C C There are a total of 11 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 14 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is q_GTP in component environment (fmol). C STATES(2) is q_E5c in component environment (fmol). C STATES(3) is q_cGMP in component environment (fmol). C STATES(4) is q_PDE in component environment (fmol). C STATES(5) is q_GTP_E5c in component environment (fmol). C STATES(6) is q_cGMP_PDE in component environment (fmol). C STATES(7) is q_GMP in component environment (fmol). C ALGBRC(8) is v_R_1a_cGMP in component cGMP (fmol_per_sec). C ALGBRC(9) is v_R_1b_cGMP in component cGMP (fmol_per_sec). C ALGBRC(10) is v_R_2a_cGMP in component cGMP (fmol_per_sec). C ALGBRC(11) is v_R_2b_cGMP in component cGMP (fmol_per_sec). C CONSTS(1) is kappa_R_1a_cGMP in component cGMP_parameters (fmol_per_sec). C CONSTS(2) is kappa_R_1b_cGMP in component cGMP_parameters (fmol_per_sec). C CONSTS(3) is kappa_R_2a_cGMP in component cGMP_parameters (fmol_per_sec). C CONSTS(4) is kappa_R_2b_cGMP in component cGMP_parameters (fmol_per_sec). C CONSTS(5) is K_GTP in component cGMP_parameters (per_fmol). C CONSTS(6) is K_E5c in component cGMP_parameters (per_fmol). C CONSTS(7) is K_cGMP in component cGMP_parameters (per_fmol). C CONSTS(8) is K_PDE in component cGMP_parameters (per_fmol). C CONSTS(9) is K_GTP_E5c in component cGMP_parameters (per_fmol). C CONSTS(10) is K_cGMP_PDE in component cGMP_parameters (per_fmol). C CONSTS(11) is K_GMP in component cGMP_parameters (per_fmol). C CONSTS(12) is R in component constants (J_per_K_per_mol). C CONSTS(13) is T in component constants (kelvin). C ALGBRC(1) is mu_GTP in component cGMP (J_per_mol). C ALGBRC(2) is mu_E5c in component cGMP (J_per_mol). C ALGBRC(3) is mu_cGMP in component cGMP (J_per_mol). C ALGBRC(4) is mu_PDE in component cGMP (J_per_mol). C ALGBRC(5) is mu_GTP_E5c in component cGMP (J_per_mol). C ALGBRC(6) is mu_cGMP_PDE in component cGMP (J_per_mol). C ALGBRC(7) is mu_GMP in component cGMP (J_per_mol). C CONSTS(14) is F in component constants (C_per_mol). C RATES(1) is d/dt q_GTP in component environment (fmol). C RATES(2) is d/dt q_E5c in component environment (fmol). C RATES(3) is d/dt q_cGMP in component environment (fmol). C RATES(4) is d/dt q_PDE in component environment (fmol). C RATES(5) is d/dt q_GTP_E5c in component environment (fmol). C RATES(6) is d/dt q_cGMP_PDE in component environment (fmol). C RATES(7) is d/dt q_GMP in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1e-18 STATES(2) = 1e-18 STATES(3) = 1e-18 STATES(4) = 1e-18 STATES(5) = 1e-18 STATES(6) = 1e-18 STATES(7) = 1e-18 CONSTS(1) = 1772.99 CONSTS(2) = 0.0302117 CONSTS(3) = 73652.7 CONSTS(4) = 0.0143623 CONSTS(5) = 1600.8 CONSTS(6) = 0.0255983 CONSTS(7) = 0.0939434 CONSTS(8) = 10.5002 CONSTS(9) = 152.027 CONSTS(10) = 7.31926 CONSTS(11) = 0.000481761 CONSTS(12) = 8.31 CONSTS(13) = 310 CONSTS(14) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(12)*CONSTS(13)*log( CONSTS(5)*STATES(1)) ALGBRC(2) = CONSTS(12)*CONSTS(13)*log( CONSTS(6)*STATES(2)) ALGBRC(5) = CONSTS(12)*CONSTS(13)*log( CONSTS(9)*STATES(5)) ALGBRC(8) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(12)*CONSTS(13))) - EXP(ALGBRC(5)/( CONSTS(12)*CONSTS(13)))) RATES(1) = - ALGBRC(8) ALGBRC(3) = CONSTS(12)*CONSTS(13)*log( CONSTS(7)*STATES(3)) ALGBRC(9) = CONSTS(2)*(EXP(ALGBRC(5)/( CONSTS(12)*CONSTS(13))) - EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(12)*CONSTS(13)))) RATES(2) = - ALGBRC(8)+ALGBRC(9) RATES(5) = ALGBRC(8) - ALGBRC(9) ALGBRC(4) = CONSTS(12)*CONSTS(13)*log( CONSTS(8)*STATES(4)) ALGBRC(6) = CONSTS(12)*CONSTS(13)*log( CONSTS(10)*STATES(6)) ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(4))/( CONSTS(12)*CONSTS(13))) - EXP(ALGBRC(6)/( CONSTS(12)*CONSTS(13)))) ALGBRC(7) = CONSTS(12)*CONSTS(13)*log( CONSTS(11)*STATES(7)) ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(6)+ALGBRC(3))/( CONSTS(12)*CONSTS(13))) - EXP((ALGBRC(7)+ALGBRC(4))/( CONSTS(12)*CONSTS(13)))) RATES(3) = (ALGBRC(9) - ALGBRC(10)) - ALGBRC(11) RATES(4) = - ALGBRC(10)+ALGBRC(11) RATES(6) = ALGBRC(10) - ALGBRC(11) RATES(7) = ALGBRC(11) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(12)*CONSTS(13)*log( CONSTS(5)*STATES(1)) ALGBRC(2) = CONSTS(12)*CONSTS(13)*log( CONSTS(6)*STATES(2)) ALGBRC(5) = CONSTS(12)*CONSTS(13)*log( CONSTS(9)*STATES(5)) ALGBRC(8) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(12)*CONSTS(13))) - EXP(ALGBRC(5)/( CONSTS(12)*CONSTS(13)))) ALGBRC(3) = CONSTS(12)*CONSTS(13)*log( CONSTS(7)*STATES(3)) ALGBRC(9) = CONSTS(2)*(EXP(ALGBRC(5)/( CONSTS(12)*CONSTS(13))) - EXP((ALGBRC(3)+ALGBRC(2))/( CONSTS(12)*CONSTS(13)))) ALGBRC(4) = CONSTS(12)*CONSTS(13)*log( CONSTS(8)*STATES(4)) ALGBRC(6) = CONSTS(12)*CONSTS(13)*log( CONSTS(10)*STATES(6)) ALGBRC(10) = CONSTS(3)*(EXP((ALGBRC(3)+ALGBRC(4))/( CONSTS(12)*CONSTS(13))) - EXP(ALGBRC(6)/( CONSTS(12)*CONSTS(13)))) ALGBRC(7) = CONSTS(12)*CONSTS(13)*log( CONSTS(11)*STATES(7)) ALGBRC(11) = CONSTS(4)*(EXP((ALGBRC(6)+ALGBRC(3))/( CONSTS(12)*CONSTS(13))) - EXP((ALGBRC(7)+ALGBRC(4))/( CONSTS(12)*CONSTS(13)))) RETURN END