/* There are a total of 15 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 29 entries in the constant variable array. */ /* * VOI is time in component environment (millisecond). * CONSTANTS[0] is A_iso in component parameters (mN_per_mm2_per_mM). * CONSTANTS[1] is k_off in component parameters (per_msec). * CONSTANTS[2] is k_on in component parameters (per_mM_per_msec). * CONSTANTS[3] is k_onI in component parameters (per_msec). * CONSTANTS[4] is k_offi in component parameters (per_msec). * CONSTANTS[5] is k_OFF in component parameters (dimensionless). * CONSTANTS[6] is k_xboff in component parameters (dimensionless). * CONSTANTS[7] is k_tmoff in component parameters (per_msec). * CONSTANTS[8] is k_tmonc in component parameters (per_msec). * CONSTANTS[9] is k_tmRU in component parameters (dimensionless). * CONSTANTS[10] is k_tmxb in component parameters (dimensionless). * CONSTANTS[11] is k_12 in component parameters (per_mM_per_msec). * CONSTANTS[12] is k_minus12 in component parameters (per_msec). * CONSTANTS[13] is k_Titin in component parameters (dimensionless). * CONSTANTS[14] is k_3c in component parameters (per_msec). * CONSTANTS[15] is k_3f in component parameters (dimensionless). * CONSTANTS[16] is k_3xb in component parameters (dimensionless). * CONSTANTS[17] is k_minus3 in component parameters (per_msec). * CONSTANTS[18] is k_4 in component parameters (per_msec). * CONSTANTS[19] is k_minus4 in component parameters (per_msec). * CONSTANTS[20] is k_5 in component parameters (per_msec). * ALGEBRAIC[0] is F_b in component active_force (mN_per_mm2). * STATES[0] is RUA_MADPPi in component RU_species (mM). * STATES[1] is RUA_MADP in component RU_species (mM). * ALGEBRAIC[8] is Q_CaB in component Ca_binding_rate (mM_per_msec). * ALGEBRAIC[4] is RUNA in component RU_species (mM). * STATES[2] is Ca in component RU_species (mM). * STATES[3] is RUTCa_off in component RU_species (mM). * ALGEBRAIC[13] is Q_TCaA in component TnI_conf_change_rate (mM_per_msec). * ALGEBRAIC[9] is k_offI in component TnI_conf_change_rate (per_msec). * STATES[4] is RUTCa_on in component RU_species (mM). * ALGEBRAIC[5] is RUA in component RU_species (mM). * CONSTANTS[21] is RU_total in component RU_species (mM). * ALGEBRAIC[10] is Q_TMA in component Tm_conf_change_rate (mM_per_msec). * ALGEBRAIC[1] is k_tmon in component Tm_conf_change_rate (per_msec). * STATES[5] is RUTM_on in component RU_species (mM). * ALGEBRAIC[11] is Q_MB in component myosin_binding_rate (mM_per_msec). * CONSTANTS[28] is KTitin in component KTitin (dimensionless). * CONSTANTS[24] is L in component length (mmeter). * CONSTANTS[22] is L_0 in component length (mmeter). * CONSTANTS[23] is MADPPi in component RU_species (mM). * ALGEBRAIC[6] is RUTM_on_eff in component RU_species (mM). * STATES[6] is RUAMADPPi in component RU_species (mM). * CONSTANTS[25] is f_titinNormal in component KTitin (dimensionless). * CONSTANTS[27] is f_titinDamaged in component KTitin (dimensionless). * ALGEBRAIC[14] is Q_Fgen in component Force_Generating_rate (mM_per_msec). * ALGEBRAIC[12] is k_3 in component Force_Generating_rate (per_msec). * ALGEBRAIC[7] is RUTCa_on_eff in component RU_species (mM). * ALGEBRAIC[2] is Q_PiR in component Pi_release_rate (mM_per_msec). * ALGEBRAIC[3] is Q_ADPR in component ADP_release_rate (mM_per_msec). * CONSTANTS[26] is alpha in component alpha (dimensionless). * RATES[3] is d/dt RUTCa_off in component RU_species (mM). * RATES[4] is