C C There are a total of 64 entries in the algebraic variable array. C There are a total of 27 entries in each of the rate and state variable arrays. C There are a total of 40 entries in the constant variable array. C C C VOI is time in component environment (second). C STATES(1) is V in component membrane (millivolt). C CONSTS(1) is R in component membrane (joule_per_kilomole_kelvin). C CONSTS(2) is T in component membrane (kelvin). C CONSTS(3) is F in component membrane (coulomb_per_mole). C CONSTS(4) is Cm in component membrane (microF). C ALGBRC(57) is i_Na in component sodium_current (nanoA). C ALGBRC(37) is i_Ca_T in component T_type_Ca_channel (nanoA). C ALGBRC(35) is i_Ca_L in component L_type_Ca_channel (nanoA). C ALGBRC(60) is i_K in component delayed_rectifying_potassium_current (nanoA). C ALGBRC(40) is i_f in component hyperpolarisation_activated_current (nanoA). C ALGBRC(64) is i_B in component linear_background_current (nanoA). C ALGBRC(41) is i_NaK in component sodium_potassium_pump (nanoA). C ALGBRC(43) is i_NaCa in component sodium_calcium_pump (nanoA). C ALGBRC(42) is i_Ca_P in component calcium_pump_current (nanoA). C CONSTS(5) is P_Na in component sodium_current (mul_per_second). C ALGBRC(55) is E_Na in component reversal_potentials (millivolt). C STATES(2) is Na_c in component cleft_space_equations (millimolar). C STATES(3) is m in component sodium_current_m_gate (dimensionless). C STATES(4) is h1 in component sodium_current_h_gate (dimensionless). C STATES(5) is h2 in component sodium_current_h_gate (dimensionless). C ALGBRC(22) is m_infinity in component sodium_current_m_gate (dimensionless). C ALGBRC(28) is tau_m in component sodium_current_m_gate (second). C ALGBRC(1) is alpha_m in component sodium_current_m_gate (per_second). C ALGBRC(12) is beta_m in component sodium_current_m_gate (per_second). C ALGBRC(23) is h1_infinity in component sodium_current_h_gate (dimensionless). C ALGBRC(34) is h2_infinity in component sodium_current_h_gate (dimensionless). C ALGBRC(29) is tau_h1 in component sodium_current_h_gate (second). C ALGBRC(36) is tau_h2 in component sodium_current_h_gate (second). C ALGBRC(2) is alpha_h1 in component sodium_current_h_gate (per_second). C ALGBRC(13) is beta_h1 in component sodium_current_h_gate (per_second). C CONSTS(6) is g_Ca_L in component L_type_Ca_channel (microS). C CONSTS(7) is E_Ca_L in component L_type_Ca_channel (millivolt). C STATES(6) is d_L in component L_type_Ca_channel_d_gate (dimensionless). C ALGBRC(33) is d_L_infinity in component L_type_Ca_channel_d_gate (dimensionless). C STATES(7) is f_L in component L_type_Ca_channel_f_gate (dimensionless). C ALGBRC(9) is alpha_d_L in component L_type_Ca_channel_d_gate (per_second). C ALGBRC(20) is beta_d_L in component L_type_Ca_channel_d_gate (per_second). C ALGBRC(27) is tau_d_L in component L_type_Ca_channel_d_gate (second). C ALGBRC(3) is alpha_f_L in component L_type_Ca_channel_f_gate (per_second). C ALGBRC(14) is beta_f_L in component L_type_Ca_channel_f_gate (per_second). C ALGBRC(30) is f_L_infinity in component L_type_Ca_channel_f_gate (dimensionless). C ALGBRC(24) is tau_f_L in component L_type_Ca_channel_f_gate (second). C