C C There are a total of 16 entries in the algebraic variable array. C There are a total of 6 entries in each of the rate and state variable arrays. C There are a total of 19 entries in the constant variable array. C C C VOI is time in component environment (second). C CONSTS(1) is q_PKACI_init in component environment (fmol). C CONSTS(2) is q_Ip_init in component environment (fmol). C CONSTS(3) is q_Ip_PKACI_init in component environment (fmol). C CONSTS(4) is q_PP2a_init in component environment (fmol). C CONSTS(5) is q_Ip_PP2a_init in component environment (fmol). C CONSTS(6) is q_I_init in component environment (fmol). C ALGBRC(1) is q_PKACI in component environment (fmol). C ALGBRC(2) is q_Ip in component environment (fmol). C ALGBRC(3) is q_Ip_PKACI in component environment (fmol). C ALGBRC(4) is q_PP2a in component environment (fmol). C ALGBRC(5) is q_Ip_PP2a in component environment (fmol). C ALGBRC(6) is q_I in component environment (fmol). C STATES(1) is q_PKACI in component Inhib1 (fmol). C STATES(2) is q_Ip in component Inhib1 (fmol). C STATES(3) is q_Ip_PKACI in component Inhib1 (fmol). C STATES(4) is q_PP2a in component Inhib1 (fmol). C STATES(5) is q_Ip_PP2a in component Inhib1 (fmol). C STATES(6) is q_I in component Inhib1 (fmol). C CONSTS(7) is kappa_PKAi1 in component Inhib1_parameters (fmol_per_sec). C CONSTS(8) is kappa_PKAi2 in component Inhib1_parameters (fmol_per_sec). C CONSTS(9) is kappa_PP2ai1 in component Inhib1_parameters (fmol_per_sec). C CONSTS(10) is kappa_PP2ai2 in component Inhib1_parameters (fmol_per_sec). C CONSTS(11) is K_PKACI in component Inhib1_parameters (per_fmol). C CONSTS(12) is K_Ip in component Inhib1_parameters (per_fmol). C CONSTS(13) is K_Ip_PKACI in component Inhib1_parameters (per_fmol). C CONSTS(14) is K_PP2a in component Inhib1_parameters (per_fmol). C CONSTS(15) is K_Ip_PP2a in component Inhib1_parameters (per_fmol). C CONSTS(16) is K_I in component Inhib1_parameters (per_fmol). C CONSTS(17) is R in component constants (J_per_K_per_mol). C CONSTS(18) is T in component constants (kelvin). C ALGBRC(13) is vPKAi1 in component Inhib1 (fmol_per_sec). C ALGBRC(14) is vPKAi2 in component Inhib1 (fmol_per_sec). C ALGBRC(15) is vPP2ai1 in component Inhib1 (fmol_per_sec). C ALGBRC(16) is vPP2ai2 in component Inhib1 (fmol_per_sec). C ALGBRC(7) is mu_PKACI in component Inhib1 (J_per_mol). C ALGBRC(8) is mu_Ip in component Inhib1 (J_per_mol). C ALGBRC(9) is mu_Ip_PKACI in component Inhib1 (J_per_mol). C ALGBRC(10) is mu_PP2a in component Inhib1 (J_per_mol). C ALGBRC(11) is mu_Ip_PP2a in component Inhib1 (J_per_mol). C ALGBRC(12) is mu_I in component Inhib1 (J_per_mol). C CONSTS(19) is F in component constants (C_per_mol). C RATES(1) is d/dt q_PKACI in component Inhib1 (fmol). C RATES(2) is d/dt q_Ip in component Inhib1 (fmol). C RATES(3) is d/dt q_Ip_PKACI in component Inhib1 (fmol). C RATES(4) is d/dt q_PP2a in component Inhib1 (fmol). C RATES(5) is d/dt q_Ip_PP2a in component