/* There are a total of 35 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 47 entries in the constant variable array. */ /* * VOI is t in component params_BG (second). * CONSTANTS[0] is R in component params_BG (J_per_K_mol). * CONSTANTS[1] is T in component params_BG (kelvin). * CONSTANTS[2] is F in component params_BG (C_per_mol). * CONSTANTS[3] is K_Nai in component params_BG (per_fmol). * CONSTANTS[38] is q_Nai in component params_BG (fmol). * CONSTANTS[4] is K_Nao in component params_BG (per_fmol). * CONSTANTS[40] is q_Nao in component params_BG (fmol). * CONSTANTS[5] is K_Hi in component params_BG (per_fmol). * CONSTANTS[42] is q_Hi in component params_BG (fmol). * CONSTANTS[6] is K_Ho in component params_BG (per_fmol). * CONSTANTS[44] is q_Ho in component params_BG (fmol). * CONSTANTS[7] is K_1 in component params_BG (per_fmol). * CONSTANTS[8] is q_init_1 in component params_BG (fmol). * CONSTANTS[9] is K_2 in component params_BG (per_fmol). * CONSTANTS[10] is q_init_2 in component params_BG (fmol). * CONSTANTS[11] is K_3 in component params_BG (per_fmol). * CONSTANTS[12] is q_init_3 in component params_BG (fmol). * CONSTANTS[13] is K_4 in component params_BG (per_fmol). * CONSTANTS[14] is q_init_4 in component params_BG (fmol). * CONSTANTS[15] is K_5 in component params_BG (per_fmol). * CONSTANTS[16] is q_init_5 in component params_BG (fmol). * CONSTANTS[17] is K_6 in component params_BG (per_fmol). * CONSTANTS[18] is q_init_6 in component params_BG (fmol). * CONSTANTS[19] is kappa_r1 in component params_BG (fmol_per_s). * CONSTANTS[20] is kappa_r2 in component params_BG (fmol_per_s). * CONSTANTS[21] is kappa_r3 in component params_BG (fmol_per_s). * CONSTANTS[22] is kappa_r4 in component params_BG (fmol_per_s). * CONSTANTS[23] is kappa_r5 in component params_BG (fmol_per_s). * CONSTANTS[24] is kappa_r6 in component params_BG (fmol_per_s). * CONSTANTS[25] is kappa_r7 in component params_BG (fmol_per_s). * CONSTANTS[39] is mu_Nai in component BG_NHE1 (J_per_mol). * CONSTANTS[41] is mu_Nao in component BG_NHE1 (J_per_mol). * CONSTANTS[43] is mu_Hi in component BG_NHE1 (J_per_mol). * CONSTANTS[45] is mu_Ho in component BG_NHE1 (J_per_mol). * ALGEBRAIC[0] is mu_1 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[33] is v_1 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[2] is mu_2 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[24] is v_2 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[4] is mu_3 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[27] is v_3 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[5] is mu_4 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[34] is v_4 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[6] is mu_5 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[30] is v_5 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[7] is mu_6 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[32] is v_6 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[3] is V_Vm in component BG_NHE1 (volt). * ALGEBRAIC[1] is V0_Vm in component params_BG (volt). * ALGEBRAIC[8] is A_f_r1 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[22] is v_r1 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[9] is A_r_r1 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[10] is A_f_r2 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[23] is v_r2 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[11] is A_r_r2 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[12] is A_f_r3 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[25] is v_r3 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[13] is A_r_r3 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[14] is A_f_r4 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[26] is v_r4 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[15] is A_r_r4 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[16] is A_f_r5 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[28] is v_r5 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[17] is A_r_r5 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[18] is