/* There are a total of 11 entries in the algebraic variable array. There are a total of 6 entries in each of the rate and state variable arrays. There are a total of 15 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is q_Eb in component environment (fmol). * STATES[1] is q_NO in component environment (fmol). * STATES[2] is q_E6c in component environment (fmol). * STATES[3] is q_E5c in component environment (fmol). * STATES[4] is q_cGMP in component environment (fmol). * STATES[5] is q_NO_product in component environment (fmol). * ALGEBRAIC[6] is v_R_1_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[7] is v_R_2_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[8] is v_R_3_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[9] is v_R_4_sGC in component sGC (fmol_per_sec). * ALGEBRAIC[10] is v_R_DNO_sGC in component sGC (fmol_per_sec). * CONSTANTS[0] is v_NO_generation in component environment (fmol_per_sec). * CONSTANTS[1] is kappa_R_1_sGC in component sGC_parameters (fmol_per_sec). * CONSTANTS[2] is kappa_R_2_sGC in component sGC_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_R_3_sGC in component sGC_parameters (fmol_per_sec). * CONSTANTS[4] is kappa_R_4_sGC in component sGC_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_R_DNO_sGC in component sGC_parameters (fmol_per_sec). * CONSTANTS[6] is K_Eb in component sGC_parameters (per_fmol). * CONSTANTS[7] is K_NO in component sGC_parameters (per_fmol). * CONSTANTS[8] is K_E6c in component sGC_parameters (per_fmol). * CONSTANTS[9] is K_E5c in component sGC_parameters (per_fmol). * CONSTANTS[10] is K_cGMP in component sGC_parameters (per_fmol). * CONSTANTS[11] is K_NO_product in component sGC_parameters (per_fmol). * CONSTANTS[12] is R in component constants (J_per_K_per_mol). * CONSTANTS[13] is T in component constants (kelvin). * ALGEBRAIC[0] is mu_Eb in component sGC (J_per_mol). * ALGEBRAIC[1] is mu_NO in component sGC (J_per_mol). * ALGEBRAIC[2] is mu_E6c in component sGC (J_per_mol). * ALGEBRAIC[3] is mu_E5c in component sGC (J_per_mol). * ALGEBRAIC[4] is mu_cGMP in component sGC (J_per_mol). * ALGEBRAIC[5] is mu_NO_product in component sGC (J_per_mol). * CONSTANTS[14] is F in component constants (C_per_mol). * RATES[0] is d/dt q_Eb in component environment (fmol). * RATES[1] is d/dt q_NO in component environment (fmol). * RATES[2] is d/dt q_E6c in component environment (fmol). * RATES[3] is d/dt q_E5c in component environment (fmol). * RATES[4] is d/dt q_cGMP in component environment (fmol). * RATES[5] is d/dt q_NO_product in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 1e-18; STATES[1] = 0.00836; STATES[2] = 1e-18; STATES[3] = 1e-18; STATES[4] = 1e-18; STATES[5] = 1e-18; CONSTANTS[0] = 0.000114; CONSTANTS[1] = 996545; CONSTANTS[2] = 0.00090595; CONSTANTS[3] = 3.20816; CONSTANTS[4] = 0.00996545; CONSTANTS[5] = 0.0236081; CONSTANTS[6] = 0.0638542; CONSTANTS[7] = 0.114174; CONSTANTS[8] = 29.7524; CONSTANTS[9] = 0.297524; CONSTANTS[10] = 0.269542; CONSTANTS[11] = 0.0114174; CONSTANTS[12] = 8.31; CONSTANTS[13] = 310; CONSTANTS[14] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[6]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[7]*STATES[1]); ALGEBRAIC[2] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[8]*STATES[2]); ALGEBRAIC[6] = CONSTANTS[1]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[2]/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[3] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[9]*STATES[3]); ALGEBRAIC[7] = CONSTANTS[2]*(exp(ALGEBRAIC[2]/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[3]/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[8] = CONSTANTS[3]*(exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13])) - exp((ALGEBRAIC[3]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13]))); RATES[2] = (ALGEBRAIC[6] - ALGEBRAIC[7]) - ALGEBRAIC[8]; ALGEBRAIC[4] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[9] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ ALGEBRAIC[4]*2.00000)/( CONSTANTS[12]*CONSTANTS[13])) - exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13]))); RATES[0] = - ALGEBRAIC[6]+ALGEBRAIC[9]; RATES[3] = (ALGEBRAIC[7]+ALGEBRAIC[8]) - ALGEBRAIC[9]; RATES[4] = - 2.00000*ALGEBRAIC[9]; ALGEBRAIC[5] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[10] = CONSTANTS[5]*(exp(ALGEBRAIC[1]/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[5]/( CONSTANTS[12]*CONSTANTS[13]))); RATES[1] = ((- ALGEBRAIC[6]+ALGEBRAIC[9]) - ALGEBRAIC[10])+CONSTANTS[0]; RATES[5] = ALGEBRAIC[10]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[6]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[7]*STATES[1]); ALGEBRAIC[2] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[8]*STATES[2]); ALGEBRAIC[6] = CONSTANTS[1]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[2]/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[3] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[9]*STATES[3]); ALGEBRAIC[7] = CONSTANTS[2]*(exp(ALGEBRAIC[2]/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[3]/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[8] = CONSTANTS[3]*(exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13])) - exp((ALGEBRAIC[3]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[4] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[10]*STATES[4]); ALGEBRAIC[9] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ ALGEBRAIC[4]*2.00000)/( CONSTANTS[12]*CONSTANTS[13])) - exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[12]*CONSTANTS[13]))); ALGEBRAIC[5] = CONSTANTS[12]*CONSTANTS[13]*log( CONSTANTS[11]*STATES[5]); ALGEBRAIC[10] = CONSTANTS[5]*(exp(ALGEBRAIC[1]/( CONSTANTS[12]*CONSTANTS[13])) - exp(ALGEBRAIC[5]/( CONSTANTS[12]*CONSTANTS[13]))); }