C C There are a total of 32 entries in the algebraic variable array. C There are a total of 9 entries in each of the rate and state variable arrays. C There are a total of 42 entries in the constant variable array. C C C VOI is t in component main (second). C CONSTS(1) is pulse_time in component main (second). C CONSTS(2) is RT in component main (J_per_mol). C CONSTS(3) is F in component main (C_per_mol). C CONSTS(4) is q_w_gut in component main (litre). C CONSTS(5) is q_w_epi in component main (litre). C CONSTS(6) is q_w_cap in component main (litre). C CONSTS(37) is q_w_tot in component main (litre). C STATES(1) is q_Na_gut in component main (mole). C STATES(2) is q_Na_epi in component main (mole). C ALGBRC(1) is q_Na_cap in component main (mole). C CONSTS(7) is q_Na_cap_init in component main (mole). C CONSTS(8) is q_Na_cap_scale in component main (dimensionless). C ALGBRC(3) is c_Na_gut in component main (mM). C ALGBRC(5) is c_Na_epi in component main (mM). C ALGBRC(6) is c_Na_cap in component main (mM). C CONSTS(9) is K_mm in component main (millimols_per_mol). C ALGBRC(4) is q_Na_tot in component main (mole). C STATES(3) is q_K_epi in component main (mole). C CONSTS(10) is q_K_cap in component main (mole). C ALGBRC(8) is c_K_epi in component main (mM). C CONSTS(38) is c_K_cap in component main (mM). C STATES(4) is q_Cl_epi in component main (mole). C CONSTS(11) is q_Cl_cap in component main (mole). C ALGBRC(11) is c_Cl_epi in component main (mM). C CONSTS(39) is c_Cl_cap in component main (mM). C STATES(5) is q_e in component main (coulomb). C CONSTS(12) is u_ee in component main (J_per_C). C ALGBRC(14) is u_e in component main (J_per_C). C CONSTS(13) is C_m in component main (C2_per_J). C ALGBRC(15) is q_Glc_gut in component main (mole). C STATES(6) is q_Glc_epi in component main (mole). C CONSTS(14) is q_Glc_cap in component main (mole). C CONSTS(15) is q_Glc_gut_init in component main (mole). C CONSTS(16) is q_Glc_gut_scale in component main (dimensionless). C ALGBRC(16) is c_Glc_gut in component main (mM). C ALGBRC(17) is c_Glc_epi in component main (mM). C CONSTS(40) is c_Glc_cap in component main (mM). C CONSTS(17) is u_w_gut in component main (kPa). C CONSTS(41) is u_w_epi in component main (kPa). C CONSTS(18) is u_w_cap in component main (kPa). C CONSTS(19) is E_w_epi in component main (joule). C CONSTS(20) is U_w_epi in component main (litre). C CONSTS(21) is L_w_epi in component main (litre). C ALGBRC(7) is v_w_epiApex in component main (L_per_s). C ALGBRC(9) is v_w_epiBase in component main (L_per_s). C CONSTS(22) is k_w_m in component main (L_per_s_per_kPa). C CONSTS(23) is c_O2 in component main (mM). C CONSTS(24) is c_CO2 in component main (mM). C CONSTS(25) is c_HCO3 in component main (mM). C STATES(7) is q_ATP in component main (mole). C STATES(8) is q_ADP in component main (mole). C STATES(9) is q_Pi in component main (mole). C CONSTS(26) is q_H in component main (mole). C ALGBRC(2) is q_adenosine in component main (mole). C ALGBRC(18) is c_ATP in