C C There are a total of 32 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 22 entries in the constant variable array. C C C VOI is t in component environment (second). C CONSTS(1) is C_m in component environment (fF). C STATES(1) is q_K_o in component environment (fmol). C STATES(2) is q_K_i in component environment (fmol). C STATES(3) is q_Sa in component environment (fmol). C STATES(4) is q_Sb in component environment (fmol). C STATES(5) is q_Sc in component environment (fmol). C STATES(6) is q_Sd in component environment (fmol). C STATES(7) is q_mem in component environment (fC). C ALGBRC(1) is Vmem in component environment (volt). C CONSTS(2) is R in component environment (J_per_K_per_mol). C CONSTS(3) is T in component environment (kelvin). C CONSTS(4) is F in component environment (C_per_mol). C ALGBRC(23) is v_Kr in component Kr (fmol_per_sec). C ALGBRC(30) is I_mem_Kr in component Kr (fA). C ALGBRC(3) is I_stim in component environment (fA). C CONSTS(5) is stimPeriod in component environment (second). C CONSTS(6) is stimDuration in component environment (second). C ALGBRC(2) is tPeriod in component environment (second). C ALGBRC(25) is i_Kr in component environment (uA_per_uF). C CONSTS(7) is kappa_Kr in component Kr_parameters (fmol_per_sec). C CONSTS(8) is kappa_xr10 in component Kr_parameters (fmol_per_sec). C CONSTS(9) is kappa_xr11 in component Kr_parameters (fmol_per_sec). C CONSTS(10) is kappa_xr20 in component Kr_parameters (fmol_per_sec). C CONSTS(11) is kappa_xr21 in component Kr_parameters (fmol_per_sec). C CONSTS(12) is K_K_i in component Kr_parameters (per_fmol). C CONSTS(13) is K_K_o in component Kr_parameters (per_fmol). C CONSTS(14) is K_Sa_Kr in component Kr_parameters (per_fmol). C CONSTS(15) is K_Sb_Kr in component Kr_parameters (per_fmol). C CONSTS(16) is K_Sc_Kr in component Kr_parameters (per_fmol). C CONSTS(17) is K_Sd_Kr in component Kr_parameters (per_fmol). C CONSTS(18) is zK in component Kr_parameters (dimensionless). C CONSTS(19) is z_xr1_f in component Kr_parameters (dimensionless). C CONSTS(20) is z_xr1_r in component Kr_parameters (dimensionless). C CONSTS(21) is z_xr2_f in component Kr_parameters (dimensionless). C CONSTS(22) is z_xr2_r in component Kr_parameters (dimensionless). C ALGBRC(4) is u_K_i in component Kr (J_per_mol). C ALGBRC(5) is u_K_o in component Kr (J_per_mol). C ALGBRC(6) is V_mem in component Kr (J_per_C). C ALGBRC(7) is Am_Kr in component Kr (J_per_mol). C ALGBRC(21) is Af_Kr in component Kr (J_per_mol). C ALGBRC(22) is Ar_Kr in component Kr (J_per_mol). C ALGBRC(19) is v_Sa in component Kr (fmol_per_sec). C ALGBRC(31) is v_Sb in component Kr (fmol_per_sec). C ALGBRC(29) is v_Sc in component Kr (fmol_per_sec). C ALGBRC(32) is v_Sd in component Kr (fmol_per_sec). C ALGBRC(14) is v_x10 in component Kr (fmol_per_sec). C ALGBRC(27) is v_x11 in component Kr (fmol_per_sec). C ALGBRC(18) is v_x20 in component Kr (fmol_per_sec). C ALGBRC(28) is v_x21 in component Kr (fmol_per_sec). C ALGBRC(8) is mu_Sa in component Kr (J_per_mol). C ALGBRC(11) is mu_Sb in component Kr (J_per_mol). C ALGBRC(15) is mu_Sc in component Kr (J_per_mol). C ALGBRC(20) is mu_Sd in component Kr (J_per_mol). C ALGBRC(9) is Af_x10 in component Kr (J_per_mol). C ALGBRC(12) is Ar_x10 in component Kr (J_per_mol). C ALGBRC(16) is Af_x11 in component Kr (J_per_mol). C ALGBRC(24) is Ar_x11 in component Kr (J_per_mol). C ALGBRC(10) is Af_x20 in component Kr (J_per_mol). C ALGBRC(17) is Ar_x20 in component Kr (J_per_mol). C ALGBRC(13) is Af_x21 in component Kr (J_per_mol). C ALGBRC(26) is Ar_x21 in component Kr (J_per_mol). C RATES(2) is d/dt q_K_i in component environment (fmol). C RATES(1) is d/dt q_K_o in component environment (fmol). C RATES(7) is d/dt q_mem in component environment (fC). C RATES(3) is d/dt q_Sa in component environment (fmol). C RATES(4) is d/dt q_Sb in component environment (fmol). C RATES(5) is d/dt q_Sc in component environment (fmol). C RATES(6) is d/dt q_Sd in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 153400 STATES(1) = 27.9828 STATES(2) = 5510 STATES(3) = 1.598306E-07 STATES(4) = 1.598306E-07 STATES(5) = 1.598306E-07 STATES(6) = 1.598306E-07 STATES(7) = -13039 CONSTS(2) = 8.31 CONSTS(3) = 310 CONSTS(4) = 96500 CONSTS(5) = 1 CONSTS(6) = 0.0001 CONSTS(7) = 271.854 CONSTS(8) = 2.51352 CONSTS(9) = 0.0672974 CONSTS(10) = 8.45146 CONSTS(11) = 68.9799 CONSTS(12) = 1.94622 CONSTS(13) = 12.9197 CONSTS(14) = 1.47312 CONSTS(15) = 0.180487 CONSTS(16) = 55.02 CONSTS(17) = 6.74109 CONSTS(18) = 1 CONSTS(19) = 1.6149028778859738 CONSTS(20) = -1.3218634652232777 CONSTS(21) = -1.0273976425216251 CONSTS(22) = -0.18153135376657775 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(6) = STATES(7)/CONSTS(1) ALGBRC(8) = CONSTS(2)*CONSTS(3)*log( CONSTS(14)*STATES(3)) ALGBRC(9) = ALGBRC(8)+ CONSTS(19)*CONSTS(4)*ALGBRC(6) ALGBRC(11) = CONSTS(2)*CONSTS(3)*log( CONSTS(15)*STATES(4)) ALGBRC(12) = ALGBRC(11)+ CONSTS(20)*CONSTS(4)*ALGBRC(6) ALGBRC(14) = CONSTS(8)*(EXP(ALGBRC(9)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(12)/( CONSTS(2)*CONSTS(3)))) ALGBRC(10) = ALGBRC(8)+ CONSTS(21)*CONSTS(4)*ALGBRC(6) ALGBRC(15) = CONSTS(2)*CONSTS(3)*log( CONSTS(16)*STATES(5)) ALGBRC(17) = ALGBRC(15)+ CONSTS(22)*CONSTS(4)*ALGBRC(6) ALGBRC(18) = CONSTS(10)*(EXP(ALGBRC(10)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(17)/( CONSTS(2)*CONSTS(3)))) ALGBRC(19) = - ALGBRC(14) - ALGBRC(18) RATES(3) = ALGBRC(19) ALGBRC(7) = CONSTS(18)*CONSTS(4)*ALGBRC(6) ALGBRC(4) = CONSTS(2)*CONSTS(3)*log( CONSTS(12)*STATES(2)) ALGBRC(20) = CONSTS(2)*CONSTS(3)*log( CONSTS(17)*STATES(6)) ALGBRC(21) = ALGBRC(20)+ALGBRC(4)+ALGBRC(7) ALGBRC(5) = CONSTS(2)*CONSTS(3)*log( CONSTS(13)*STATES(1)) ALGBRC(22) = ALGBRC(20)+ALGBRC(5) ALGBRC(23) = TERNRY(ALGBRC(7).EQ.0.00000, 1.00000*CONSTS(7)*(EXP(ALGBRC(21)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(22)/( CONSTS(2)*CONSTS(3)))), ((( 1.00000*CONSTS(7)*ALGBRC(7))/( CONSTS(2)*CONSTS(3)))/(EXP(ALGBRC(7)/( CONSTS(2)*CONSTS(3))) - 1.00000))*(EXP(ALGBRC(21)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(22)/( CONSTS(2)*CONSTS(3))))) RATES(2) = - ALGBRC(23) RATES(1) = ALGBRC(23) ALGBRC(16) = ALGBRC(15)+ CONSTS(19)*CONSTS(4)*ALGBRC(6) ALGBRC(24) = ALGBRC(20)+ CONSTS(20)*CONSTS(4)*ALGBRC(6) ALGBRC(27) = CONSTS(9)*(EXP(ALGBRC(16)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(24)/( CONSTS(2)*CONSTS(3)))) ALGBRC(29) = ALGBRC(18) - ALGBRC(27) RATES(5) = ALGBRC(29) ALGBRC(13) = ALGBRC(11)+ CONSTS(21)*CONSTS(4)*ALGBRC(6) ALGBRC(26) = ALGBRC(20)+ CONSTS(22)*CONSTS(4)*ALGBRC(6) ALGBRC(28) = CONSTS(11)*(EXP(ALGBRC(13)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(26)/( CONSTS(2)*CONSTS(3)))) ALGBRC(30) = CONSTS(4)*( - CONSTS(18)*ALGBRC(23)+ ALGBRC(14)*(CONSTS(20) - CONSTS(19))+ ALGBRC(27)*(CONSTS(20) - CONSTS(20))+ ALGBRC(18)*(CONSTS(22) - CONSTS(21))+ ALGBRC(28)*(CONSTS(22) - CONSTS(21))) ALGBRC(2) = VOI - INT(VOI/CONSTS(5))*CONSTS(5) ALGBRC(3) = TERNRY(ALGBRC(2).GE.0.300000.AND.ALGBRC(2).LE.0.300000+CONSTS(6), ( 0.00000*0.0750000*CONSTS(1))/CONSTS(6), 0.00000) RATES(7) = ALGBRC(30)+ALGBRC(3) ALGBRC(31) = ALGBRC(14) - ALGBRC(28) RATES(4) = ALGBRC(31) ALGBRC(32) = ALGBRC(27)+ALGBRC(28) RATES(6) = ALGBRC(32) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(6) = STATES(7)/CONSTS(1) ALGBRC(8) = CONSTS(2)*CONSTS(3)*log( CONSTS(14)*STATES(3)) ALGBRC(9) = ALGBRC(8)+ CONSTS(19)*CONSTS(4)*ALGBRC(6) ALGBRC(11) = CONSTS(2)*CONSTS(3)*log( CONSTS(15)*STATES(4)) ALGBRC(12) = ALGBRC(11)+ CONSTS(20)*CONSTS(4)*ALGBRC(6) ALGBRC(14) = CONSTS(8)*(EXP(ALGBRC(9)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(12)/( CONSTS(2)*CONSTS(3)))) ALGBRC(10) = ALGBRC(8)+ CONSTS(21)*CONSTS(4)*ALGBRC(6) ALGBRC(15) = CONSTS(2)*CONSTS(3)*log( CONSTS(16)*STATES(5)) ALGBRC(17) = ALGBRC(15)+ CONSTS(22)*CONSTS(4)*ALGBRC(6) ALGBRC(18) = CONSTS(10)*(EXP(ALGBRC(10)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(17)/( CONSTS(2)*CONSTS(3)))) ALGBRC(19) = - ALGBRC(14) - ALGBRC(18) ALGBRC(7) = CONSTS(18)*CONSTS(4)*ALGBRC(6) ALGBRC(4) = CONSTS(2)*CONSTS(3)*log( CONSTS(12)*STATES(2)) ALGBRC(20) = CONSTS(2)*CONSTS(3)*log( CONSTS(17)*STATES(6)) ALGBRC(21) = ALGBRC(20)+ALGBRC(4)+ALGBRC(7) ALGBRC(5) = CONSTS(2)*CONSTS(3)*log( CONSTS(13)*STATES(1)) ALGBRC(22) = ALGBRC(20)+ALGBRC(5) ALGBRC(23) = TERNRY(ALGBRC(7).EQ.0.00000, 1.00000*CONSTS(7)*(EXP(ALGBRC(21)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(22)/( CONSTS(2)*CONSTS(3)))), ((( 1.00000*CONSTS(7)*ALGBRC(7))/( CONSTS(2)*CONSTS(3)))/(EXP(ALGBRC(7)/( CONSTS(2)*CONSTS(3))) - 1.00000))*(EXP(ALGBRC(21)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(22)/( CONSTS(2)*CONSTS(3))))) ALGBRC(16) = ALGBRC(15)+ CONSTS(19)*CONSTS(4)*ALGBRC(6) ALGBRC(24) = ALGBRC(20)+ CONSTS(20)*CONSTS(4)*ALGBRC(6) ALGBRC(27) = CONSTS(9)*(EXP(ALGBRC(16)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(24)/( CONSTS(2)*CONSTS(3)))) ALGBRC(29) = ALGBRC(18) - ALGBRC(27) ALGBRC(13) = ALGBRC(11)+ CONSTS(21)*CONSTS(4)*ALGBRC(6) ALGBRC(26) = ALGBRC(20)+ CONSTS(22)*CONSTS(4)*ALGBRC(6) ALGBRC(28) = CONSTS(11)*(EXP(ALGBRC(13)/( CONSTS(2)*CONSTS(3))) - EXP(ALGBRC(26)/( CONSTS(2)*CONSTS(3)))) ALGBRC(30) = CONSTS(4)*( - CONSTS(18)*ALGBRC(23)+ ALGBRC(14)*(CONSTS(20) - CONSTS(19))+ ALGBRC(27)*(CONSTS(20) - CONSTS(20))+ ALGBRC(18)*(CONSTS(22) - CONSTS(21))+ ALGBRC(28)*(CONSTS(22) - CONSTS(21))) ALGBRC(2) = VOI - INT(VOI/CONSTS(5))*CONSTS(5) ALGBRC(3) = TERNRY(ALGBRC(2).GE.0.300000.AND.ALGBRC(2).LE.0.300000+CONSTS(6), ( 0.00000*0.0750000*CONSTS(1))/CONSTS(6), 0.00000) ALGBRC(31) = ALGBRC(14) - ALGBRC(28) ALGBRC(32) = ALGBRC(27)+ALGBRC(28) CALL minimize(minfunc_0, CONSTS, VARIABLES, ALGBRC(1)) ALGBRC(25) = (( 1.00000e-09*CONSTS(4))/CONSTS(1))*ALGBRC(23) RETURN END REAL FUNCTION minfunc_0(CONSTS, VARIABLES) REAL CONSTS(*), VARIABLES(*) minfunc_0 = abs(STATES(7) - ALGBRC(1)*CONSTS(1)) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END