Generated Code
The following is matlab code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction()
% This is the "main function". In Matlab, things work best if you rename this function to match the filename.
[VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel();
end
function [algebraicVariableCount] = getAlgebraicVariableCount()
% Used later when setting a global variable with the number of algebraic variables.
% Note: This is not the "main method".
algebraicVariableCount =10;
end
% There are a total of 4 entries in each of the rate and state variable arrays.
% There are a total of 21 entries in the constant variable array.
%
function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel()
% Create ALGEBRAIC of correct size
global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount();
% Initialise constants and state variables
[INIT_STATES, CONSTANTS] = initConsts;
% Set timespan to solve over
tspan = [0, 10];
% Set numerical accuracy options for ODE solver
options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1);
% Solve model with ODE solver
[VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options);
% Compute algebraic variables
[RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS);
ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI);
% Plot state variables against variable of integration
[LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends();
figure();
plot(VOI, STATES);
xlabel(LEGEND_VOI);
l = legend(LEGEND_STATES);
set(l,'Interpreter','none');
end
function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends()
LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = '';
LEGEND_VOI = strpad('time in component environment (millisecond)');
LEGEND_CONSTANTS(:,1) = strpad('Cm in component membrane (femtoF)');
LEGEND_STATES(:,1) = strpad('V in component membrane (millivolt)');
LEGEND_ALGEBRAIC(:,5) = strpad('ICa in component Ca_current (femtoA)');
LEGEND_ALGEBRAIC(:,7) = strpad('IK in component rapid_K_current (femtoA)');
LEGEND_ALGEBRAIC(:,10) = strpad('Il in component leak_current (femtoA)');
LEGEND_ALGEBRAIC(:,8) = strpad('Is1 in component slow_K_current (femtoA)');
LEGEND_ALGEBRAIC(:,9) = strpad('Is2 in component very_slow_K_current (femtoA)');
LEGEND_CONSTANTS(:,2) = strpad('Vm in component Ca_current (millivolt)');
LEGEND_CONSTANTS(:,3) = strpad('VCa in component Ca_current (millivolt)');
LEGEND_CONSTANTS(:,4) = strpad('gCa in component Ca_current (picoS)');
LEGEND_ALGEBRAIC(:,1) = strpad('minf in component Ca_current (dimensionless)');
LEGEND_CONSTANTS(:,5) = strpad('sm in component Ca_current (millivolt)');
LEGEND_CONSTANTS(:,6) = strpad('VK in component rapid_K_current (millivolt)');
LEGEND_CONSTANTS(:,7) = strpad('gK in component rapid_K_current (picoS)');
LEGEND_STATES(:,2) = strpad('n in component rapid_K_current (dimensionless)');
LEGEND_CONSTANTS(:,8) = strpad('lambda in component rapid_K_current (dimensionless)');
LEGEND_CONSTANTS(:,9) = strpad('tnbar in component rapid_K_current (dimensionless)');
LEGEND_CONSTANTS(:,10) = strpad('Vn in component rapid_K_current (millivolt)');
LEGEND_CONSTANTS(:,11) = strpad('sn in component rapid_K_current (millivolt)');
LEGEND_ALGEBRAIC(:,6) = strpad('taun in component rapid_K_current (dimensionless)');
LEGEND_ALGEBRAIC(:,2) = strpad('ninf in component rapid_K_current (dimensionless)');
LEGEND_CONSTANTS(:,12) = strpad('gs1 in component slow_K_current (picoS)');
LEGEND_STATES(:,3) = strpad('s1 in component slow_K_current (dimensionless)');
LEGEND_ALGEBRAIC(:,3) = strpad('s1inf in component slow_K_current (dimensionless)');
LEGEND_CONSTANTS(:,13) = strpad('Vs1 in component slow_K_current (millivolt)');
LEGEND_CONSTANTS(:,14) = strpad('ss1 in component slow_K_current (millivolt)');
LEGEND_CONSTANTS(:,15) = strpad('taus1 in component slow_K_current (dimensionless)');
LEGEND_CONSTANTS(:,16) = strpad('Vs2 in component very_slow_K_current (millivolt)');
LEGEND_STATES(:,4) = strpad('s2 in component very_slow_K_current (dimensionless)');
LEGEND_ALGEBRAIC(:,4) = strpad('s2inf in component very_slow_K_current (dimensionless)');
LEGEND_CONSTANTS(:,17) = strpad('ss2 in component very_slow_K_current (millivolt)');
LEGEND_CONSTANTS(:,18) = strpad('gs2 in component very_slow_K_current (picoS)');
LEGEND_CONSTANTS(:,19) = strpad('taus2 in component very_slow_K_current (dimensionless)');
LEGEND_CONSTANTS(:,20) = strpad('gl in component leak_current (picoS)');
