C C There are a total of 36 entries in the algebraic variable array. C There are a total of 14 entries in each of the rate and state variable arrays. C There are a total of 39 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is q_cAMP_init in component environment (fmol). C CONSTS(2) is q_PKI_init in component environment (fmol). C CONSTS(3) is q_PKACI_init in component environment (fmol). C CONSTS(4) is q_ARCI_init in component environment (fmol). C CONSTS(5) is q_A2RCI_init in component environment (fmol). C CONSTS(6) is q_CI_init in component environment (fmol). C CONSTS(7) is q_A2RI_init in component environment (fmol). C CONSTS(8) is q_PKACI_PKI_init in component environment (fmol). C CONSTS(9) is q_PKACII_init in component environment (fmol). C CONSTS(10) is q_ARCII_init in component environment (fmol). C CONSTS(11) is q_A2RCII_init in component environment (fmol). C CONSTS(12) is q_CII_init in component environment (fmol). C CONSTS(13) is q_A2RII_init in component environment (fmol). C CONSTS(14) is q_PKACII_PKI_init in component environment (fmol). C ALGBRC(1) is q_cAMP in component environment (fmol). C ALGBRC(2) is q_PKI in component environment (fmol). C ALGBRC(3) is q_PKACI in component environment (fmol). C ALGBRC(4) is q_ARCI in component environment (fmol). C ALGBRC(5) is q_A2RCI in component environment (fmol). C ALGBRC(6) is q_CI in component environment (fmol). C ALGBRC(7) is q_A2RI in component environment (fmol). C ALGBRC(8) is q_PKACI_PKI in component environment (fmol). C ALGBRC(9) is q_PKACII in component environment (fmol). C ALGBRC(10) is q_ARCII in component environment (fmol). C ALGBRC(11) is q_A2RCII in component environment (fmol). C ALGBRC(12) is q_CII in component environment (fmol). C ALGBRC(13) is q_A2RII in component environment (fmol). C ALGBRC(14) is q_PKACII_PKI in component environment (fmol). C STATES(1) is q_cAMP in component PKA (fmol). C STATES(2) is q_PKI in component PKA (fmol). C STATES(3) is q_PKACI in component PKA (fmol). C STATES(4) is q_ARCI in component PKA (fmol). C STATES(5) is q_A2RCI in component PKA (fmol). C STATES(6) is q_CI in component PKA (fmol). C STATES(7) is q_A2RI in component PKA (fmol). C STATES(8) is q_PKACI_PKI in component PKA (fmol). C STATES(9) is q_PKACII in component PKA (fmol). C STATES(10) is q_ARCII in component PKA (fmol). C STATES(11) is q_A2RCII in component PKA (fmol). C STATES(12) is q_CII in component PKA (fmol). C STATES(13) is q_A2RII in component PKA (fmol). C STATES(14) is q_PKACII_PKI in component PKA (fmol). C CONSTS(15) is kappa_aI in component PKA_parameters (fmol_per_sec). C CONSTS(16) is kappa_bI in component PKA_parameters (fmol_per_sec). C CONSTS(17) is kappa_dI in component PKA_parameters (fmol_per_sec). C CONSTS(18) is kappa_iI in component PKA_parameters (fmol_per_sec). C CONSTS(19) is kappa_aII in component PKA_parameters (fmol_per_sec). C CONSTS(20) is kappa_bII in component PKA_parameters (fmol_per_sec). C CONSTS(21) is kappa_dII in component PKA_parameters (fmol_per_sec). C CONSTS(22) is kappa_iII in component PKA_parameters (fmol_per_sec). C CONSTS(23) is