CONSTS(8) is g_Ca_T in component T_type_Ca_channel (microS). C CONSTS(9) is E_Ca_T in component T_type_Ca_channel (millivolt). C STATES(8) is d_T in component T_type_Ca_channel_d_gate (dimensionless). C STATES(9) is f_T in component T_type_Ca_channel_f_gate (dimensionless). C ALGBRC(4) is alpha_d_T in component T_type_Ca_channel_d_gate (per_second). C ALGBRC(15) is beta_d_T in component T_type_Ca_channel_d_gate (per_second). C ALGBRC(31) is d_T_infinity in component T_type_Ca_channel_d_gate (dimensionless). C ALGBRC(25) is tau_d_T in component T_type_Ca_channel_d_gate (second). C ALGBRC(5) is alpha_f_T in component T_type_Ca_channel_f_gate (per_second). C ALGBRC(16) is beta_f_T in component T_type_Ca_channel_f_gate (per_second). C ALGBRC(32) is f_T_infinity in component T_type_Ca_channel_f_gate (dimensionless). C ALGBRC(26) is tau_f_T in component T_type_Ca_channel_f_gate (second). C CONSTS(35) is g_K in component delayed_rectifying_potassium_current (microS). C ALGBRC(59) is E_K in component reversal_potentials (millivolt). C CONSTS(10) is K_b in component cleft_space_equations (millimolar). C STATES(10) is P_a in component delayed_rectifying_potassium_current_P_a_gate (dimensionless). C STATES(11) is P_i in component delayed_rectifying_potassium_current_P_i_gate (dimensionless). C ALGBRC(17) is tau_P_a in component delayed_rectifying_potassium_current_P_a_gate (second). C ALGBRC(6) is P_a_infinity in component delayed_rectifying_potassium_current_P_a_gate (dimensionless). C ALGBRC(7) is alpha_P_i in component delayed_rectifying_potassium_current_P_i_gate (per_second). C ALGBRC(18) is beta_P_i in component delayed_rectifying_potassium_current_P_i_gate (per_second). C ALGBRC(58) is i_B_Na in component linear_background_current (nanoA). C ALGBRC(63) is i_B_Ca in component linear_background_current (nanoA). C ALGBRC(61) is i_B_K in component linear_background_current (nanoA). C CONSTS(11) is g_B_Na in component linear_background_current (microS). C CONSTS(12) is g_B_Ca in component linear_background_current (microS). C CONSTS(13) is g_B_K in component linear_background_current (microS). C ALGBRC(62) is E_Ca in component reversal_potentials (millivolt). C ALGBRC(38) is i_f_Na in component hyperpolarisation_activated_current (nanoA). C ALGBRC(39) is i_f_K in component hyperpolarisation_activated_current (nanoA). C CONSTS(14) is g_f_Na in component hyperpolarisation_activated_current (microS). C CONSTS(15) is g_f_K in component hyperpolarisation_activated_current (microS). C STATES(12) is y in component hyperpolarisation_activated_current_y_gate (dimensionless). C ALGBRC(8) is y_infinity in component hyperpolarisation_activated_current_y_gate (dimensionless). C ALGBRC(19) is tau_y in component hyperpolarisation_activated_current_y_gate (second). C CONSTS(16) is K_m_Na in component sodium_potassium_pump (millimolar). C CONSTS(17) is K_m_K in component sodium_potassium_pump (millimolar). C CONSTS(18) is i_NaK_max in component sodium_potassium_pump (nanoA). C STATES(13) is Na_i in component intracellular_concentrations_and_buffer_equations (millimolar). C STATES(14) is K_c in component cleft_space_equations (millimolar). C CONSTS(19) is i_Ca_P_max