C C There are a total of 13 entries in the algebraic variable array. C There are a total of 8 entries in each of the rate and state variable arrays. C There are a total of 16 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is q_PLB in component environment (fmol). C STATES(2) is q_PKACI in component environment (fmol). C STATES(3) is q_PLB_PKACI in component environment (fmol). C STATES(4) is q_PP1 in component environment (fmol). C STATES(5) is q_PLBp_PP1 in component environment (fmol). C STATES(6) is q_PLBp in component environment (fmol). C STATES(7) is q_Ip in component environment (fmol). C STATES(8) is q_Ip_PP1 in component environment (fmol). C ALGBRC(9) is v_PLBph1 in component PLB (fmol_per_sec). C ALGBRC(10) is v_PLBph2 in component PLB (fmol_per_sec). C ALGBRC(11) is v_PLBd1 in component PLB (fmol_per_sec). C ALGBRC(12) is v_PLBd2 in component PLB (fmol_per_sec). C ALGBRC(13) is v_Inh in component PLB (fmol_per_sec). C CONSTS(1) is kappa_PLBph1 in component PLB_parameters (fmol_per_sec). C CONSTS(2) is kappa_PLBph2 in component PLB_parameters (fmol_per_sec). C CONSTS(3) is kappa_PLBd1 in component PLB_parameters (fmol_per_sec). C CONSTS(4) is kappa_PLBd2 in component PLB_parameters (fmol_per_sec). C CONSTS(5) is kappa_Inh in component PLB_parameters (fmol_per_sec). C CONSTS(6) is K_PLB in component PLB_parameters (per_fmol). C CONSTS(7) is K_PKACI in component PLB_parameters (per_fmol). C CONSTS(8) is K_PLB_PKACI in component PLB_parameters (per_fmol). C CONSTS(9) is K_PP1 in component PLB_parameters (per_fmol). C CONSTS(10) is K_PLBp_PP1 in component PLB_parameters (per_fmol). C CONSTS(11) is K_PLBp in component PLB_parameters (per_fmol). C CONSTS(12) is K_Ip in component PLB_parameters (per_fmol). C CONSTS(13) is K_Ip_PP1 in component PLB_parameters (per_fmol). C CONSTS(14) is R in component constants (J_per_K_per_mol). C CONSTS(15) is T in component constants (kelvin). C ALGBRC(1) is mu_PLB in component PLB (J_per_mol). C ALGBRC(2) is mu_PKACI in component PLB (J_per_mol). C ALGBRC(3) is mu_PLB_PKACI in component PLB (J_per_mol). C ALGBRC(4) is mu_PP1 in component PLB (J_per_mol). C ALGBRC(5) is mu_PLBp_PP1 in component PLB (J_per_mol). C ALGBRC(6) is mu_PLBp in component PLB (J_per_mol). C ALGBRC(7) is mu_Ip in component PLB (J_per_mol). C ALGBRC(8) is mu_Ip_PP1 in component PLB (J_per_mol). C CONSTS(16) is F in component constants (C_per_mol). C RATES(1) is d/dt q_PLB in component environment (fmol). C RATES(2) is d/dt q_PKACI in component environment (fmol). C RATES(3) is d/dt q_PLB_PKACI in component environment (fmol). C RATES(4) is d/dt q_PP1 in component environment (fmol). C RATES(5) is d/dt q_PLBp_PP1 in component environment (fmol). C RATES(6) is d/dt q_PLBp in component environment (fmol). C RATES(7) is d/dt q_Ip in component environment (fmol). C RATES(8) is d/dt q_Ip_PP1 