K_cAMP in component PKA_parameters (per_fmol). C CONSTS(24) is K_PKI in component PKA_parameters (per_fmol). C CONSTS(25) is K_PKACI in component PKA_parameters (per_fmol). C CONSTS(26) is K_ARCI in component PKA_parameters (per_fmol). C CONSTS(27) is K_A2RCI in component PKA_parameters (per_fmol). C CONSTS(28) is K_CI in component PKA_parameters (per_fmol). C CONSTS(29) is K_A2RI in component PKA_parameters (per_fmol). C CONSTS(30) is K_PKACI_PKI in component PKA_parameters (per_fmol). C CONSTS(31) is K_PKACII in component PKA_parameters (per_fmol). C CONSTS(32) is K_ARCII in component PKA_parameters (per_fmol). C CONSTS(33) is K_A2RCII in component PKA_parameters (per_fmol). C CONSTS(34) is K_CII in component PKA_parameters (per_fmol). C CONSTS(35) is K_A2RII in component PKA_parameters (per_fmol). C CONSTS(36) is K_PKACII_PKI in component PKA_parameters (per_fmol). C CONSTS(37) is R in component constants (J_per_K_per_mol). C CONSTS(38) is T in component constants (kelvin). C ALGBRC(29) is vaI in component PKA (fmol_per_sec). C ALGBRC(30) is vbI in component PKA (fmol_per_sec). C ALGBRC(31) is vdI in component PKA (fmol_per_sec). C ALGBRC(32) is viI in component PKA (fmol_per_sec). C ALGBRC(33) is vaII in component PKA (fmol_per_sec). C ALGBRC(34) is vbII in component PKA (fmol_per_sec). C ALGBRC(35) is vdII in component PKA (fmol_per_sec). C ALGBRC(36) is viII in component PKA (fmol_per_sec). C ALGBRC(15) is mu_cAMP in component PKA (J_per_mol). C ALGBRC(16) is mu_PKI in component PKA (J_per_mol). C ALGBRC(17) is mu_PKACI in component PKA (J_per_mol). C ALGBRC(18) is mu_ARCI in component PKA (J_per_mol). C ALGBRC(19) is mu_A2RCI in component PKA (J_per_mol). C ALGBRC(20) is mu_CI in component PKA (J_per_mol). C ALGBRC(21) is mu_A2RI in component PKA (J_per_mol). C ALGBRC(22) is mu_PKACI_PKI in component PKA (J_per_mol). C ALGBRC(23) is mu_PKACII in component PKA (J_per_mol). C ALGBRC(24) is mu_ARCII in component PKA (J_per_mol). C ALGBRC(25) is mu_A2RCII in component PKA (J_per_mol). C ALGBRC(26) is mu_CII in component PKA (J_per_mol). C ALGBRC(27) is mu_A2RII in component PKA (J_per_mol). C ALGBRC(28) is mu_PKACII_PKI in component PKA (J_per_mol). C CONSTS(39) is F in component constants (C_per_mol). C RATES(1) is d/dt q_cAMP in component PKA (fmol). C RATES(2) is d/dt q_PKI in component PKA (fmol). C RATES(3) is d/dt q_PKACI in component PKA (fmol). C RATES(4) is d/dt q_ARCI in component PKA (fmol). C RATES(5) is d/dt q_A2RCI in component PKA (fmol). C RATES(6) is d/dt q_CI in component PKA (fmol). C RATES(7) is d/dt q_A2RI in component PKA (fmol). C RATES(8) is d/dt q_PKACI_PKI in component PKA (fmol). C RATES(9) is d/dt q_PKACII in component PKA (fmol). C RATES(10) is d/dt q_ARCII in component PKA (fmol). C RATES(11) is d/dt q_A2RCII in component PKA (fmol). C RATES(12) is d/dt q_CII in component PKA (fmol). C RATES(13) is d/dt q_A2RII in component PKA (fmol). C RATES(14) is d/dt q_PKACII_PKI in component PKA (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 3.212E-02 CONSTS(2) = 6.840E-03 CONSTS(3) = 2.242E-02 CONSTS(4) = 3.800E-15 CONSTS(5) = 3.800E-15 