in component calcium_pump_current (nanoA). C STATES(15) is Ca_i in component intracellular_concentrations_and_buffer_equations (millimolar). C CONSTS(20) is K_NaCa in component sodium_calcium_pump (nanoA). C CONSTS(21) is d_NaCa in component sodium_calcium_pump (dimensionless). C CONSTS(22) is gamma in component sodium_calcium_pump (dimensionless). C STATES(16) is Ca_c in component cleft_space_equations (millimolar). C STATES(17) is K_i in component intracellular_concentrations_and_buffer_equations (millimolar). C STATES(18) is Ca_Calmod in component intracellular_concentrations_and_buffer_equations (dimensionless). C STATES(19) is Ca_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C STATES(20) is Ca_Mg_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C STATES(21) is Mg_Mg_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C ALGBRC(44) is phi_C in component intracellular_concentrations_and_buffer_equations (per_second). C ALGBRC(45) is phi_TC in component intracellular_concentrations_and_buffer_equations (per_second). C ALGBRC(46) is phi_TMgC in component intracellular_concentrations_and_buffer_equations (per_second). C ALGBRC(10) is phi_TMgM in component intracellular_concentrations_and_buffer_equations (per_second). C ALGBRC(50) is phi_B in component intracellular_concentrations_and_buffer_equations (millimolar_per_second). C CONSTS(23) is Mg_i in component intracellular_concentrations_and_buffer_equations (millimolar). C ALGBRC(47) is F_C in component intracellular_concentrations_and_buffer_equations (millimolar_per_second). C ALGBRC(48) is F_TC in component intracellular_concentrations_and_buffer_equations (millimolar_per_second). C ALGBRC(49) is F_TMgC in component intracellular_concentrations_and_buffer_equations (millimolar_per_second). C CONSTS(24) is Vol in component cleft_space_equations (microLitre). C CONSTS(36) is V_i in component intracellular_concentrations_and_buffer_equations (microLitre). C ALGBRC(53) is i_up in component SR_Ca_uptake_and_release (nanoA). C ALGBRC(54) is i_rel in component SR_Ca_uptake_and_release (nanoA). C CONSTS(25) is Na_b in component cleft_space_equations (millimolar). C CONSTS(26) is Ca_b in component cleft_space_equations (millimolar). C CONSTS(37) is V_c in component cleft_space_equations (microLitre). C CONSTS(27) is tau_p in component cleft_space_equations (second). C ALGBRC(56) is i_tr in component SR_Ca_uptake_and_release (nanoA). C STATES(22) is Ca_up in component SR_Ca_uptake_and_release (millimolar). C STATES(23) is Ca_rel in component SR_Ca_uptake_and_release (millimolar). C CONSTS(28) is alpha_up in component SR_Ca_uptake_and_release (nanoA). C CONSTS(29) is beta_up in component SR_Ca_uptake_and_release (nanoA). C CONSTS(30) is alpha_rel in component SR_Ca_uptake_and_release (nanoA_per_millimolar). C CONSTS(38) is K1 in component SR_Ca_uptake_and_release (dimensionless). C ALGBRC(52) is K2 in component SR_Ca_uptake_and_release (millimolar). C CONSTS(31) is k_cyca in component SR_Ca_uptake_and_release (millimolar). C CONSTS(32) is k_xcs in component SR_Ca_uptake_and_release (dimensionless). C CONSTS(33) is k_SRCa in component SR_Ca_uptake_and_release (millimolar). C CONSTS(34) is