Inhib1 (fmol). C RATES(6) is d/dt q_I in component Inhib1 (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 1.117E-03 CONSTS(2) = 9.994E-04 CONSTS(3) = 1e-13 CONSTS(4) = 8.512E-03 CONSTS(5) = 1e-13 CONSTS(6) = 1.140E-02 STATES(1) = 1e-16 STATES(2) = 1e-16 STATES(3) = 1e-16 STATES(4) = 1e-16 STATES(5) = 1e-16 STATES(6) = 1e-16 CONSTS(7) = 20.9606 CONSTS(8) = 22.2706 CONSTS(9) = 5.39341 CONSTS(10) = 5.30013 CONSTS(11) = 0.284433 CONSTS(12) = 0.133405 CONSTS(13) = 1.38688 CONSTS(14) = 0.0704691 CONSTS(15) = 0.342795 CONSTS(16) = 0.150247 CONSTS(17) = 8.31 CONSTS(18) = 310 CONSTS(19) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(1)+CONSTS(1) ALGBRC(7) = CONSTS(17)*CONSTS(18)*log( CONSTS(11)*ALGBRC(1)) ALGBRC(3) = STATES(3)+CONSTS(3) ALGBRC(9) = CONSTS(17)*CONSTS(18)*log( CONSTS(13)*ALGBRC(3)) ALGBRC(6) = STATES(6)+CONSTS(6) ALGBRC(12) = CONSTS(17)*CONSTS(18)*log( CONSTS(16)*ALGBRC(6)) ALGBRC(13) = CONSTS(7)*(EXP((ALGBRC(7)+ALGBRC(12))/( CONSTS(17)*CONSTS(18))) - EXP(ALGBRC(9)/( CONSTS(17)*CONSTS(18)))) ALGBRC(2) = STATES(2)+CONSTS(2) ALGBRC(8) = CONSTS(17)*CONSTS(18)*log( CONSTS(12)*ALGBRC(2)) ALGBRC(14) = CONSTS(8)*(EXP(ALGBRC(9)/( CONSTS(17)*CONSTS(18))) - EXP((ALGBRC(7)+ALGBRC(8))/( CONSTS(17)*CONSTS(18)))) RATES(1) = ALGBRC(14) - ALGBRC(13) RATES(3) = ALGBRC(13) - ALGBRC(14) ALGBRC(4) = STATES(4)+CONSTS(4) ALGBRC(10) = CONSTS(17)*CONSTS(18)*log( CONSTS(14)*ALGBRC(4)) ALGBRC(5) = STATES(5)+CONSTS(5) ALGBRC(11) = CONSTS(17)*CONSTS(18)*log( CONSTS(15)*ALGBRC(5)) ALGBRC(15) = CONSTS(9)*(EXP((ALGBRC(10)+ALGBRC(8))/( CONSTS(17)*CONSTS(18))) - EXP(ALGBRC(11)/( CONSTS(17)*CONSTS(18)))) RATES(2) = ALGBRC(14) - ALGBRC(15) ALGBRC(16) = CONSTS(10)*(EXP(ALGBRC(11)/( CONSTS(17)*CONSTS(18))) - EXP((ALGBRC(10)+ALGBRC(12))/( CONSTS(17)*CONSTS(18)))) RATES(4) = ALGBRC(16) - ALGBRC(15) RATES(5) = ALGBRC(15) - ALGBRC(16) RATES(6) = ALGBRC(16) - ALGBRC(13) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(1)+CONSTS(1) ALGBRC(7) = CONSTS(17)*CONSTS(18)*log( CONSTS(11)*ALGBRC(1)) ALGBRC(3) = STATES(3)+CONSTS(3) ALGBRC(9) = CONSTS(17)*CONSTS(18)*log( CONSTS(13)*ALGBRC(3)) ALGBRC(6) = STATES(6)+CONSTS(6) ALGBRC(12) = CONSTS(17)*CONSTS(18)*log( CONSTS(16)*ALGBRC(6)) ALGBRC(13) = CONSTS(7)*(EXP((ALGBRC(7)+ALGBRC(12))/( CONSTS(17)*CONSTS(18))) - EXP(ALGBRC(9)/( CONSTS(17)*CONSTS(18)))) ALGBRC(2) = STATES(2)+CONSTS(2) ALGBRC(8) = CONSTS(17)*CONSTS(18)*log( CONSTS(12)*ALGBRC(2)) ALGBRC(14) = CONSTS(8)*(EXP(ALGBRC(9)/( CONSTS(17)*CONSTS(18))) - EXP((ALGBRC(7)+ALGBRC(8))/( CONSTS(17)*CONSTS(18)))) ALGBRC(4) = STATES(4)+CONSTS(4) ALGBRC(10) = CONSTS(17)*CONSTS(18)*log( CONSTS(14)*ALGBRC(4)) ALGBRC(5) = STATES(5)+CONSTS(5) ALGBRC(11) = CONSTS(17)*CONSTS(18)*log( CONSTS(15)*ALGBRC(5)) ALGBRC(15) = CONSTS(9)*(EXP((ALGBRC(10)+ALGBRC(8))/( CONSTS(17)*CONSTS(18))) - EXP(ALGBRC(11)/( CONSTS(17)*CONSTS(18)))) ALGBRC(16) = CONSTS(10)*(EXP(ALGBRC(11)/( CONSTS(17)*CONSTS(18))) - EXP((ALGBRC(10)+ALGBRC(12))/( CONSTS(17)*CONSTS(18)))) RETURN END