d/dt RUTCa_on in component RU_species (mM). * RATES[5] is d/dt RUTM_on in component RU_species (mM). * RATES[6] is d/dt RUAMADPPi in component RU_species (mM). * RATES[0] is d/dt RUA_MADPPi in component RU_species (mM). * RATES[1] is d/dt RUA_MADP in component RU_species (mM). * RATES[2] is d/dt Ca in component RU_species (mM). * There are a total of 0 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 9000; CONSTANTS[1] = 0.2; CONSTANTS[2] = 17.3; CONSTANTS[3] = 0.2; CONSTANTS[4] = 0.075; CONSTANTS[5] = -0.32; CONSTANTS[6] = -1.37; CONSTANTS[7] = 0.067; CONSTANTS[8] = 0.014; CONSTANTS[9] = 10; CONSTANTS[10] = -1.86; CONSTANTS[11] = 2; CONSTANTS[12] = 0.6; CONSTANTS[13] = 0.2; CONSTANTS[14] = 0.025; CONSTANTS[15] = 50; CONSTANTS[16] = -1.23; CONSTANTS[17] = 0.008; CONSTANTS[18] = 0.077; CONSTANTS[19] = 0.001; CONSTANTS[20] = 0.03723; STATES[0] = 0; STATES[1] = 0; STATES[2] = 0.01; STATES[3] = 0; STATES[4] = 0; CONSTANTS[21] = 0.0726; STATES[5] = 0; CONSTANTS[22] = 0.001; CONSTANTS[23] = 0.1375; STATES[6] = 0; CONSTANTS[24] = CONSTANTS[22]; CONSTANTS[25] = CONSTANTS[13]*(9.96630/(1.00000+exp((CONSTANTS[24]/CONSTANTS[22]+1.06390)/0.0696000))); CONSTANTS[26] = (CONSTANTS[24]<1.00000 ? 1.50000*(CONSTANTS[24]/CONSTANTS[22]) - 0.500000 : 1.00000<=CONSTANTS[24]&&CONSTANTS[24]<1.10000 ? 1.00000 : - 1.60000*(CONSTANTS[24]/CONSTANTS[22])+2.76000); CONSTANTS[27] = CONSTANTS[13]*( - 31.0000*(CONSTANTS[24]/CONSTANTS[22])+40.0000); CONSTANTS[28] = (CONSTANTS[24]<=1.10000 ? CONSTANTS[25] : CONSTANTS[27]); RATES[3] = 0.1001; RATES[4] = 0.1001; RATES[5] = 0.1001; RATES[6] = 0.1001; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[3] - ALGEBRAIC[8] - ALGEBRAIC[13]; resid[1] = RATES[4] - ALGEBRAIC[13] - ALGEBRAIC[10]; resid[2] = RATES[5] - (ALGEBRAIC[10] - ALGEBRAIC[11])+ALGEBRAIC[3]; resid[3] = RATES[6] - ALGEBRAIC[11] - ALGEBRAIC[14]; resid[4] = RATES[0] - ALGEBRAIC[14] - ALGEBRAIC[2]; resid[5] = RATES[1] - ALGEBRAIC[2] - ALGEBRAIC[3]; resid[6] = RATES[2] - - ALGEBRAIC[8]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[0]*(STATES[0]+STATES[1]); } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[2] = CONSTANTS[18]*STATES[0] - CONSTANTS[19]*STATES[1]; ALGEBRAIC[3] = CONSTANTS[20]*STATES[1]; ALGEBRAIC[4] = CONSTANTS[21] - (STATES[3]+STATES[4]+STATES[5]+STATES[6]+STATES[0]+STATES[1]); ALGEBRAIC[8] = CONSTANTS[2]*ALGEBRAIC[4]*STATES[2] - CONSTANTS[1]*STATES[3]; ALGEBRAIC[1] = CONSTANTS[8]*(STATES[4]/CONSTANTS[21])*pow(1.00000+ CONSTANTS[9]*(STATES[5]/CONSTANTS[21]), 2.00000)*pow(1.00000+ CONSTANTS[10]*((STATES[0]+STATES[1])/CONSTANTS[21]), 2.00000); ALGEBRAIC[10] = ALGEBRAIC[1]*STATES[4] - CONSTANTS[7]*STATES[5]; ALGEBRAIC[6] = CONSTANTS[26]*STATES[5]; ALGEBRAIC[11] = CONSTANTS[11]*CONSTANTS[28]*CONSTANTS[23]*ALGEBRAIC[6] - CONSTANTS[12]*STATES[6]; ALGEBRAIC[5] = STATES[4]+STATES[5]+STATES[6]+STATES[0]+STATES[1]; ALGEBRAIC[9] = CONSTANTS[4]*pow(1.00000+ CONSTANTS[5]*(ALGEBRAIC[5]/CONSTANTS[21]), 2.00000)*pow(1.00000+ CONSTANTS[6]*((STATES[0]+STATES[1])/CONSTANTS[21]), 4.40000); ALGEBRAIC[13] = CONSTANTS[3]*STATES[3] - ALGEBRAIC[9]*STATES[4]; ALGEBRAIC[7] = CONSTANTS[26]*STATES[4]; ALGEBRAIC[12] = CONSTANTS[14]*pow(1.00000+( CONSTANTS[15]*(ALGEBRAIC[7]+ALGEBRAIC[6]+STATES[6]))/CONSTANTS[21], 2.00000)*pow(1.00000+( CONSTANTS[16]*(STATES[0]+STATES[1]))/CONSTANTS[21], 2.00000); ALGEBRAIC[14] = ALGEBRAIC[12]*STATES[6] - CONSTANTS[17]*STATES[0]; } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { }