Generated Code
The following is c_ida code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 37 entries in the algebraic variable array.
There are a total of 19 entries in each of the rate and state variable arrays.
There are a total of 39 entries in the constant variable array.
*/
/*
* VOI is time in component environment (second).
* STATES[0] is q_RM2_inactive in component environment (fmol).
* STATES[1] is q_L_RM2_inactive in component environment (fmol).
* ALGEBRAIC[4] is q_LM2 in component environment (fmol).
* ALGEBRAIC[0] is q_LM2_stim in component environment (fmol).
* STATES[2] is q_LM2_ode in component environment (fmol).
* STATES[3] is q_RM2 in component environment (fmol).
* STATES[4] is q_Gi in component environment (fmol).
* STATES[5] is q_RM2_Gi in component environment (fmol).
* STATES[6] is q_L_RM2 in component environment (fmol).
* STATES[7] is q_L_RM2_Gi in component environment (fmol).
* STATES[8] is q_Gia_GTP in component environment (fmol).
* STATES[9] is q_Gibetagamma in component environment (fmol).
* STATES[10] is q_Gia_GDP in component environment (fmol).
* STATES[11] is q_GTP in component environment (fmol).
* STATES[12] is q_GDP in component environment (fmol).
* STATES[13] is q_Pi in component environment (fmol).
* STATES[14] is q_RM2_tag in component environment (fmol).
* STATES[15] is q_L_RM2_tag in component environment (fmol).
* STATES[16] is q_RM2_GRKArr in component environment (fmol).
* STATES[17] is q_L_RM2_GRKArr in component environment (fmol).
* STATES[18] is q_GRKArr in component environment (fmol).
* CONSTANTS[0] is stimSt in component environment (second).
* CONSTANTS[1] is stimDur in component environment (second).
* CONSTANTS[2] is tR in component environment (second).
* CONSTANTS[3] is stimMag in component environment (fmol).
* CONSTANTS[4] is stimHolding in component environment (fmol).
* CONSTANTS[38] is m in component environment (fmol_per_sec).
* ALGEBRAIC[1] is conserv_R_T in component environment (fmol).
* ALGEBRAIC[35] is conserv_L_T in component environment (fmol).
* ALGEBRAIC[3] is conserv_G_T in component environment (fmol).
* ALGEBRAIC[2] is total_R in component environment (fmol).
* ALGEBRAIC[24] is v_Rswitch_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[25] is v_LRswitch_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[26] is v_C_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[27] is v_R_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[28] is v_L_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[29] is v_Act1_Gi in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[30] is v_Act2_Gi in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[31] is v_Hyd_Gi in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[32] is v_Reassoc_Gi in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[33] is v_InternR_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[34] is v_InternLR_M2 in component GPCR_M2_reduced (fmol_per_sec).
* ALGEBRAIC[36] is v_Rsynthesis in component environment (fmol_per_sec).
* CONSTANTS[5] is kappa_Rswitch_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[6] is kappa_LRswitch_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[7] is kappa_C_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[8] is kappa_R_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[9] is kappa_L_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[10] is kappa_Act1_Gi in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[11] is kappa_Act2_Gi in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[12] is kappa_Hyd_Gi in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[13] is kappa_Reassoc_Gi in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[14] is kappa_InternR_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[15] is kappa_InternLR_M2 in component GPCR_M2_reduced_parameters (fmol_per_sec).
* CONSTANTS[16] is K_RM2_inactive in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[17] is K_L_RM2_inactive in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[18] is K_LM2 in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[19] is K_RM2 in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[20] is K_Gi in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[21] is K_RM2_Gi in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[22] is K_L_RM2 in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[23] is K_L_RM2_Gi in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[24] is K_Gia_GTP in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[25] is K_Gibetagamma in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[26] is K_Gia_GDP in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[27] is K_GTP in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[28] is K_GDP in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[29] is K_Pi in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[30] is K_RM2_tag in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[31] is K_L_RM2_tag in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[32] is K_RM2_GRKArr in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[33] is K_L_RM2_GRKArr in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[34] is K_GRKArr in component GPCR_M2_reduced_parameters (per_fmol).
* CONSTANTS[35] is R in component constants (J_per_K_per_mol).
* CONSTANTS[36] is T in component constants (kelvin).
