C C There are a total of 27 entries in the algebraic variable array. C There are a total of 6 entries in each of the rate and state variable arrays. C There are a total of 27 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is C_m in component environment (fF). C STATES(1) is q_Ca_o in component environment (fmol). C STATES(2) is q_Ca_i in component environment (fmol). C STATES(3) is q_s00_TCC in component environment (fmol). C STATES(4) is q_s10_TCC in component environment (fmol). C STATES(5) is q_s01_TCC in component environment (fmol). C STATES(6) is q_s11_TCC in component environment (fmol). C CONSTS(2) is q_mem in component environment (fC). C CONSTS(24) is V_mem in component environment (volt). C CONSTS(3) is R in component environment (J_per_K_per_mol). C CONSTS(4) is T in component environment (kelvin). C CONSTS(5) is F in component environment (C_per_mol). C ALGBRC(19) is v_TCC in component TCC (fmol_per_sec). C ALGBRC(25) is I_mem_TCC in component TCC (fA). C CONSTS(25) is I_stim in component environment (fA). C CONSTS(6) is stimPeriod in component environment (second). C CONSTS(7) is stimDuration in component environment (second). C ALGBRC(1) is tPeriod in component environment (second). C CONSTS(8) is kappa_TCC in component TCC_parameters (fmol_per_sec). C CONSTS(9) is kappa_R1_TCC in component TCC_parameters (fmol_per_sec). C CONSTS(10) is kappa_R2_TCC in component TCC_parameters (fmol_per_sec). C CONSTS(11) is kappa_R3_TCC in component TCC_parameters (fmol_per_sec). C CONSTS(12) is kappa_R4_TCC in component TCC_parameters (fmol_per_sec). C CONSTS(13) is K_Ca_i in component TCC_parameters (per_fmol). C CONSTS(14) is K_Ca_o in component TCC_parameters (per_fmol). C CONSTS(15) is K_S00_TCC in component TCC_parameters (per_fmol). C CONSTS(16) is K_S10_TCC in component TCC_parameters (per_fmol). C CONSTS(17) is K_S01_TCC in component TCC_parameters (per_fmol). C CONSTS(18) is K_S11_TCC in component TCC_parameters (per_fmol). C CONSTS(19) is zCa in component TCC_parameters (dimensionless). C CONSTS(20) is z_df in component TCC_parameters (dimensionless). C CONSTS(21) is z_ff in component TCC_parameters (dimensionless). C CONSTS(22) is z_dr in component TCC_parameters (dimensionless). C CONSTS(23) is z_fr in component TCC_parameters (dimensionless). C ALGBRC(2) is u_Ca_i in component TCC (J_per_mol). C ALGBRC(3) is u_Ca_o in component TCC (J_per_mol). C CONSTS(26) is V_mem in component TCC (J_per_C). C CONSTS(27) is Am_TCC in component TCC (J_per_mol). C ALGBRC(17) is Af_Ca in component TCC (J_per_mol). C ALGBRC(18) is Ar_Ca in component TCC (J_per_mol). C ALGBRC(15) is v_s00_TCC in component TCC (fmol_per_sec). C ALGBRC(26) is v_s10_TCC in component TCC (fmol_per_sec). C ALGBRC(23) is v_s01_TCC in component TCC (fmol_per_sec). C ALGBRC(27) is v_s11_TCC in component TCC (fmol_per_sec). C ALGBRC(10) is v_R1_TCC in component TCC (fmol_per_sec). C ALGBRC(22) is v_R2_TCC in component TCC (fmol_per_sec). C ALGBRC(14) is v_R3_TCC in component TCC (fmol_per_sec). C ALGBRC(24) is v_R4_TCC in component TCC (fmol_per_sec). C ALGBRC(4) is