component main (mM). C ALGBRC(21) is c_ADP in component main (mM). C ALGBRC(22) is c_Pi in component main (mM). C CONSTS(42) is c_H in component main (mM). C CONSTS(27) is kappa_SGLT1 in component main (mol_per_s). C ALGBRC(23) is v_SGLT1 in component main (mol_per_s). C CONSTS(28) is kappa_GLUT2 in component main (mol_per_s). C ALGBRC(25) is v_GLUT2 in component main (mol_per_s). C CONSTS(29) is k_ATP_eq in component main (mM2). C CONSTS(30) is kappa_NKE in component main (mol_per_s). C ALGBRC(26) is v_NKE in component main (mol_per_s). C CONSTS(31) is kappa_NKCC1 in component main (mol_per_s). C ALGBRC(27) is v_NKCC1 in component main (mol_per_s). C CONSTS(32) is kappa_KCC1 in component main (mol_per_s). C ALGBRC(29) is v_KCC1 in component main (mol_per_s). C CONSTS(33) is kappa_K in component main (C_per_J_per_s). C ALGBRC(31) is v_K in component main (mol_per_s). C ALGBRC(30) is GHKterm in component main (J_per_C). C CONSTS(34) is kappa_Na in component main (per_s_per_V). C ALGBRC(32) is v_Na in component main (mol_per_s). C CONSTS(35) is k_AM_eq in component main (per_mM). C CONSTS(36) is kappa_AM in component main (mol_per_s). C ALGBRC(28) is v_AM in component main (mol_per_s). C ALGBRC(19) is u_SGLT1_reversal in component main (J_per_C). C ALGBRC(12) is u_K_reversal in component main (J_per_C). C ALGBRC(10) is u_Na_reversal in component main (J_per_C). C ALGBRC(20) is c_Na_gutThreshold in component main (mM). C ALGBRC(24) is c_Na_epiEquilibrium in component main (mM). C ALGBRC(13) is c_Cl_epiEquilibrium in component main (mM). C RATES(1) is d/dt q_Na_gut in component main (mole). C RATES(2) is d/dt q_Na_epi in component main (mole). C RATES(3) is d/dt q_K_epi in component main (mole). C RATES(4) is d/dt q_Cl_epi in component main (mole). C RATES(5) is d/dt q_e in component main (coulomb). C RATES(6) is d/dt q_Glc_epi in component main (mole). C RATES(7) is d/dt q_ATP in component main (mole). C RATES(8) is d/dt q_ADP in component main (mole). C RATES(9) is d/dt q_Pi in component main (mole). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.1 CONSTS(2) = 2.5e3 CONSTS(3) = 0.965e5 CONSTS(4) = 1 CONSTS(5) = 1 CONSTS(6) = 1 STATES(1) = 0.1 STATES(2) = 0.001 CONSTS(7) = 0.140 CONSTS(8) = 1.0 CONSTS(9) = 1.e3 STATES(3) = 0.130 CONSTS(10) = 0.004 STATES(4) = 0.001 CONSTS(11) = 0.100 STATES(5) = 1e-5 CONSTS(12) = -0.08 CONSTS(13) = 5e4 STATES(6) = 0.001 CONSTS(14) = 0.01 CONSTS(15) = 0.01 CONSTS(16) = 1.0 CONSTS(17) = 1 CONSTS(18) = 1 CONSTS(19) = 1 CONSTS(20) = 0.5 CONSTS(21) = 5 CONSTS(22) = 1e-4 CONSTS(23) = 9.25 CONSTS(24) = 1.20 CONSTS(25) = 25.0 STATES(7) = 0.003 STATES(8) = 0.0025 STATES(9) = 0.003 CONSTS(26) = 1e-7 CONSTS(27) = 1e-2 CONSTS(28) = 1e1 CONSTS(29) = 2e4 CONSTS(30) = 1e2 CONSTS(31) = 1e-1 CONSTS(32) = 1e-1 CONSTS(33) = 2e3 CONSTS(34) = 0 CONSTS(35) = 1e0 CONSTS(36) = 1e1 CONSTS(37) = CONSTS(4)+CONSTS(5)+CONSTS(6) CONSTS(38) = ( CONSTS(10)*CONSTS(9))/CONSTS(6) CONSTS(39) = ( CONSTS(11)*CONSTS(9))/CONSTS(6) CONSTS(40) = ( CONSTS(14)*CONSTS(9))/CONSTS(6) CONSTS(41) = ( CONSTS(19)*(CONSTS(5) - CONSTS(20)))/CONSTS(21) - CONSTS(5) ** 