/* There are a total of 6 entries in the algebraic variable array. There are a total of 12 entries in each of the rate and state variable arrays. There are a total of 34 entries in the constant variable array. */ /* * VOI is time in component environment (minute). * CONSTANTS[0] is k1 in component rate_constants (first_order_rate_constant). * CONSTANTS[1] is k2 in component rate_constants (first_order_rate_constant). * CONSTANTS[2] is k3 in component rate_constants (first_order_rate_constant). * CONSTANTS[3] is k4 in component rate_constants (first_order_rate_constant). * CONSTANTS[4] is k5 in component rate_constants (first_order_rate_constant). * CONSTANTS[5] is k6 in component rate_constants (first_order_rate_constant). * CONSTANTS[6] is k7 in component rate_constants (first_order_rate_constant). * CONSTANTS[7] is k8 in component rate_constants (first_order_rate_constant). * CONSTANTS[8] is k9 in component rate_constants (first_order_rate_constant). * CONSTANTS[9] is k10 in component rate_constants (first_order_rate_constant). * CONSTANTS[10] is k11 in component rate_constants (first_order_rate_constant). * CONSTANTS[11] is k12 in component rate_constants (first_order_rate_constant). * CONSTANTS[12] is k13 in component rate_constants (first_order_rate_constant). * CONSTANTS[13] is k14 in component rate_constants (first_order_rate_constant). * CONSTANTS[14] is k15 in component rate_constants (first_order_rate_constant). * CONSTANTS[15] is k16 in component rate_constants (first_order_rate_constant). * CONSTANTS[16] is k2u in component rate_constants (first_order_rate_constant). * CONSTANTS[17] is k7u in component rate_constants (first_order_rate_constant). * CONSTANTS[18] is k16u in component rate_constants (first_order_rate_constant). * CONSTANTS[19] is az in component rate_constants (first_order_rate_constant). * CONSTANTS[20] is bz in component rate_constants (first_order_rate_constant). * CONSTANTS[21] is cz in component rate_constants (first_order_rate_constant). * CONSTANTS[22] is aw in component rate_constants (first_order_rate_constant). * CONSTANTS[23] is bw in component rate_constants (first_order_rate_constant). * CONSTANTS[24] is cw in component rate_constants (first_order_rate_constant). * CONSTANTS[25] is ai in component rate_constants (first_order_rate_constant). * CONSTANTS[26] is bi in component rate_constants (first_order_rate_constant). * CONSTANTS[27] is ci in component rate_constants (first_order_rate_constant). * STATES[0] is cyclin_CDK_active in component cyclin_CDK_active (dimensionless). * ALGEBRAIC[0] is kplus_z in component rate_constants (first_order_rate_constant). * ALGEBRAIC[1] is kplus_w in component rate_constants (first_order_rate_constant). * ALGEBRAIC[2] is kplus_i in component rate_constants (first_order_rate_constant). * CONSTANTS[31] is kminus_z in component rate_constants (first_order_rate_constant). * CONSTANTS[32] is kminus_w in component rate_constants (first_order_rate_constant). * CONSTANTS[33] is kminus_i in component rate_constants (first_order_rate_constant). * STATES[1] is cyclin in component cyclin (dimensionless). * STATES[2] is cyclin_CDK_inactive in component cyclin_CDK_inactive (dimensionless). * ALGEBRAIC[3] is CDK in component CDK (dimensionless). * STATES[3] is APC in component APC (dimensionless). * STATES[4] is wee1 in component wee1 (dimensionless). * STATES[5] is Cdc25_2P in component Cdc25_2P (dimensionless). * STATES[6] is CKI in component CKI (dimensionless). * STATES[7] is cyclin_CDK_CKI in component cyclin_CDK_CKI (dimensionless). * STATES[8] is cyclin_CDK_CKI_P in component cyclin_CDK_CKI_P (dimensionless). * STATES[9] is Cdc25 in component Cdc25 (dimensionless). * STATES[10] is Cdc25_P in component Cdc25_P (dimensionless). * STATES[11] is wee1_P in component wee1_P (dimensionless). * CONSTANTS[28] is tau in component APC (minute). * ALGEBRAIC[4] is h_x in component APC (dimensionless). * CONSTANTS[29] is a in component APC (dimensionless). * CONSTANTS[30] is CDK_T in component CDK (dimensionless). * ALGEBRAIC[5] is cyclin_T in component cyclin_T (dimensionless). * RATES[1] is d/dt