A_f_r6 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[29] is v_r6 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[19] is A_r_r6 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[20] is A_f_r7 in component BG_NHE1 (J_per_mol). * ALGEBRAIC[31] is v_r7 in component BG_NHE1 (fmol_per_s). * ALGEBRAIC[21] is A_r_r7 in component BG_NHE1 (J_per_mol). * STATES[0] is q_1 in component BG_NHE1 (fmol). * STATES[1] is q_2 in component BG_NHE1 (fmol). * STATES[2] is q_3 in component BG_NHE1 (fmol). * STATES[3] is q_4 in component BG_NHE1 (fmol). * STATES[4] is q_5 in component BG_NHE1 (fmol). * STATES[5] is q_6 in component BG_NHE1 (fmol). * CONSTANTS[26] is nNa in component BG_NHE1 (dimensionless). * CONSTANTS[27] is z_zf1 in component params_BG (dimensionless). * CONSTANTS[28] is z_zr1 in component params_BG (dimensionless). * CONSTANTS[29] is z_zf2 in component params_BG (dimensionless). * CONSTANTS[30] is z_zr2 in component params_BG (dimensionless). * CONSTANTS[31] is Nai in component params_BG (mM). * CONSTANTS[32] is Nao in component params_BG (mM). * CONSTANTS[33] is Hi in component params_BG (mM). * CONSTANTS[34] is Ho in component params_BG (mM). * CONSTANTS[35] is V_i in component params_BG (pL). * CONSTANTS[36] is V_o in component params_BG (pL). * STATES[6] is V_E in component params_BG (volt). * CONSTANTS[37] is dt in component params_BG (second). * RATES[0] is d/dt q_1 in component BG_NHE1 (fmol). * RATES[1] is d/dt q_2 in component BG_NHE1 (fmol). * RATES[2] is d/dt q_3 in component BG_NHE1 (fmol). * RATES[3] is d/dt q_4 in component BG_NHE1 (fmol). * RATES[4] is d/dt q_5 in component BG_NHE1 (fmol). * RATES[5] is d/dt q_6 in component BG_NHE1 (fmol). * RATES[6] is d/dt V_E in component params_BG (volt). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 8.31; CONSTANTS[1] = 293; CONSTANTS[2] = 96485; CONSTANTS[3] = 1e-08; CONSTANTS[4] = 1e-08; CONSTANTS[5] = 1e-06; CONSTANTS[6] = 1e-06; CONSTANTS[7] = 1; CONSTANTS[8] = 1; CONSTANTS[9] = 1; CONSTANTS[10] = 1; CONSTANTS[11] = 1; CONSTANTS[12] = 1; CONSTANTS[13] = 1; CONSTANTS[14] = 1; CONSTANTS[15] = 1; CONSTANTS[16] = 1; CONSTANTS[17] = 1; CONSTANTS[18] = 1; CONSTANTS[19] = 1; CONSTANTS[20] = 1; CONSTANTS[21] = 1; CONSTANTS[22] = 1; CONSTANTS[23] = 1; CONSTANTS[24] = 1; CONSTANTS[25] = 1; CONSTANTS[26] = 1; CONSTANTS[27] = 1; CONSTANTS[28] = 1; CONSTANTS[29] = 1; CONSTANTS[30] = 1; CONSTANTS[31] = 20; CONSTANTS[32] = 100; CONSTANTS[33] = 10e-3; CONSTANTS[34] = 1e-12; CONSTANTS[35] = 8.5e5; CONSTANTS[36] = 8.5e5; STATES[6] = -0.05; CONSTANTS[37] = 1e-3; CONSTANTS[38] = CONSTANTS[31]*CONSTANTS[35]; CONSTANTS[46] = 0.00000; CONSTANTS[39] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[3]*CONSTANTS[38]); CONSTANTS[40] = CONSTANTS[32]*CONSTANTS[36]; CONSTANTS[41] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[4]*CONSTANTS[40]); CONSTANTS[42] = CONSTANTS[33]*CONSTANTS[35]; CONSTANTS[43] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[5]*CONSTANTS[42]); CONSTANTS[44] = CONSTANTS[34]*CONSTANTS[36]; CONSTANTS[45] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[6]*CONSTANTS[44]); STATES[0] = CONSTANTS[8]; STATES[1] = CONSTANTS[10]; STATES[2] = CONSTANTS[12]; STATES[3] = CONSTANTS[14]; STATES[4] = CONSTANTS[16]; STATES[5] = CONSTANTS[18]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[6] = CONSTANTS[46]; ALGEBRAIC[0] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[7]*STATES[0]); ALGEBRAIC[8] = CONSTANTS[26]*CONSTANTS[41]+ALGEBRAIC[0]; ALGEBRAIC[2] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[9] = ALGEBRAIC[2]; ALGEBRAIC[22] = CONSTANTS[19]*(exp(ALGEBRAIC[8]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[9]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[10] = ALGEBRAIC[2]; ALGEBRAIC[4] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[11]*STATES[2]); ALGEBRAIC[11] = ALGEBRAIC[4]; ALGEBRAIC[23] = CONSTANTS[20]*(exp(ALGEBRAIC[10]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[11]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[24] = ALGEBRAIC[22] - ALGEBRAIC[23]; RATES[1] = ALGEBRAIC[24]; ALGEBRAIC[12] = ALGEBRAIC[4]; ALGEBRAIC[5] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[13]*STATES[3]); ALGEBRAIC[13] = ALGEBRAIC[5]+ CONSTANTS[26]*CONSTANTS[39]; ALGEBRAIC[25] = CONSTANTS[21]*(exp(ALGEBRAIC[12]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[13]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[27] = ALGEBRAIC[23] - ALGEBRAIC[25]; RATES[2] = ALGEBRAIC[27]; ALGEBRAIC[14] = ALGEBRAIC[5]+CONSTANTS[43]; ALGEBRAIC[6] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[4]); ALGEBRAIC[15] = ALGEBRAIC[6]; ALGEBRAIC[26] = CONSTANTS[22]*(exp(ALGEBRAIC[14]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[15]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[16] = ALGEBRAIC[6]; ALGEBRAIC[7] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[17]*STATES[5]); ALGEBRAIC[17] = ALGEBRAIC[7]; ALGEBRAIC[28] = CONSTANTS[23]*(exp(ALGEBRAIC[16]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[17]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[30] = ALGEBRAIC[26] - ALGEBRAIC[28]; RATES[4] = ALGEBRAIC[30]; ALGEBRAIC[18] = ALGEBRAIC[7]; ALGEBRAIC[19] = ALGEBRAIC[0]+CONSTANTS[45]; ALGEBRAIC[29] = CONSTANTS[24]*(exp(ALGEBRAIC[18]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[19]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[32] = ALGEBRAIC[28] - ALGEBRAIC[29]; RATES[5] = ALGEBRAIC[32]; ALGEBRAIC[20] = ALGEBRAIC[0]; ALGEBRAIC[21] = ALGEBRAIC[5]; ALGEBRAIC[31] = CONSTANTS[25]*(exp(ALGEBRAIC[20]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[21]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[33] = (ALGEBRAIC[29] - ALGEBRAIC[22]) - ALGEBRAIC[31]; RATES[0] = ALGEBRAIC[33]; ALGEBRAIC[34] = (ALGEBRAIC[25]+ALGEBRAIC[31]) - ALGEBRAIC[26]; RATES[3] = ALGEBRAIC[34]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[7]*STATES[0]); ALGEBRAIC[8] = CONSTANTS[26]*CONSTANTS[41]+ALGEBRAIC[0]; ALGEBRAIC[2] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[9]*STATES[1]); ALGEBRAIC[9] = ALGEBRAIC[2]; ALGEBRAIC[22] = CONSTANTS[19]*(exp(ALGEBRAIC[8]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[9]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[10] = ALGEBRAIC[2]; ALGEBRAIC[4] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[11]*STATES[2]); ALGEBRAIC[11] = ALGEBRAIC[4]; ALGEBRAIC[23] = CONSTANTS[20]*(exp(ALGEBRAIC[10]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[11]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[24] = ALGEBRAIC[22] - ALGEBRAIC[23]; ALGEBRAIC[12] = ALGEBRAIC[4]; ALGEBRAIC[5] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[13]*STATES[3]); ALGEBRAIC[13] = ALGEBRAIC[5]+ CONSTANTS[26]*CONSTANTS[39]; ALGEBRAIC[25] = CONSTANTS[21]*(exp(ALGEBRAIC[12]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[13]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[27] = ALGEBRAIC[23] - ALGEBRAIC[25]; ALGEBRAIC[14] = ALGEBRAIC[5]+CONSTANTS[43]; ALGEBRAIC[6] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[15]*STATES[4]); ALGEBRAIC[15] = ALGEBRAIC[6]; ALGEBRAIC[26] = CONSTANTS[22]*(exp(ALGEBRAIC[14]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[15]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[16] = ALGEBRAIC[6]; ALGEBRAIC[7] = CONSTANTS[0]*CONSTANTS[1]*log( CONSTANTS[17]*STATES[5]); ALGEBRAIC[17] = ALGEBRAIC[7]; ALGEBRAIC[28] = CONSTANTS[23]*(exp(ALGEBRAIC[16]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[17]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[30] = ALGEBRAIC[26] - ALGEBRAIC[28]; ALGEBRAIC[18] = ALGEBRAIC[7]; ALGEBRAIC[19] = ALGEBRAIC[0]+CONSTANTS[45]; ALGEBRAIC[29] = CONSTANTS[24]*(exp(ALGEBRAIC[18]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[19]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[32] = ALGEBRAIC[28] - ALGEBRAIC[29]; ALGEBRAIC[20] = ALGEBRAIC[0]; ALGEBRAIC[21] = ALGEBRAIC[5]; ALGEBRAIC[31] = CONSTANTS[25]*(exp(ALGEBRAIC[20]/( CONSTANTS[0]*CONSTANTS[1])) - exp(ALGEBRAIC[21]/( CONSTANTS[0]*CONSTANTS[1]))); ALGEBRAIC[33] = (ALGEBRAIC[29] - ALGEBRAIC[22]) - ALGEBRAIC[31]; ALGEBRAIC[34] = (ALGEBRAIC[25]+ALGEBRAIC[31]) - ALGEBRAIC[26]; ALGEBRAIC[1] = STATES[6]; ALGEBRAIC[3] = ALGEBRAIC[1]; }