mu_s00_TCC in component TCC (J_per_mol). C ALGBRC(7) is mu_s10_TCC in component TCC (J_per_mol). C ALGBRC(11) is mu_s01_TCC in component TCC (J_per_mol). C ALGBRC(16) is mu_s11_TCC in component TCC (J_per_mol). C ALGBRC(5) is Af_R1_TCC in component TCC (J_per_mol). C ALGBRC(8) is Ar_R1_TCC in component TCC (J_per_mol). C ALGBRC(12) is Af_R2_TCC in component TCC (J_per_mol). C ALGBRC(20) is Ar_R2_TCC in component TCC (J_per_mol). C ALGBRC(6) is Af_R3_TCC in component TCC (J_per_mol). C ALGBRC(13) is Ar_R3_TCC in component TCC (J_per_mol). C ALGBRC(9) is Af_R4_TCC in component TCC (J_per_mol). C ALGBRC(21) is Ar_R4_TCC in component TCC (J_per_mol). C RATES(2) is d/dt q_Ca_i in component environment (fmol). C RATES(1) is d/dt q_Ca_o in component environment (fmol). C RATES(3) is d/dt q_s00_TCC in component environment (fmol). C RATES(4) is d/dt q_s10_TCC in component environment (fmol). C RATES(5) is d/dt q_s01_TCC in component environment (fmol). C RATES(6) is d/dt q_s11_TCC in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 153400 STATES(1) = 9.3276 STATES(2) = 0.00456 STATES(3) = 3.653271338425772e-07 STATES(4) = 1e-16 STATES(5) = 1e-16 STATES(6) = 1e-16 CONSTS(2) = -13039 CONSTS(3) = 8.31 CONSTS(4) = 310 CONSTS(5) = 96500 CONSTS(6) = 1 CONSTS(7) = 0.0001 CONSTS(8) = 5746.42 CONSTS(9) = 1266.14 CONSTS(10) = 4.33488 CONSTS(11) = 1.34962 CONSTS(12) = 7.44777 CONSTS(13) = 2.20364 CONSTS(14) = 14.6286 CONSTS(15) = 2.10659 CONSTS(16) = 0.381738 CONSTS(17) = 615.294 CONSTS(18) = 111.498 CONSTS(19) = 2 CONSTS(20) = 0.876568910405296 CONSTS(21) = -0.576510778245838 CONSTS(22) = -0.872117216889333 CONSTS(23) = 1.73582739545622 CALL minimize(minfunc_0, CONSTS, VARIABLES, CONSTS(24)) CONSTS(25) = 0.00000 CONSTS(26) = CONSTS(2)/CONSTS(1) CONSTS(27) = CONSTS(19)*CONSTS(5)*CONSTS(26) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(4) = CONSTS(3)*CONSTS(4)*log( CONSTS(15)*STATES(3)) ALGBRC(5) = ALGBRC(4)+ CONSTS(20)*CONSTS(5)*CONSTS(26) ALGBRC(7) = CONSTS(3)*CONSTS(4)*log( CONSTS(16)*STATES(4)) ALGBRC(8) = ALGBRC(7)+ CONSTS(22)*CONSTS(5)*CONSTS(26) ALGBRC(10) = CONSTS(9)*(EXP(ALGBRC(5)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(8)/( CONSTS(3)*CONSTS(4)))) ALGBRC(6) = ALGBRC(4)+ CONSTS(21)*CONSTS(5)*CONSTS(26) ALGBRC(11) = CONSTS(3)*CONSTS(4)*log( CONSTS(17)*STATES(5)) ALGBRC(13) = ALGBRC(11)+ CONSTS(23)*CONSTS(5)*CONSTS(26) ALGBRC(14) = CONSTS(11)*(EXP(ALGBRC(6)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(13)/( CONSTS(3)*CONSTS(4)))) ALGBRC(15) = - ALGBRC(10) - ALGBRC(14) RATES(3) = ALGBRC(15) ALGBRC(2) = CONSTS(3)*CONSTS(4)*log( CONSTS(13)*STATES(2)) ALGBRC(16) = CONSTS(3)*CONSTS(4)*log( CONSTS(18)*STATES(6)) ALGBRC(17) = ALGBRC(16)+ALGBRC(2)+CONSTS(27) ALGBRC(3) = CONSTS(3)*CONSTS(4)*log( CONSTS(14)*STATES(1)) ALGBRC(18) = ALGBRC(16)+ALGBRC(3) ALGBRC(19) = TERNRY(CONSTS(27).EQ.0.00000, CONSTS(8)*(EXP(ALGBRC(17)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(18)/( CONSTS(3)*CONSTS(4)))), ((( CONSTS(8)*CONSTS(27))/( CONSTS(3)*CONSTS(4)))/(EXP(CONSTS(27)/( CONSTS(3)*CONSTS(4))) - 