cyclin in component cyclin (dimensionless). * RATES[2] is d/dt cyclin_CDK_inactive in component cyclin_CDK_inactive (dimensionless). * RATES[0] is d/dt cyclin_CDK_active in component cyclin_CDK_active (dimensionless). * RATES[9] is d/dt Cdc25 in component Cdc25 (dimensionless). * RATES[10] is d/dt Cdc25_P in component Cdc25_P (dimensionless). * RATES[5] is d/dt Cdc25_2P in component Cdc25_2P (dimensionless). * RATES[4] is d/dt wee1 in component wee1 (dimensionless). * RATES[11] is d/dt wee1_P in component wee1_P (dimensionless). * RATES[3] is d/dt APC in component APC (dimensionless). * RATES[6] is d/dt CKI in component CKI (dimensionless). * RATES[7] is d/dt cyclin_CDK_CKI in component cyclin_CDK_CKI (dimensionless). * RATES[8] is d/dt cyclin_CDK_CKI_P in component cyclin_CDK_CKI_P (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 300; CONSTANTS[1] = 5; CONSTANTS[2] = 30; CONSTANTS[3] = 30; CONSTANTS[4] = 0.1; CONSTANTS[5] = 1; CONSTANTS[6] = 10; CONSTANTS[7] = 100; CONSTANTS[8] = 1; CONSTANTS[9] = 10; CONSTANTS[10] = 1; CONSTANTS[11] = 0; CONSTANTS[12] = 1; CONSTANTS[13] = 1; CONSTANTS[14] = 1; CONSTANTS[15] = 2; CONSTANTS[16] = 50; CONSTANTS[17] = 0; CONSTANTS[18] = 25; CONSTANTS[19] = 10; CONSTANTS[20] = 0.1; CONSTANTS[21] = 1; CONSTANTS[22] = 10; CONSTANTS[23] = 0.1; CONSTANTS[24] = 1; CONSTANTS[25] = 10; CONSTANTS[26] = 0.1; CONSTANTS[27] = 1; STATES[0] = 0.1; STATES[1] = 0; STATES[2] = 0.1; STATES[3] = 0; STATES[4] = 0; STATES[5] = 0; STATES[6] = 0; STATES[7] = 0; STATES[8] = 0; STATES[9] = 0; STATES[10] = 0; STATES[11] = 0; CONSTANTS[28] = 25; CONSTANTS[29] = 4; CONSTANTS[30] = 200; CONSTANTS[31] = CONSTANTS[19]; CONSTANTS[32] = CONSTANTS[22]; CONSTANTS[33] = CONSTANTS[25]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[0] = ((((( CONSTANTS[4]*STATES[2]+ STATES[5]*STATES[2]*1.00000) - CONSTANTS[5]*STATES[0]) - STATES[4]*STATES[0]*1.00000) - (CONSTANTS[6]+ CONSTANTS[17]*STATES[3])*STATES[0]) - CONSTANTS[13]*STATES[0]*STATES[6])+ CONSTANTS[14]*STATES[7]+ (CONSTANTS[15]+ CONSTANTS[18]*STATES[3])*STATES[8]; RATES[6] = ((CONSTANTS[11] - CONSTANTS[12]*STATES[6]) - CONSTANTS[11]*STATES[0]*STATES[6])+ CONSTANTS[14]*STATES[7]; ALGEBRAIC[3] = ((((CONSTANTS[30] - STATES[0]) - STATES[2]) - STATES[7]) - STATES[8])/CONSTANTS[30]; RATES[1] = ((CONSTANTS[0]+ CONSTANTS[3]*STATES[2]) - CONSTANTS[2]*STATES[1]*ALGEBRAIC[3]) - (CONSTANTS[1]+ CONSTANTS[16]*STATES[3])*STATES[1]; RATES[2] = ((( CONSTANTS[2]*STATES[1]*ALGEBRAIC[3]+ CONSTANTS[5]*STATES[0]+ STATES[4]*STATES[0]*1.00000) - CONSTANTS[3]*STATES[2]) - CONSTANTS[4]*STATES[2]) - STATES[5]*STATES[2]*1.00000; ALGEBRAIC[0] = CONSTANTS[20]+ CONSTANTS[21]*STATES[0]; RATES[9] = ((CONSTANTS[7]+ CONSTANTS[31]*STATES[10]) - ALGEBRAIC[0]*STATES[9]) - CONSTANTS[8]*STATES[9]; RATES[10] = ( ALGEBRAIC[0]*(STATES[9] - STATES[10])+ CONSTANTS[31]*(STATES[5] - STATES[10])) - CONSTANTS[8]*STATES[10]; RATES[5] = ( ALGEBRAIC[0]*STATES[10] - CONSTANTS[31]*STATES[5]) - CONSTANTS[8]*STATES[5]; ALGEBRAIC[1] = CONSTANTS[23]+ CONSTANTS[24]*STATES[0]; RATES[4] = ((CONSTANTS[9]+ CONSTANTS[32]*STATES[11]) - ALGEBRAIC[1]*STATES[4]) - CONSTANTS[10]*STATES[4]; RATES[11] = ( ALGEBRAIC[1]*STATES[4] - CONSTANTS[32]*STATES[11]) - CONSTANTS[10]*STATES[11]; ALGEBRAIC[4] = pow(STATES[0], 2.00000)/(pow(CONSTANTS[29], 2.00000)+pow(STATES[0], 2.00000)); RATES[3] = (ALGEBRAIC[4] - STATES[3])/CONSTANTS[28]; ALGEBRAIC[2] = CONSTANTS[26]+ CONSTANTS[27]*STATES[0]; RATES[7] = (( CONSTANTS[13]*STATES[0]*STATES[6] - CONSTANTS[14]*STATES[7])+ CONSTANTS[33]*STATES[8]) - ALGEBRAIC[2]*STATES[7]; RATES[8] = ( ALGEBRAIC[2]*STATES[7] - CONSTANTS[33]*STATES[8]) - (CONSTANTS[15]+ CONSTANTS[18]*STATES[3])*STATES[8]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[3] = ((((CONSTANTS[30] - STATES[0]) - STATES[2]) - STATES[7]) - STATES[8])/CONSTANTS[30]; ALGEBRAIC[0] = CONSTANTS[20]+ CONSTANTS[21]*STATES[0]; ALGEBRAIC[1] = CONSTANTS[23]+ CONSTANTS[24]*STATES[0]; ALGEBRAIC[4] = pow(STATES[0], 2.00000)/(pow(CONSTANTS[29], 2.00000)+pow(STATES[0], 2.00000)); ALGEBRAIC[2] = CONSTANTS[26]+ CONSTANTS[27]*STATES[0]; ALGEBRAIC[5] = STATES[1]+STATES[0]+STATES[2]; }