C C There are a total of 17 entries in the algebraic variable array. C There are a total of 11 entries in each of the rate and state variable arrays. C There are a total of 20 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is q_L in component environment (fmol). C STATES(2) is q_K1 in component environment (fmol). C STATES(3) is q_K2 in component environment (fmol). C STATES(4) is q_LK1 in component environment (fmol). C STATES(5) is q_P in component environment (fmol). C STATES(6) is q_LK1K2 in component environment (fmol). C STATES(7) is q_LK1K2P in component environment (fmol). C STATES(8) is q_Ubiq in component environment (fmol). C STATES(9) is q_LKKPU in component environment (fmol). C STATES(10) is q_LKKPUtag in component environment (fmol). C STATES(11) is q_LPUtag in component environment (fmol). C ALGBRC(12) is v_Re1 in component RTK (fmol_per_sec). C ALGBRC(13) is v_Re2 in component RTK (fmol_per_sec). C ALGBRC(14) is v_Re3 in component RTK (fmol_per_sec). C ALGBRC(15) is v_Re4 in component RTK (fmol_per_sec). C ALGBRC(16) is v_Re5 in component RTK (fmol_per_sec). C ALGBRC(17) is v_Re6 in component RTK (fmol_per_sec). C CONSTS(1) is kappa_Re1 in component RTK_parameters (fmol_per_sec). C CONSTS(2) is kappa_Re2 in component RTK_parameters (fmol_per_sec). C CONSTS(3) is kappa_Re3 in component RTK_parameters (fmol_per_sec). C CONSTS(4) is kappa_Re4 in component RTK_parameters (fmol_per_sec). C CONSTS(5) is kappa_Re5 in component RTK_parameters (fmol_per_sec). C CONSTS(6) is kappa_Re6 in component RTK_parameters (fmol_per_sec). C CONSTS(7) is K_L in component RTK_parameters (per_fmol). C CONSTS(8) is K_K1 in component RTK_parameters (per_fmol). C CONSTS(9) is K_K2 in component RTK_parameters (per_fmol). C CONSTS(10) is K_LK1 in component RTK_parameters (per_fmol). C CONSTS(11) is K_P in component RTK_parameters (per_fmol). C CONSTS(12) is K_LK1K2 in component RTK_parameters (per_fmol). C CONSTS(13) is K_LK1K2P in component RTK_parameters (per_fmol). C CONSTS(14) is K_Ubiq in component RTK_parameters (per_fmol). C CONSTS(15) is K_LKKPU in component RTK_parameters (per_fmol). C CONSTS(16) is K_LKKPUtag in component RTK_parameters (per_fmol). C CONSTS(17) is K_LPUtag in component RTK_parameters (per_fmol). C CONSTS(18) is R in component constants (J_per_K_per_mol). C CONSTS(19) is T in component constants (kelvin). C ALGBRC(1) is mu_L in component RTK (J_per_mol). C ALGBRC(2) is mu_K1 in component RTK (J_per_mol). C ALGBRC(3) is mu_K2 in component RTK (J_per_mol). C ALGBRC(4) is mu_LK1 in component RTK (J_per_mol). C ALGBRC(5) is mu_P in component RTK (J_per_mol). C ALGBRC(6) is mu_LK1K2 in component RTK (J_per_mol). C ALGBRC(7) is mu_LK1K2P in component RTK (J_per_mol). C ALGBRC(8) is mu_Ubiq in component RTK (J_per_mol). C ALGBRC(9) is mu_LKKPU in component RTK (J_per_mol). C ALGBRC(10) is mu_LKKPUtag in component RTK (J_per_mol). C ALGBRC(11) is mu_LPUtag in component RTK (J_per_mol). C CONSTS(20) is F in component constants (C_per_mol). C RATES(1) is d/dt q_L in component environment (fmol). C RATES(2) is d/dt q_K1 in component environment (fmol). C RATES(3) is d/dt q_K2 in component environment (fmol). C RATES(4) is d/dt q_LK1 in component environment (fmol). C RATES(5) is d/dt q_P in component environment (fmol). C RATES(6) is d/dt q_LK1K2 in component environment (fmol). C RATES(7) is d/dt q_LK1K2P in component environment (fmol). C RATES(8) is d/dt q_Ubiq in component environment (fmol). C RATES(9) is d/dt q_LKKPU in component environment (fmol). C RATES(10) is d/dt q_LKKPUtag in component environment (fmol). C RATES(11) is d/dt q_LPUtag in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 1 STATES(2) = 1e-3 STATES(3) = 1e-3 STATES(4) = 1e-6 STATES(5) = 1 STATES(6) = 1e-9 STATES(7) = 1e-9 