C C There are a total of 30 entries in the algebraic variable array. C There are a total of 18 entries in each of the rate and state variable arrays. C There are a total of 33 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is q_ATP in component environment (fmol). C STATES(2) is q_AC in component environment (fmol). C STATES(3) is q_cAMP in component environment (fmol). C STATES(4) is q_AC_ATP in component environment (fmol). C STATES(5) is q_FSK in component environment (fmol). C STATES(6) is q_FSK_AC in component environment (fmol). C STATES(7) is q_FSK_AC_ATP in component environment (fmol). C STATES(8) is q_Gsa_GTP in component environment (fmol). C STATES(9) is q_Gsa_GTP_AC in component environment (fmol). C STATES(10) is q_Gsa_GTP_AC_ATP in component environment (fmol). C STATES(11) is q_PDE in component environment (fmol). C STATES(12) is q_PDEinh in component environment (fmol). C STATES(13) is q_PDE_cAMP in component environment (fmol). C STATES(14) is q_IBMX in component environment (fmol). C STATES(15) is q_five_AMP in component environment (fmol). C STATES(16) is q_Gia_GTP in component environment (fmol). C STATES(17) is q_ACinh in component environment (fmol). C STATES(18) is q_PPi in component environment (fmol). C ALGBRC(19) is v_1a in component cAMP (fmol_per_sec). C ALGBRC(20) is v_1b in component cAMP (fmol_per_sec). C ALGBRC(21) is v_2a in component cAMP (fmol_per_sec). C ALGBRC(22) is v_2b in component cAMP (fmol_per_sec). C ALGBRC(23) is v_3a in component cAMP (fmol_per_sec). C ALGBRC(24) is v_3b in component cAMP (fmol_per_sec). C ALGBRC(25) is v_4a in component cAMP (fmol_per_sec). C ALGBRC(27) is v_4b in component cAMP (fmol_per_sec). C ALGBRC(29) is v_5 in component cAMP (fmol_per_sec). C ALGBRC(26) is v_6 in component cAMP (fmol_per_sec). C ALGBRC(28) is v_7 in component cAMP (fmol_per_sec). C ALGBRC(30) is v_GiAC in component cAMP (fmol_per_sec). C CONSTS(1) is kappa_1a in component cAMP_parameters (fmol_per_sec). C CONSTS(2) is kappa_1b in component cAMP_parameters (fmol_per_sec). C CONSTS(3) is kappa_2a in component cAMP_parameters (fmol_per_sec). C CONSTS(4) is kappa_2b in component cAMP_parameters (fmol_per_sec). C CONSTS(5) is kappa_3a in component cAMP_parameters (fmol_per_sec). C CONSTS(6) is kappa_3b in component cAMP_parameters (fmol_per_sec). C CONSTS(7) is kappa_4a in component cAMP_parameters (fmol_per_sec). C CONSTS(8) is kappa_4b in component cAMP_parameters (fmol_per_sec). C CONSTS(9) is kappa_5 in component cAMP_parameters (fmol_per_sec). C CONSTS(10) is kappa_6 in component cAMP_parameters (fmol_per_sec). C CONSTS(11) is kappa_7 in component cAMP_parameters (fmol_per_sec). C CONSTS(12) is kappa_GiAC in component cAMP_parameters (fmol_per_sec). C CONSTS(13) is K_ATP in component cAMP_parameters (per_fmol). C CONSTS(14) is K_cAMP in component cAMP_parameters (per_fmol). C CONSTS(15) is K_AC in component cAMP_parameters (per_fmol). C CONSTS(16) is K_AC_ATP in component cAMP_parameters (per_fmol). C CONSTS(17) is K_Gsa_GTP_AC in component cAMP_parameters (per_fmol). C CONSTS(18) is K_Gsa_GTP_AC_ATP in component cAMP_parameters (per_fmol). C CONSTS(19) is K_FSK_AC in component cAMP_parameters (per_fmol). C CONSTS(20) is K_FSK_AC_ATP in component cAMP_parameters (per_fmol). C CONSTS(21) is K_PDE in component cAMP_parameters (per_fmol). C CONSTS(22) is K_PDE_cAMP