C C There are a total of 64 entries in the algebraic variable array. C There are a total of 19 entries in each of the rate and state variable arrays. C There are a total of 73 entries in the constant variable array. C C C VOI is t in component environment (ms). C CONSTS(1) is R in component environment (mJ_per_mole_kelvin). C CONSTS(2) is T in component environment (kelvin). C CONSTS(3) is F in component environment (coulomb_per_mole). C CONSTS(65) is V_tau in component environment (mV). C CONSTS(4) is Ca_o in component environment (mM). C CONSTS(5) is Na_o in component environment (mM). C CONSTS(6) is K_o in component environment (mM). C CONSTS(7) is dia in component environment (cm). C CONSTS(62) is vol_cyt in component environment (pl). C CONSTS(58) is vol_pmu in component environment (pl). C CONSTS(8) is fr_cyt in component environment (dimensionless). C ALGBRC(1) is V in component Membrane (mV). C ALGBRC(2) is VD in component Membrane (dimensionless). C CONSTS(9) is C_sp in component Membrane (pF_per_sqcm). C STATES(1) is Ca_i in component Cytosol (mM). C STATES(2) is Na_i in component Cytosol (mM). C STATES(3) is K_i in component Cytosol (mM). C CONSTS(69) is anoff in component Membrane (mM). C ALGBRC(4) is V_Ca in component Membrane (dimensionless). C ALGBRC(6) is V_Na in component Membrane (dimensionless). C ALGBRC(8) is V_K in component Membrane (dimensionless). C CONSTS(67) is A_pmu in component Membrane (sqcm). C CONSTS(64) is SVR_pmu in component Membrane (per_cm). C CONSTS(10) is svr in component Membrane (dimensionless). C CONSTS(70) is C_m in component Membrane (pF). C CONSTS(11) is atp in component Cytosol (mM). C ALGBRC(64) is J_Ca in component calcium_dynamics (mM_per_ms). C ALGBRC(63) is J_Na in component sodium_dynamics (mM_per_ms). C ALGBRC(46) is J_K in component potassium_dynamics (mM_per_ms). C ALGBRC(62) is J_ca in component calcium_dynamics (mM_per_ms). C ALGBRC(21) is I_CaL in component L_type_Ca_channel (pA). C ALGBRC(22) is I_CaT in component T_type_Ca_channel (pA). C ALGBRC(23) is I_CaHVA in component HVA_Ca_channel (pA). C ALGBRC(50) is I_pmca in component PMCA (pA). C ALGBRC(60) is I_xm in component Membrane_NaCa (pA). C ALGBRC(17) is J_calb in component calcium_buffer_dynamics (mM_per_ms). C ALGBRC(19) is J_cam in component calcium_buffer_dynamics (mM_per_ms). C ALGBRC(25) is I_Na in component transient_Na_channel (pA). C ALGBRC(26) is I_Nalk in component Leak_Na_channel (pA). C ALGBRC(27) is I_NaHCN in component HCN_channel (pA). C ALGBRC(43) is I_nk in component sodium_pump (pA). C ALGBRC(37) is I_K in component potassium_dynamics (pA). C ALGBRC(30) is I_Ksk in component SK_K_channel (pA). C ALGBRC(32) is I_Kdr in component DR_K_channel (pA). C ALGBRC(34) is I_Ka in component Atype_K_channel (pA). C ALGBRC(36) is I_Kir in component IR_K_channel (pA). C ALGBRC(28) is I_KHCN in component HCN_channel (pA). C STATES(4) is Calb in component calcium_buffer_dynamics (mM). C STATES(5) is Cam in component calcium_buffer_dynamics (mM). C CONSTS(12) is Calbtot in component calcium_buffer_dynamics (mM). C CONSTS(13) is Camtot in