k_rel in component SR_Ca_uptake_and_release (millimolar). C ALGBRC(11) is r_act in component SR_Ca_uptake_and_release (per_second). C ALGBRC(21) is r_inact in component SR_Ca_uptake_and_release (per_second). C STATES(24) is Ca_Calse in component SR_Ca_uptake_and_release (dimensionless). C ALGBRC(51) is phi_Calse in component SR_Ca_uptake_and_release (per_second). C STATES(25) is F1 in component SR_Ca_uptake_and_release (dimensionless). C STATES(26) is F2 in component SR_Ca_uptake_and_release (dimensionless). C STATES(27) is F3 in component SR_Ca_uptake_and_release (dimensionless). C CONSTS(39) is V_up in component SR_Ca_uptake_and_release (microLitre). C CONSTS(40) is V_rel in component SR_Ca_uptake_and_release (microLitre). C RATES(1) is d/dt V in component membrane (millivolt). C RATES(3) is d/dt m in component sodium_current_m_gate (dimensionless). C RATES(4) is d/dt h1 in component sodium_current_h_gate (dimensionless). C RATES(5) is d/dt h2 in component sodium_current_h_gate (dimensionless). C RATES(6) is d/dt d_L in component L_type_Ca_channel_d_gate (dimensionless). C RATES(7) is d/dt f_L in component L_type_Ca_channel_f_gate (dimensionless). C RATES(8) is d/dt d_T in component T_type_Ca_channel_d_gate (dimensionless). C RATES(9) is d/dt f_T in component T_type_Ca_channel_f_gate (dimensionless). C RATES(10) is d/dt P_a in component delayed_rectifying_potassium_current_P_a_gate (dimensionless). C RATES(11) is d/dt P_i in component delayed_rectifying_potassium_current_P_i_gate (dimensionless). C RATES(12) is d/dt y in component hyperpolarisation_activated_current_y_gate (dimensionless). C RATES(18) is d/dt Ca_Calmod in component intracellular_concentrations_and_buffer_equations (dimensionless). C RATES(19) is d/dt Ca_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C RATES(20) is d/dt Ca_Mg_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C RATES(21) is d/dt Mg_Mg_Trop in component intracellular_concentrations_and_buffer_equations (dimensionless). C RATES(13) is d/dt Na_i in component intracellular_concentrations_and_buffer_equations (millimolar). C RATES(17) is d/dt K_i in component intracellular_concentrations_and_buffer_equations (millimolar). C RATES(15) is d/dt Ca_i in component intracellular_concentrations_and_buffer_equations (millimolar). C RATES(2) is d/dt Na_c in component cleft_space_equations (millimolar). C RATES(14) is d/dt K_c in component cleft_space_equations (millimolar). C RATES(16) is d/dt Ca_c in component cleft_space_equations (millimolar). C RATES(24) is d/dt Ca_Calse in component SR_Ca_uptake_and_release (dimensionless). C RATES(25) is d/dt F1 in component SR_Ca_uptake_and_release (dimensionless). C RATES(26) is d/dt F2 in component SR_Ca_uptake_and_release (dimensionless). C RATES(27) is d/dt F3 in component SR_Ca_uptake_and_release (dimensionless). C RATES(22) is d/dt Ca_up in component SR_Ca_uptake_and_release (millimolar). C RATES(23) is d/dt Ca_rel in component SR_Ca_uptake_and_release (millimolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -49.54105 CONSTS(1) = 8314.472 CONSTS(2) = 310 CONSTS(3) = 96485.3415 CONSTS(4) = 5.5e-5 CONSTS(5) = 0.00344 STATES(2) = 139.9988 STATES(3) = 0.250113 