? (( ( - 25428.0*exp( 0.244400*STATES[0]) - 6.94800e-06*exp( - 0.0439100*STATES[0]))*(STATES[0]+37.7800))/1.00000)/(1.00000+exp( 0.311000*(STATES[0]+79.2300))) : 0.00000); ALGEBRAIC[32] = (STATES[0]<- 40.0000 ? ( 0.0242400*exp( - 0.0105200*STATES[0]))/(1.00000+exp( - 0.137800*(STATES[0]+40.1400))) : ( 0.600000*exp( 0.0570000*STATES[0]))/(1.00000+exp( - 0.100000*(STATES[0]+32.0000)))); ALGEBRAIC[41] = 1.00000/(ALGEBRAIC[19]+ALGEBRAIC[32]); ALGEBRAIC[7] = 1.00000/(1.00000+exp((- 5.00000 - STATES[0])/7.50000)); ALGEBRAIC[20] = 1.40000/(1.00000+exp((- 35.0000 - STATES[0])/13.0000))+0.250000; ALGEBRAIC[33] = 1.40000/(1.00000+exp((STATES[0]+5.00000)/5.00000)); ALGEBRAIC[42] = 1.00000/(1.00000+exp((50.0000 - STATES[0])/20.0000)); ALGEBRAIC[45] = 1.00000*ALGEBRAIC[20]*ALGEBRAIC[33]+ALGEBRAIC[42]; ALGEBRAIC[9] = 1.00000/(1.00000+pow(STATES[3]/0.000325000, 8.00000)); ALGEBRAIC[22] = 0.100000/(1.00000+exp((STATES[3] - 0.000500000)/0.000100000)); ALGEBRAIC[34] = 0.200000/(1.00000+exp((STATES[3] - 0.000750000)/0.000800000)); ALGEBRAIC[43] = (ALGEBRAIC[9]+ALGEBRAIC[22]+ALGEBRAIC[34]+0.230000)/1.46000; ALGEBRAIC[46] = (ALGEBRAIC[43] - STATES[12])/CONSTANTS[45]; ALGEBRAIC[58] = (( (( CONSTANTS[21]*CONSTANTS[10])/(CONSTANTS[10]+CONSTANTS[22]))*STATES[2])/(STATES[2]+CONSTANTS[23]))/(1.00000+ 0.124500*exp(( - 0.100000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))+ 0.0353000*exp(( - STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[13] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[11]/STATES[2]); ALGEBRAIC[53] = CONSTANTS[16]*pow(STATES[7], 3.00000)*STATES[8]*STATES[9]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[54] = CONSTANTS[17]*(STATES[0] - ALGEBRAIC[13]); ALGEBRAIC[59] = ( CONSTANTS[24]*( exp(( CONSTANTS[27]*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(STATES[2], 3.00000)*CONSTANTS[12] - exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1]))*pow(CONSTANTS[11], 3.00000)*STATES[3]*CONSTANTS[26]))/( (pow(CONSTANTS[29], 3.00000)+pow(CONSTANTS[11], 3.00000))*(CONSTANTS[28]+CONSTANTS[12])*(1.00000+ CONSTANTS[25]*exp(( (CONSTANTS[27] - 1.00000)*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])))); ALGEBRAIC[26] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[10]/STATES[1]); ALGEBRAIC[47] = 0.100000/(1.00000+exp( 0.0600000*((STATES[0] - ALGEBRAIC[26]) - 200.000))); ALGEBRAIC[48] = ( 3.00000*exp( 0.000200000*((STATES[0] - ALGEBRAIC[26])+100.000))+ 1.00000*exp( 0.100000*((STATES[0] - ALGEBRAIC[26]) - 10.0000)))/(1.00000+exp( - 0.500000*(STATES[0] - ALGEBRAIC[26]))); ALGEBRAIC[49] = ALGEBRAIC[47]/(ALGEBRAIC[47]+ALGEBRAIC[48]); ALGEBRAIC[50] = CONSTANTS[13]*ALGEBRAIC[49]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[57] = CONSTANTS[20]*STATES[14]*STATES[13]*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[51] = CONSTANTS[14]* pow((CONSTANTS[10]/5.40000), 1.0 / 2)*STATES[4]*STATES[5]*(STATES[0] - ALGEBRAIC[26]); ALGEBRAIC[35] = (( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log((CONSTANTS[10]+ CONSTANTS[9]*CONSTANTS[11])/(STATES[1]+ CONSTANTS[9]*STATES[2])); ALGEBRAIC[52] = CONSTANTS[15]*pow(STATES[6], 2.00000)*(STATES[0] - ALGEBRAIC[35]); ALGEBRAIC[55] = ( (( CONSTANTS[18]*STATES[10]*STATES[11]*STATES[12]*4.00000*STATES[0]*pow(CONSTANTS[2], 2.00000))/( CONSTANTS[0]*CONSTANTS[1]))*( STATES[3]*exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 0.341000*CONSTANTS[12]))/(exp(( 2.00000*STATES[0]*CONSTANTS[2])/( CONSTANTS[0]*CONSTANTS[1])) - 1.00000); ALGEBRAIC[44] = (( 0.500000*CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2])*log(CONSTANTS[12]/STATES[3]); ALGEBRAIC[56] = CONSTANTS[19]*(STATES[0] - ALGEBRAIC[44]); ALGEBRAIC[61] = ( CONSTANTS[32]*(STATES[0] - ALGEBRAIC[26]))/(1.00000+exp((25.0000 - STATES[0])/5.98000)); ALGEBRAIC[60] = ( CONSTANTS[30]*STATES[3])/(STATES[3]+CONSTANTS[31]); ALGEBRAIC[0] = (VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]>=CONSTANTS[5]&&VOI - floor(VOI/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[5]+CONSTANTS[7] ? CONSTANTS[8] : 0.00000); ALGEBRAIC[62] = (( CONSTANTS[34]*pow(STATES[15], 2.00000))/(pow(CONSTANTS[35], 2.00000)+pow(STATES[15], 2.00000))+CONSTANTS[36])*STATES[10]*STATES[16]; ALGEBRAIC[63] = CONSTANTS[39]/(1.00000+pow(CONSTANTS[37], 2.00000)/pow(STATES[3], 2.00000)); ALGEBRAIC[64] = CONSTANTS[38]*(STATES[15] - STATES[3]); ALGEBRAIC[65] = (( (- ((ALGEBRAIC[55]+ALGEBRAIC[56]+ALGEBRAIC[60]) - 2.00000*ALGEBRAIC[59])/( 2.00000*CONSTANTS[4]*CONSTANTS[2]))*CONSTANTS[3]+ALGEBRAIC[64]) - ALGEBRAIC[63])+ALGEBRAIC[62]; ALGEBRAIC[67] = 1.00000/(1.00000+( CONSTANTS[40]*CONSTANTS[41])/pow(STATES[3]+CONSTANTS[41], 2.00000)); ALGEBRAIC[66] = (CONSTANTS[4]/CONSTANTS[44])*(ALGEBRAIC[63] - (ALGEBRAIC[62]+ALGEBRAIC[64])); ALGEBRAIC[68] = 1.00000/(1.00000+( CONSTANTS[42]*CONSTANTS[43])/pow(STATES[15]+CONSTANTS[43], 2.00000)); }