1.00000))*(EXP(ALGBRC(17)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(18)/( CONSTS(3)*CONSTS(4))))) RATES(2) = - ALGBRC(19) RATES(1) = ALGBRC(19) ALGBRC(12) = ALGBRC(11)+ CONSTS(20)*CONSTS(5)*CONSTS(26) ALGBRC(20) = ALGBRC(16)+ CONSTS(22)*CONSTS(5)*CONSTS(26) ALGBRC(22) = CONSTS(10)*(EXP(ALGBRC(12)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(20)/( CONSTS(3)*CONSTS(4)))) ALGBRC(23) = ALGBRC(14) - ALGBRC(22) RATES(5) = ALGBRC(23) ALGBRC(9) = ALGBRC(7)+ CONSTS(21)*CONSTS(5)*CONSTS(26) ALGBRC(21) = ALGBRC(16)+ CONSTS(23)*CONSTS(5)*CONSTS(26) ALGBRC(24) = CONSTS(12)*(EXP(ALGBRC(9)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(21)/( CONSTS(3)*CONSTS(4)))) ALGBRC(26) = ALGBRC(10) - ALGBRC(24) RATES(4) = ALGBRC(26) ALGBRC(27) = ALGBRC(22)+ALGBRC(24) RATES(6) = ALGBRC(27) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(4) = CONSTS(3)*CONSTS(4)*log( CONSTS(15)*STATES(3)) ALGBRC(5) = ALGBRC(4)+ CONSTS(20)*CONSTS(5)*CONSTS(26) ALGBRC(7) = CONSTS(3)*CONSTS(4)*log( CONSTS(16)*STATES(4)) ALGBRC(8) = ALGBRC(7)+ CONSTS(22)*CONSTS(5)*CONSTS(26) ALGBRC(10) = CONSTS(9)*(EXP(ALGBRC(5)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(8)/( CONSTS(3)*CONSTS(4)))) ALGBRC(6) = ALGBRC(4)+ CONSTS(21)*CONSTS(5)*CONSTS(26) ALGBRC(11) = CONSTS(3)*CONSTS(4)*log( CONSTS(17)*STATES(5)) ALGBRC(13) = ALGBRC(11)+ CONSTS(23)*CONSTS(5)*CONSTS(26) ALGBRC(14) = CONSTS(11)*(EXP(ALGBRC(6)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(13)/( CONSTS(3)*CONSTS(4)))) ALGBRC(15) = - ALGBRC(10) - ALGBRC(14) ALGBRC(2) = CONSTS(3)*CONSTS(4)*log( CONSTS(13)*STATES(2)) ALGBRC(16) = CONSTS(3)*CONSTS(4)*log( CONSTS(18)*STATES(6)) ALGBRC(17) = ALGBRC(16)+ALGBRC(2)+CONSTS(27) ALGBRC(3) = CONSTS(3)*CONSTS(4)*log( CONSTS(14)*STATES(1)) ALGBRC(18) = ALGBRC(16)+ALGBRC(3) ALGBRC(19) = TERNRY(CONSTS(27).EQ.0.00000, CONSTS(8)*(EXP(ALGBRC(17)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(18)/( CONSTS(3)*CONSTS(4)))), ((( CONSTS(8)*CONSTS(27))/( CONSTS(3)*CONSTS(4)))/(EXP(CONSTS(27)/( CONSTS(3)*CONSTS(4))) - 1.00000))*(EXP(ALGBRC(17)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(18)/( CONSTS(3)*CONSTS(4))))) ALGBRC(12) = ALGBRC(11)+ CONSTS(20)*CONSTS(5)*CONSTS(26) ALGBRC(20) = ALGBRC(16)+ CONSTS(22)*CONSTS(5)*CONSTS(26) ALGBRC(22) = CONSTS(10)*(EXP(ALGBRC(12)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(20)/( CONSTS(3)*CONSTS(4)))) ALGBRC(23) = ALGBRC(14) - ALGBRC(22) ALGBRC(9) = ALGBRC(7)+ CONSTS(21)*CONSTS(5)*CONSTS(26) ALGBRC(21) = ALGBRC(16)+ CONSTS(23)*CONSTS(5)*CONSTS(26) ALGBRC(24) = CONSTS(12)*(EXP(ALGBRC(9)/( CONSTS(3)*CONSTS(4))) - EXP(ALGBRC(21)/( CONSTS(3)*CONSTS(4)))) ALGBRC(26) = ALGBRC(10) - ALGBRC(24) ALGBRC(27) = ALGBRC(22)+ALGBRC(24) ALGBRC(1) = VOI - INT(VOI/CONSTS(6))*CONSTS(6) ALGBRC(25) = CONSTS(5)*( - CONSTS(19)*ALGBRC(19)+ ALGBRC(10)*(CONSTS(22) - CONSTS(20))+ ALGBRC(22)*(CONSTS(22) - CONSTS(20))+ ALGBRC(14)*(CONSTS(23) - CONSTS(21))+ ALGBRC(24)*(CONSTS(23) - CONSTS(21))) RETURN END REAL FUNCTION minfunc_0(CONSTS, VARIABLES) REAL CONSTS(*), VARIABLES(*) minfunc_0 = abs(CONSTS(2) - CONSTS(24)*CONSTS(1)) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END