/* There are a total of 11 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 14 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is q_GTP in component environment (fmol). * STATES[1] is q_E5c in component environment (fmol). * STATES[2] is q_cGMP in component environment (fmol). * STATES[3] is q_PDE in component environment (fmol). * STATES[4] is q_GTP_E5c in component environment (fmol). * STATES[5] is q_cGMP_PDE in component environment (fmol). * STATES[6] is q_GMP in component environment (fmol). * ALGEBRAIC[7] is v_R_1a_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[8] is v_R_1b_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[9] is v_R_2a_cGMP in component cGMP (fmol_per_sec). * ALGEBRAIC[10] is v_R_2b_cGMP in component cGMP (fmol_per_sec). * CONSTANTS[0] is kappa_R_1a_cGMP in component cGMP_parameters (fmol_per_sec). * CONSTANTS[1] is kappa_R_1b_cGMP in component cGMP_parameters (fmol_per_sec). * CONSTANTS[2] is kappa_R_2a_cGMP in component cGMP_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_R_2b_cGMP in component cGMP_parameters (fmol_per_sec). * CONSTANTS[4] is K_GTP in component cGMP_parameters (per_fmol). * CONSTANTS[5] is K_E5c in component cGMP_parameters (per_fmol). * CONSTANTS[6] is K_cGMP in component cGMP_parameters (per_fmol). * CONSTANTS[7] is K_PDE in component cGMP_parameters (per_fmol). * CONSTANTS[8] is K_GTP_E5c in component cGMP_parameters (per_fmol). * CONSTANTS[9] is K_cGMP_PDE in component cGMP_parameters (per_fmol). * CONSTANTS[10] is K_GMP in component cGMP_parameters (per_fmol). * CONSTANTS[11] is R in component constants (J_per_K_per_mol). * CONSTANTS[12] is T in component constants (kelvin). * ALGEBRAIC[0] is mu_GTP in component cGMP (J_per_mol). * ALGEBRAIC[1] is mu_E5c in component cGMP (J_per_mol). * ALGEBRAIC[2] is mu_cGMP in component cGMP (J_per_mol). * ALGEBRAIC[3] is mu_PDE in component cGMP (J_per_mol). * ALGEBRAIC[4] is mu_GTP_E5c in component cGMP (J_per_mol). * ALGEBRAIC[5] is mu_cGMP_PDE in component cGMP (J_per_mol). * ALGEBRAIC[6] is mu_GMP in component cGMP (J_per_mol). * CONSTANTS[13] is F in component constants (C_per_mol). * RATES[0] is d/dt q_GTP in component environment (fmol). * RATES[1] is d/dt q_E5c in component environment (fmol). * RATES[2] is d/dt q_cGMP in component environment (fmol). * RATES[3] is d/dt q_PDE in component environment (fmol). * RATES[4] is d/dt q_GTP_E5c in component environment (fmol). * RATES[5] is d/dt q_cGMP_PDE in component environment (fmol). * RATES[6] is d/dt q_GMP in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 1e-18; STATES[1] = 1e-18; STATES[2] = 1e-18; STATES[3] = 1e-18; STATES[4] = 1e-18; STATES[5] = 1e-18; STATES[6] = 1e-18; CONSTANTS[0] = 1772.99; CONSTANTS[1] = 0.0302117; CONSTANTS[2] = 73652.7; CONSTANTS[3] = 0.0143623; CONSTANTS[4] = 1600.8; CONSTANTS[5] = 0.0255983; CONSTANTS[6] = 0.0939434; CONSTANTS[7] = 10.5002; CONSTANTS[8] = 152.027; CONSTANTS[9] = 7.31926; CONSTANTS[10] = 0.000481761; CONSTANTS[11] = 8.31; CONSTANTS[12] = 310; CONSTANTS[13] = 96485; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[4]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[5]*STATES[1]); ALGEBRAIC[4] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[8]*STATES[4]); ALGEBRAIC[7] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[11]*CONSTANTS[12])) - exp(ALGEBRAIC[4]/( CONSTANTS[11]*CONSTANTS[12]))); RATES[0] = - ALGEBRAIC[7]; ALGEBRAIC[2] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[6]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[1]*(exp(ALGEBRAIC[4]/( CONSTANTS[11]*CONSTANTS[12])) - exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[11]*CONSTANTS[12]))); RATES[1] = - ALGEBRAIC[7]+ALGEBRAIC[8]; RATES[4] = ALGEBRAIC[7] - ALGEBRAIC[8]; ALGEBRAIC[3] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[7]*STATES[3]); ALGEBRAIC[5] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[9]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[3])/( CONSTANTS[11]*CONSTANTS[12])) - exp(ALGEBRAIC[5]/( CONSTANTS[11]*CONSTANTS[12]))); ALGEBRAIC[6] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[10]*STATES[6]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[5]+ALGEBRAIC[2])/( CONSTANTS[11]*CONSTANTS[12])) - exp((ALGEBRAIC[6]+ALGEBRAIC[3])/( CONSTANTS[11]*CONSTANTS[12]))); RATES[2] = (ALGEBRAIC[8] - ALGEBRAIC[9]) - ALGEBRAIC[10]; RATES[3] = - ALGEBRAIC[9]+ALGEBRAIC[10]; RATES[5] = ALGEBRAIC[9] - ALGEBRAIC[10]; RATES[6] = ALGEBRAIC[10]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[4]*STATES[0]); ALGEBRAIC[1] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[5]*STATES[1]); ALGEBRAIC[4] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[8]*STATES[4]); ALGEBRAIC[7] = CONSTANTS[0]*(exp((ALGEBRAIC[0]+ALGEBRAIC[1])/( CONSTANTS[11]*CONSTANTS[12])) - exp(ALGEBRAIC[4]/( CONSTANTS[11]*CONSTANTS[12]))); ALGEBRAIC[2] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[6]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[1]*(exp(ALGEBRAIC[4]/( CONSTANTS[11]*CONSTANTS[12])) - exp((ALGEBRAIC[2]+ALGEBRAIC[1])/( CONSTANTS[11]*CONSTANTS[12]))); ALGEBRAIC[3] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[7]*STATES[3]); ALGEBRAIC[5] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[9]*STATES[5]); ALGEBRAIC[9] = CONSTANTS[2]*(exp((ALGEBRAIC[2]+ALGEBRAIC[3])/( CONSTANTS[11]*CONSTANTS[12])) - exp(ALGEBRAIC[5]/( CONSTANTS[11]*CONSTANTS[12]))); ALGEBRAIC[6] = CONSTANTS[11]*CONSTANTS[12]*log( CONSTANTS[10]*STATES[6]); ALGEBRAIC[10] = CONSTANTS[3]*(exp((ALGEBRAIC[5]+ALGEBRAIC[2])/( CONSTANTS[11]*CONSTANTS[12])) - exp((ALGEBRAIC[6]+ALGEBRAIC[3])/( CONSTANTS[11]*CONSTANTS[12]))); }