This model has been curated by Penny Noble
Richard
James
Lawson
Kohl
P
calcium dynamics
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes
14(1)
134
123
Units checked, curated.
Department of Physiology, Anatomy & Genetics, University of Oxford
Canadian Journal of Cardiology
Richard
James
Lawson
9487284
Noble
P
excitation-contraction coupling
diadic space
cardiac
guinea-pig
ventricular myocyte
electrophysiology
keyword
Penny
Noble
Note that the missing i_NCX_ds component was added to the dCai/dt rather than the dCads/dt equation in order to achieve balance in the model.
Penny Noble was informed by a community member that INaCads was not included in the dCads/dt ODE and hence the system was out of balance. This has been fixed in version 07. An alteration was also made to the model to remove two differential expressions in the intracellular_calcium concentration component to allow PCEnv 0.2 to run the model.
100000
bdf15
0.001
Changed stim_end in stimulus protocol from 10.1 to 1,000,000 seconds
Penny
J
Noble
2006-05-03T00:00:00+00:00
James
Lawson
Richard
2008-05-14T03:16:52+12:00
Varghese
A
James Lawson
Several variables have been given cmeta:id's to allow creation of a PCEnv session file.
2007-02-06T13:00:00+13:00
James Lawson
This version was created by Penny Noble and is known to read into COR. James Lawson fixed an error (19/04/07) that prevented it reading in PCEnv (unsupported predefined operator diff in component intracellular_calcium_concentration. This variant of version 06 is the STRETCH model, which includes acetylcholine dependent modulation and the electromechanical processes simulated by Variant 02, and also includes simulation of stretch and fibroblasts. This model is parameterised the same as the BASIC model, with all additional variables set to zero.
To simulate multiple action potentials with this model the following integrator parameters must be used: max step size must be 0.001 or less, max point density must be 10,000 or more.
2007-06-22T13:59:26+12:00
Noble
J
Penny
Oxford University
Department of Physiology, Anatomy & Genetics
J
Penny
Noble
2007-12-04T15:11:55+13:00
D
Noble
2007-09-06T13:01:21+12:00
0.001
50000
penny.noble@dpag.ox.ac.uk
2007-07-18T12:59:52+12:00
This file is a CellML description of Noble, Carghese, Kohl and Noble's 1998 extension of their 1991 guinea pig ventricular cell model. This model incorporates a diadic space, IKr and IKs currents, and length and tension dependent processes. Variant 3 is parameterised for the 'stretch' model.
1998-01-00 00:00