C C There are a total of 35 entries in the algebraic variable array. C There are a total of 18 entries in each of the rate and state variable arrays. C There are a total of 37 entries in the constant variable array. C C C CONSTS(1) is kappa_R_12 in component BG_parameters (fmol_per_sec). C CONSTS(2) is kappa_R_34 in component BG_parameters (fmol_per_sec). C CONSTS(3) is kappa_R_56 in component BG_parameters (fmol_per_sec). C CONSTS(4) is kappa_R_78 in component BG_parameters (fmol_per_sec). C CONSTS(5) is kappa_R_1a_cGMP in component BG_parameters (fmol_per_sec). C CONSTS(6) is kappa_R_1b_cGMP in component BG_parameters (fmol_per_sec). C CONSTS(7) is kappa_R_2a_cGMP in component BG_parameters (fmol_per_sec). C CONSTS(8) is kappa_R_2b_cGMP in component BG_parameters (fmol_per_sec). C CONSTS(9) is kappa_R_1_sGC in component BG_parameters (fmol_per_sec). C CONSTS(10) is kappa_R_2_sGC in component BG_parameters (fmol_per_sec). C CONSTS(11) is kappa_R_3_sGC in component BG_parameters (fmol_per_sec). C CONSTS(12) is kappa_R_4_sGC in component BG_parameters (fmol_per_sec). C CONSTS(13) is kappa_R_DNO_sGC in component BG_parameters (fmol_per_sec). C CONSTS(14) is K_A in component BG_parameters (per_fmol). C CONSTS(15) is K_M in component BG_parameters (per_fmol). C CONSTS(16) is K_Mp in component BG_parameters (per_fmol). C CONSTS(17) is K_AM in component BG_parameters (per_fmol). C CONSTS(18) is K_AMp in component BG_parameters (per_fmol). C CONSTS(19) is K_Pi in component BG_parameters (per_fmol). C CONSTS(20) is K_Ca_i in component BG_parameters (per_fmol). C CONSTS(21) is K_cGMP in component BG_parameters (per_fmol). C CONSTS(22) is K_GTP in component BG_parameters (per_fmol). C CONSTS(23) is K_E5c in component BG_parameters (per_fmol). C CONSTS(24) is K_PDE in component BG_parameters (per_fmol). C CONSTS(25) is K_GTP_E5c in component BG_parameters (per_fmol). C CONSTS(26) is K_cGMP_PDE in component BG_parameters (per_fmol). C CONSTS(27) is K_GMP in component BG_parameters (per_fmol). C CONSTS(28) is K_Eb in component BG_parameters (per_fmol). C CONSTS(29) is K_NO in component BG_parameters (per_fmol). C CONSTS(30) is K_E6c in component BG_parameters (per_fmol). C CONSTS(31) is K_NO_product in component BG_parameters (per_fmol). C VOI is t in component environment (second). C CONSTS(32) is vol_myo in component environment (pL). C STATES(1) is q_A in component environment (fmol). C STATES(2) is q_M in component environment (fmol). C STATES(3) is q_Mp in component environment (fmol). C STATES(4) is q_AM in component environment (fmol). C STATES(5) is q_AMp in component environment (fmol). C STATES(6) is q_Pi in component environment (fmol). C STATES(7) is q_Ca_i in component environment (fmol). C STATES(8) is q_cGMP in component environment (fmol). C STATES(9) is q_GTP in component environment (fmol). C STATES(10) is q_E5c