LEGEND_CONSTANTS(:,21) = strpad('Vl in component leak_current (millivolt)');
LEGEND_RATES(:,1) = strpad('d/dt V in component membrane (millivolt)');
LEGEND_RATES(:,2) = strpad('d/dt n in component rapid_K_current (dimensionless)');
LEGEND_RATES(:,3) = strpad('d/dt s1 in component slow_K_current (dimensionless)');
LEGEND_RATES(:,4) = strpad('d/dt s2 in component very_slow_K_current (dimensionless)');
LEGEND_STATES = LEGEND_STATES';
LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC';
LEGEND_RATES = LEGEND_RATES';
LEGEND_CONSTANTS = LEGEND_CONSTANTS';
end
function [STATES, CONSTANTS] = initConsts()
VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = [];
CONSTANTS(:,1) = 4524;
STATES(:,1) = -43;
CONSTANTS(:,2) = -22;
CONSTANTS(:,3) = 100;
CONSTANTS(:,4) = 280;
CONSTANTS(:,5) = 7.5;
CONSTANTS(:,6) = -80;
CONSTANTS(:,7) = 1300;
STATES(:,2) = 0.03;
CONSTANTS(:,8) = 1.1;
CONSTANTS(:,9) = 9.09;
CONSTANTS(:,10) = -9;
CONSTANTS(:,11) = 10;
CONSTANTS(:,12) = 7;
STATES(:,3) = 0.1;
CONSTANTS(:,13) = -40;
CONSTANTS(:,14) = 0.5;
CONSTANTS(:,15) = 1000;
CONSTANTS(:,16) = -42;
STATES(:,4) = 0.434;
CONSTANTS(:,17) = 0.4;
CONSTANTS(:,18) = 32;
CONSTANTS(:,19) = 120000;
CONSTANTS(:,20) = 25;
CONSTANTS(:,21) = -40;
if (isempty(STATES)), warning('Initial values for states not set');, end
end
function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS)
global algebraicVariableCount;
statesSize = size(STATES);
statesColumnCount = statesSize(2);
if ( statesColumnCount == 1)
STATES = STATES';
ALGEBRAIC = zeros(1, algebraicVariableCount);
utilOnes = 1;
else
statesRowCount = statesSize(1);
ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount);
RATES = zeros(statesRowCount, statesColumnCount);
utilOnes = ones(statesRowCount, 1);
end
ALGEBRAIC(:,3) = 1.00000./(1.00000+exp((CONSTANTS(:,13) - STATES(:,1))./CONSTANTS(:,14)));
RATES(:,3) = (ALGEBRAIC(:,3) - STATES(:,3))./( CONSTANTS(:,15).*1.00000);
ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((CONSTANTS(:,16) - STATES(:,1))./CONSTANTS(:,17)));
RATES(:,4) = (ALGEBRAIC(:,4) - STATES(:,4))./( CONSTANTS(:,19).*1.00000);
ALGEBRAIC(:,6) = CONSTANTS(:,9)./(1.00000+exp((STATES(:,1) - CONSTANTS(:,10))./CONSTANTS(:,11)));
ALGEBRAIC(:,2) = 1.00000./(1.00000+exp((CONSTANTS(:,10) - STATES(:,1))./CONSTANTS(:,11)));
RATES(:,2) = ( CONSTANTS(:,8).*(ALGEBRAIC(:,2) - STATES(:,2)))./( ALGEBRAIC(:,6).*1.00000);
ALGEBRAIC(:,1) = 1.00000./(1.00000+exp((CONSTANTS(:,2) - STATES(:,1))./CONSTANTS(:,5)));
ALGEBRAIC(:,5) = CONSTANTS(:,4).*ALGEBRAIC(:,1).*(STATES(:,1) - CONSTANTS(:,3));
ALGEBRAIC(:,7) = CONSTANTS(:,7).*STATES(:,2).*(STATES(:,1) - CONSTANTS(:,6));
ALGEBRAIC(:,10) = CONSTANTS(:,20).*(STATES(:,1) - CONSTANTS(:,21));
ALGEBRAIC(:,8) = CONSTANTS(:,12).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,6));
ALGEBRAIC(:,9) = CONSTANTS(:,18).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,6));
RATES(:,1) = - (ALGEBRAIC(:,5)+ALGEBRAIC(:,7)+ALGEBRAIC(:,10)+ALGEBRAIC(:,8)+ALGEBRAIC(:,9))./CONSTANTS(:,1);
RATES = RATES';
end
% Calculate algebraic variables
function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI)
statesSize = size(STATES);
statesColumnCount = statesSize(2);
if ( statesColumnCount == 1)
STATES = STATES';
utilOnes = 1;
else
statesRowCount = statesSize(1);
utilOnes = ones(statesRowCount, 1);
end
ALGEBRAIC(:,3) = 1.00000./(1.00000+exp((CONSTANTS(:,13) - STATES(:,1))./CONSTANTS(:,14)));
ALGEBRAIC(:,4) = 1.00000./(1.00000+exp((CONSTANTS(:,16) - STATES(:,1))./CONSTANTS(:,17)));
ALGEBRAIC(:,6) = CONSTANTS(:,9)./(1.00000+exp((STATES(:,1) - CONSTANTS(:,10))./CONSTANTS(:,11)));
ALGEBRAIC(:,2) = 1.00000./(1.00000+exp((CONSTANTS(:,10) - STATES(:,1))./CONSTANTS(:,11)));
ALGEBRAIC(:,1) = 1.00000./(1.00000+exp((CONSTANTS(:,2) - STATES(:,1))./CONSTANTS(:,5)));
ALGEBRAIC(:,5) = CONSTANTS(:,4).*ALGEBRAIC(:,1).*(STATES(:,1) - CONSTANTS(:,3));
ALGEBRAIC(:,7) = CONSTANTS(:,7).*STATES(:,2).*(STATES(:,1) - CONSTANTS(:,6));
ALGEBRAIC(:,10) = CONSTANTS(:,20).*(STATES(:,1) - CONSTANTS(:,21));
ALGEBRAIC(:,8) = CONSTANTS(:,12).*STATES(:,3).*(STATES(:,1) - CONSTANTS(:,6));
ALGEBRAIC(:,9) = CONSTANTS(:,18).*STATES(:,4).*(STATES(:,1) - CONSTANTS(:,6));
end
% Pad out or shorten strings to a set length
function strout = strpad(strin)
req_length = 160;
insize = size(strin,2);
if insize > req_length
strout = strin(1:req_length);
else
strout = [strin, blanks(req_length - insize)];
end
end