/* There are a total of 13 entries in the algebraic variable array. There are a total of 8 entries in each of the rate and state variable arrays. There are a total of 16 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is q_PLB in component environment (fmol). * STATES[1] is q_PKACI in component environment (fmol). * STATES[2] is q_PLB_PKACI in component environment (fmol). * STATES[3] is q_PP1 in component environment (fmol). * STATES[4] is q_PLBp_PP1 in component environment (fmol). * STATES[5] is q_PLBp in component environment (fmol). * STATES[6] is q_Ip in component environment (fmol). * STATES[7] is q_Ip_PP1 in component environment (fmol). * ALGEBRAIC[8] is v_PLBph1 in component PLB (fmol_per_sec). * ALGEBRAIC[9] is v_PLBph2 in component PLB (fmol_per_sec). * ALGEBRAIC[10] is v_PLBd1 in component PLB (fmol_per_sec). * ALGEBRAIC[11] is v_PLBd2 in component PLB (fmol_per_sec). * ALGEBRAIC[12] is v_Inh in component PLB (fmol_per_sec). * CONSTANTS[0] is kappa_PLBph1 in component PLB_parameters (fmol_per_sec). * CONSTANTS[1] is kappa_PLBph2 in component PLB_parameters (fmol_per_sec). * CONSTANTS[2] is kappa_PLBd1 in component PLB_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_PLBd2 in component PLB_parameters (fmol_per_sec). * CONSTANTS[4] is kappa_Inh in component PLB_parameters (fmol_per_sec). * CONSTANTS[5] is K_PLB in component PLB_parameters (per_fmol). * CONSTANTS[6] is K_PKACI in component PLB_parameters (per_fmol). * CONSTANTS[7] is K_PLB_PKACI in component PLB_parameters (per_fmol). * CONSTANTS[8] is K_PP1 in component PLB_parameters (per_fmol). * CONSTANTS[9] is K_PLBp_PP1 in component PLB_parameters (per_fmol). * CONSTANTS[10] is K_PLBp in component PLB_parameters (per_fmol). * CONSTANTS[11] is K_Ip in component PLB_parameters (per_fmol). * CONSTANTS[12] is K_Ip_PP1 in component PLB_parameters (per_fmol). * CONSTANTS[13] is R in component constants (J_per_K_per_mol). * CONSTANTS[14] is T in component constants (kelvin). * ALGEBRAIC[0] is mu_PLB in component PLB (J_per_mol). * ALGEBRAIC[1] is mu_PKACI in component PLB (J_per_mol). * ALGEBRAIC[2] is mu_PLB_PKACI in component PLB (J_per_mol). * ALGEBRAIC[3] is mu_PP1 in component PLB (J_per_mol). * ALGEBRAIC[4] is mu_PLBp_PP1 in component PLB (J_per_mol). * ALGEBRAIC[5] is mu_PLBp in component PLB (J_per_mol). * ALGEBRAIC[6] is mu_Ip in component PLB (J_per_mol). * ALGEBRAIC[7] is mu_Ip_PP1 in component PLB (J_per_mol). * CONSTANTS[15] is F in component constants (C_per_mol). * RATES[0] is d/dt q_PLB in component environment (fmol). * RATES[1] is d/dt q_PKACI in component environment (fmol). * RATES[2] is d/dt q_PLB_PKACI in component environment (fmol). * RATES[3] is d/dt q_PP1 in component environment (fmol). * RATES[4] is d/dt q_PLBp_PP1 in component environment (fmol). * RATES[5] is d/dt q_PLBp in component environment (fmol). * RATES[6] is d/dt q_Ip in component environment (fmol). * RATES[7] is d/dt q_Ip_PP1 in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 4.028E+00; STATES[1] = 1.117E-03; STATES[2] = 1e-13; STATES[3] = 3.382E-02; STATES[4] = 1e-13; STATES[5] = 1.560E-01; STATES[6] = 9.994E-04; STATES[7] = 1e-13; CONSTANTS[0] = 45.5263; CONSTANTS[1] = 6.55904; CONSTANTS[2] = 0.386674; CONSTANTS[3] = 1.21269; CONSTANTS[4] = 431.435; CONSTANTS[5] = 0.00235741; CONSTANTS[6] = 0.395191; CONSTANTS[7] = 0.638527; CONSTANTS[8] = 0.361989; CONSTANTS[9] = 0.203757; CONSTANTS[10] = 0.326014; CONSTANTS[11] = 5.41093; CONSTANTS[12] = 0.0673793; CONSTANTS[13] = 8.31; CONSTANTS[14] = 310; CONSTANTS[15] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[5]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[6]*STATES[1]); ALGEBRAIC[2] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[7]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[5] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[10]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[1]*(exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[5]+ALGEBRAIC[1])/( CONSTANTS[13]*CONSTANTS[14]))); RATES[1] = ALGEBRAIC[9] - ALGEBRAIC[8]; RATES[2] = ALGEBRAIC[8] - ALGEBRAIC[9]; ALGEBRAIC[3] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[8]*STATES[3]); ALGEBRAIC[4] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[9]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[2]*(exp((ALGEBRAIC[5]+ALGEBRAIC[3])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14]))); RATES[5] = ALGEBRAIC[9] - ALGEBRAIC[10]; ALGEBRAIC[11] = CONSTANTS[3]*(exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[0]+ALGEBRAIC[3])/( CONSTANTS[13]*CONSTANTS[14]))); RATES[0] = ALGEBRAIC[11] - ALGEBRAIC[8]; RATES[4] = ALGEBRAIC[10] - ALGEBRAIC[11]; ALGEBRAIC[6] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[11]*STATES[6]); ALGEBRAIC[7] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[12]*STATES[7]); ALGEBRAIC[12] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ALGEBRAIC[6])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[7]/( CONSTANTS[13]*CONSTANTS[14]))); RATES[3] = (ALGEBRAIC[11] - ALGEBRAIC[10]) - ALGEBRAIC[12]; RATES[6] = - ALGEBRAIC[12]; RATES[7] = ALGEBRAIC[12]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[5]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[6]*STATES[1]); ALGEBRAIC[2] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[7]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[5] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[10]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[1]*(exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[5]+ALGEBRAIC[1])/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[3] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[8]*STATES[3]); ALGEBRAIC[4] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[9]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[2]*(exp((ALGEBRAIC[5]+ALGEBRAIC[3])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[11] = CONSTANTS[3]*(exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[0]+ALGEBRAIC[3])/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[6] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[11]*STATES[6]); ALGEBRAIC[7] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[12]*STATES[7]); ALGEBRAIC[12] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ALGEBRAIC[6])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[7]/( CONSTANTS[13]*CONSTANTS[14]))); }