Funny current channel knowledge page
About
Landing page for the pacemaker channel HCN (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel). This channel creates the pacemaker current, also known as the funny current.
The HCN group is highly expressed in cardiac myocytes in order to generate action potentials for establishing heart beats. It is permeable to both potassium and sodium ions, with preference for potassium.
HCN is thought to be a homotetramer, where the channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. It is activated by membrane hyperpolarisation, and all subfamilies except HCN3 are also activated by cAMP binding to their cyclic nucleotide binding domain.
Model
The below image shows the bond graph diagram of the channel operating under normal physiological conditions.
Protein knowledge
Rendered image of the HCN1 tetramer
Subfamilies
The following is a list of all known subfamilies of the HCN channel.
| Channel name | Gene | Structure |
|---|---|---|
| HCN1 | Uniprot 1 | PDB 1 |
| HCN2 | Uniprot 2 | PDB 2 |
| HCN3 | Uniprot 3 | PDB 3 |
| HCN4 | Uniprot 4 | PDB 4 |
Literature
| Title | Author |
|---|---|
| A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources | Kernik et al. |
Existing models
| Title | Author |
|---|---|
| BG_funny | S Fong |
| IPSC-model | Kernik et al. |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.
Other annotations
| Item | Database |
|---|---|
| HCN channel complex | Gene Ontology Complex |