/* There are a total of 16 entries in the algebraic variable array. There are a total of 6 entries in each of the rate and state variable arrays. There are a total of 19 entries in the constant variable array. */ /* * VOI is time in component environment (second). * CONSTANTS[0] is q_PKACI_init in component environment (fmol). * CONSTANTS[1] is q_Ip_init in component environment (fmol). * CONSTANTS[2] is q_Ip_PKACI_init in component environment (fmol). * CONSTANTS[3] is q_PP2a_init in component environment (fmol). * CONSTANTS[4] is q_Ip_PP2a_init in component environment (fmol). * CONSTANTS[5] is q_I_init in component environment (fmol). * ALGEBRAIC[0] is q_PKACI in component environment (fmol). * ALGEBRAIC[1] is q_Ip in component environment (fmol). * ALGEBRAIC[2] is q_Ip_PKACI in component environment (fmol). * ALGEBRAIC[3] is q_PP2a in component environment (fmol). * ALGEBRAIC[4] is q_Ip_PP2a in component environment (fmol). * ALGEBRAIC[5] is q_I in component environment (fmol). * STATES[0] is q_PKACI in component Inhib1 (fmol). * STATES[1] is q_Ip in component Inhib1 (fmol). * STATES[2] is q_Ip_PKACI in component Inhib1 (fmol). * STATES[3] is q_PP2a in component Inhib1 (fmol). * STATES[4] is q_Ip_PP2a in component Inhib1 (fmol). * STATES[5] is q_I in component Inhib1 (fmol). * CONSTANTS[6] is kappa_PKAi1 in component Inhib1_parameters (fmol_per_sec). * CONSTANTS[7] is kappa_PKAi2 in component Inhib1_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_PP2ai1 in component Inhib1_parameters (fmol_per_sec). * CONSTANTS[9] is kappa_PP2ai2 in component Inhib1_parameters (fmol_per_sec). * CONSTANTS[10] is K_PKACI in component Inhib1_parameters (per_fmol). * CONSTANTS[11] is K_Ip in component Inhib1_parameters (per_fmol). * CONSTANTS[12] is K_Ip_PKACI in component Inhib1_parameters (per_fmol). * CONSTANTS[13] is K_PP2a in component Inhib1_parameters (per_fmol). * CONSTANTS[14] is K_Ip_PP2a in component Inhib1_parameters (per_fmol). * CONSTANTS[15] is K_I in component Inhib1_parameters (per_fmol). * CONSTANTS[16] is R in component constants (J_per_K_per_mol). * CONSTANTS[17] is T in component constants (kelvin). * ALGEBRAIC[12] is vPKAi1 in component Inhib1 (fmol_per_sec). * ALGEBRAIC[13] is vPKAi2 in component Inhib1 (fmol_per_sec). * ALGEBRAIC[14] is vPP2ai1 in component Inhib1 (fmol_per_sec). * ALGEBRAIC[15] is vPP2ai2 in component Inhib1 (fmol_per_sec). * ALGEBRAIC[6] is mu_PKACI in component Inhib1 (J_per_mol). * ALGEBRAIC[7] is mu_Ip in component Inhib1 (J_per_mol). * ALGEBRAIC[8] is mu_Ip_PKACI in component Inhib1 (J_per_mol). * ALGEBRAIC[9] is mu_PP2a in component Inhib1 (J_per_mol). * ALGEBRAIC[10] is mu_Ip_PP2a in component Inhib1 (J_per_mol). * ALGEBRAIC[11] is mu_I in component Inhib1 (J_per_mol). * CONSTANTS[18] is F in component constants (C_per_mol). * RATES[0] is d/dt q_PKACI in component Inhib1 (fmol). * RATES[1] is d/dt q_Ip in component Inhib1 (fmol). * RATES[2] is d/dt q_Ip_PKACI in component Inhib1 (fmol). * RATES[3] is d/dt q_PP2a in component Inhib1 (fmol). * RATES[4] is d/dt q_Ip_PP2a in component Inhib1 (fmol). * RATES[5] is d/dt q_I in component Inhib1 (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1.117E-03; CONSTANTS[1] = 9.994E-04; CONSTANTS[2] = 1e-13; CONSTANTS[3] = 8.512E-03; CONSTANTS[4] = 1e-13; CONSTANTS[5] = 1.140E-02; STATES[0] = 1e-16; STATES[1] = 1e-16; STATES[2] = 