component calcium_buffer_dynamics (mM). C ALGBRC(16) is CaCalb in component calcium_buffer_dynamics (mM). C ALGBRC(18) is CaCam in component calcium_buffer_dynamics (mM). C CONSTS(14) is kcal_1 in component calcium_buffer_dynamics (per_mM_ms). C CONSTS(15) is kcal_2 in component calcium_buffer_dynamics (per_ms). C ALGBRC(10) is kcam_cb in component calcium_buffer_dynamics (per_ms). C CONSTS(16) is kcam_cd in component calcium_buffer_dynamics (per_ms). C ALGBRC(12) is kcam_nb in component calcium_buffer_dynamics (per_ms). C CONSTS(17) is kcam_nd in component calcium_buffer_dynamics (per_ms). C ALGBRC(14) is alpha_cam in component calcium_buffer_dynamics (per_ms). C ALGBRC(15) is beta_cam in component calcium_buffer_dynamics (per_ms). C STATES(6) is m_cal in component L_type_Ca_channel (dimensionless). C ALGBRC(20) is h_cal in component L_type_Ca_channel (dimensionless). C CONSTS(18) is g_cal in component L_type_Ca_channel (pA_per_mM). C STATES(7) is m_cat in component T_type_Ca_channel (dimensionless). C STATES(8) is h_cat in component T_type_Ca_channel (dimensionless). C CONSTS(19) is g_cat in component T_type_Ca_channel (pA_per_mM). C STATES(9) is m_cah in component HVA_Ca_channel (dimensionless). C STATES(10) is h_cah in component HVA_Ca_channel (dimensionless). C CONSTS(20) is g_cah in component HVA_Ca_channel (pA_per_mM). C CONSTS(21) is g_na in component transient_Na_channel (pA_per_mM). C ALGBRC(24) is O_na in component transient_Na_channel (dimensionless). C STATES(11) is m_na in component transient_Na_channel (dimensionless). C STATES(12) is h_na in component transient_Na_channel (dimensionless). C CONSTS(22) is A_mna in component transient_Na_channel (per_ms). C CONSTS(23) is B_mna in component transient_Na_channel (per_ms). C CONSTS(24) is A_hna in component transient_Na_channel (per_ms). C CONSTS(25) is B_hna in component transient_Na_channel (per_ms). C CONSTS(26) is za_mna in component transient_Na_channel (dimensionless). C CONSTS(27) is zb_mna in component transient_Na_channel (dimensionless). C CONSTS(28) is za_hna in component transient_Na_channel (dimensionless). C CONSTS(29) is zb_hna in component transient_Na_channel (dimensionless). C CONSTS(30) is g_nalk in component Leak_Na_channel (pA_per_mM). C CONSTS(31) is g_nahcn in component HCN_channel (pA_per_mM). C STATES(13) is O_hcn in component HCN_channel (dimensionless). C CONSTS(32) is g_khcn in component HCN_channel (pA_per_mM). C ALGBRC(9) is kf_hcn in component HCN_channel (per_ms). C ALGBRC(13) is kr_hcn in component HCN_channel (per_ms). C ALGBRC(3) is kf_free in component HCN_channel (per_ms). C ALGBRC(5) is kr_free in component HCN_channel (per_ms). C ALGBRC(7) is kf_bnd in component HCN_channel (per_ms). C ALGBRC(11) is kr_bnd in component HCN_channel (per_ms). C CONSTS(68) is P_c in component HCN_channel (dimensionless). C CONSTS(71) is P_o in component HCN_channel (dimensionless). C CONSTS(33) is cAMP in component HCN_channel (mM). C ALGBRC(29) is O_sk in component SK_K_channel (dimensionless). C CONSTS(34) is g_ksk in component SK_K_channel (pA_per_mM). C ALGBRC(31) is O_kdr