2.00000 CONSTS(42) = ( CONSTS(26)*CONSTS(9))/CONSTS(5) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = ( STATES(1)*CONSTS(9))/CONSTS(4) ALGBRC(5) = ( STATES(2)*CONSTS(9))/CONSTS(5) ALGBRC(14) = STATES(5)/CONSTS(13) ALGBRC(15) = TERNRY(VOI.GT.CONSTS(1), CONSTS(15)*CONSTS(16), CONSTS(15)) ALGBRC(16) = ( ALGBRC(15)*CONSTS(9))/CONSTS(4) ALGBRC(17) = ( STATES(6)*CONSTS(9))/CONSTS(5) ALGBRC(23) = ( CONSTS(27)*(( ALGBRC(3)/ALGBRC(5) ** 2.00000*ALGBRC(16))/ALGBRC(17) - EXP(( 2.00000*CONSTS(3)*ALGBRC(14))/CONSTS(2))))/( (1.00000+ALGBRC(3)/20.0000 ** 2.00000)*(1.00000+ALGBRC(5)/100.000 ** 2.00000)) RATES(1) = - 2.00000*ALGBRC(23) ALGBRC(25) = ( CONSTS(28)*(ALGBRC(17)/CONSTS(40) - 1.00000))/(1.00000+ALGBRC(17)/5.00000+CONSTS(40)/10.0000+( ALGBRC(17)*CONSTS(40))/100.000) ALGBRC(18) = ( STATES(7)*CONSTS(9))/CONSTS(5) ALGBRC(21) = ( STATES(8)*CONSTS(9))/CONSTS(5) ALGBRC(28) = CONSTS(36)*(( CONSTS(35)*ALGBRC(17)*ALGBRC(21))/ALGBRC(18) - 1.00000) RATES(6) = (ALGBRC(23) - ALGBRC(25)) - ALGBRC(28) ALGBRC(1) = TERNRY(VOI.GT.CONSTS(1), CONSTS(7)*CONSTS(8), CONSTS(7)) ALGBRC(6) = ( ALGBRC(1)*CONSTS(9))/CONSTS(6) ALGBRC(8) = ( STATES(3)*CONSTS(9))/CONSTS(5) ALGBRC(22) = ( STATES(9)*CONSTS(9))/CONSTS(5) ALGBRC(26) = ( CONSTS(30)*(( ALGBRC(5)/ALGBRC(6) ** 3.00000*ALGBRC(18)*CONSTS(29))/( ALGBRC(21)*ALGBRC(22)*CONSTS(42)) - ALGBRC(8)/CONSTS(38) ** 2.00000*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2))))/( (1.00000+ALGBRC(5)/1.00000 ** 3.00000)*(1.00000+ALGBRC(6)/100.000 ** 3.00000)) RATES(7) = - ALGBRC(26)+ 32.0000*ALGBRC(28) RATES(8) = ALGBRC(26) - 32.0000*ALGBRC(28) RATES(9) = ALGBRC(26) - 32.0000*ALGBRC(28) ALGBRC(11) = ( STATES(4)*CONSTS(9))/CONSTS(5) ALGBRC(27) = ( CONSTS(31)*( (( (ALGBRC(6)/ALGBRC(5))*CONSTS(38))/ALGBRC(8))*CONSTS(39)/ALGBRC(11) ** 2.00000 - 1.00000))/( (1.00000+ALGBRC(6)/70.0000)*(1.00000+ALGBRC(5)/5.00000)*(1.00000+CONSTS(38)/2.00000)*(1.00000+ALGBRC(8)/60.0000)*(1.00000+CONSTS(39)/50.0000 ** 2.00000)*(1.00000+ALGBRC(11)/10.0000 ** 2.00000)) ALGBRC(29) = ( CONSTS(32)*(( (ALGBRC(8)/CONSTS(38))*ALGBRC(11))/CONSTS(39) - 1.00000))/( (1.00000+CONSTS(39)/50.0000)*(1.00000+CONSTS(38)/2.00000)*(1.00000+ALGBRC(11)/10.0000)*(1.00000+ALGBRC(8)/60.0000)) RATES(4) = 2.00000*ALGBRC(27) - ALGBRC(29) ALGBRC(30) = ALGBRC(14)/(EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)) - 1.00000) ALGBRC(31) = CONSTS(33)*( STATES(3)*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)) - CONSTS(10))*ALGBRC(30) RATES(3) = (( 2.00000*ALGBRC(26) - ALGBRC(31))+ALGBRC(27)) - ALGBRC(29) ALGBRC(32) = CONSTS(34)*(ALGBRC(1) - STATES(2)*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)))*ALGBRC(30) RATES(2) = ( 2.00000*ALGBRC(23) - 3.00000*ALGBRC(26))+ALGBRC(27)+ALGBRC(32) RATES(5) = CONSTS(3)*((( 