in component environment (fmol). C STATES(11) is q_PDE in component environment (fmol). C STATES(12) is q_GTP_E5c in component environment (fmol). C STATES(13) is q_cGMP_PDE in component environment (fmol). C STATES(14) is q_GMP in component environment (fmol). C STATES(15) is q_Eb in component environment (fmol). C STATES(16) is q_NO in component environment (fmol). C STATES(17) is q_E6c in component environment (fmol). C STATES(18) is q_NO_product in component environment (fmol). C ALGBRC(10) is v_R_12 in component HaiMurphy (fmol_per_sec). C ALGBRC(11) is v_R_34 in component HaiMurphy (fmol_per_sec). C ALGBRC(12) is v_R_56 in component HaiMurphy (fmol_per_sec). C ALGBRC(13) is v_R_78 in component HaiMurphy (fmol_per_sec). C CONSTS(33) is n_Cai_SM in component environment (dimensionless). C ALGBRC(21) is v_R_1a_cGMP in component cGMP (fmol_per_sec). C ALGBRC(22) is v_R_1b_cGMP in component cGMP (fmol_per_sec). C ALGBRC(23) is v_R_2a_cGMP in component cGMP (fmol_per_sec). C ALGBRC(24) is v_R_2b_cGMP in component cGMP (fmol_per_sec). C ALGBRC(31) is v_R_1_sGC in component sGC (fmol_per_sec). C ALGBRC(32) is v_R_2_sGC in component sGC (fmol_per_sec). C ALGBRC(33) is v_R_3_sGC in component sGC (fmol_per_sec). C ALGBRC(34) is v_R_4_sGC in component sGC (fmol_per_sec). C ALGBRC(35) is v_R_DNO_sGC in component sGC (fmol_per_sec). C CONSTS(34) is v_NO_generation in component environment (fmol_per_sec). C ALGBRC(2) is stress in component environment (dimensionless). C CONSTS(35) is R in component constants (J_per_K_per_mol). C CONSTS(36) is T in component constants (kelvin). C CONSTS(37) is F in component constants (C_per_mol). C ALGBRC(1) is mu_A in component HaiMurphy (J_per_mol). C ALGBRC(3) is mu_M in component HaiMurphy (J_per_mol). C ALGBRC(4) is mu_Mp in component HaiMurphy (J_per_mol). C ALGBRC(5) is mu_AM in component HaiMurphy (J_per_mol). C ALGBRC(6) is mu_AMp in component HaiMurphy (J_per_mol). C ALGBRC(7) is mu_Pi in component HaiMurphy (J_per_mol). C ALGBRC(8) is mu_Ca_i in component HaiMurphy (J_per_mol). C ALGBRC(9) is mu_cGMP in component HaiMurphy (J_per_mol). C ALGBRC(14) is mu_GTP in component cGMP (J_per_mol). C ALGBRC(15) is mu_E5c in component cGMP (J_per_mol). C ALGBRC(16) is mu_cGMP in component cGMP (J_per_mol). C ALGBRC(17) is mu_PDE in component cGMP (J_per_mol). C ALGBRC(18) is mu_GTP_E5c in component cGMP (J_per_mol). C ALGBRC(19) is mu_cGMP_PDE in component cGMP (J_per_mol). C ALGBRC(20) is mu_GMP in component cGMP (J_per_mol). C ALGBRC(25) is mu_Eb in component sGC (J_per_mol). C ALGBRC(26) is mu_NO in component sGC (J_per_mol). C ALGBRC(27) is mu_E6c in component sGC (J_per_mol). C ALGBRC(28) is mu_E5c in component sGC (J_per_mol). C ALGBRC(29) is mu_cGMP in component sGC (J_per_mol). C ALGBRC(30) is mu_NO_product in component sGC (J_per_mol). C RATES(1) is d/dt q_A in component environment (fmol). C RATES(2) is d/dt q_M in component environment (fmol). C RATES(3) is d/dt q_Mp in component environment (fmol). C RATES(4) is d/dt q_AM in component environment (fmol). C RATES(5) is d/dt q_AMp in component environment (fmol). C RATES(6) is d/dt q_Pi in component environment (fmol). C RATES(7) is d/dt q_Ca_i in component environment (fmol). C RATES(8) is d/dt q_cGMP in component environment (fmol). C RATES(9) is d/dt q_GTP in component environment (fmol). C RATES(10) is d/dt q_E5c in component environment (fmol). C RATES(11) is d/dt q_PDE in component environment (fmol). C RATES(12) is d/dt q_GTP_E5c in component environment (fmol). C RATES(13) is d/dt q_cGMP_PDE in component environment (fmol). C RATES(14) is d/dt q_GMP in component environment (fmol). C RATES(15) is d/dt q_Eb in component environment (fmol). C RATES(16) is d/dt q_NO in component environment (fmol). C RATES(17) is d/dt q_E6c in component environment (fmol). C RATES(18) is d/dt q_NO_product in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.0628586 CONSTS(2) = 10.3507 CONSTS(3) = 1.13145 CONSTS(4) = 0.031236 CONSTS(5) = 192.663 CONSTS(6) = 0.00328297 CONSTS(7) = 56591.2 CONSTS(8) = 0.0110353 CONSTS(9) = 3.61127e+06 CONSTS(10) = 0.00328297 CONSTS(11) = 4.92446 CONSTS(12) = 0.0361127 CONSTS(13) = 0.01 CONSTS(14) = 1.65213 CONSTS(15) = 15.6959 CONSTS(16) = 0.105259 CONSTS(17) = 1.44065 CONSTS(18) = 0.00966114 CONSTS(19) = 723.915 CONSTS(20) = 1 CONSTS(21) = 1 CONSTS(22) = 17040 CONSTS(23) = 0.304602 CONSTS(24) = 17.6706 CONSTS(25) = 5190.42 CONSTS(26) = 35.3412 CONSTS(27) = 0.0051282 CONSTS(28) = 0.0276911 CONSTS(29) = 1 CONSTS(30) = 30.4602 CONSTS(31) = 0.1 CONSTS(32) = 1 STATES(1) = 1e-6 STATES(2) = 1e-6 STATES(3) = 0 STATES(4) = 0 STATES(5) = 0 STATES(6) = 15 STATES(7) = 1e-3 STATES(8) = 1e-6 STATES(9) = 0.0005 STATES(10) = 1e-16 STATES(11) = 1e-10 STATES(12) = 1e-16 STATES(13) = 1e-16 STATES(14) = 1e-16 STATES(15) = 1e-6 STATES(16) = 0.00836 STATES(17) = 1e-16 STATES(18) = 1e-16 CONSTS(33) = 1.66 CONSTS(34) = 0.000114 CONSTS(35) = 8.31 CONSTS(36) = 310 CONSTS(37) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = CONSTS(35)*CONSTS(36)*log( CONSTS(15)*STATES(2)) ALGBRC(4) = CONSTS(35)*CONSTS(36)*log( CONSTS(16)*STATES(3)) ALGBRC(7) = CONSTS(35)*CONSTS(36)*log( CONSTS(19)*STATES(6)) ALGBRC(8) = CONSTS(35)*CONSTS(36)*log( CONSTS(20)*STATES(7)) ALGBRC(9) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(10) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(35)*CONSTS(36)))) ALGBRC(1) = CONSTS(35)*CONSTS(36)*log( CONSTS(14)*STATES(1)) ALGBRC(6) = CONSTS(35)*CONSTS(36)*log( CONSTS(18)*STATES(5)) ALGBRC(11) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(6)/( CONSTS(35)*CONSTS(36)))) RATES(3) = ALGBRC(10) - ALGBRC(11) ALGBRC(5) = CONSTS(35)*CONSTS(36)*log( CONSTS(17)*STATES(4)) ALGBRC(12) = CONSTS(3)*(EXP((ALGBRC(6)