in component DR_K_channel (dimensionless). C STATES(14) is m_kdr in component DR_K_channel (dimensionless). C CONSTS(35) is g_kdr in component DR_K_channel (pA_per_mV). C ALGBRC(33) is O_ka in component Atype_K_channel (dimensionless). C STATES(15) is p_ka in component Atype_K_channel (dimensionless). C STATES(16) is q_ka in component Atype_K_channel (dimensionless). C CONSTS(36) is g_ka in component Atype_K_channel (pA_per_mV). C ALGBRC(35) is O_kir in component IR_K_channel (dimensionless). C CONSTS(37) is g_kir in component IR_K_channel (pA_per_mV). C ALGBRC(38) is Na_eff in component sodium_pump (mM). C STATES(17) is y_nk in component sodium_pump (dimensionless). C ALGBRC(41) is alpha_nk in component sodium_pump (per_ms). C ALGBRC(47) is beta_nk in component sodium_pump (per_ms). C ALGBRC(39) is P_E1Snk in component sodium_pump (dimensionless). C ALGBRC(42) is P_E2Snk in component sodium_pump (dimensionless). C ALGBRC(40) is P_E1Dnk in component sodium_pump (dimensionless). C ALGBRC(44) is P_E2Dnk in component sodium_pump (dimensionless). C CONSTS(59) is k_1nk in component sodium_pump (per_ms). C CONSTS(38) is k_2nk in component sodium_pump (per_ms). C CONSTS(39) is k_3nk in component sodium_pump (per_ms). C CONSTS(40) is k_4nk in component sodium_pump (per_ms). C CONSTS(41) is K_nknai in component sodium_pump (mM). C CONSTS(42) is K_nknao in component sodium_pump (mM). C CONSTS(43) is K_nkki in component sodium_pump (mM). C CONSTS(44) is K_nkko in component sodium_pump (mM). C CONSTS(45) is k_nk in component sodium_pump (pA). C STATES(18) is y_pc in component PMCA (dimensionless). C ALGBRC(45) is K_pmca in component PMCA (pA). C CONSTS(60) is k_1pc in component PMCA (per_ms). C CONSTS(46) is k_2pc in component PMCA (per_ms). C CONSTS(47) is k_3pc in component PMCA (per_ms). C CONSTS(48) is k_4pc in component PMCA (per_ms). C ALGBRC(49) is P_E1Spc in component PMCA (dimensionless). C CONSTS(61) is P_E2Spc in component PMCA (dimensionless). C ALGBRC(51) is P_E1pc in component PMCA (dimensionless). C CONSTS(63) is P_E2pc in component PMCA (dimensionless). C ALGBRC(53) is alpha_pc in component PMCA (per_ms). C CONSTS(66) is beta_pc in component PMCA (per_ms). C ALGBRC(48) is K_pci in component PMCA (mM). C CONSTS(49) is K_pco in component PMCA (mM). C CONSTS(50) is k_pmca in component PMCA (dimensionless). C CONSTS(73) is P_E2Dxm in component Membrane_NaCa (dimensionless). C ALGBRC(54) is P_E1Dxm in component Membrane_NaCa (dimensionless). C ALGBRC(52) is P_E1Sxm in component Membrane_NaCa (dimensionless). C CONSTS(72) is P_E2Sxm in component Membrane_NaCa (dimensionless). C ALGBRC(55) is k_1xm in component Membrane_NaCa (per_ms). C ALGBRC(56) is k_2xm in component Membrane_NaCa (per_ms). C ALGBRC(57) is k_3xm in component Membrane_NaCa (per_ms). C ALGBRC(59) is k_4xm in component Membrane_NaCa (per_ms). C ALGBRC(61) is beta_xm in component Membrane_NaCa (per_ms). C ALGBRC(58) is alpha_xm in component Membrane_NaCa (per_ms). C CONSTS(51) is K_xmnai in component Membrane_NaCa (mM). C CONSTS(52) is K_xmnao in component Membrane_NaCa (mM). C CONSTS(53) is