STATES(8) = 1 STATES(9) = 1e-88 STATES(10) = 1e-88 STATES(11) = 1e-88 CONSTS(1) = 1.31758e-07 CONSTS(2) = 0.0862846 CONSTS(3) = 0.00038952 CONSTS(4) = 2.66799e-09 CONSTS(5) = 26.6799 CONSTS(6) = 2667.99 CONSTS(7) = 8.32274e+08 CONSTS(8) = 0.000770619 CONSTS(9) = 44390 CONSTS(10) = 0.22063 CONSTS(11) = 6.4394e+12 CONSTS(12) = 3.36906e-07 CONSTS(13) = 7.46298e-05 CONSTS(14) = 4.24411e+13 CONSTS(15) = 10.8958 CONSTS(16) = 1.08958e-11 CONSTS(17) = 2.69163e-14 CONSTS(18) = 8.31 CONSTS(19) = 310 CONSTS(20) = 96485 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(18)*CONSTS(19)*log( CONSTS(7)*STATES(1)) ALGBRC(2) = CONSTS(18)*CONSTS(19)*log( CONSTS(8)*STATES(2)) ALGBRC(4) = CONSTS(18)*CONSTS(19)*log( CONSTS(10)*STATES(4)) ALGBRC(12) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(4)/( CONSTS(18)*CONSTS(19)))) RATES(1) = - ALGBRC(12) ALGBRC(3) = CONSTS(18)*CONSTS(19)*log( CONSTS(9)*STATES(3)) ALGBRC(6) = CONSTS(18)*CONSTS(19)*log( CONSTS(12)*STATES(6)) ALGBRC(13) = CONSTS(2)*(EXP((ALGBRC(4)+ALGBRC(3))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(6)/( CONSTS(18)*CONSTS(19)))) RATES(4) = ALGBRC(12) - ALGBRC(13) ALGBRC(5) = CONSTS(18)*CONSTS(19)*log( CONSTS(11)*STATES(5)) ALGBRC(7) = CONSTS(18)*CONSTS(19)*log( CONSTS(13)*STATES(7)) ALGBRC(14) = CONSTS(3)*(EXP((ALGBRC(5)+ALGBRC(6))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(7)/( CONSTS(18)*CONSTS(19)))) RATES(5) = - ALGBRC(14) RATES(6) = ALGBRC(13) - ALGBRC(14) ALGBRC(8) = CONSTS(18)*CONSTS(19)*log( CONSTS(14)*STATES(8)) ALGBRC(9) = CONSTS(18)*CONSTS(19)*log( CONSTS(15)*STATES(9)) ALGBRC(15) = CONSTS(4)*(EXP((ALGBRC(8)+ALGBRC(7))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19)))) RATES(7) = ALGBRC(14) - ALGBRC(15) RATES(8) = - ALGBRC(15) ALGBRC(11) = CONSTS(18)*CONSTS(19)*log( CONSTS(17)*STATES(11)) ALGBRC(16) = CONSTS(5)*(EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19))) - EXP((ALGBRC(2)+ALGBRC(3)+ALGBRC(11))/( CONSTS(18)*CONSTS(19)))) RATES(2) = - ALGBRC(12)+ALGBRC(16) RATES(3) = - ALGBRC(13)+ALGBRC(16) RATES(11) = ALGBRC(16) ALGBRC(10) = CONSTS(18)*CONSTS(19)*log( CONSTS(16)*STATES(10)) ALGBRC(17) = CONSTS(6)*(EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(10)/( CONSTS(18)*CONSTS(19)))) RATES(9) = (ALGBRC(15) - ALGBRC(16)) - ALGBRC(17) RATES(10) = ALGBRC(17) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(18)*CONSTS(19)*log( CONSTS(7)*STATES(1)) ALGBRC(2) = CONSTS(18)*CONSTS(19)*log( CONSTS(8)*STATES(2)) ALGBRC(4) = CONSTS(18)*CONSTS(19)*log( CONSTS(10)*STATES(4)) ALGBRC(12) = CONSTS(1)*(EXP((ALGBRC(1)+ALGBRC(2))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(4)/( CONSTS(18)*CONSTS(19)))) ALGBRC(3) = CONSTS(18)*CONSTS(19)*log( CONSTS(9)*STATES(3)) ALGBRC(6) = CONSTS(18)*CONSTS(19)*log( CONSTS(12)*STATES(6)) ALGBRC(13) = CONSTS(2)*(EXP((ALGBRC(4)+ALGBRC(3))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(6)/( CONSTS(18)*CONSTS(19)))) ALGBRC(5) = CONSTS(18)*CONSTS(19)*log( CONSTS(11)*STATES(5)) ALGBRC(7) = CONSTS(18)*CONSTS(19)*log( CONSTS(13)*STATES(7)) ALGBRC(14) = CONSTS(3)*(EXP((ALGBRC(5)+ALGBRC(6))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(7)/( CONSTS(18)*CONSTS(19)))) ALGBRC(8) = CONSTS(18)*CONSTS(19)*log( CONSTS(14)*STATES(8)) ALGBRC(9) = CONSTS(18)*CONSTS(19)*log( CONSTS(15)*STATES(9)) ALGBRC(15) = CONSTS(4)*(EXP((ALGBRC(8)+ALGBRC(7))/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19)))) ALGBRC(11) = CONSTS(18)*CONSTS(19)*log( CONSTS(17)*STATES(11)) ALGBRC(16) = CONSTS(5)*(EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19))) - EXP((ALGBRC(2)+ALGBRC(3)+ALGBRC(11))/( CONSTS(18)*CONSTS(19)))) ALGBRC(10) = CONSTS(18)*CONSTS(19)*log( CONSTS(16)*STATES(10)) ALGBRC(17) = CONSTS(6)*(EXP(ALGBRC(9)/( CONSTS(18)*CONSTS(19))) - EXP(ALGBRC(10)/( CONSTS(18)*CONSTS(19)))) RETURN END