* ALGEBRAIC[5] is mu_RM2_inactive in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[6] is mu_L_RM2_inactive in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[7] is mu_LM2 in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[8] is mu_RM2 in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[9] is mu_Gi in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[10] is mu_RM2_Gi in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[11] is mu_L_RM2 in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[12] is mu_L_RM2_Gi in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[13] is mu_Gia_GTP in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[14] is mu_Gibetagamma in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[15] is mu_Gia_GDP in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[16] is mu_GTP in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[17] is mu_GDP in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[18] is mu_Pi in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[19] is mu_RM2_tag in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[20] is mu_L_RM2_tag in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[21] is mu_RM2_GRKArr in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[22] is mu_L_RM2_GRKArr in component GPCR_M2_reduced (J_per_mol).
* ALGEBRAIC[23] is mu_GRKArr in component GPCR_M2_reduced (J_per_mol).
* CONSTANTS[37] is F in component constants (C_per_mol).
* RATES[0] is d/dt q_RM2_inactive in component environment (fmol).
* RATES[1] is d/dt q_L_RM2_inactive in component environment (fmol).
* RATES[2] is d/dt q_LM2_ode in component environment (fmol).
* RATES[3] is d/dt q_RM2 in component environment (fmol).
* RATES[4] is d/dt q_Gi in component environment (fmol).
* RATES[5] is d/dt q_RM2_Gi in component environment (fmol).
* RATES[6] is d/dt q_L_RM2 in component environment (fmol).
* RATES[7] is d/dt q_L_RM2_Gi in component environment (fmol).
* RATES[8] is d/dt q_Gia_GTP in component environment (fmol).
* RATES[9] is d/dt q_Gibetagamma in component environment (fmol).
* RATES[10] is d/dt q_Gia_GDP in component environment (fmol).
* RATES[11] is d/dt q_GTP in component environment (fmol).
* RATES[12] is d/dt q_GDP in component environment (fmol).
* RATES[13] is d/dt q_Pi in component environment (fmol).
* RATES[14] is d/dt q_RM2_tag in component environment (fmol).
* RATES[15] is d/dt q_L_RM2_tag in component environment (fmol).
* RATES[16] is d/dt q_RM2_GRKArr in component environment (fmol).
* RATES[17] is d/dt q_L_RM2_GRKArr in component environment (fmol).
* RATES[18] is d/dt q_GRKArr in component environment (fmol).
* There are a total of 6 condition variables.
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = 0.00072162;
STATES[1] = 1e-18;
STATES[2] = 0;
STATES[3] = 1e-2;
STATES[4] = 0.00836;
STATES[5] = 1e-18;
STATES[6] = 1e-18;
STATES[7] = 1e-18;
STATES[8] = 1e-18;
STATES[9] = 1e-18;
STATES[10] = 1e-18;
STATES[11] = 2.2;
STATES[12] = 1.1;
STATES[13] = 570;
STATES[14] = 1e-18;
STATES[15] = 1e-18;
STATES[16] = 1e-18;
STATES[17] = 1e-18;
STATES[18] = 1e-18;
CONSTANTS[0] = 2e1;
CONSTANTS[1] = 2e1;
CONSTANTS[2] = 1e1;
CONSTANTS[3] = 1e2;
CONSTANTS[4] = 1e-8;
CONSTANTS[5] = 3.25763;
CONSTANTS[6] = 0.00165864;
CONSTANTS[7] = 14461.5;
CONSTANTS[8] = 736.312;
CONSTANTS[9] = 5769.58;
CONSTANTS[10] = 0.0114404;
CONSTANTS[11] = 0.381268;
CONSTANTS[12] = 0.585749;
CONSTANTS[13] = 0.0140382;
CONSTANTS[14] = 0.0665538;
CONSTANTS[15] = 2.218;
CONSTANTS[16] = 0.892359;
CONSTANTS[17] = 1752.63;