K_xmcai in component Membrane_NaCa (mM). C CONSTS(54) is K_xmcao in component Membrane_NaCa (mM). C CONSTS(55) is delta_xmca in component Membrane_NaCa (dimensionless). C CONSTS(56) is delta_xmna in component Membrane_NaCa (dimensionless). C STATES(19) is y_xm in component Membrane_NaCa (dimensionless). C CONSTS(57) is k_xm in component Membrane_NaCa (pA_ms). C RATES(1) is d/dt Ca_i in component Cytosol (mM). C RATES(2) is d/dt Na_i in component Cytosol (mM). C RATES(3) is d/dt K_i in component Cytosol (mM). C RATES(4) is d/dt Calb in component calcium_buffer_dynamics (mM). C RATES(5) is d/dt Cam in component calcium_buffer_dynamics (mM). C RATES(6) is d/dt m_cal in component L_type_Ca_channel (dimensionless). C RATES(7) is d/dt m_cat in component T_type_Ca_channel (dimensionless). C RATES(8) is d/dt h_cat in component T_type_Ca_channel (dimensionless). C RATES(9) is d/dt m_cah in component HVA_Ca_channel (dimensionless). C RATES(10) is d/dt h_cah in component HVA_Ca_channel (dimensionless). C RATES(11) is d/dt m_na in component transient_Na_channel (dimensionless). C RATES(12) is d/dt h_na in component transient_Na_channel (dimensionless). C RATES(13) is d/dt O_hcn in component HCN_channel (dimensionless). C RATES(14) is d/dt m_kdr in component DR_K_channel (dimensionless). C RATES(15) is d/dt p_ka in component Atype_K_channel (dimensionless). C RATES(16) is d/dt q_ka in component Atype_K_channel (dimensionless). C RATES(17) is d/dt y_nk in component sodium_pump (dimensionless). C RATES(18) is d/dt y_pc in component PMCA (dimensionless). C RATES(19) is d/dt y_xm in component Membrane_NaCa (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 8314.472 CONSTS(2) = 310.15 CONSTS(3) = 96485.30929 CONSTS(4) = 1.8 CONSTS(5) = 137 CONSTS(6) = 5.4 CONSTS(7) = 30e-4 CONSTS(8) = 1 CONSTS(9) = 0.9e6 STATES(1) = 0.00015 STATES(2) = 6 STATES(3) = 140 CONSTS(10) = 6 CONSTS(11) = 2 STATES(4) = 0.0011 STATES(5) = 0.0487 CONSTS(12) = 0.002 CONSTS(13) = 0.0489 CONSTS(14) = 10 CONSTS(15) = 2e-3 CONSTS(16) = 0.003 CONSTS(17) = 3 STATES(6) = 0.0004 CONSTS(18) = 1158.2 STATES(7) = 0.1099 STATES(8) = 0.5716 CONSTS(19) = 10 STATES(9) = 0.3021 STATES(10) = 0.454 CONSTS(20) = 78.5 CONSTS(21) = 395.14 STATES(11) = 0.0758 STATES(12) = 0.2272 CONSTS(22) = 1.9651 CONSTS(23) = 0.0424 CONSTS(24) = 9.566e-5 CONSTS(25) = 0.5296 CONSTS(26) = 1.7127 CONSTS(27) = 1.5581 CONSTS(28) = -2.4317 CONSTS(29) = -1.1868 CONSTS(30) = 0.0039 CONSTS(31) = 3 STATES(13) = 0 CONSTS(32) = 10 CONSTS(33) = 1e-5 CONSTS(34) = 15 STATES(14) = 0.0043 CONSTS(35) = 10 STATES(15) = 0.2577 STATES(16) = 0.827 CONSTS(36) = 0.2234 CONSTS(37) = 5 STATES(17) = 0.555 CONSTS(38) = 0.04 CONSTS(39) = 0.01 CONSTS(40) = 0.165 CONSTS(41) = 4.05 CONSTS(42) = 69.8 CONSTS(43) = 32.88 CONSTS(44) = 0.258 CONSTS(45) = 200 STATES(18) = 0.001 CONSTS(46) = 0.001 CONSTS(47) = 0.001 CONSTS(48) = 1 CONSTS(49) = 2 CONSTS(50) = 10 CONSTS(51) = 8.75 CONSTS(52) = 87.5 CONSTS(53) = 0.00138 CONSTS(54) = 1.38 CONSTS(55) = 0.68 CONSTS(56) = 0.32 STATES(19) = 0.343 CONSTS(57) = 25 CONSTS(58) = ( (( 3.14159265358979*CONSTS(7) ** 