Moore, Li, 2004

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

Chronic myelogenous leukemia (CML) is a cancer that affects cells circulating in the blood system. The disease represents approximately 15% of all leukemias in adults. The immune system is known to play a role in determining the dynamics of CML, and in the publication described here by Moore and Li (2004), the authors develop a mathematical model which describes the human immune system's response to CML in a hypothetical patient.

The mathematical model (see the figure below), consists of a system of three nonlinear ordinary differential equations. These equations consider the rates of change for naive and effector T cells, as well as the CML cancer cell population. The parameter values are based on experimental data and estimates. Model simulation results suggest that changes in most parameters, such as naive and effector T cell death rates, have little effect on the long-term outcome of the system. However, changes in the CML cancer growth rate or death rate, result in significantly different outcomes of the system.

The complete original paper reference is cited below:

A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction, Helen Moore and Natasha K. Li, 2004, Journal of Theoretical Biology , 11, 369-391. (Full text (HTML) and PDF versions of the article are available to subscribers on the Journal of Theoretical Biology website.) PubMed ID: 15038986