2.00000*ALGBRC(23) - ALGBRC(26)) - ALGBRC(31))+ALGBRC(32)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(3) = ( STATES(1)*CONSTS(9))/CONSTS(4) ALGBRC(5) = ( STATES(2)*CONSTS(9))/CONSTS(5) ALGBRC(14) = STATES(5)/CONSTS(13) ALGBRC(15) = TERNRY(VOI.GT.CONSTS(1), CONSTS(15)*CONSTS(16), CONSTS(15)) ALGBRC(16) = ( ALGBRC(15)*CONSTS(9))/CONSTS(4) ALGBRC(17) = ( STATES(6)*CONSTS(9))/CONSTS(5) ALGBRC(23) = ( CONSTS(27)*(( ALGBRC(3)/ALGBRC(5) ** 2.00000*ALGBRC(16))/ALGBRC(17) - EXP(( 2.00000*CONSTS(3)*ALGBRC(14))/CONSTS(2))))/( (1.00000+ALGBRC(3)/20.0000 ** 2.00000)*(1.00000+ALGBRC(5)/100.000 ** 2.00000)) ALGBRC(25) = ( CONSTS(28)*(ALGBRC(17)/CONSTS(40) - 1.00000))/(1.00000+ALGBRC(17)/5.00000+CONSTS(40)/10.0000+( ALGBRC(17)*CONSTS(40))/100.000) ALGBRC(18) = ( STATES(7)*CONSTS(9))/CONSTS(5) ALGBRC(21) = ( STATES(8)*CONSTS(9))/CONSTS(5) ALGBRC(28) = CONSTS(36)*(( CONSTS(35)*ALGBRC(17)*ALGBRC(21))/ALGBRC(18) - 1.00000) ALGBRC(1) = TERNRY(VOI.GT.CONSTS(1), CONSTS(7)*CONSTS(8), CONSTS(7)) ALGBRC(6) = ( ALGBRC(1)*CONSTS(9))/CONSTS(6) ALGBRC(8) = ( STATES(3)*CONSTS(9))/CONSTS(5) ALGBRC(22) = ( STATES(9)*CONSTS(9))/CONSTS(5) ALGBRC(26) = ( CONSTS(30)*(( ALGBRC(5)/ALGBRC(6) ** 3.00000*ALGBRC(18)*CONSTS(29))/( ALGBRC(21)*ALGBRC(22)*CONSTS(42)) - ALGBRC(8)/CONSTS(38) ** 2.00000*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2))))/( (1.00000+ALGBRC(5)/1.00000 ** 3.00000)*(1.00000+ALGBRC(6)/100.000 ** 3.00000)) ALGBRC(11) = ( STATES(4)*CONSTS(9))/CONSTS(5) ALGBRC(27) = ( CONSTS(31)*( (( (ALGBRC(6)/ALGBRC(5))*CONSTS(38))/ALGBRC(8))*CONSTS(39)/ALGBRC(11) ** 2.00000 - 1.00000))/( (1.00000+ALGBRC(6)/70.0000)*(1.00000+ALGBRC(5)/5.00000)*(1.00000+CONSTS(38)/2.00000)*(1.00000+ALGBRC(8)/60.0000)*(1.00000+CONSTS(39)/50.0000 ** 2.00000)*(1.00000+ALGBRC(11)/10.0000 ** 2.00000)) ALGBRC(29) = ( CONSTS(32)*(( (ALGBRC(8)/CONSTS(38))*ALGBRC(11))/CONSTS(39) - 1.00000))/( (1.00000+CONSTS(39)/50.0000)*(1.00000+CONSTS(38)/2.00000)*(1.00000+ALGBRC(11)/10.0000)*(1.00000+ALGBRC(8)/60.0000)) ALGBRC(30) = ALGBRC(14)/(EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)) - 1.00000) ALGBRC(31) = CONSTS(33)*( STATES(3)*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)) - CONSTS(10))*ALGBRC(30) ALGBRC(32) = CONSTS(34)*(ALGBRC(1) - STATES(2)*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)))*ALGBRC(30) ALGBRC(2) = STATES(7)+STATES(8) ALGBRC(4) = STATES(1)+STATES(2)+ALGBRC(1) ALGBRC(7) = CONSTS(22)*((CONSTS(17) - CONSTS(41)) - (CONSTS(2)/CONSTS(9))*(ALGBRC(3) - ALGBRC(5))) ALGBRC(9) = CONSTS(22)*((CONSTS(41) - CONSTS(18)) - (CONSTS(2)/CONSTS(9))*(ALGBRC(5) - ALGBRC(6))) ALGBRC(10) = (CONSTS(2)/CONSTS(3))*log(ALGBRC(6)/ALGBRC(5)) ALGBRC(12) = (CONSTS(2)/CONSTS(3))*log(CONSTS(38)/ALGBRC(8)) ALGBRC(13) = CONSTS(39)* (( (ALGBRC(6)/ALGBRC(5))*CONSTS(38))/ALGBRC(8)) ** (1.0 / 2) ALGBRC(19) = (CONSTS(2)/( 2.00000*CONSTS(3)))*log(( ALGBRC(3)/ALGBRC(5) ** 2.00000*ALGBRC(16))/ALGBRC(17)) ALGBRC(20) = ALGBRC(5)* (ALGBRC(17)/ALGBRC(16)) ** (1.0 / 2)*EXP(( CONSTS(3)*ALGBRC(14))/CONSTS(2)) ALGBRC(24) = ALGBRC(6)*( (ALGBRC(21)/ALGBRC(18))*ALGBRC(22)*CONSTS(42))/CONSTS(29) ** 0.333340*ALGBRC(8)/CONSTS(38) ** 0.666670*EXP(( CONSTS(3)*ALGBRC(14))/( 3.00000*CONSTS(2))) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END