3.00000)/6.00000)*1.00000e+09)/( 1.00000*1.00000*1.00000) CONSTS(59) = 0.370000/(1.00000+0.0940000/CONSTS(11)) CONSTS(60) = 1.00000/(1.00000+0.100000/CONSTS(11)) CONSTS(61) = 1.00000/(1.00000+CONSTS(49)/CONSTS(4)) CONSTS(62) = CONSTS(8)*CONSTS(58) CONSTS(63) = 1.00000 - CONSTS(61) CONSTS(64) = CONSTS(10)/CONSTS(7) CONSTS(65) = ( CONSTS(1)*CONSTS(2))/CONSTS(3) CONSTS(66) = CONSTS(46)*CONSTS(61)+ CONSTS(48)*CONSTS(63) CONSTS(67) = ( CONSTS(64)*CONSTS(58)*0.00100000*0.00100000*0.00100000)/1.00000 CONSTS(68) = 1.00000/(1.00000+CONSTS(33)/0.00116300) CONSTS(69) = ((( - 52.3100*CONSTS(9)*CONSTS(67))/( CONSTS(3)*CONSTS(62)) - 2.00000*(0.000150000 - CONSTS(4))) - (6.00000 - CONSTS(5))) - (140.000 - CONSTS(6)) CONSTS(70) = CONSTS(9)*CONSTS(67) CONSTS(71) = 1.00000/(1.00000+CONSTS(33)/1.45000e-05) CONSTS(72) = 1.00000/(1.00000+ (CONSTS(54)/CONSTS(4))*(1.00000+CONSTS(5)/CONSTS(52) ** 3.00000)) CONSTS(73) = 1.00000/(1.00000+ CONSTS(52)/CONSTS(5) ** 3.00000*(1.00000+CONSTS(4)/CONSTS(54))) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = (( CONSTS(3)*CONSTS(62))/( CONSTS(9)*CONSTS(67)))*((((STATES(3) - CONSTS(6))+ 2.00000*(STATES(1) - CONSTS(4))+STATES(2)) - CONSTS(5))+CONSTS(69)) RATES(6) = (1.00000/(1.00000+EXP(- (ALGBRC(1)+15.0000)/7.00000)) - STATES(6))/( 10.0000*EXP(- (ALGBRC(1)+86.4000)/23.2000 ** 2.00000)+0.943000) RATES(7) = (1.00000/(1.00000+EXP(- (ALGBRC(1)+63.0000)/1.50000)) - STATES(7))/( 65.0000*EXP(- (ALGBRC(1)+68.0000)/6.00000 ** 2.00000)+12.0000) RATES(8) = (1.00000/(1.00000+EXP((ALGBRC(1)+76.2000)/3.00000)) - STATES(8))/( 50.0000*EXP(- (ALGBRC(1)+72.0000)/10.0000 ** 2.00000)+10.0000) RATES(9) = (1.00000/(1.00000+EXP(- (ALGBRC(1)+10.0000)/10.0000)) - STATES(9))/( 0.100000*EXP(- (ALGBRC(1)+62.0000)/13.0000 ** 2.00000)+0.0500000) RATES(10) = (1.00000/(1.00000+EXP((ALGBRC(1)+48.0000)/5.00000)) - STATES(10))/( 0.500000*EXP(- (ALGBRC(1)+55.6000)/18.0000 ** 2.00000)+0.500000) RATES(14) = (1.00000/(1.00000+EXP(- (ALGBRC(1)+25.0000)/12.0000)) - STATES(14))/(18.0000/(1.00000+EXP((ALGBRC(1)+39.0000)/8.00000))+1.00000) RATES(15) = (1.00000/(1.00000+EXP(- (ALGBRC(1)+43.0000)/24.0000)) - STATES(15))/( 2.00000*EXP(- (ALGBRC(1)+50.0000)/23.4500 ** 2.00000)+1.10000) RATES(16) = (1.00000/(1.00000+EXP((ALGBRC(1)+56.0000)/8.00000)) - STATES(16))/20.0000 ALGBRC(2) = ALGBRC(1)/CONSTS(65) RATES(11) = CONSTS(22)*EXP( CONSTS(26)*ALGBRC(2))*(1.00000 - STATES(11)) - CONSTS(23)*EXP( - CONSTS(27)*ALGBRC(2))*STATES(11) RATES(12) = CONSTS(24)*EXP( CONSTS(28)*ALGBRC(2))*(1.00000 - STATES(12)) - CONSTS(25)*EXP( - CONSTS(29)*ALGBRC(2))*STATES(12) ALGBRC(3) = 0.00600000/(1.00000+EXP((ALGBRC(1)+87.7000)/6.45000)) ALGBRC(7) = 0.0268000/(1.00000+EXP((ALGBRC(1)+94.2000)/13.3000)) ALGBRC(9) = ALGBRC(3)*CONSTS(68)+ ALGBRC(7)*(1.00000 - CONSTS(68)) ALGBRC(5) = 0.0800000/(1.00000+EXP(- (ALGBRC(1)+51.7000)/7.00000)) ALGBRC(11) = 0.0800000/(1.00000+EXP(- (ALGBRC(1)+35.5000)/7.00000)) ALGBRC(13) = ALGBRC(5)*CONSTS(71)+ ALGBRC(11)*(1.00000 - CONSTS(71)) RATES(13) = ALGBRC(9)*(1.00000 - STATES(13)) - ALGBRC(13)*STATES(13) ALGBRC(16) = CONSTS(12) - STATES(4) ALGBRC(17) = CONSTS(14)*STATES(4)*STATES(1) - CONSTS(15)*ALGBRC(16) RATES(4) = - ALGBRC(17) ALGBRC(18) = CONSTS(13) - STATES(5) ALGBRC(10) = 