STATES(4) = 0.001386897 STATES(5) = 0.002065463 CONSTS(6) = 0.02115 CONSTS(7) = 46.4 STATES(6) = 0.002572773 STATES(7) = 0.98651 CONSTS(8) = 0.02521 CONSTS(9) = 45 STATES(8) = 0.02012114 STATES(9) = 0.1945111 CONSTS(10) = 5.4 STATES(10) = 0.02302278 STATES(11) = 0.3777728 CONSTS(11) = 0.00016 CONSTS(12) = 0.0000364 CONSTS(13) = 0.0000694 CONSTS(14) = 0.0067478 CONSTS(15) = 0.0128821 STATES(12) = 0.09227776 CONSTS(16) = 5.46 CONSTS(17) = 0.621 CONSTS(18) = 0.2192 STATES(13) = 9.701621 STATES(14) = 5.389014 CONSTS(19) = 0.02869 STATES(15) = 3.787018e-4 CONSTS(20) = 0.00001248 CONSTS(21) = 0.0001 CONSTS(22) = 0.5 STATES(16) = 2.00474 STATES(17) = 1.407347e2 STATES(18) = 0.1411678 STATES(19) = 0.07331396 STATES(20) = 0.7618549 STATES(21) = 0.2097049 CONSTS(23) = 2.5 CONSTS(24) = 3.497e-6 CONSTS(25) = 140 CONSTS(26) = 2 CONSTS(27) = 0.01 STATES(22) = 16.95311 STATES(23) = 16.85024 CONSTS(28) = 0.08 CONSTS(29) = 0.072 CONSTS(30) = 0.5 CONSTS(31) = 0.00005 CONSTS(32) = 0.9 CONSTS(33) = 22 CONSTS(34) = 0.004 STATES(24) = 0.9528726 STATES(25) = 0.1133251 STATES(26) = 0.0007594214 STATES(27) = 0.8859153 CONSTS(35) = 0.00693000*CONSTS(10)/1.00000 ** 0.590000 CONSTS(36) = 0.465000*CONSTS(24) CONSTS(37) = 0.136000*CONSTS(24) CONSTS(38) = ( CONSTS(31)*CONSTS(32))/CONSTS(33) CONSTS(39) = 0.0116600*CONSTS(36) CONSTS(40) = 0.00129600*CONSTS(36) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(10) = 1290.00*CONSTS(23)*(1.00000 - (STATES(20)+STATES(21))) - 429.000*STATES(21) RATES(21) = ALGBRC(10) ALGBRC(11) = 240.000*EXP( (STATES(1) - 40.0000)*0.0800000)+ 240.000*STATES(15)/(STATES(15)+CONSTS(34)) ** 4.00000 RATES(25) = 0.960000*STATES(27) - ALGBRC(11)*STATES(25) ALGBRC(17) = 1.00000/( 17.0000*EXP( 0.0398000*STATES(1))+ 2.11000*EXP( - 0.0510000*STATES(1))) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+5.10000)/- 7.40000)) RATES(10) = (ALGBRC(6) - STATES(10))/ALGBRC(17) ALGBRC(7) = 100.000*EXP( - 0.0183000*STATES(1)) ALGBRC(18) = 656.000*EXP( 0.00942000*STATES(1)) RATES(11) = ALGBRC(7)*(1.00000 - STATES(11)) - ALGBRC(18)*STATES(11) ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+72.2000)/9.00000)) ALGBRC(19) = 1.00000/( 1.64830*EXP((STATES(1)+54.0600)/- 24.3300)+14.0106/(0.700000+EXP((STATES(1)+60.0000)/- 5.50000))) RATES(12) = (ALGBRC(8) - STATES(12))/ALGBRC(19) ALGBRC(21) = 40.0000+ 240.000*STATES(15)/(STATES(15)+CONSTS(34)) ** 4.00000 RATES(26) = ALGBRC(11)*STATES(25) - ALGBRC(21)*STATES(26) RATES(27) = ALGBRC(21)*STATES(26) - 0.960000*STATES(27) ALGBRC(1) = ( - 824.000*(STATES(1)+51.9000))/(EXP((STATES(1)+51.9000)/- 8.90000) - 1.00000) ALGBRC(12) = 32960.0*EXP((STATES(1)+51.9000)/- 8.90000) ALGBRC(22) = ALGBRC(1)/(ALGBRC(1)+ALGBRC(12)) ALGBRC(28) = 1.00000/(ALGBRC(1)+ALGBRC(12))+1.50000e-05 RATES(3) = (ALGBRC(22) - STATES(3))/ALGBRC(28) ALGBRC(2) = 165.000*EXP((STATES(1)+101.300)/- 12.6000) ALGBRC(13) = 12360.0/( 320.000*EXP((STATES(1)+101.300)/- 12.6000)+1.00000) ALGBRC(23) = ALGBRC(2)/(ALGBRC(2)+ALGBRC(13)) ALGBRC(29) = 1.00000/(ALGBRC(2)+ALGBRC(13)) RATES(4) = (ALGBRC(23) - STATES(4))/ALGBRC(29) ALGBRC(33) = 1.00000/(1.00000+EXP((STATES(1)+14.1000)/- 6.00000)) ALGBRC(9) = ( - 28.3900*(STATES(1)+35.0000))/(EXP((STATES(1)+35.0000)/- 