CONSTANTS[18] = 0.0519039;
CONSTANTS[19] = 0.00892359;
CONSTANTS[20] = 0.0207076;
CONSTANTS[21] = 0.1907;
CONSTANTS[22] = 0.175263;
CONSTANTS[23] = 0.286109;
CONSTANTS[24] = 0.0397027;
CONSTANTS[25] = 0.412109;
CONSTANTS[26] = 0.176744;
CONSTANTS[27] = 0.019367;
CONSTANTS[28] = 0.000190324;
CONSTANTS[29] = 8.16257e-05;
CONSTANTS[30] = 0.200446;
CONSTANTS[31] = 0.00601463;
CONSTANTS[32] = 0.00436786;
CONSTANTS[33] = 0.000131063;
CONSTANTS[34] = 6.3345;
CONSTANTS[35] = 8.31;
CONSTANTS[36] = 310;
CONSTANTS[37] = 96485;
CONSTANTS[38] = CONSTANTS[3]/CONSTANTS[2];
RATES[0] = 0.1001;
RATES[1] = 0.1001;
RATES[2] = 0.1001;
RATES[3] = 0.1001;
RATES[4] = 0.1001;
RATES[5] = 0.1001;
RATES[6] = 0.1001;
RATES[7] = 0.1001;
RATES[8] = 0.1001;
RATES[9] = 0.1001;
RATES[10] = 0.1001;
RATES[11] = 0.1001;
RATES[12] = 0.1001;
RATES[13] = 0.1001;
RATES[14] = 0.1001;
RATES[15] = 0.1001;
RATES[16] = 0.1001;
RATES[17] = 0.1001;
RATES[18] = 0.1001;
}
void
computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
resid[0] = RATES[0] - - ALGEBRAIC[24] - ALGEBRAIC[28];
resid[1] = RATES[1] - - ALGEBRAIC[25];
resid[2] = RATES[2] - - ALGEBRAIC[28];
resid[3] = RATES[3] - (- ALGEBRAIC[26] - ALGEBRAIC[28])+ 1.00000*ALGEBRAIC[36]+ALGEBRAIC[24];
resid[4] = RATES[4] - (- ALGEBRAIC[26] - ALGEBRAIC[27])+ALGEBRAIC[32];
resid[5] = RATES[5] - ALGEBRAIC[26] - ALGEBRAIC[29];
resid[6] = RATES[6] - - ALGEBRAIC[27]+ALGEBRAIC[28]+ALGEBRAIC[25];
resid[7] = RATES[7] - ALGEBRAIC[27] - ALGEBRAIC[30];
resid[8] = RATES[8] - (ALGEBRAIC[29]+ALGEBRAIC[30]) - ALGEBRAIC[31];
resid[9] = RATES[9] - (ALGEBRAIC[29]+ALGEBRAIC[30]) - ALGEBRAIC[32];
resid[10] = RATES[10] - ALGEBRAIC[31] - ALGEBRAIC[32];
resid[11] = RATES[11] - - ALGEBRAIC[29] - ALGEBRAIC[30];
resid[12] = RATES[12] - ALGEBRAIC[29]+ALGEBRAIC[30];
resid[13] = RATES[13] - ALGEBRAIC[31];
resid[14] = RATES[14] - ALGEBRAIC[29] - ALGEBRAIC[33];
resid[15] = RATES[15] - ALGEBRAIC[30] - ALGEBRAIC[34];
resid[16] = RATES[16] - ALGEBRAIC[33];
resid[17] = RATES[17] - ALGEBRAIC[34];
resid[18] = RATES[18] - - ALGEBRAIC[33] - ALGEBRAIC[34];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[1] = STATES[3]+STATES[5]+STATES[6]+STATES[7]+STATES[14]+STATES[15]+STATES[16]+STATES[17]+STATES[0]+STATES[1];
ALGEBRAIC[2] = STATES[3]+STATES[5]+STATES[6]+STATES[7]+STATES[0]+STATES[1];
ALGEBRAIC[3] = STATES[4]+STATES[5]+STATES[7]+STATES[8]+STATES[10];
ALGEBRAIC[35] = ALGEBRAIC[4]+STATES[6]+STATES[7]+STATES[15]+STATES[17]+STATES[1];
}
void
computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[5] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[16]*STATES[0]);
ALGEBRAIC[8] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[19]*STATES[3]);
ALGEBRAIC[24] = CONSTANTS[5]*(exp(ALGEBRAIC[5]/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[8]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[6] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[17]*STATES[1]);
ALGEBRAIC[11] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[22]*STATES[6]);
ALGEBRAIC[25] = CONSTANTS[6]*(exp(ALGEBRAIC[6]/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[11]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[9] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[20]*STATES[4]);
ALGEBRAIC[10] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[21]*STATES[5]);
ALGEBRAIC[26] = CONSTANTS[7]*(exp((ALGEBRAIC[8]+ALGEBRAIC[9])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[10]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[12] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[23]*STATES[7]);