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(35)*CONSTS(36)))) RATES(5) = ALGBRC(11) - ALGBRC(12) RATES(6) = - ALGBRC(10)+ALGBRC(12) RATES(7) = CONSTS(33)*(- ALGBRC(10) - ALGBRC(12)) ALGBRC(13) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(35)*CONSTS(36)))) RATES(1) = - ALGBRC(11)+ALGBRC(13) RATES(2) = - ALGBRC(10)+ALGBRC(13) RATES(4) = ALGBRC(12) - ALGBRC(13) ALGBRC(14) = CONSTS(35)*CONSTS(36)*log( CONSTS(22)*STATES(9)) ALGBRC(15) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10)) ALGBRC(18) = CONSTS(35)*CONSTS(36)*log( CONSTS(25)*STATES(12)) ALGBRC(21) = CONSTS(5)*(EXP((ALGBRC(14)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36)))) RATES(9) = - ALGBRC(21) ALGBRC(16) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(22) = CONSTS(6)*(EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(16)+ALGBRC(15))/( CONSTS(35)*CONSTS(36)))) RATES(12) = ALGBRC(21) - ALGBRC(22) ALGBRC(17) = CONSTS(35)*CONSTS(36)*log( CONSTS(24)*STATES(11)) ALGBRC(19) = CONSTS(35)*CONSTS(36)*log( CONSTS(26)*STATES(13)) ALGBRC(23) = CONSTS(7)*(EXP((ALGBRC(16)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(19)/( CONSTS(35)*CONSTS(36)))) ALGBRC(20) = CONSTS(35)*CONSTS(36)*log( CONSTS(27)*STATES(14)) ALGBRC(24) = CONSTS(8)*(EXP((ALGBRC(19)+ALGBRC(16))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(20)+ALGBRC(17))/( CONSTS(35)*CONSTS(36)))) RATES(11) = - ALGBRC(23)+ALGBRC(24) RATES(13) = ALGBRC(23) - ALGBRC(24) RATES(14) = ALGBRC(24) ALGBRC(25) = CONSTS(35)*CONSTS(36)*log( CONSTS(28)*STATES(15)) ALGBRC(26) = CONSTS(35)*CONSTS(36)*log( CONSTS(29)*STATES(16)) ALGBRC(27) = CONSTS(35)*CONSTS(36)*log( CONSTS(30)*STATES(17)) ALGBRC(31) = CONSTS(9)*(EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36)))) ALGBRC(28) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10)) ALGBRC(32) = CONSTS(10)*(EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(28)/( CONSTS(35)*CONSTS(36)))) ALGBRC(33) = CONSTS(11)*(EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(28)+ALGBRC(26))/( CONSTS(35)*CONSTS(36)))) RATES(17) = (ALGBRC(31) - ALGBRC(32)) - ALGBRC(33) ALGBRC(29) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(34) = CONSTS(12)*(EXP((ALGBRC(28)+ ALGBRC(29)*2.00000)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36)))) RATES(8) = (((ALGBRC(10)+ALGBRC(12)+ALGBRC(22)) - ALGBRC(23)) - ALGBRC(24)) - 2.00000*ALGBRC(34) RATES(10) = (- ALGBRC(21)+ALGBRC(22)+ALGBRC(32)+ALGBRC(33)) - ALGBRC(34) RATES(15) = - ALGBRC(31)+ALGBRC(34) ALGBRC(30) = CONSTS(35)*CONSTS(36)*log( CONSTS(31)*STATES(18)) ALGBRC(35) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(30)/( CONSTS(35)*CONSTS(36)))) RATES(16) = ((- ALGBRC(31)+ALGBRC(34)) - ALGBRC(35))+CONSTS(34) RATES(18) = ALGBRC(35) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = CONSTS(35)*CONSTS(36)*log( CONSTS(15)*STATES(2)) ALGBRC(4) = CONSTS(35)*CONSTS(36)*log( CONSTS(16)*STATES(3)) ALGBRC(7) = CONSTS(35)*CONSTS(36)*log( CONSTS(19)*STATES(6)) ALGBRC(8) = CONSTS(35)*CONSTS(36)*log( CONSTS(20)*STATES(7)) ALGBRC(9) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(10) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(7)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(4)+ALGBRC(9))/( CONSTS(35)*CONSTS(36)))) ALGBRC(1) = CONSTS(35)*CONSTS(36)*log( CONSTS(14)*STATES(1)) ALGBRC(6) = CONSTS(35)*CONSTS(36)*log( CONSTS(18)*STATES(5)) ALGBRC(11) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(6)/( CONSTS(35)*CONSTS(36)))) ALGBRC(5) = CONSTS(35)*CONSTS(36)*log( CONSTS(17)*STATES(4)) ALGBRC(12) = CONSTS(3)*(EXP((ALGBRC(6)+ CONSTS(33)*ALGBRC(8))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(5)+ALGBRC(7)+ALGBRC(9))/( CONSTS(35)*CONSTS(36)))) ALGBRC(13) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(1)+ALGBRC(3))/( CONSTS(35)*CONSTS(36)))) ALGBRC(14) = CONSTS(35)*CONSTS(36)*log( CONSTS(22)*STATES(9)) ALGBRC(15) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10)) ALGBRC(18) = CONSTS(35)*CONSTS(36)*log( CONSTS(25)*STATES(12)) ALGBRC(21) = CONSTS(5)*(EXP((ALGBRC(14)+ALGBRC(15))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36)))) ALGBRC(16) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(22) = CONSTS(6)*(EXP(ALGBRC(18)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(16)+ALGBRC(15))/( CONSTS(35)*CONSTS(36)))) ALGBRC(17) = CONSTS(35)*CONSTS(36)*log( CONSTS(24)*STATES(11)) ALGBRC(19) = CONSTS(35)*CONSTS(36)*log( CONSTS(26)*STATES(13)) ALGBRC(23) = CONSTS(7)*(EXP((ALGBRC(16)+ALGBRC(17))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(19)/( CONSTS(35)*CONSTS(36)))) ALGBRC(20) = CONSTS(35)*CONSTS(36)*log( CONSTS(27)*STATES(14)) ALGBRC(24) = CONSTS(8)*(EXP((ALGBRC(19)+ALGBRC(16))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(20)+ALGBRC(17))/( CONSTS(35)*CONSTS(36)))) ALGBRC(25) = CONSTS(35)*CONSTS(36)*log( CONSTS(28)*STATES(15)) ALGBRC(26) = CONSTS(35)*CONSTS(36)*log( CONSTS(29)*STATES(16)) ALGBRC(27) = CONSTS(35)*CONSTS(36)*log( CONSTS(30)*STATES(17)) ALGBRC(31) = CONSTS(9)*(EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36)))) ALGBRC(28) = CONSTS(35)*CONSTS(36)*log( CONSTS(23)*STATES(10)) ALGBRC(32) = CONSTS(10)*(EXP(ALGBRC(27)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(28)/( CONSTS(35)*CONSTS(36)))) ALGBRC(33) = CONSTS(11)*(EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(28)+ALGBRC(26))/( CONSTS(35)*CONSTS(36)))) ALGBRC(29) = CONSTS(35)*CONSTS(36)*log( CONSTS(21)*STATES(8)) ALGBRC(34) = CONSTS(12)*(EXP((ALGBRC(28)+ ALGBRC(29)*2.00000)/( CONSTS(35)*CONSTS(36))) - EXP((ALGBRC(25)+ALGBRC(26))/( CONSTS(35)*CONSTS(36)))) ALGBRC(30) = CONSTS(35)*CONSTS(36)*log( CONSTS(31)*STATES(18)) ALGBRC(35) = CONSTS(13)*(EXP(ALGBRC(26)/( CONSTS(35)*CONSTS(36))) - EXP(ALGBRC(30)/( CONSTS(35)*CONSTS(36)))) ALGBRC(2) = (STATES(4)+STATES(5))/1.00000 RETURN END