2.50000) - 1.00000)+( - 84.9000*STATES(1))/(EXP( - 0.208000*STATES(1)) - 1.00000) ALGBRC(20) = ( 11.4300*(STATES(1) - 5.00000))/(EXP( 0.400000*(STATES(1) - 5.00000)) - 1.00000) ALGBRC(27) = 1.00000/(ALGBRC(9)+ALGBRC(20)) RATES(6) = (ALGBRC(33) - STATES(6))/ALGBRC(27) ALGBRC(30) = 1.00000/(1.00000+EXP((STATES(1)+30.0000)/5.00000)) ALGBRC(3) = ( 3.75000*(STATES(1)+28.0000))/(EXP((STATES(1)+28.0000)/4.00000) - 1.00000) ALGBRC(14) = 30.0000/(1.00000+EXP((STATES(1)+28.0000)/- 4.00000)) ALGBRC(24) = 1.00000/(ALGBRC(3)+ALGBRC(14)) RATES(7) = (ALGBRC(30) - STATES(7))/ALGBRC(24) ALGBRC(31) = 1.00000/(1.00000+EXP((STATES(1)+26.3000)/- 6.00000)) ALGBRC(4) = 1068.00*EXP((STATES(1)+26.3000)/30.0000) ALGBRC(15) = 1068.00*EXP((STATES(1)+26.3000)/- 30.0000) ALGBRC(25) = 1.00000/(ALGBRC(4)+ALGBRC(15)) RATES(8) = (ALGBRC(31) - STATES(8))/ALGBRC(25) ALGBRC(32) = 1.00000/(1.00000+EXP((STATES(1)+61.7000)/5.60000)) ALGBRC(5) = 15.3000*EXP((STATES(1)+61.7000)/- 83.3000) ALGBRC(16) = 15.0000*EXP((STATES(1)+61.7000)/15.3800) ALGBRC(26) = 1.00000/(ALGBRC(5)+ALGBRC(16)) RATES(9) = (ALGBRC(32) - STATES(9))/ALGBRC(26) ALGBRC(34) = ALGBRC(23) ALGBRC(36) = 20.0000*ALGBRC(29) RATES(5) = (ALGBRC(34) - STATES(5))/ALGBRC(36) ALGBRC(44) = 129000.*STATES(15)*(1.00000 - STATES(18)) - 307.000*STATES(18) RATES(18) = ALGBRC(44) ALGBRC(45) = 50500.0*STATES(15)*(1.00000 - STATES(19)) - 252.000*STATES(19) RATES(19) = ALGBRC(45) ALGBRC(46) = 129000.*STATES(15)*(1.00000 - (STATES(20)+STATES(21))) - 4.25000*STATES(20) RATES(20) = ALGBRC(46) ALGBRC(51) = 770.000*STATES(23)*(1.00000 - STATES(24)) - 641.000*STATES(24) RATES(24) = ALGBRC(51) ALGBRC(52) = STATES(15)+ STATES(22)*CONSTS(38)+ CONSTS(31)*CONSTS(32)+CONSTS(31) ALGBRC(53) = ( CONSTS(28)*STATES(15) - CONSTS(29)*STATES(22)*CONSTS(38))/ALGBRC(52) ALGBRC(56) = ( (STATES(22) - STATES(23))*2.00000*CONSTS(3)*CONSTS(39))/0.0641800 RATES(22) = (ALGBRC(53) - ALGBRC(56))/( 2.00000*CONSTS(39)*CONSTS(3)) ALGBRC(54) = CONSTS(30)*STATES(26)/(STATES(26)+0.250000) ** 2.00000*STATES(23) RATES(23) = (ALGBRC(56) - ALGBRC(54))/( 2.00000*CONSTS(40)*CONSTS(3)) - 11.4800*ALGBRC(51) ALGBRC(55) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(2)/STATES(13)) ALGBRC(57) = ( (( CONSTS(5)*STATES(3) ** 3.00000*STATES(4)*STATES(5)*STATES(2)*STATES(1)*CONSTS(3) ** 2.00000)/( CONSTS(1)*CONSTS(2)))*(EXP(( (STATES(1) - ALGBRC(55))*CONSTS(3))/( CONSTS(1)*CONSTS(2))) - 1.00000))/(EXP(( STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2))) - 1.00000) ALGBRC(41) = ( CONSTS(18)*STATES(13)/(CONSTS(16)+STATES(13)) ** 3.00000*STATES(14)/(CONSTS(17)+STATES(14)) ** 2.00000*1.60000)/(1.50000+EXP((STATES(1)+60.0000)/- 40.0000)) ALGBRC(43) = ( CONSTS(20)*( STATES(13) ** 3.00000*STATES(16)*EXP( 0.0374300*STATES(1)*CONSTS(22)) - STATES(2) ** 3.00000*STATES(15)*EXP( 0.0374300*STATES(1)*(CONSTS(22) - 1.00000))))/(1.00000+ CONSTS(21)*( STATES(15)*STATES(2) ** 3.00000+ STATES(16)*STATES(13) ** 3.00000)) ALGBRC(58) = CONSTS(11)*(STATES(1) - ALGBRC(55)) ALGBRC(38) = CONSTS(14)*STATES(12) ** 2.00000*(STATES(1) - 75.0000) RATES(13) = - ( 3.00000*ALGBRC(41)+ 3.00000*ALGBRC(43)+ALGBRC(58)+ALGBRC(38)+ALGBRC(57))/( CONSTS(3)*CONSTS(36)) RATES(2) = (CONSTS(25) - STATES(2))/CONSTS(27)+(ALGBRC(57)+ 