/* There are a total of 3 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 19 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * CONSTANTS[0] is VM2 in component parameters (micromolar_min). * CONSTANTS[1] is VM3 in component parameters (micromolar_min). * CONSTANTS[2] is KR in component parameters (micromolar). * CONSTANTS[3] is KA in component parameters (micromolar). * CONSTANTS[4] is KP in component parameters (micromolar). * CONSTANTS[5] is n in component parameters (dimensionless). * CONSTANTS[6] is m in component parameters (dimensionless). * CONSTANTS[7] is p in component parameters (dimensionless). * CONSTANTS[8] is kf in component parameters (per_minute). * CONSTANTS[9] is k in component parameters (per_minute). * STATES[0] is Y in component insensitive_pool (micromolar). * STATES[1] is Z in component cytosol (micromolar). * ALGEBRAIC[0] is v2 in component parameters (micromolar_min). * ALGEBRAIC[2] is v3 in component parameters (micromolar_min). * CONSTANTS[10] is v0 in component cytosol (micromolar_min). * CONSTANTS[11] is v1beta in component cytosol (micromolar_min). * CONSTANTS[12] is vP in component phosphorylation (micromolar_min). * ALGEBRAIC[1] is vK in component kinase_reaction (micromolar_min). * CONSTANTS[13] is K1 in component phosphorylation (dimensionless). * CONSTANTS[14] is K2 in component phosphorylation (dimensionless). * CONSTANTS[15] is WT in component phosphorylation (micromolar). * STATES[2] is Wstar in component phosphorylation (dimensionless). * CONSTANTS[16] is vMK in component kinase_reaction (micromolar_min). * CONSTANTS[17] is Ka in component kinase_reaction (micromolar). * CONSTANTS[18] is q in component kinase_reaction (dimensionless). * RATES[1] is d/dt Z in component cytosol (micromolar). * RATES[0] is d/dt Y in component insensitive_pool (micromolar). * RATES[2] is d/dt Wstar in component phosphorylation (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 65; CONSTANTS[1] = 500; CONSTANTS[2] = 2; CONSTANTS[3] = 0.9; CONSTANTS[4] = 1; CONSTANTS[5] = 2; CONSTANTS[6] = 2; CONSTANTS[7] = 4; CONSTANTS[8] = 1; CONSTANTS[9] = 10; STATES[0] = 1.7; STATES[1] = 0.26; CONSTANTS[10] = 1; CONSTANTS[11] = 2.7; CONSTANTS[12] = 2.5; CONSTANTS[13] = 0.01; CONSTANTS[14] = 0.01; CONSTANTS[15] = 1; STATES[2] = 0.37; CONSTANTS[16] = 20; CONSTANTS[17] = 2.5; CONSTANTS[18] = 1; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[16]*(pow(STATES[1], CONSTANTS[18])/(pow(CONSTANTS[17], CONSTANTS[18])+pow(STATES[1], CONSTANTS[18]))); RATES[2] = (CONSTANTS[12]/CONSTANTS[15])*(( (ALGEBRAIC[1]/CONSTANTS[12])*(1.00000 - STATES[2]))/((CONSTANTS[13]+1.00000) - STATES[2]) - STATES[2]/(CONSTANTS[14]+STATES[2])); ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[5]))/(pow(CONSTANTS[4], CONSTANTS[5])+pow(STATES[1], CONSTANTS[5])); ALGEBRAIC[2] = CONSTANTS[1]*(pow(STATES[0], CONSTANTS[6])/(pow(CONSTANTS[2], CONSTANTS[6])+pow(STATES[0], CONSTANTS[6])))*(pow(STATES[1], CONSTANTS[7])/(pow(CONSTANTS[3], CONSTANTS[7])+pow(STATES[1], CONSTANTS[7]))); RATES[1] = (((CONSTANTS[10]+CONSTANTS[11]) - ALGEBRAIC[0])+ALGEBRAIC[2]+ CONSTANTS[8]*STATES[0]) - CONSTANTS[9]*STATES[1]; RATES[0] = (ALGEBRAIC[0] - ALGEBRAIC[2]) - CONSTANTS[8]*STATES[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = CONSTANTS[16]*(pow(STATES[1], CONSTANTS[18])/(pow(CONSTANTS[17], CONSTANTS[18])+pow(STATES[1], CONSTANTS[18]))); ALGEBRAIC[0] = ( CONSTANTS[0]*pow(STATES[1], CONSTANTS[5]))/(pow(CONSTANTS[4], CONSTANTS[5])+pow(STATES[1], CONSTANTS[5])); ALGEBRAIC[2] = CONSTANTS[1]*(pow(STATES[0], CONSTANTS[6])/(pow(CONSTANTS[2], CONSTANTS[6])+pow(STATES[0], CONSTANTS[6])))*(pow(STATES[1], CONSTANTS[7])/(pow(CONSTANTS[3], CONSTANTS[7])+pow(STATES[1], CONSTANTS[7]))); }