12000.0*STATES(1) ** 2.00000 ALGBRC(12) = 3.70000e+06*STATES(1) ** 2.00000 ALGBRC(14) = ALGBRC(10)*ALGBRC(12)*(1.00000/(ALGBRC(10)+CONSTS(17))+1.00000/(CONSTS(16)+CONSTS(17))) ALGBRC(15) = CONSTS(16)*CONSTS(17)*(1.00000/(ALGBRC(10)+CONSTS(17))+1.00000/(CONSTS(16)+CONSTS(17))) ALGBRC(19) = ALGBRC(14)*STATES(5) - ALGBRC(15)*ALGBRC(18) RATES(5) = - ALGBRC(19) ALGBRC(39) = 1.00000/(1.00000+ (CONSTS(41)/STATES(2))*(1.00000+STATES(3)/CONSTS(43))) ALGBRC(38) = CONSTS(5)*EXP( - 0.820000*ALGBRC(2)) ALGBRC(42) = 1.00000/(1.00000+ (CONSTS(42)/ALGBRC(38))*(1.00000+CONSTS(6)/CONSTS(44))) ALGBRC(43) = CONSTS(45)*( CONSTS(59)*ALGBRC(39)*STATES(17) - CONSTS(38)*ALGBRC(42)*(1.00000 - STATES(17)))*1.00000 ALGBRC(8) = log(CONSTS(6)/STATES(3)) ALGBRC(29) = STATES(1) ** 4.20000/(0.000350000 ** 4.20000+STATES(1) ** 4.20000) ALGBRC(30) = ( CONSTS(34)*ALGBRC(29)* ( STATES(3)*CONSTS(6)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(8))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(31) = STATES(14) ** 3.00000 ALGBRC(32) = CONSTS(35)*ALGBRC(31)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(33) = STATES(15) ** 3.00000*STATES(16) ALGBRC(34) = CONSTS(36)*ALGBRC(33)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(35) = 1.00000/(1.00000+EXP((ALGBRC(1)+90.0000)/12.1000)) ALGBRC(36) = CONSTS(37)*ALGBRC(35)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(28) = ( CONSTS(32)*STATES(13)* ( STATES(3)*CONSTS(6)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(8))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(37) = ALGBRC(30)+ALGBRC(28)+ALGBRC(34)+ALGBRC(32)+ALGBRC(36) ALGBRC(46) = (- 1.00000/( CONSTS(3)*CONSTS(62)))*(ALGBRC(37) - 2.00000*ALGBRC(43)) RATES(3) = ALGBRC(46) ALGBRC(40) = 1.00000/(1.00000+ (CONSTS(43)/STATES(3))*(1.00000+STATES(2)/CONSTS(41))) ALGBRC(41) = CONSTS(59)*ALGBRC(39)+ CONSTS(39)*ALGBRC(40) ALGBRC(44) = 1.00000/(1.00000+ (CONSTS(44)/CONSTS(6))*(1.00000+ALGBRC(38)/CONSTS(42))) ALGBRC(47) = CONSTS(38)*ALGBRC(42)+ CONSTS(40)*ALGBRC(44) RATES(17) = ALGBRC(47)*(1.00000 - STATES(17)) - ALGBRC(41)*STATES(17) ALGBRC(48) = (173.600/(1.00000+ALGBRC(18)/5.00000e-05)+6.40000)*1.00000e-05 ALGBRC(49) = 1.00000/(1.00000+ALGBRC(48)/STATES(1)) ALGBRC(51) = 1.00000 - ALGBRC(49) ALGBRC(53) = CONSTS(60)*ALGBRC(49)+ CONSTS(47)*ALGBRC(51) RATES(18) = CONSTS(66)*(1.00000 - STATES(18)) - ALGBRC(53)*STATES(18) ALGBRC(56) = 1.00000*EXP( (1.00000 - CONSTS(55))*ALGBRC(2)) ALGBRC(59) = 1.00000*EXP( - CONSTS(56)*ALGBRC(2)) ALGBRC(61) = ALGBRC(56)*CONSTS(72)+ ALGBRC(59)*CONSTS(73) ALGBRC(54) = 1.00000/(1.00000+ CONSTS(51)/STATES(2) ** 3.00000*(1.00000+STATES(1)/CONSTS(53))) ALGBRC(52) = 1.00000/(1.00000+ (CONSTS(53)/STATES(1))*(1.00000+STATES(2)/CONSTS(51) ** 3.00000)) ALGBRC(55) = 1.00000*EXP( - CONSTS(55)*ALGBRC(2)) ALGBRC(57) = 1.00000*EXP( (1.00000 - CONSTS(56))*ALGBRC(2)) ALGBRC(58) = ALGBRC(55)*ALGBRC(52)+ ALGBRC(57)*ALGBRC(54) RATES(19) = ALGBRC(61)*(1.00000 - STATES(19)) - ALGBRC(58)*STATES(19) ALGBRC(60) = CONSTS(57)*( ALGBRC(57)*ALGBRC(54)*STATES(19) - ALGBRC(59)*CONSTS(73)*(1.00000 - STATES(19))) ALGBRC(6) = log(CONSTS(5)/STATES(2)) ALGBRC(24) = STATES(11) ** 3.00000*STATES(12) ALGBRC(25) = ( CONSTS(21)*ALGBRC(24)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(26) = ( CONSTS(30)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(27) = ( CONSTS(31)*STATES(13)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(63) = (- 1.00000/( CONSTS(3)*CONSTS(62)))*( 3.00000*ALGBRC(43)+ 3.00000*ALGBRC(60)+ALGBRC(25)+ALGBRC(26)+ALGBRC(27)) RATES(2) = ALGBRC(63) ALGBRC(4) = 0.500000*log(CONSTS(4)/STATES(1)) ALGBRC(20) = 0.000450000/(0.000450000+STATES(1)) ALGBRC(21) = ( CONSTS(18)*STATES(6)*ALGBRC(20)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(22) = ( CONSTS(19)*STATES(7)*STATES(8)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(23) = ( CONSTS(20)*STATES(9)*STATES(10)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(45) = CONSTS(50)*(( 10.5600*ALGBRC(18))/(ALGBRC(18)+5.00000e-05)+1.20000) ALGBRC(50) = ALGBRC(45)*( CONSTS(60)*ALGBRC(49)*STATES(18) - CONSTS(46)*CONSTS(61)*(1.00000 - STATES(18)))*1.00000 ALGBRC(62) = (- 1.00000/( 2.00000*CONSTS(3)*CONSTS(62)))*((ALGBRC(21)+ALGBRC(22)+ALGBRC(23)+ 2.00000*ALGBRC(50)) - 2.00000*ALGBRC(60)) ALGBRC(64) = ALGBRC(62) - (ALGBRC(17)+ 4.00000*ALGBRC(19)) RATES(1) = ALGBRC(64) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = (( CONSTS(3)*CONSTS(62))/( CONSTS(9)*CONSTS(67)))*((((STATES(3) - CONSTS(6))+ 2.00000*(STATES(1) - CONSTS(4))+STATES(2)) - CONSTS(5))+CONSTS(69)) ALGBRC(2) = ALGBRC(1)/CONSTS(65) ALGBRC(3) = 0.00600000/(1.00000+EXP((ALGBRC(1)+87.7000)/6.45000)) ALGBRC(7) = 0.0268000/(1.00000+EXP((ALGBRC(1)+94.2000)/13.3000)) ALGBRC(9) = ALGBRC(3)*CONSTS(68)+ ALGBRC(7)*(1.00000 - CONSTS(68)) ALGBRC(5) = 0.0800000/(1.00000+EXP(- (ALGBRC(1)+51.7000)/7.00000)) ALGBRC(11) = 0.0800000/(1.00000+EXP(- (ALGBRC(1)+35.5000)/7.00000)) ALGBRC(13) = ALGBRC(5)*CONSTS(71)+ ALGBRC(11)*(1.00000 - CONSTS(71)) ALGBRC(16) = CONSTS(12) - STATES(4) ALGBRC(17) = CONSTS(14)*STATES(4)*STATES(1) - CONSTS(15)*ALGBRC(16) ALGBRC(18) = CONSTS(13) - STATES(5) ALGBRC(10) = 12000.0*STATES(1) ** 2.00000 ALGBRC(12) = 3.70000e+06*STATES(1) ** 2.00000 ALGBRC(14) = ALGBRC(10)*ALGBRC(12)*(1.00000/(ALGBRC(10)+CONSTS(17))+1.00000/(CONSTS(16)+CONSTS(17))) ALGBRC(15) = CONSTS(16)*CONSTS(17)*(1.00000/(ALGBRC(10)+CONSTS(17))+1.00000/(CONSTS(16)+CONSTS(17))) ALGBRC(19) = ALGBRC(14)*STATES(5) - ALGBRC(15)*ALGBRC(18) ALGBRC(39) = 1.00000/(1.00000+ (CONSTS(41)/STATES(2))*(1.00000+STATES(3)/CONSTS(43))) ALGBRC(38) = CONSTS(5)*EXP( - 0.820000*ALGBRC(2)) ALGBRC(42) = 1.00000/(1.00000+ (CONSTS(42)/ALGBRC(38))*(1.00000+CONSTS(6)/CONSTS(44))) ALGBRC(43) = CONSTS(45)*( CONSTS(59)*ALGBRC(39)*STATES(17) - CONSTS(38)*ALGBRC(42)*(1.00000 - STATES(17)))*1.00000 ALGBRC(8) = log(CONSTS(6)/STATES(3)) ALGBRC(29) = STATES(1) ** 4.20000/(0.000350000 ** 4.20000+STATES(1) ** 4.20000) ALGBRC(30) = ( CONSTS(34)*ALGBRC(29)* ( STATES(3)*CONSTS(6)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(8))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(31) = STATES(14) ** 3.00000 