3.00000*ALGBRC(43)+ 3.00000*ALGBRC(41)+ALGBRC(58)+ALGBRC(38))/( CONSTS(3)*CONSTS(37)) ALGBRC(59) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(14)/STATES(17)) ALGBRC(60) = CONSTS(35)*STATES(10)*STATES(11)*(STATES(1) - ALGBRC(59)) ALGBRC(61) = CONSTS(13)*(STATES(1) - ALGBRC(59)) ALGBRC(39) = CONSTS(15)*STATES(12) ** 2.00000*(STATES(1)+85.0000) RATES(17) = ( 2.00000*ALGBRC(41) - (ALGBRC(60)+ALGBRC(39)+ALGBRC(61)))/( CONSTS(3)*CONSTS(36)) RATES(14) = (CONSTS(10) - STATES(14))/CONSTS(27)+( - 2.00000*ALGBRC(41)+ALGBRC(60)+ALGBRC(61)+ALGBRC(39))/( CONSTS(3)*CONSTS(37)) ALGBRC(37) = CONSTS(8)*STATES(8)*STATES(9)*(STATES(1) - CONSTS(9)) ALGBRC(35) = CONSTS(6)*( STATES(7)*STATES(6)+ 0.0950000*ALGBRC(33))*(STATES(1) - CONSTS(7)) ALGBRC(42) = ( CONSTS(19)*STATES(15))/(STATES(15)+0.000400000) ALGBRC(62) = (( 0.500000*CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(16)/STATES(15)) ALGBRC(63) = CONSTS(12)*(STATES(1) - ALGBRC(62)) ALGBRC(47) = 0.0900000*ALGBRC(44) ALGBRC(48) = 0.0310000*ALGBRC(45) ALGBRC(49) = 0.0620000*ALGBRC(46) ALGBRC(50) = ALGBRC(47)+ALGBRC(48)+ALGBRC(49) RATES(15) = (( 2.00000*ALGBRC(43)+ALGBRC(54)) - (ALGBRC(35)+ALGBRC(37)+ALGBRC(42)+ALGBRC(63)+ALGBRC(53)))/( 2.00000*CONSTS(36)*CONSTS(3)) - ALGBRC(50) RATES(16) = (CONSTS(26) - STATES(16))/CONSTS(27)+( - 2.00000*ALGBRC(43)+ALGBRC(35)+ALGBRC(37)+ALGBRC(42)+ALGBRC(63))/( 2.00000*CONSTS(3)*CONSTS(37)) ALGBRC(40) = ALGBRC(38)+ALGBRC(39) ALGBRC(64) = ALGBRC(58)+ALGBRC(63)+ALGBRC(61) RATES(1) = - (ALGBRC(57)+ALGBRC(37)+ALGBRC(35)+ALGBRC(60)+ALGBRC(40)+ALGBRC(64)+ALGBRC(41)+ALGBRC(43)+ALGBRC(42))/CONSTS(4) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(10) = 1290.00*CONSTS(23)*(1.00000 - (STATES(20)+STATES(21))) - 429.000*STATES(21) ALGBRC(11) = 240.000*EXP( (STATES(1) - 40.0000)*0.0800000)+ 240.000*STATES(15)/(STATES(15)+CONSTS(34)) ** 4.00000 ALGBRC(17) = 1.00000/( 17.0000*EXP( 0.0398000*STATES(1))+ 2.11000*EXP( - 0.0510000*STATES(1))) ALGBRC(6) = 1.00000/(1.00000+EXP((STATES(1)+5.10000)/- 7.40000)) ALGBRC(7) = 100.000*EXP( - 0.0183000*STATES(1)) ALGBRC(18) = 656.000*EXP( 0.00942000*STATES(1)) ALGBRC(8) = 1.00000/(1.00000+EXP((STATES(1)+72.2000)/9.00000)) ALGBRC(19) = 1.00000/( 1.64830*EXP((STATES(1)+54.0600)/- 24.3300)+14.0106/(0.700000+EXP((STATES(1)+60.0000)/- 5.50000))) ALGBRC(21) = 40.0000+ 240.000*STATES(15)/(STATES(15)+CONSTS(34)) ** 4.00000 ALGBRC(1) = ( - 824.000*(STATES(1)+51.9000))/(EXP((STATES(1)+51.9000)/- 8.90000) - 1.00000) ALGBRC(12) = 32960.0*EXP((STATES(1)+51.9000)/- 8.90000) ALGBRC(22) = ALGBRC(1)/(ALGBRC(1)+ALGBRC(12)) ALGBRC(28) = 1.00000/(ALGBRC(1)+ALGBRC(12))+1.50000e-05 ALGBRC(2) = 165.000*EXP((STATES(1)+101.300)/- 12.6000) ALGBRC(13) = 12360.0/( 320.000*EXP((STATES(1)+101.300)/- 12.6000)+1.00000) ALGBRC(23) = ALGBRC(2)/(ALGBRC(2)+ALGBRC(13)) ALGBRC(29) = 1.00000/(ALGBRC(2)+ALGBRC(13)) ALGBRC(33) = 1.00000/(1.00000+EXP((STATES(1)+14.1000)/- 6.00000)) ALGBRC(9) = ( - 28.3900*(STATES(1)+35.0000))/(EXP((STATES(1)+35.0000)/- 2.50000) - 1.00000)+( - 84.9000*STATES(1))/(EXP( - 0.208000*STATES(1)) - 1.00000) ALGBRC(20) = ( 11.4300*(STATES(1) - 5.00000))/(EXP( 0.400000*(STATES(1) - 5.00000)) - 1.00000) ALGBRC(27) = 