in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 4.028E+00 STATES(2) = 1.117E-03 STATES(3) = 1e-13 STATES(4) = 3.382E-02 STATES(5) = 1e-13 STATES(6) = 1.560E-01 STATES(7) = 9.994E-04 STATES(8) = 1e-13 CONSTS(1) = 45.5263 CONSTS(2) = 6.55904 CONSTS(3) = 0.386674 CONSTS(4) = 1.21269 CONSTS(5) = 431.435 CONSTS(6) = 0.00235741 CONSTS(7) = 0.395191 CONSTS(8) = 0.638527 CONSTS(9) = 0.361989 CONSTS(10) = 0.203757 CONSTS(11) = 0.326014 CONSTS(12) = 5.41093 CONSTS(13) = 0.0673793 CONSTS(14) = 8.31 CONSTS(15) = 310 CONSTS(16) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(14)*CONSTS(15)*log( CONSTS(6)*STATES(1)) ALGBRC(2) = CONSTS(14)*CONSTS(15)*log( CONSTS(7)*STATES(2)) ALGBRC(3) = CONSTS(14)*CONSTS(15)*log( CONSTS(8)*STATES(3)) ALGBRC(9) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15)))) ALGBRC(6) = CONSTS(14)*CONSTS(15)*log( CONSTS(11)*STATES(6)) ALGBRC(10) = CONSTS(2)*(EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(6)+ALGBRC(2))/( CONSTS(14)*CONSTS(15)))) RATES(2) = ALGBRC(10) - ALGBRC(9) RATES(3) = ALGBRC(9) - ALGBRC(10) ALGBRC(4) = CONSTS(14)*CONSTS(15)*log( CONSTS(9)*STATES(4)) ALGBRC(5) = CONSTS(14)*CONSTS(15)*log( CONSTS(10)*STATES(5)) ALGBRC(11) = CONSTS(3)*(EXP((ALGBRC(6)+ALGBRC(4))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15)))) RATES(6) = ALGBRC(10) - ALGBRC(11) ALGBRC(12) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(14)*CONSTS(15)))) RATES(1) = ALGBRC(12) - ALGBRC(9) RATES(5) = ALGBRC(11) - ALGBRC(12) ALGBRC(7) = CONSTS(14)*CONSTS(15)*log( CONSTS(12)*STATES(7)) ALGBRC(8) = CONSTS(14)*CONSTS(15)*log( CONSTS(13)*STATES(8)) ALGBRC(13) = CONSTS(5)*(EXP((ALGBRC(4)+ALGBRC(7))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(8)/( CONSTS(14)*CONSTS(15)))) RATES(4) = (ALGBRC(12) - ALGBRC(11)) - ALGBRC(13) RATES(7) = - ALGBRC(13) RATES(8) = ALGBRC(13) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(14)*CONSTS(15)*log( CONSTS(6)*STATES(1)) ALGBRC(2) = CONSTS(14)*CONSTS(15)*log( CONSTS(7)*STATES(2)) ALGBRC(3) = CONSTS(14)*CONSTS(15)*log( CONSTS(8)*STATES(3)) ALGBRC(9) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15)))) ALGBRC(6) = CONSTS(14)*CONSTS(15)*log( CONSTS(11)*STATES(6)) ALGBRC(10) = CONSTS(2)*(EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(6)+ALGBRC(2))/( CONSTS(14)*CONSTS(15)))) ALGBRC(4) = CONSTS(14)*CONSTS(15)*log( CONSTS(9)*STATES(4)) ALGBRC(5) = CONSTS(14)*CONSTS(15)*log( CONSTS(10)*STATES(5)) ALGBRC(11) = CONSTS(3)*(EXP((ALGBRC(6)+ALGBRC(4))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15)))) ALGBRC(12) = CONSTS(4)*(EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(1)+ALGBRC(4))/( CONSTS(14)*CONSTS(15)))) ALGBRC(7) = CONSTS(14)*CONSTS(15)*log( CONSTS(12)*STATES(7)) ALGBRC(8) = CONSTS(14)*CONSTS(15)*log( CONSTS(13)*STATES(8)) ALGBRC(13) = CONSTS(5)*(EXP((ALGBRC(4)+ALGBRC(7))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(8)/( CONSTS(14)*CONSTS(15)))) RETURN END