ALGEBRAIC[27] = CONSTANTS[8]*(exp((ALGEBRAIC[11]+ALGEBRAIC[9])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[12]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[0] = (CONDVAR[0]<0.00000&&CONDVAR[1]>0.00000 ? CONSTANTS[4]+ CONSTANTS[38]*((VOI - CONSTANTS[0])+CONSTANTS[2]) : CONDVAR[2]>=0.00000&&CONDVAR[3]<0.00000 ? CONSTANTS[3]+CONSTANTS[4] : CONDVAR[4]<0.00000&&CONDVAR[5]>=0.00000 ? CONSTANTS[4]+ - CONSTANTS[38]*(((VOI - CONSTANTS[0]) - CONSTANTS[2]) - CONSTANTS[1]) : CONSTANTS[4]);
ALGEBRAIC[4] = ALGEBRAIC[0]+STATES[2];
ALGEBRAIC[7] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[18]*ALGEBRAIC[4]);
ALGEBRAIC[28] = CONSTANTS[9]*(exp((ALGEBRAIC[8]+ALGEBRAIC[7])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[11]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[13] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[24]*STATES[8]);
ALGEBRAIC[14] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[25]*STATES[9]);
ALGEBRAIC[16] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[27]*STATES[11]);
ALGEBRAIC[17] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[28]*STATES[12]);
ALGEBRAIC[19] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[30]*STATES[14]);
ALGEBRAIC[29] = CONSTANTS[10]*(exp((ALGEBRAIC[10]+ALGEBRAIC[16])/( CONSTANTS[35]*CONSTANTS[36])) - exp((ALGEBRAIC[13]+ALGEBRAIC[14]+ALGEBRAIC[19]+ALGEBRAIC[17])/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[20] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[31]*STATES[15]);
ALGEBRAIC[30] = CONSTANTS[11]*(exp((ALGEBRAIC[12]+ALGEBRAIC[16])/( CONSTANTS[35]*CONSTANTS[36])) - exp((ALGEBRAIC[13]+ALGEBRAIC[14]+ALGEBRAIC[20]+ALGEBRAIC[17])/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[15] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[26]*STATES[10]);
ALGEBRAIC[18] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[29]*STATES[13]);
ALGEBRAIC[31] = CONSTANTS[12]*(exp(ALGEBRAIC[13]/( CONSTANTS[35]*CONSTANTS[36])) - exp((ALGEBRAIC[15]+ALGEBRAIC[18])/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[32] = CONSTANTS[13]*(exp((ALGEBRAIC[15]+ALGEBRAIC[14])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[9]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[21] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[32]*STATES[16]);
ALGEBRAIC[23] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[34]*STATES[18]);
ALGEBRAIC[33] = CONSTANTS[14]*(exp((ALGEBRAIC[19]+ALGEBRAIC[23])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[21]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[22] = CONSTANTS[35]*CONSTANTS[36]*log( CONSTANTS[33]*STATES[17]);
ALGEBRAIC[34] = CONSTANTS[15]*(exp((ALGEBRAIC[20]+ALGEBRAIC[23])/( CONSTANTS[35]*CONSTANTS[36])) - exp(ALGEBRAIC[22]/( CONSTANTS[35]*CONSTANTS[36])));
ALGEBRAIC[36] = (ALGEBRAIC[26])+ALGEBRAIC[28];
}
void
getStateInformation(double* SI)
{
SI[0] = 1.0;
SI[1] = 1.0;
SI[2] = 1.0;
SI[3] = 1.0;
SI[4] = 1.0;
SI[5] = 1.0;
SI[6] = 1.0;
SI[7] = 1.0;
SI[8] = 1.0;
SI[9] = 1.0;
SI[10] = 1.0;
SI[11] = 1.0;
SI[12] = 1.0;
SI[13] = 1.0;
SI[14] = 1.0;
SI[15] = 1.0;
SI[16] = 1.0;
SI[17] = 1.0;
SI[18] = 1.0;
}
void
computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES,
double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS)
{
CONDVAR[0] = VOI - CONSTANTS[0];
CONDVAR[1] = VOI - (CONSTANTS[0] - CONSTANTS[2]);
CONDVAR[2] = VOI - CONSTANTS[0];
CONDVAR[3] = VOI - (CONSTANTS[0]+CONSTANTS[1]);
CONDVAR[4] = VOI - (CONSTANTS[0]+CONSTANTS[2]+CONSTANTS[1]);
CONDVAR[5] = VOI - (CONSTANTS[0]+CONSTANTS[1]);
}