1.00000/(ALGBRC(9)+ALGBRC(20)) ALGBRC(30) = 1.00000/(1.00000+EXP((STATES(1)+30.0000)/5.00000)) ALGBRC(3) = ( 3.75000*(STATES(1)+28.0000))/(EXP((STATES(1)+28.0000)/4.00000) - 1.00000) ALGBRC(14) = 30.0000/(1.00000+EXP((STATES(1)+28.0000)/- 4.00000)) ALGBRC(24) = 1.00000/(ALGBRC(3)+ALGBRC(14)) ALGBRC(31) = 1.00000/(1.00000+EXP((STATES(1)+26.3000)/- 6.00000)) ALGBRC(4) = 1068.00*EXP((STATES(1)+26.3000)/30.0000) ALGBRC(15) = 1068.00*EXP((STATES(1)+26.3000)/- 30.0000) ALGBRC(25) = 1.00000/(ALGBRC(4)+ALGBRC(15)) ALGBRC(32) = 1.00000/(1.00000+EXP((STATES(1)+61.7000)/5.60000)) ALGBRC(5) = 15.3000*EXP((STATES(1)+61.7000)/- 83.3000) ALGBRC(16) = 15.0000*EXP((STATES(1)+61.7000)/15.3800) ALGBRC(26) = 1.00000/(ALGBRC(5)+ALGBRC(16)) ALGBRC(34) = ALGBRC(23) ALGBRC(36) = 20.0000*ALGBRC(29) ALGBRC(44) = 129000.*STATES(15)*(1.00000 - STATES(18)) - 307.000*STATES(18) ALGBRC(45) = 50500.0*STATES(15)*(1.00000 - STATES(19)) - 252.000*STATES(19) ALGBRC(46) = 129000.*STATES(15)*(1.00000 - (STATES(20)+STATES(21))) - 4.25000*STATES(20) ALGBRC(51) = 770.000*STATES(23)*(1.00000 - STATES(24)) - 641.000*STATES(24) ALGBRC(52) = STATES(15)+ STATES(22)*CONSTS(38)+ CONSTS(31)*CONSTS(32)+CONSTS(31) ALGBRC(53) = ( CONSTS(28)*STATES(15) - CONSTS(29)*STATES(22)*CONSTS(38))/ALGBRC(52) ALGBRC(56) = ( (STATES(22) - STATES(23))*2.00000*CONSTS(3)*CONSTS(39))/0.0641800 ALGBRC(54) = CONSTS(30)*STATES(26)/(STATES(26)+0.250000) ** 2.00000*STATES(23) ALGBRC(55) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(2)/STATES(13)) ALGBRC(57) = ( (( CONSTS(5)*STATES(3) ** 3.00000*STATES(4)*STATES(5)*STATES(2)*STATES(1)*CONSTS(3) ** 2.00000)/( CONSTS(1)*CONSTS(2)))*(EXP(( (STATES(1) - ALGBRC(55))*CONSTS(3))/( CONSTS(1)*CONSTS(2))) - 1.00000))/(EXP(( STATES(1)*CONSTS(3))/( CONSTS(1)*CONSTS(2))) - 1.00000) ALGBRC(41) = ( CONSTS(18)*STATES(13)/(CONSTS(16)+STATES(13)) ** 3.00000*STATES(14)/(CONSTS(17)+STATES(14)) ** 2.00000*1.60000)/(1.50000+EXP((STATES(1)+60.0000)/- 40.0000)) ALGBRC(43) = ( CONSTS(20)*( STATES(13) ** 3.00000*STATES(16)*EXP( 0.0374300*STATES(1)*CONSTS(22)) - STATES(2) ** 3.00000*STATES(15)*EXP( 0.0374300*STATES(1)*(CONSTS(22) - 1.00000))))/(1.00000+ CONSTS(21)*( STATES(15)*STATES(2) ** 3.00000+ STATES(16)*STATES(13) ** 3.00000)) ALGBRC(58) = CONSTS(11)*(STATES(1) - ALGBRC(55)) ALGBRC(38) = CONSTS(14)*STATES(12) ** 2.00000*(STATES(1) - 75.0000) ALGBRC(59) = (( CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(14)/STATES(17)) ALGBRC(60) = CONSTS(35)*STATES(10)*STATES(11)*(STATES(1) - ALGBRC(59)) ALGBRC(61) = CONSTS(13)*(STATES(1) - ALGBRC(59)) ALGBRC(39) = CONSTS(15)*STATES(12) ** 2.00000*(STATES(1)+85.0000) ALGBRC(37) = CONSTS(8)*STATES(8)*STATES(9)*(STATES(1) - CONSTS(9)) ALGBRC(35) = CONSTS(6)*( STATES(7)*STATES(6)+ 0.0950000*ALGBRC(33))*(STATES(1) - CONSTS(7)) ALGBRC(42) = ( CONSTS(19)*STATES(15))/(STATES(15)+0.000400000) ALGBRC(62) = (( 0.500000*CONSTS(1)*CONSTS(2))/CONSTS(3))*log(STATES(16)/STATES(15)) ALGBRC(63) = CONSTS(12)*(STATES(1) - ALGBRC(62)) ALGBRC(47) = 0.0900000*ALGBRC(44) ALGBRC(48) = 0.0310000*ALGBRC(45) ALGBRC(49) = 0.0620000*ALGBRC(46) ALGBRC(50) = ALGBRC(47)+ALGBRC(48)+ALGBRC(49) ALGBRC(40) = ALGBRC(38)+ALGBRC(39) ALGBRC(64) = ALGBRC(58)+ALGBRC(63)+ALGBRC(61) RETURN END