C C There are a total of 3 entries in the algebraic variable array. C There are a total of 3 entries in each of the rate and state variable arrays. C There are a total of 19 entries in the constant variable array. C C C VOI is time in component environment (minute). C CONSTS(1) is VM2 in component parameters (micromolar_min). C CONSTS(2) is VM3 in component parameters (micromolar_min). C CONSTS(3) is KR in component parameters (micromolar). C CONSTS(4) is KA in component parameters (micromolar). C CONSTS(5) is KP in component parameters (micromolar). C CONSTS(6) is n in component parameters (dimensionless). C CONSTS(7) is m in component parameters (dimensionless). C CONSTS(8) is p in component parameters (dimensionless). C CONSTS(9) is kf in component parameters (per_minute). C CONSTS(10) is k in component parameters (per_minute). C STATES(1) is Y in component insensitive_pool (micromolar). C STATES(2) is Z in component cytosol (micromolar). C ALGBRC(1) is v2 in component parameters (micromolar_min). C ALGBRC(3) is v3 in component parameters (micromolar_min). C CONSTS(11) is v0 in component cytosol (micromolar_min). C CONSTS(12) is v1beta in component cytosol (micromolar_min). C CONSTS(13) is vP in component phosphorylation (micromolar_min). C ALGBRC(2) is vK in component kinase_reaction (micromolar_min). C CONSTS(14) is K1 in component phosphorylation (dimensionless). C CONSTS(15) is K2 in component phosphorylation (dimensionless). C CONSTS(16) is WT in component phosphorylation (micromolar). C STATES(3) is Wstar in component phosphorylation (dimensionless). C CONSTS(17) is vMK in component kinase_reaction (micromolar_min). C CONSTS(18) is Ka in component kinase_reaction (micromolar). C CONSTS(19) is q in component kinase_reaction (dimensionless). C RATES(2) is d/dt Z in component cytosol (micromolar). C RATES(1) is d/dt Y in component insensitive_pool (micromolar). C RATES(3) is d/dt Wstar in component phosphorylation (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 65 CONSTS(2) = 500 CONSTS(3) = 2 CONSTS(4) = 0.9 CONSTS(5) = 1 CONSTS(6) = 2 CONSTS(7) = 2 CONSTS(8) = 4 CONSTS(9) = 1 CONSTS(10) = 10 STATES(1) = 1.7 STATES(2) = 0.26 CONSTS(11) = 1 CONSTS(12) = 2.7 CONSTS(13) = 2.5 CONSTS(14) = 0.01 CONSTS(15) = 0.01 CONSTS(16) = 1 STATES(3) = 0.37 CONSTS(17) = 20 CONSTS(18) = 2.5 CONSTS(19) = 1 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(17)*(STATES(2) ** CONSTS(19)/(CONSTS(18) ** CONSTS(19)+STATES(2) ** CONSTS(19))) RATES(3) = (CONSTS(13)/CONSTS(16))*(( (ALGBRC(2)/CONSTS(13))*(1.00000 - STATES(3)))/((CONSTS(14)+1.00000) - STATES(3)) - STATES(3)/(CONSTS(15)+STATES(3))) ALGBRC(1) = ( CONSTS(1)*STATES(2) ** CONSTS(6))/(CONSTS(5) ** CONSTS(6)+STATES(2) ** CONSTS(6)) ALGBRC(3) = CONSTS(2)*(STATES(1) ** CONSTS(7)/(CONSTS(3) ** CONSTS(7)+STATES(1) ** CONSTS(7)))*(STATES(2) ** CONSTS(8)/(CONSTS(4) ** CONSTS(8)+STATES(2) ** CONSTS(8))) RATES(2) = (((CONSTS(11)+CONSTS(12)) - ALGBRC(1))+ALGBRC(3)+ CONSTS(9)*STATES(1)) - CONSTS(10)*STATES(2) RATES(1) = (ALGBRC(1) - ALGBRC(3)) - CONSTS(9)*STATES(1) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = CONSTS(17)*(STATES(2) ** CONSTS(19)/(CONSTS(18) ** CONSTS(19)+STATES(2) ** CONSTS(19))) ALGBRC(1) = ( CONSTS(1)*STATES(2) ** CONSTS(6))/(CONSTS(5) ** CONSTS(6)+STATES(2) ** CONSTS(6)) ALGBRC(3) = CONSTS(2)*(STATES(1) ** CONSTS(7)/(CONSTS(3) ** CONSTS(7)+STATES(1) ** CONSTS(7)))*(STATES(2) ** CONSTS(8)/(CONSTS(4) ** CONSTS(8)+STATES(2) ** CONSTS(8))) RETURN END