/* There are a total of 20 entries in the algebraic variable array. There are a total of 14 entries in each of the rate and state variable arrays. There are a total of 24 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is NatP in component NatP (molecules). * CONSTANTS[22] is v1 in component v1 (flux). * ALGEBRAIC[0] is v2 in component v2 (flux). * ALGEBRAIC[4] is v5 in component v5 (flux). * STATES[1] is MisP in component MisP (molecules). * ALGEBRAIC[1] is v3 in component v3 (flux). * ALGEBRAIC[3] is v4 in component v4 (flux). * ALGEBRAIC[5] is v6 in component v6 (flux). * ALGEBRAIC[6] is v7 in component v7 (flux). * STATES[2] is MCom in component MCom (molecules). * STATES[3] is Hsp90 in component Hsp90 (molecules). * ALGEBRAIC[8] is v9 in component v9 (flux). * ALGEBRAIC[16] is v16 in component v16 (flux). * ALGEBRAIC[7] is v8 in component v8 (flux). * ALGEBRAIC[17] is v17 in component v17 (flux). * STATES[4] is HCom in component HCom (molecules). * STATES[5] is HSF1 in component HSF1 (molecules). * ALGEBRAIC[14] is v13 in component v13 (flux). * ALGEBRAIC[12] is v12 in component v12 (flux). * ALGEBRAIC[10] is v10 in component v10 (flux). * ALGEBRAIC[11] is v11 in component v11 (flux). * STATES[6] is DiH in component DiH (molecules). * STATES[7] is TriH in component TriH (molecules). * ALGEBRAIC[13] is v14 in component v14 (flux). * ALGEBRAIC[15] is v15 in component v15 (flux). * STATES[8] is HSE_TriH in component HSE_TriH (molecules). * STATES[9] is HSE in component HSE (molecules). * STATES[10] is AggP in component AggP (molecules). * ALGEBRAIC[9] is v7b in component v7b (flux). * STATES[11] is ROS in component ROS (molecules). * CONSTANTS[23] is v20 in component v20 (flux). * ALGEBRAIC[2] is v21 in component v21 (flux). * STATES[12] is ATP in component ATP (molecules). * ALGEBRAIC[18] is v18 in component v18 (flux). * ALGEBRAIC[19] is v19 in component v19 (flux). * STATES[13] is ADP in component ADP (molecules). * CONSTANTS[0] is k1 in component v1 (flux). * CONSTANTS[1] is k2 in component v2 (second_order_rate_constant). * CONSTANTS[2] is k3 in component v3 (second_order_rate_constant). * CONSTANTS[3] is k4 in component v4 (first_order_rate_constant). * CONSTANTS[4] is k5 in component v5 (second_order_rate_constant). * CONSTANTS[5] is k6 in component v6 (second_order_rate_constant). * CONSTANTS[6] is k7 in component v7 (second_order_rate_constant). * CONSTANTS[7] is k7 in component v7b (second_order_rate_constant). * CONSTANTS[8] is k8 in component v8 (second_order_rate_constant). * CONSTANTS[9] is k9 in component v9 (first_order_rate_constant). * CONSTANTS[10] is k10 in component v10 (second_order_rate_constant). * CONSTANTS[11] is k11 in component v11 (second_order_rate_constant). * CONSTANTS[12] is k12 in component v12 (first_order_rate_constant). * CONSTANTS[13] is k13 in component v13 (first_order_rate_constant). * CONSTANTS[14] is k14 in component v14 (second_order_rate_constant). * CONSTANTS[15] is k15 in component v15 (first_order_rate_constant). * CONSTANTS[16] is k16 in component v16 (first_order_rate_constant). * CONSTANTS[17] is k17 in component v17 (second_order_rate_constant). * CONSTANTS[18] is k18 in component v18 (first_order_rate_constant). * CONSTANTS[19] is k19 in component v19 (first_order_rate_constant). * CONSTANTS[20] is k20 in component v20 (flux). * CONSTANTS[21] is k21 in component v21 (first_order_rate_constant). * RATES[0] is d/dt NatP in component NatP (molecules). * RATES[1] is d/dt MisP in component MisP (molecules). * RATES[2] is d/dt MCom in component MCom (molecules). * RATES[3] is d/dt Hsp90 in component Hsp90 (molecules). * RATES[4] is d/dt HCom in component HCom (molecules). * RATES[5] is d/dt HSF1 in component HSF1 (molecules). * RATES[6] is d/dt DiH in component DiH (molecules). * RATES[7] is d/dt TriH in component TriH (molecules). * RATES[8] is d/dt HSE_TriH in component HSE_TriH (molecules). * RATES[9] is d/dt HSE in component HSE (molecules). * RATES[10] is d/dt AggP in component AggP (molecules). * RATES[11] is d/dt ROS in component ROS (molecules). * RATES[12] is d/dt ATP in component ATP (molecules). * RATES[13] is d/dt ADP in component ADP (molecules). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 6000000; STATES[1] = 0; STATES[2] = 0; STATES[3] = 300000; STATES[4] = 5900; STATES[5] = 100; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 1; STATES[10] = 0; STATES[11] = 100; STATES[12] = 10000; STATES[13] = 1000; CONSTANTS[0] = 10; CONSTANTS[1] = 0.00002; CONSTANTS[2] = 50; CONSTANTS[3] = 0.00001; CONSTANTS[4] = 4e-6; CONSTANTS[5] = 6e-7; CONSTANTS[6] = 1e-7; CONSTANTS[7] = 1e-7; CONSTANTS[8] = 500; CONSTANTS[9] = 1; CONSTANTS[10] = 0.01; CONSTANTS[11] = 100; CONSTANTS[12] = 0.5; CONSTANTS[13] = 0.5; CONSTANTS[14] = 0.05; CONSTANTS[15] = 0.08; CONSTANTS[16] = 1000; CONSTANTS[17] = 8.02e-9; CONSTANTS[18] = 12; CONSTANTS[19] = 0.02; CONSTANTS[20] = 0.1; CONSTANTS[21] = 0.00001; CONSTANTS[22] = CONSTANTS[0]; CONSTANTS[23] = CONSTANTS[20]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[1]*STATES[0]*STATES[11]; ALGEBRAIC[2] = CONSTANTS[21]*STATES[11]; RATES[11] = (ALGEBRAIC[0]+CONSTANTS[23]) - (ALGEBRAIC[0]+ALGEBRAIC[2]); ALGEBRAIC[4] = CONSTANTS[4]*STATES[2]*STATES[12]; RATES[0] = (CONSTANTS[22]+ALGEBRAIC[4]) - ALGEBRAIC[0]; ALGEBRAIC[1] = CONSTANTS[2]*STATES[1]*STATES[3]; ALGEBRAIC[3] = CONSTANTS[3]*STATES[2]; RATES[2] = ALGEBRAIC[1] - (ALGEBRAIC[3]+ALGEBRAIC[4]); ALGEBRAIC[5] = CONSTANTS[5]*STATES[1]*STATES[12]; ALGEBRAIC[6] = CONSTANTS[6]*STATES[1]*STATES[1]; RATES[1] = (ALGEBRAIC[0]+ALGEBRAIC[3]) - (ALGEBRAIC[1]+ALGEBRAIC[5]+ 2.00000*ALGEBRAIC[6]); ALGEBRAIC[8] = CONSTANTS[9]*STATES[4]; ALGEBRAIC[7] = CONSTANTS[8]*STATES[5]*STATES[3]; RATES[4] = ALGEBRAIC[7] - ALGEBRAIC[8]; ALGEBRAIC[9] = CONSTANTS[7]*STATES[1]*STATES[10]; RATES[10] = (ALGEBRAIC[6]+ 2.00000*ALGEBRAIC[9]) - ALGEBRAIC[9]; ALGEBRAIC[14] = CONSTANTS[13]*STATES[6]; ALGEBRAIC[12] = CONSTANTS[12]*STATES[7]; ALGEBRAIC[10] = CONSTANTS[10]*STATES[5]*STATES[5]; ALGEBRAIC[11] = CONSTANTS[11]*STATES[6]*STATES[5]; RATES[5] = (ALGEBRAIC[8]+ 2.00000*ALGEBRAIC[14]+ALGEBRAIC[12]) - (ALGEBRAIC[7]+ 2.00000*ALGEBRAIC[10]+ALGEBRAIC[11]); RATES[6] = (ALGEBRAIC[10]+ALGEBRAIC[12]) - (ALGEBRAIC[11]+ALGEBRAIC[14]); ALGEBRAIC[13] = CONSTANTS[14]*STATES[9]*STATES[7]; ALGEBRAIC[15] = CONSTANTS[15]*STATES[8]; RATES[7] = (ALGEBRAIC[11]+ALGEBRAIC[15]) - (ALGEBRAIC[12]+ALGEBRAIC[13]); RATES[9] = ALGEBRAIC[15] - ALGEBRAIC[13]; ALGEBRAIC[16] = CONSTANTS[16]*STATES[8]; RATES[8] = (ALGEBRAIC[13]+ALGEBRAIC[16]) - (ALGEBRAIC[15]+ALGEBRAIC[16]); ALGEBRAIC[17] = CONSTANTS[17]*STATES[3]*STATES[12]; RATES[3] = (ALGEBRAIC[4]+ALGEBRAIC[3]+ALGEBRAIC[8]+ALGEBRAIC[16]) - (ALGEBRAIC[1]+ALGEBRAIC[7]+ALGEBRAIC[17]); ALGEBRAIC[18] = CONSTANTS[18]*STATES[13]; ALGEBRAIC[19] = CONSTANTS[19]*STATES[12]; RATES[12] = ALGEBRAIC[18] - (ALGEBRAIC[4]+ALGEBRAIC[5]+ALGEBRAIC[17]+ALGEBRAIC[19]); RATES[13] = (ALGEBRAIC[4]+ALGEBRAIC[5]+ALGEBRAIC[17]+ALGEBRAIC[19]) - ALGEBRAIC[18]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[1]*STATES[0]*STATES[11]; ALGEBRAIC[2] = CONSTANTS[21]*STATES[11]; ALGEBRAIC[4] = CONSTANTS[4]*STATES[2]*STATES[12]; ALGEBRAIC[1] = CONSTANTS[2]*STATES[1]*STATES[3]; ALGEBRAIC[3] = CONSTANTS[3]*STATES[2]; ALGEBRAIC[5] = CONSTANTS[5]*STATES[1]*STATES[12]; ALGEBRAIC[6] = CONSTANTS[6]*STATES[1]*STATES[1]; ALGEBRAIC[8] = CONSTANTS[9]*STATES[4]; ALGEBRAIC[7] = CONSTANTS[8]*STATES[5]*STATES[3]; ALGEBRAIC[9] = CONSTANTS[7]*STATES[1]*STATES[10]; ALGEBRAIC[14] = CONSTANTS[13]*STATES[6]; ALGEBRAIC[12] = CONSTANTS[12]*STATES[7]; ALGEBRAIC[10] = CONSTANTS[10]*STATES[5]*STATES[5]; ALGEBRAIC[11] = CONSTANTS[11]*STATES[6]*STATES[5]; ALGEBRAIC[13] = CONSTANTS[14]*STATES[9]*STATES[7]; ALGEBRAIC[15] = CONSTANTS[15]*STATES[8]; ALGEBRAIC[16] = CONSTANTS[16]*STATES[8]; ALGEBRAIC[17] = CONSTANTS[17]*STATES[3]*STATES[12]; ALGEBRAIC[18] = CONSTANTS[18]*STATES[13]; ALGEBRAIC[19] = CONSTANTS[19]*STATES[12]; }