C C There are a total of 11 entries in the algebraic variable array. C There are a total of 6 entries in each of the rate and state variable arrays. C There are a total of 15 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is q_Eb in component environment (fmol). C STATES(2) is q_NO in component environment (fmol). C STATES(3) is q_E6c in component environment (fmol). C STATES(4) is q_E5c in component environment (fmol). C STATES(5) is q_cGMP in component environment (fmol). C STATES(6) is q_NO_product in component environment (fmol). C ALGBRC(7) is v_R_1_sGC in component sGC (fmol_per_sec). C ALGBRC(8) is v_R_2_sGC in component sGC (fmol_per_sec). C ALGBRC(9) is v_R_3_sGC in component sGC (fmol_per_sec). C ALGBRC(10) is v_R_4_sGC in component sGC (fmol_per_sec). C ALGBRC(11) is v_R_DNO_sGC in component sGC (fmol_per_sec). C CONSTS(1) is v_NO_generation in component environment (fmol_per_sec). C CONSTS(2) is kappa_R_1_sGC in component sGC_parameters (fmol_per_sec). C CONSTS(3) is kappa_R_2_sGC in component sGC_parameters (fmol_per_sec). C CONSTS(4) is kappa_R_3_sGC in component sGC_parameters (fmol_per_sec). C CONSTS(5) is kappa_R_4_sGC in component sGC_parameters (fmol_per_sec). C CONSTS(6) is kappa_R_DNO_sGC in component sGC_parameters (fmol_per_sec). C CONSTS(7) is K_Eb in component sGC_parameters (per_fmol). C CONSTS(8) is K_NO in component sGC_parameters (per_fmol). C CONSTS(9) is K_E6c in component sGC_parameters (per_fmol). C CONSTS(10) is K_E5c in component sGC_parameters (per_fmol). C CONSTS(11) is K_cGMP in component sGC_parameters (per_fmol). C CONSTS(12) is K_NO_product in component sGC_parameters (per_fmol). C CONSTS(13) is R in component constants (J_per_K_per_mol). C CONSTS(14) is T in component constants (kelvin). C ALGBRC(1) is mu_Eb in component sGC (J_per_mol). C ALGBRC(2) is mu_NO in component sGC (J_per_mol). C ALGBRC(3) is mu_E6c in component sGC (J_per_mol). C ALGBRC(4) is mu_E5c in component sGC (J_per_mol). C ALGBRC(5) is mu_cGMP in component sGC (J_per_mol). C ALGBRC(6) is mu_NO_product in component sGC (J_per_mol). C CONSTS(15) is F in component constants (C_per_mol). C RATES(1) is d/dt q_Eb in component environment (fmol). C RATES(2) is d/dt q_NO in component environment (fmol). C RATES(3) is d/dt q_E6c in component environment (fmol). C RATES(4) is d/dt q_E5c in component environment (fmol). C RATES(5) is d/dt q_cGMP in component environment (fmol). C RATES(6) is d/dt q_NO_product in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1e-18 STATES(2) = 0.00836 STATES(3) = 1e-18 STATES(4) = 1e-18 STATES(5) = 1e-18 STATES(6) = 1e-18 CONSTS(1) = 0.000114 CONSTS(2) = 996545 CONSTS(3) = 0.00090595 CONSTS(4) = 3.20816 CONSTS(5) = 0.00996545 CONSTS(6) = 0.0236081 CONSTS(7) = 0.0638542 CONSTS(8) = 0.114174 CONSTS(9) = 29.7524 CONSTS(10) = 0.297524 CONSTS(11) = 0.269542 CONSTS(12) = 0.0114174 CONSTS(13) = 8.31 CONSTS(14) = 310 CONSTS(15) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(13)*CONSTS(14)*log( CONSTS(7)*STATES(1)) ALGBRC(2) = CONSTS(13)*CONSTS(14)*log( CONSTS(8)*STATES(2)) ALGBRC(3) = CONSTS(13)*CONSTS(14)*log( CONSTS(9)*STATES(3)) ALGBRC(7) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(3)/( CONSTS(13)*CONSTS(14)))) ALGBRC(4) = CONSTS(13)*CONSTS(14)*log( CONSTS(10)*STATES(4)) ALGBRC(8) = CONSTS(3)*(EXP(ALGBRC(3)/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(4)/( CONSTS(13)*CONSTS(14)))) ALGBRC(9) = CONSTS(4)*(EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(13)*CONSTS(14))) - EXP((ALGBRC(4)+ALGBRC(2))/( CONSTS(13)*CONSTS(14)))) RATES(3) = (ALGBRC(7) - ALGBRC(8)) - ALGBRC(9) ALGBRC(5) = CONSTS(13)*CONSTS(14)*log( CONSTS(11)*STATES(5)) ALGBRC(10) = CONSTS(5)*(EXP((ALGBRC(4)+ ALGBRC(5)*2.00000)/( CONSTS(13)*CONSTS(14))) - EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(13)*CONSTS(14)))) RATES(1) = - ALGBRC(7)+ALGBRC(10) RATES(4) = (ALGBRC(8)+ALGBRC(9)) - ALGBRC(10) RATES(5) = - 2.00000*ALGBRC(10) ALGBRC(6) = CONSTS(13)*CONSTS(14)*log( CONSTS(12)*STATES(6)) ALGBRC(11) = CONSTS(6)*(EXP(ALGBRC(2)/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(6)/( CONSTS(13)*CONSTS(14)))) RATES(2) = ((- ALGBRC(7)+ALGBRC(10)) - ALGBRC(11))+CONSTS(1) RATES(6) = ALGBRC(11) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(13)*CONSTS(14)*log( CONSTS(7)*STATES(1)) ALGBRC(2) = CONSTS(13)*CONSTS(14)*log( CONSTS(8)*STATES(2)) ALGBRC(3) = CONSTS(13)*CONSTS(14)*log( CONSTS(9)*STATES(3)) ALGBRC(7) = CONSTS(2)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(3)/( CONSTS(13)*CONSTS(14)))) ALGBRC(4) = CONSTS(13)*CONSTS(14)*log( CONSTS(10)*STATES(4)) ALGBRC(8) = CONSTS(3)*(EXP(ALGBRC(3)/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(4)/( CONSTS(13)*CONSTS(14)))) ALGBRC(9) = CONSTS(4)*(EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(13)*CONSTS(14))) - EXP((ALGBRC(4)+ALGBRC(2))/( CONSTS(13)*CONSTS(14)))) ALGBRC(5) = CONSTS(13)*CONSTS(14)*log( CONSTS(11)*STATES(5)) ALGBRC(10) = CONSTS(5)*(EXP((ALGBRC(4)+ ALGBRC(5)*2.00000)/( CONSTS(13)*CONSTS(14))) - EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(13)*CONSTS(14)))) ALGBRC(6) = CONSTS(13)*CONSTS(14)*log( CONSTS(12)*STATES(6)) ALGBRC(11) = CONSTS(6)*(EXP(ALGBRC(2)/( CONSTS(13)*CONSTS(14))) - EXP(ALGBRC(6)/( CONSTS(13)*CONSTS(14)))) RETURN END