CONSTS(6) = 3.800E-15 CONSTS(7) = 3.800E-15 CONSTS(8) = 3.800E-15 CONSTS(9) = 9.500E-04 CONSTS(10) = 3.800E-15 CONSTS(11) = 3.800E-15 CONSTS(12) = 3.800E-15 CONSTS(13) = 3.800E-15 CONSTS(14) = 3.800E-15 STATES(1) = 1e-16 STATES(2) = 1e-16 STATES(3) = 1e-16 STATES(4) = 1e-16 STATES(5) = 1e-16 STATES(6) = 1e-16 STATES(7) = 1e-16 STATES(8) = 1e-16 STATES(9) = 1e-16 STATES(10) = 1e-16 STATES(11) = 1e-16 STATES(12) = 1e-16 STATES(13) = 1e-16 STATES(14) = 1e-16 CONSTS(15) = 48.0417 CONSTS(16) = 21.1895 CONSTS(17) = 4.84331 CONSTS(18) = 149.139 CONSTS(19) = 48.0417 CONSTS(20) = 21.1895 CONSTS(21) = 4.84331 CONSTS(22) = 149.139 CONSTS(23) = 0.0401879 CONSTS(24) = 14.3814 CONSTS(25) = 0.0478876 CONSTS(26) = 0.605095 CONSTS(27) = 1.3719 CONSTS(28) = 1.96997 CONSTS(29) = 0.0885687 CONSTS(30) = 0.194918 CONSTS(31) = 0.0478876 CONSTS(32) = 0.605095 CONSTS(33) = 1.3719 CONSTS(34) = 1.96997 CONSTS(35) = 0.0885687 CONSTS(36) = 0.194918 CONSTS(37) = 8.31 CONSTS(38) = 310 CONSTS(39) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(1)+CONSTS(1) ALGBRC(15) = CONSTS(37)*CONSTS(38)*log( CONSTS(23)*ALGBRC(1)) ALGBRC(3) = STATES(3)+CONSTS(3) ALGBRC(17) = CONSTS(37)*CONSTS(38)*log( CONSTS(25)*ALGBRC(3)) ALGBRC(4) = STATES(4)+CONSTS(4) ALGBRC(18) = CONSTS(37)*CONSTS(38)*log( CONSTS(26)*ALGBRC(4)) ALGBRC(29) = CONSTS(15)*(EXP((ALGBRC(17)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(18)/( CONSTS(37)*CONSTS(38)))) RATES(3) = - ALGBRC(29) ALGBRC(5) = STATES(5)+CONSTS(5) ALGBRC(19) = CONSTS(37)*CONSTS(38)*log( CONSTS(27)*ALGBRC(5)) ALGBRC(30) = CONSTS(16)*(EXP((ALGBRC(18)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(19)/( CONSTS(37)*CONSTS(38)))) RATES(4) = ALGBRC(29) - ALGBRC(30) ALGBRC(6) = STATES(6)+CONSTS(6) ALGBRC(20) = CONSTS(37)*CONSTS(38)*log( CONSTS(28)*ALGBRC(6)) ALGBRC(7) = STATES(7)+CONSTS(7) ALGBRC(21) = CONSTS(37)*CONSTS(38)*log( CONSTS(29)*ALGBRC(7)) ALGBRC(31) = CONSTS(17)*(EXP(ALGBRC(19)/( CONSTS(37)*CONSTS(38))) - EXP((ALGBRC(21)+ALGBRC(20))/( CONSTS(37)*CONSTS(38)))) RATES(5) = ALGBRC(30) - ALGBRC(31) RATES(7) = ALGBRC(31) ALGBRC(2) = STATES(2)+CONSTS(2) ALGBRC(16) = CONSTS(37)*CONSTS(38)*log( CONSTS(24)*ALGBRC(2)) ALGBRC(8) = STATES(8)+CONSTS(8) ALGBRC(22) = CONSTS(37)*CONSTS(38)*log( CONSTS(30)*ALGBRC(8)) ALGBRC(32) = CONSTS(18)*(EXP((ALGBRC(20)+ALGBRC(16))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(22)/( CONSTS(37)*CONSTS(38)))) RATES(6) = ALGBRC(31) - ALGBRC(32) RATES(8) = ALGBRC(32) ALGBRC(9) = STATES(9)+CONSTS(9) ALGBRC(23) = CONSTS(37)*CONSTS(38)*log( CONSTS(31)*ALGBRC(9)) ALGBRC(10) = STATES(10)+CONSTS(10) ALGBRC(24) = CONSTS(37)*CONSTS(38)*log( CONSTS(32)*ALGBRC(10)) ALGBRC(33) = CONSTS(19)*(EXP((ALGBRC(23)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(24)/( CONSTS(37)*CONSTS(38)))) RATES(9) = - ALGBRC(33) ALGBRC(11) = STATES(11)+CONSTS(11) ALGBRC(25) = CONSTS(37)*CONSTS(38)*log( CONSTS(33)*ALGBRC(11)) ALGBRC(34) = CONSTS(20)*(EXP((ALGBRC(24)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(25)/( CONSTS(37)*CONSTS(38)))) RATES(1) = ((- ALGBRC(29) - ALGBRC(30)) - ALGBRC(33)) - ALGBRC(34) RATES(10) = ALGBRC(33) - ALGBRC(34) ALGBRC(12) = STATES(12)+CONSTS(12) ALGBRC(26) = CONSTS(37)*CONSTS(38)*log( CONSTS(34)*ALGBRC(12)) ALGBRC(13) = STATES(13)+CONSTS(13) ALGBRC(27) = CONSTS(37)*CONSTS(38)*log( CONSTS(35)*ALGBRC(13)) ALGBRC(35) = CONSTS(21)*(EXP(ALGBRC(25)/( CONSTS(37)*CONSTS(38))) - EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(37)*CONSTS(38)))) RATES(11) = ALGBRC(34) - ALGBRC(35) RATES(13) = ALGBRC(35) ALGBRC(14) = STATES(14)+CONSTS(14) ALGBRC(28) = CONSTS(37)*CONSTS(38)*log( CONSTS(36)*ALGBRC(14)) ALGBRC(36) = CONSTS(22)*(EXP((ALGBRC(26)+ALGBRC(16))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(28)/( CONSTS(37)*CONSTS(38)))) RATES(2) = - ALGBRC(32) - ALGBRC(36) RATES(12) = ALGBRC(35) - ALGBRC(36) RATES(14) = ALGBRC(36) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(1)+CONSTS(1) ALGBRC(15) = CONSTS(37)*CONSTS(38)*log( CONSTS(23)*ALGBRC(1)) ALGBRC(3) = STATES(3)+CONSTS(3) ALGBRC(17) = CONSTS(37)*CONSTS(38)*log( CONSTS(25)*ALGBRC(3)) ALGBRC(4) = STATES(4)+CONSTS(4) ALGBRC(18) = CONSTS(37)*CONSTS(38)*log( CONSTS(26)*ALGBRC(4)) ALGBRC(29) = CONSTS(15)*(EXP((ALGBRC(17)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(18)/( CONSTS(37)*CONSTS(38)))) ALGBRC(5) = STATES(5)+CONSTS(5) ALGBRC(19) = CONSTS(37)*CONSTS(38)*log( CONSTS(27)*ALGBRC(5)) ALGBRC(30) = CONSTS(16)*(EXP((ALGBRC(18)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(19)/( CONSTS(37)*CONSTS(38)))) ALGBRC(6) = STATES(6)+CONSTS(6) ALGBRC(20) = CONSTS(37)*CONSTS(38)*log( CONSTS(28)*ALGBRC(6)) ALGBRC(7) = STATES(7)+CONSTS(7) ALGBRC(21) = CONSTS(37)*CONSTS(38)*log( CONSTS(29)*ALGBRC(7)) ALGBRC(31) = CONSTS(17)*(EXP(ALGBRC(19)/( CONSTS(37)*CONSTS(38))) - EXP((ALGBRC(21)+ALGBRC(20))/( CONSTS(37)*CONSTS(38)))) ALGBRC(2) = STATES(2)+CONSTS(2) ALGBRC(16) = CONSTS(37)*CONSTS(38)*log( CONSTS(24)*ALGBRC(2)) ALGBRC(8) = STATES(8)+CONSTS(8) ALGBRC(22) = CONSTS(37)*CONSTS(38)*log( CONSTS(30)*ALGBRC(8)) ALGBRC(32) = CONSTS(18)*(EXP((ALGBRC(20)+ALGBRC(16))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(22)/( CONSTS(37)*CONSTS(38)))) ALGBRC(9) = STATES(9)+CONSTS(9) ALGBRC(23) = CONSTS(37)*CONSTS(38)*log( CONSTS(31)*ALGBRC(9)) ALGBRC(10) = STATES(10)+CONSTS(10) ALGBRC(24) = CONSTS(37)*CONSTS(38)*log( CONSTS(32)*ALGBRC(10)) ALGBRC(33) = CONSTS(19)*(EXP((ALGBRC(23)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(24)/( CONSTS(37)*CONSTS(38)))) ALGBRC(11) = STATES(11)+CONSTS(11) ALGBRC(25) = CONSTS(37)*CONSTS(38)*log( CONSTS(33)*ALGBRC(11)) ALGBRC(34) = CONSTS(20)*(EXP((ALGBRC(24)+ALGBRC(15))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(25)/( CONSTS(37)*CONSTS(38)))) ALGBRC(12) = STATES(12)+CONSTS(12) ALGBRC(26) = CONSTS(37)*CONSTS(38)*log( CONSTS(34)*ALGBRC(12)) ALGBRC(13) = STATES(13)+CONSTS(13) ALGBRC(27) = CONSTS(37)*CONSTS(38)*log( CONSTS(35)*ALGBRC(13)) ALGBRC(35) = CONSTS(21)*(EXP(ALGBRC(25)/( CONSTS(37)*CONSTS(38))) - EXP((ALGBRC(27)+ALGBRC(26))/( CONSTS(37)*CONSTS(38)))) ALGBRC(14) = STATES(14)+CONSTS(14) ALGBRC(28) = CONSTS(37)*CONSTS(38)*log( CONSTS(36)*ALGBRC(14)) ALGBRC(36) = CONSTS(22)*(EXP((ALGBRC(26)+ALGBRC(16))/( CONSTS(37)*CONSTS(38))) - EXP(ALGBRC(28)/( CONSTS(37)*CONSTS(38)))) RETURN END