in component cAMP_parameters (per_fmol). C CONSTS(23) is K_five_AMP in component cAMP_parameters (per_fmol). C CONSTS(24) is K_IBMX in component cAMP_parameters (per_fmol). C CONSTS(25) is K_PDEinh in component cAMP_parameters (per_fmol). C CONSTS(26) is K_Gsa_GTP in component cAMP_parameters (per_fmol). C CONSTS(27) is K_FSK in component cAMP_parameters (per_fmol). C CONSTS(28) is K_Gia_GTP in component cAMP_parameters (per_fmol). C CONSTS(29) is K_ACinh in component cAMP_parameters (per_fmol). C CONSTS(30) is K_PPi in component cAMP_parameters (per_fmol). C CONSTS(31) is R in component constants (J_per_K_per_mol). C CONSTS(32) is T in component constants (kelvin). C ALGBRC(1) is mu_ATP in component cAMP (J_per_mol). C ALGBRC(2) is mu_cAMP in component cAMP (J_per_mol). C ALGBRC(3) is mu_AC in component cAMP (J_per_mol). C ALGBRC(4) is mu_AC_ATP in component cAMP (J_per_mol). C ALGBRC(5) is mu_Gsa_GTP_AC in component cAMP (J_per_mol). C ALGBRC(6) is mu_Gsa_GTP_AC_ATP in component cAMP (J_per_mol). C ALGBRC(7) is mu_FSK_AC in component cAMP (J_per_mol). C ALGBRC(8) is mu_FSK_AC_ATP in component cAMP (J_per_mol). C ALGBRC(9) is mu_PDE in component cAMP (J_per_mol). C ALGBRC(10) is mu_PDE_cAMP in component cAMP (J_per_mol). C ALGBRC(11) is mu_five_AMP in component cAMP (J_per_mol). C ALGBRC(12) is mu_IBMX in component cAMP (J_per_mol). C ALGBRC(13) is mu_PDEinh in component cAMP (J_per_mol). C ALGBRC(14) is mu_Gsa_GTP in component cAMP (J_per_mol). C ALGBRC(15) is mu_FSK in component cAMP (J_per_mol). C ALGBRC(16) is mu_Gia_GTP in component cAMP (J_per_mol). C ALGBRC(17) is mu_ACinh in component cAMP (J_per_mol). C ALGBRC(18) is mu_PPi in component cAMP (J_per_mol). C CONSTS(33) is F in component constants (C_per_mol). C RATES(1) is d/dt q_ATP in component environment (fmol). C RATES(2) is d/dt q_AC in component environment (fmol). C RATES(4) is d/dt q_AC_ATP in component environment (fmol). C RATES(3) is d/dt q_cAMP in component environment (fmol). C RATES(5) is d/dt q_FSK in component environment (fmol). C RATES(6) is d/dt q_FSK_AC in component environment (fmol). C RATES(7) is d/dt q_FSK_AC_ATP in component environment (fmol). C RATES(8) is d/dt q_Gsa_GTP in component environment (fmol). C RATES(9) is d/dt q_Gsa_GTP_AC in component environment (fmol). C RATES(10) is d/dt q_Gsa_GTP_AC_ATP in component environment (fmol). C RATES(13) is d/dt q_PDE_cAMP in component environment (fmol). C RATES(11) is d/dt q_PDE in component environment (fmol). C RATES(14) is d/dt q_IBMX in component environment (fmol). C RATES(12) is d/dt q_PDEinh in component environment (fmol). C RATES(15) is d/dt q_five_AMP in component environment (fmol). C RATES(16) is d/dt q_Gia_GTP in component environment (fmol). C RATES(17) is d/dt q_ACinh in component environment (fmol). C RATES(18) is d/dt q_PPi in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 190 STATES(2) = 1.889E-03 STATES(3) = 3.212E-02 STATES(4) = 1e-18 STATES(5) = 3.8e-5 STATES(6) = 1e-18 STATES(7) = 1e-18 STATES(8) = 9.519E-04 STATES(9) = 1e-18 STATES(10) = 1e-18 STATES(11) = 1.482E-03 STATES(12) = 1e-18 STATES(13) = 1e-18 STATES(14) = 3.80E-06 STATES(15) = 1e-18 STATES(16) = 4.81E-04 STATES(17) = 1e-18 STATES(18) = 1e-18 CONSTS(1) = 9.47329e+06 CONSTS(2) = 0.00197793 CONSTS(3) = 176000 CONSTS(4) = 0.047492 CONSTS(5) = 5.07667e+08 CONSTS(6) = 5.9031e-17 CONSTS(7) = 