1e-16; STATES[3] = 1e-16; STATES[4] = 1e-16; STATES[5] = 1e-16; CONSTANTS[6] = 20.9606; CONSTANTS[7] = 22.2706; CONSTANTS[8] = 5.39341; CONSTANTS[9] = 5.30013; CONSTANTS[10] = 0.284433; CONSTANTS[11] = 0.133405; CONSTANTS[12] = 1.38688; CONSTANTS[13] = 0.0704691; CONSTANTS[14] = 0.342795; CONSTANTS[15] = 0.150247; CONSTANTS[16] = 8.31; CONSTANTS[17] = 310; CONSTANTS[18] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[0]+CONSTANTS[0]; ALGEBRAIC[6] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[10]*ALGEBRAIC[0]); ALGEBRAIC[2] = STATES[2]+CONSTANTS[2]; ALGEBRAIC[8] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[12]*ALGEBRAIC[2]); ALGEBRAIC[5] = STATES[5]+CONSTANTS[5]; ALGEBRAIC[11] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[15]*ALGEBRAIC[5]); ALGEBRAIC[12] = CONSTANTS[6]*(exp((ALGEBRAIC[6]+ALGEBRAIC[11])/( CONSTANTS[16]*CONSTANTS[17])) - exp(ALGEBRAIC[8]/( CONSTANTS[16]*CONSTANTS[17]))); ALGEBRAIC[1] = STATES[1]+CONSTANTS[1]; ALGEBRAIC[7] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[11]*ALGEBRAIC[1]); ALGEBRAIC[13] = CONSTANTS[7]*(exp(ALGEBRAIC[8]/( CONSTANTS[16]*CONSTANTS[17])) - exp((ALGEBRAIC[6]+ALGEBRAIC[7])/( CONSTANTS[16]*CONSTANTS[17]))); RATES[0] = ALGEBRAIC[13] - ALGEBRAIC[12]; RATES[2] = ALGEBRAIC[12] - ALGEBRAIC[13]; ALGEBRAIC[3] = STATES[3]+CONSTANTS[3]; ALGEBRAIC[9] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[13]*ALGEBRAIC[3]); ALGEBRAIC[4] = STATES[4]+CONSTANTS[4]; ALGEBRAIC[10] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[14]*ALGEBRAIC[4]); ALGEBRAIC[14] = CONSTANTS[8]*(exp((ALGEBRAIC[9]+ALGEBRAIC[7])/( CONSTANTS[16]*CONSTANTS[17])) - exp(ALGEBRAIC[10]/( CONSTANTS[16]*CONSTANTS[17]))); RATES[1] = ALGEBRAIC[13] - ALGEBRAIC[14]; ALGEBRAIC[15] = CONSTANTS[9]*(exp(ALGEBRAIC[10]/( CONSTANTS[16]*CONSTANTS[17])) - exp((ALGEBRAIC[9]+ALGEBRAIC[11])/( CONSTANTS[16]*CONSTANTS[17]))); RATES[3] = ALGEBRAIC[15] - ALGEBRAIC[14]; RATES[4] = ALGEBRAIC[14] - ALGEBRAIC[15]; RATES[5] = ALGEBRAIC[15] - ALGEBRAIC[12]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = STATES[0]+CONSTANTS[0]; ALGEBRAIC[6] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[10]*ALGEBRAIC[0]); ALGEBRAIC[2] = STATES[2]+CONSTANTS[2]; ALGEBRAIC[8] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[12]*ALGEBRAIC[2]); ALGEBRAIC[5] = STATES[5]+CONSTANTS[5]; ALGEBRAIC[11] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[15]*ALGEBRAIC[5]); ALGEBRAIC[12] = CONSTANTS[6]*(exp((ALGEBRAIC[6]+ALGEBRAIC[11])/( CONSTANTS[16]*CONSTANTS[17])) - exp(ALGEBRAIC[8]/( CONSTANTS[16]*CONSTANTS[17]))); ALGEBRAIC[1] = STATES[1]+CONSTANTS[1]; ALGEBRAIC[7] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[11]*ALGEBRAIC[1]); ALGEBRAIC[13] = CONSTANTS[7]*(exp(ALGEBRAIC[8]/( CONSTANTS[16]*CONSTANTS[17])) - exp((ALGEBRAIC[6]+ALGEBRAIC[7])/( CONSTANTS[16]*CONSTANTS[17]))); ALGEBRAIC[3] = STATES[3]+CONSTANTS[3]; ALGEBRAIC[9] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[13]*ALGEBRAIC[3]); ALGEBRAIC[4] = STATES[4]+CONSTANTS[4]; ALGEBRAIC[10] = CONSTANTS[16]*CONSTANTS[17]*log( CONSTANTS[14]*ALGEBRAIC[4]); ALGEBRAIC[14] = CONSTANTS[8]*(exp((ALGEBRAIC[9]+ALGEBRAIC[7])/( CONSTANTS[16]*CONSTANTS[17])) - exp(ALGEBRAIC[10]/( CONSTANTS[16]*CONSTANTS[17]))); ALGEBRAIC[15] = CONSTANTS[9]*(exp(ALGEBRAIC[10]/( CONSTANTS[16]*CONSTANTS[17])) - exp((ALGEBRAIC[9]+ALGEBRAIC[11])/( CONSTANTS[16]*CONSTANTS[17]))); }