ALGBRC(32) = CONSTS(35)*ALGBRC(31)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(33) = STATES(15) ** 3.00000*STATES(16) ALGBRC(34) = CONSTS(36)*ALGBRC(33)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(35) = 1.00000/(1.00000+EXP((ALGBRC(1)+90.0000)/12.1000)) ALGBRC(36) = CONSTS(37)*ALGBRC(35)*(ALGBRC(1) - ALGBRC(8)*CONSTS(65)) ALGBRC(28) = ( CONSTS(32)*STATES(13)* ( STATES(3)*CONSTS(6)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(8))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(37) = ALGBRC(30)+ALGBRC(28)+ALGBRC(34)+ALGBRC(32)+ALGBRC(36) ALGBRC(46) = (- 1.00000/( CONSTS(3)*CONSTS(62)))*(ALGBRC(37) - 2.00000*ALGBRC(43)) ALGBRC(40) = 1.00000/(1.00000+ (CONSTS(43)/STATES(3))*(1.00000+STATES(2)/CONSTS(41))) ALGBRC(41) = CONSTS(59)*ALGBRC(39)+ CONSTS(39)*ALGBRC(40) ALGBRC(44) = 1.00000/(1.00000+ (CONSTS(44)/CONSTS(6))*(1.00000+ALGBRC(38)/CONSTS(42))) ALGBRC(47) = CONSTS(38)*ALGBRC(42)+ CONSTS(40)*ALGBRC(44) ALGBRC(48) = (173.600/(1.00000+ALGBRC(18)/5.00000e-05)+6.40000)*1.00000e-05 ALGBRC(49) = 1.00000/(1.00000+ALGBRC(48)/STATES(1)) ALGBRC(51) = 1.00000 - ALGBRC(49) ALGBRC(53) = CONSTS(60)*ALGBRC(49)+ CONSTS(47)*ALGBRC(51) ALGBRC(56) = 1.00000*EXP( (1.00000 - CONSTS(55))*ALGBRC(2)) ALGBRC(59) = 1.00000*EXP( - CONSTS(56)*ALGBRC(2)) ALGBRC(61) = ALGBRC(56)*CONSTS(72)+ ALGBRC(59)*CONSTS(73) ALGBRC(54) = 1.00000/(1.00000+ CONSTS(51)/STATES(2) ** 3.00000*(1.00000+STATES(1)/CONSTS(53))) ALGBRC(52) = 1.00000/(1.00000+ (CONSTS(53)/STATES(1))*(1.00000+STATES(2)/CONSTS(51) ** 3.00000)) ALGBRC(55) = 1.00000*EXP( - CONSTS(55)*ALGBRC(2)) ALGBRC(57) = 1.00000*EXP( (1.00000 - CONSTS(56))*ALGBRC(2)) ALGBRC(58) = ALGBRC(55)*ALGBRC(52)+ ALGBRC(57)*ALGBRC(54) ALGBRC(60) = CONSTS(57)*( ALGBRC(57)*ALGBRC(54)*STATES(19) - ALGBRC(59)*CONSTS(73)*(1.00000 - STATES(19))) ALGBRC(6) = log(CONSTS(5)/STATES(2)) ALGBRC(24) = STATES(11) ** 3.00000*STATES(12) ALGBRC(25) = ( CONSTS(21)*ALGBRC(24)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(26) = ( CONSTS(30)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(27) = ( CONSTS(31)*STATES(13)* ( STATES(2)*CONSTS(5)) ** (1.0 / 2)* sinh( 0.500000*(ALGBRC(2) - ALGBRC(6))))/( sinh( 0.500000*ALGBRC(2))/( 0.500000*ALGBRC(2))) ALGBRC(63) = (- 1.00000/( CONSTS(3)*CONSTS(62)))*( 3.00000*ALGBRC(43)+ 3.00000*ALGBRC(60)+ALGBRC(25)+ALGBRC(26)+ALGBRC(27)) ALGBRC(4) = 0.500000*log(CONSTS(4)/STATES(1)) ALGBRC(20) = 0.000450000/(0.000450000+STATES(1)) ALGBRC(21) = ( CONSTS(18)*STATES(6)*ALGBRC(20)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(22) = ( CONSTS(19)*STATES(7)*STATES(8)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(23) = ( CONSTS(20)*STATES(9)*STATES(10)* ( STATES(1)*CONSTS(4)) ** (1.0 / 2)* sinh(ALGBRC(2) - ALGBRC(4)))/( sinh(ALGBRC(2))/ALGBRC(2)) ALGBRC(45) = CONSTS(50)*(( 10.5600*ALGBRC(18))/(ALGBRC(18)+5.00000e-05)+1.20000) ALGBRC(50) = ALGBRC(45)*( CONSTS(60)*ALGBRC(49)*STATES(18) - CONSTS(46)*CONSTS(61)*(1.00000 - STATES(18)))*1.00000 ALGBRC(62) = (- 1.00000/( 2.00000*CONSTS(3)*CONSTS(62)))*((ALGBRC(21)+ALGBRC(22)+ALGBRC(23)+ 2.00000*ALGBRC(50)) - 2.00000*ALGBRC(60)) ALGBRC(64) = ALGBRC(62) - (ALGBRC(17)+ 4.00000*ALGBRC(19)) RETURN END