36084.5 CONSTS(8) = 0.138787 CONSTS(9) = 751.564 CONSTS(10) = 556.617 CONSTS(11) = 160555 CONSTS(12) = 685.521 CONSTS(13) = 9.19362e-06 CONSTS(14) = 0.0102598 CONSTS(15) = 9.02358 CONSTS(16) = 2.93942 CONSTS(17) = 52.2258 CONSTS(18) = 5.20284 CONSTS(19) = 0.181058 CONSTS(20) = 0.0492449 CONSTS(21) = 2.28256 CONSTS(22) = 1.04728 CONSTS(23) = 0.0102598 CONSTS(24) = 0.01642 CONSTS(25) = 38.679 CONSTS(26) = 0.420618 CONSTS(27) = 1.32565e-05 CONSTS(28) = 0.013661 CONSTS(29) = 42.4053 CONSTS(30) = 2.60488e-05 CONSTS(31) = 8.31 CONSTS(32) = 310 CONSTS(33) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(31)*CONSTS(32)*log( CONSTS(13)*STATES(1)) ALGBRC(3) = CONSTS(31)*CONSTS(32)*log( CONSTS(15)*STATES(2)) ALGBRC(4) = CONSTS(31)*CONSTS(32)*log( CONSTS(16)*STATES(4)) ALGBRC(19) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(4)/( CONSTS(31)*CONSTS(32)))) ALGBRC(2) = CONSTS(31)*CONSTS(32)*log( CONSTS(14)*STATES(3)) ALGBRC(18) = CONSTS(31)*CONSTS(32)*log( CONSTS(30)*STATES(18)) ALGBRC(20) = CONSTS(2)*(EXP(ALGBRC(4)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(3)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) RATES(4) = ALGBRC(19) - ALGBRC(20) ALGBRC(5) = CONSTS(31)*CONSTS(32)*log( CONSTS(17)*STATES(9)) ALGBRC(6) = CONSTS(31)*CONSTS(32)*log( CONSTS(18)*STATES(10)) ALGBRC(21) = CONSTS(3)*(EXP((ALGBRC(5)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(6)/( CONSTS(31)*CONSTS(32)))) ALGBRC(22) = CONSTS(4)*(EXP(ALGBRC(6)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(5)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) RATES(10) = ALGBRC(21) - ALGBRC(22) ALGBRC(7) = CONSTS(31)*CONSTS(32)*log( CONSTS(19)*STATES(6)) ALGBRC(8) = CONSTS(31)*CONSTS(32)*log( CONSTS(20)*STATES(7)) ALGBRC(23) = CONSTS(5)*(EXP((ALGBRC(7)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(8)/( CONSTS(31)*CONSTS(32)))) RATES(1) = (- ALGBRC(19) - ALGBRC(23)) - ALGBRC(21) ALGBRC(24) = CONSTS(6)*(EXP(ALGBRC(8)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(7)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) RATES(7) = ALGBRC(23) - ALGBRC(24) ALGBRC(9) = CONSTS(31)*CONSTS(32)*log( CONSTS(21)*STATES(11)) ALGBRC(10) = CONSTS(31)*CONSTS(32)*log( CONSTS(22)*STATES(13)) ALGBRC(25) = CONSTS(7)*(EXP((ALGBRC(9)+ALGBRC(2))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(10)/( CONSTS(31)*CONSTS(32)))) RATES(3) = (ALGBRC(20)+ALGBRC(24)+ALGBRC(22)) - ALGBRC(25) ALGBRC(14) = CONSTS(31)*CONSTS(32)*log( CONSTS(26)*STATES(8)) ALGBRC(26) = CONSTS(10)*(EXP((ALGBRC(3)+ALGBRC(14))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(5)/( CONSTS(31)*CONSTS(32)))) RATES(8) = - ALGBRC(26) RATES(9) = (ALGBRC(26) - ALGBRC(21))+ALGBRC(22) ALGBRC(15) = CONSTS(31)*CONSTS(32)*log( CONSTS(27)*STATES(5)) ALGBRC(28) = CONSTS(11)*(EXP((ALGBRC(15)+ALGBRC(3))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(7)/( CONSTS(31)*CONSTS(32)))) RATES(5) = - ALGBRC(28) RATES(6) = (ALGBRC(28)+ALGBRC(24)) - ALGBRC(23) ALGBRC(11) = CONSTS(31)*CONSTS(32)*log( CONSTS(23)*STATES(15)) ALGBRC(27) = CONSTS(8)*(EXP(ALGBRC(10)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(9)+ALGBRC(11))/( CONSTS(31)*CONSTS(32)))) RATES(13) = ALGBRC(25) - ALGBRC(27) RATES(15) = ALGBRC(27) ALGBRC(16) = CONSTS(31)*CONSTS(32)*log( CONSTS(28)*STATES(16)) ALGBRC(17) = CONSTS(31)*CONSTS(32)*log( CONSTS(29)*STATES(17)) ALGBRC(30) = CONSTS(12)*(EXP((ALGBRC(3)+ALGBRC(16))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(17)/( CONSTS(31)*CONSTS(32)))) RATES(2) = (((ALGBRC(20) - ALGBRC(19)) - ALGBRC(26)) - ALGBRC(28)) - ALGBRC(30) ALGBRC(12) = CONSTS(31)*CONSTS(32)*log( CONSTS(24)*STATES(14)) ALGBRC(13) = CONSTS(31)*CONSTS(32)*log( CONSTS(25)*STATES(12)) ALGBRC(29) = CONSTS(9)*(EXP((ALGBRC(9)+ALGBRC(12))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(13)/( CONSTS(31)*CONSTS(32)))) RATES(11) = (ALGBRC(27) - ALGBRC(25)) - ALGBRC(29) RATES(14) = - ALGBRC(29) RATES(12) = ALGBRC(29) RATES(16) = - ALGBRC(30) RATES(17) = ALGBRC(30) RATES(18) = ALGBRC(30) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(31)*CONSTS(32)*log( CONSTS(13)*STATES(1)) ALGBRC(3) = CONSTS(31)*CONSTS(32)*log( CONSTS(15)*STATES(2)) ALGBRC(4) = CONSTS(31)*CONSTS(32)*log( CONSTS(16)*STATES(4)) ALGBRC(19) = CONSTS(1)*(EXP((ALGBRC(3)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(4)/( CONSTS(31)*CONSTS(32)))) ALGBRC(2) = CONSTS(31)*CONSTS(32)*log( CONSTS(14)*STATES(3)) ALGBRC(18) = CONSTS(31)*CONSTS(32)*log( CONSTS(30)*STATES(18)) ALGBRC(20) = CONSTS(2)*(EXP(ALGBRC(4)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(3)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) ALGBRC(5) = CONSTS(31)*CONSTS(32)*log( CONSTS(17)*STATES(9)) ALGBRC(6) = CONSTS(31)*CONSTS(32)*log( CONSTS(18)*STATES(10)) ALGBRC(21) = CONSTS(3)*(EXP((ALGBRC(5)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(6)/( CONSTS(31)*CONSTS(32)))) ALGBRC(22) = CONSTS(4)*(EXP(ALGBRC(6)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(5)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) ALGBRC(7) = CONSTS(31)*CONSTS(32)*log( CONSTS(19)*STATES(6)) ALGBRC(8) = CONSTS(31)*CONSTS(32)*log( CONSTS(20)*STATES(7)) ALGBRC(23) = CONSTS(5)*(EXP((ALGBRC(7)+ALGBRC(1))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(8)/( CONSTS(31)*CONSTS(32)))) ALGBRC(24) = CONSTS(6)*(EXP(ALGBRC(8)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(7)+ALGBRC(2)+ALGBRC(18))/( CONSTS(31)*CONSTS(32)))) ALGBRC(9) = CONSTS(31)*CONSTS(32)*log( CONSTS(21)*STATES(11)) ALGBRC(10) = CONSTS(31)*CONSTS(32)*log( CONSTS(22)*STATES(13)) ALGBRC(25) = CONSTS(7)*(EXP((ALGBRC(9)+ALGBRC(2))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(10)/( CONSTS(31)*CONSTS(32)))) ALGBRC(14) = CONSTS(31)*CONSTS(32)*log( CONSTS(26)*STATES(8)) ALGBRC(26) = CONSTS(10)*(EXP((ALGBRC(3)+ALGBRC(14))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(5)/( CONSTS(31)*CONSTS(32)))) ALGBRC(15) = CONSTS(31)*CONSTS(32)*log( CONSTS(27)*STATES(5)) ALGBRC(28) = CONSTS(11)*(EXP((ALGBRC(15)+ALGBRC(3))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(7)/( CONSTS(31)*CONSTS(32)))) ALGBRC(11) = CONSTS(31)*CONSTS(32)*log( CONSTS(23)*STATES(15)) ALGBRC(27) = CONSTS(8)*(EXP(ALGBRC(10)/( CONSTS(31)*CONSTS(32))) - EXP((ALGBRC(9)+ALGBRC(11))/( CONSTS(31)*CONSTS(32)))) ALGBRC(16) = CONSTS(31)*CONSTS(32)*log( CONSTS(28)*STATES(16)) ALGBRC(17) = CONSTS(31)*CONSTS(32)*log( CONSTS(29)*STATES(17)) ALGBRC(30) = CONSTS(12)*(EXP((ALGBRC(3)+ALGBRC(16))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(17)/( CONSTS(31)*CONSTS(32)))) ALGBRC(12) = CONSTS(31)*CONSTS(32)*log( CONSTS(24)*STATES(14)) ALGBRC(13) = CONSTS(31)*CONSTS(32)*log( CONSTS(25)*STATES(12)) ALGBRC(29) = CONSTS(9)*(EXP((ALGBRC(9)+ALGBRC(12))/( CONSTS(31)*CONSTS(32))) - EXP(ALGBRC(13)/( CONSTS(31)*CONSTS(32)))) RETURN END