/* There are a total of 41 entries in the algebraic variable array. There are a total of 16 entries in each of the rate and state variable arrays. There are a total of 54 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is R in component membrane (joule_per_kilomole_kelvin). * CONSTANTS[1] is T in component membrane (kelvin). * CONSTANTS[2] is F in component membrane (coulomb_per_mole). * CONSTANTS[49] is RTONF in component membrane (millivolt). * CONSTANTS[3] is C_m in component membrane (microF). * ALGEBRAIC[26] is i_b_K in component potassium_background_current (nanoA). * ALGEBRAIC[27] is i_K1 in component time_independent_potassium_current (nanoA). * ALGEBRAIC[18] is i_to in component transient_outward_current (nanoA). * ALGEBRAIC[22] is i_b_Na in component sodium_background_current (nanoA). * ALGEBRAIC[24] is i_b_Ca in component calcium_background_current (nanoA). * ALGEBRAIC[20] is i_NaK in component sodium_potassium_pump (nanoA). * ALGEBRAIC[25] is i_NaCa in component Na_Ca_exchanger (nanoA). * ALGEBRAIC[14] is i_Na in component fast_sodium_current (nanoA). * ALGEBRAIC[38] is i_Ca_L in component L_type_calcium_current (nanoA). * ALGEBRAIC[4] is i_Stim in component membrane (nanoA). * CONSTANTS[4] is stim_start in component membrane (second). * CONSTANTS[5] is stim_end in component membrane (second). * CONSTANTS[6] is stim_period in component membrane (second). * CONSTANTS[7] is stim_duration in component membrane (second). * CONSTANTS[8] is stim_amplitude in component membrane (nanoA). * CONSTANTS[9] is g_Na in component fast_sodium_current (microS). * ALGEBRAIC[10] is E_mh in component fast_sodium_current (millivolt). * CONSTANTS[10] is Na_o in component extracellular_sodium_concentration (millimolar). * STATES[1] is Na_i in component intracellular_sodium_concentration (millimolar). * CONSTANTS[11] is K_c in component extracellular_potassium_concentration (millimolar). * STATES[2] is K_i in component intracellular_potassium_concentration (millimolar). * STATES[3] is m in component fast_sodium_current_m_gate (dimensionless). * STATES[4] is h in component fast_sodium_current_h_gate (dimensionless). * ALGEBRAIC[6] is alpha_m in component fast_sodium_current_m_gate (per_second). * ALGEBRAIC[12] is beta_m in component fast_sodium_current_m_gate (per_second). * CONSTANTS[12] is delta_m in component fast_sodium_current_m_gate (millivolt). * ALGEBRAIC[0] is E0_m in component fast_sodium_current_m_gate (millivolt). * ALGEBRAIC[1] is alpha_h in component fast_sodium_current_h_gate (per_second). * ALGEBRAIC[7] is beta_h in component fast_sodium_current_h_gate (per_second). * CONSTANTS[13] is g_to in component transient_outward_current (microS). * ALGEBRAIC[16] is E_K in component transient_outward_current (millivolt). * CONSTANTS[14] is g_to_s in component transient_outward_current (dimensionless). * STATES[5] is r in component transient_outward_current_r_gate (dimensionless). * STATES[6] is s in component transient_outward_current_s_gate (dimensionless). * ALGEBRAIC[2] is alpha_s in component transient_outward_current_s_gate (per_second). * ALGEBRAIC[8] is beta_s in component transient_outward_current_s_gate (per_second). * CONSTANTS[15] is i_NaK_max in component sodium_potassium_pump (nanoA). * CONSTANTS[16] is K_mK in component sodium_potassium_pump (millimolar). * CONSTANTS[17] is K_mNa in component sodium_potassium_pump (millimolar). * ALGEBRAIC[21] is E_Na in component sodium_background_current (millivolt). * CONSTANTS[18] is g_b_Na in component sodium_background_current (microS). * ALGEBRAIC[23] is E_Ca in component calcium_background_current (millivolt). * CONSTANTS[19] is g_b_Ca in component calcium_background_current (microS). * CONSTANTS[20] is Ca_o in component extracellular_calcium_concentration (millimolar). * STATES[7] is Ca_i in component intracellular_calcium_concentration (millimolar). * CONSTANTS[21] is k_NaCa in component Na_Ca_exchanger (nanoA). * CONSTANTS[22] is n_NaCa in component Na_Ca_exchanger (dimensionless). * CONSTANTS[23] is d_NaCa in component Na_Ca_exchanger (dimensionless). * CONSTANTS[24] is gamma in component Na_Ca_exchanger (dimensionless). * CONSTANTS[25] is g_b_K in component potassium_background_current (microS). * CONSTANTS[26] is g_K1 in component time_independent_potassium_current (microS). * CONSTANTS[27] is K_m_K1 in component time_independent_potassium_current (millimolar). * ALGEBRAIC[33] is i_Ca_L_Ca in component L_type_calcium_current (nanoA). * ALGEBRAIC[34] is i_Ca_L_K in component L_type_calcium_current (nanoA). * ALGEBRAIC[36] is i_Ca_L_Na in component L_type_calcium_current (nanoA). * CONSTANTS[28] is P_Ca_L in component L_type_calcium_current (nanoA_per_millimolar). * STATES[8] is d in component L_type_calcium_current_d_gate (dimensionless). * STATES[9] is f_Ca in component L_type_calcium_current_f_Ca_gate (dimensionless). * ALGEBRAIC[32] is CaChon in component L_type_calcium_current_f_Ca_gate (dimensionless). * ALGEBRAIC[9] is alpha_d in component L_type_calcium_current_d_gate (per_second). * ALGEBRAIC[13] is beta_d in component L_type_calcium_current_d_gate (per_second). * ALGEBRAIC[3] is E0_d in component L_type_calcium_current_d_gate (millivolt). * ALGEBRAIC[29] is alpha_f_Ca in component L_type_calcium_current_f_Ca_gate (per_second). * ALGEBRAIC[30] is beta_f_Ca in component L_type_calcium_current_f_Ca_gate (per_second). * ALGEBRAIC[31] is CaChoff in component L_type_calcium_current_f_Ca_gate (dimensionless). * ALGEBRAIC[28] is E0_f in component L_type_calcium_current_f_Ca_gate (millivolt). * ALGEBRAIC[37] is i_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * CONSTANTS[51] is K_1 in component sarcoplasmic_reticulum_calcium_pump (dimensionless). * ALGEBRAIC[35] is K_2 in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[29] is K_cyca in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[30] is K_xcs in component sarcoplasmic_reticulum_calcium_pump (dimensionless). * CONSTANTS[31] is K_srca in component sarcoplasmic_reticulum_calcium_pump (millimolar). * CONSTANTS[32] is alpha_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * CONSTANTS[33] is beta_up in component sarcoplasmic_reticulum_calcium_pump (millimolar_per_second). * STATES[10] is Ca_up in component intracellular_calcium_concentration (millimolar). * ALGEBRAIC[39] is i_rel in component calcium_release (millimolar_per_second). * ALGEBRAIC[11] is VoltDep in component calcium_release (dimensionless). * ALGEBRAIC[15] is RegBindSite in component calcium_release (dimensionless). * ALGEBRAIC[17] is ActRate in component calcium_release (per_second). * ALGEBRAIC[19] is InactRate in component calcium_release (per_second). * CONSTANTS[34] is K_leak_rate in component calcium_release (per_second). * CONSTANTS[35] is K_m_rel in component calcium_release (per_second). * ALGEBRAIC[5] is PrecFrac in component calcium_release (dimensionless). * STATES[11] is ActFrac in component calcium_release (dimensionless). * STATES[12] is ProdFrac in component calcium_release (dimensionless). * CONSTANTS[36] is ProdFracRate in component calcium_release (per_second). * STATES[13] is Ca_rel in component intracellular_calcium_concentration (millimolar). * ALGEBRAIC[40] is i_trans in component calcium_translocation (millimolar_per_second). * CONSTANTS[37] is alpha_tr in component calcium_translocation (per_second). * CONSTANTS[53] is V_i in component intracellular_calcium_concentration (micrometre3). * STATES[14] is Ca_Calmod in component intracellular_calcium_concentration (millimolar). * STATES[15] is Ca_Trop in component intracellular_calcium_concentration (millimolar). * CONSTANTS[38] is Calmod in component intracellular_calcium_concentration (millimolar). * CONSTANTS[39] is Trop in component intracellular_calcium_concentration (millimolar). * CONSTANTS[40] is alpha_Calmod in component intracellular_calcium_concentration (per_millimolar_second). * CONSTANTS[41] is beta_Calmod in component intracellular_calcium_concentration (per_second). * CONSTANTS[42] is alpha_Trop in component intracellular_calcium_concentration (per_millimolar_second). * CONSTANTS[43] is beta_Trop in component intracellular_calcium_concentration (per_second). * CONSTANTS[44] is radius in component intracellular_calcium_concentration (micrometre). * CONSTANTS[45] is length in component intracellular_calcium_concentration (micrometre). * CONSTANTS[50] is V_Cell in component intracellular_calcium_concentration (micrometre3). * CONSTANTS[52] is V_i_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[46] is V_rel_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[47] is V_e_ratio in component intracellular_calcium_concentration (dimensionless). * CONSTANTS[48] is V_up_ratio in component intracellular_calcium_concentration (dimensionless). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[3] is d/dt m in component fast_sodium_current_m_gate (dimensionless). * RATES[4] is d/dt h in component fast_sodium_current_h_gate (dimensionless). * RATES[5] is d/dt r in component transient_outward_current_r_gate (dimensionless). * RATES[6] is d/dt s in component transient_outward_current_s_gate (dimensionless). * RATES[8] is d/dt d in component L_type_calcium_current_d_gate (dimensionless). * RATES[9] is d/dt f_Ca in component L_type_calcium_current_f_Ca_gate (dimensionless). * RATES[11] is d/dt ActFrac in component calcium_release (dimensionless). * RATES[12] is d/dt ProdFrac in component calcium_release (dimensionless). * RATES[1] is d/dt Na_i in component intracellular_sodium_concentration (millimolar). * RATES[2] is d/dt K_i in component intracellular_potassium_concentration (millimolar). * RATES[7] is d/dt Ca_i in component intracellular_calcium_concentration (millimolar). * RATES[14] is d/dt Ca_Calmod in component intracellular_calcium_concentration (millimolar). * RATES[15] is d/dt Ca_Trop in component intracellular_calcium_concentration (millimolar). * RATES[10] is d/dt Ca_up in component intracellular_calcium_concentration (millimolar). * RATES[13] is d/dt Ca_rel in component intracellular_calcium_concentration (millimolar). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -91.6; CONSTANTS[0] = 8314.472; CONSTANTS[1] = 310; CONSTANTS[2] = 96485.3415; CONSTANTS[3] = 4e-5; CONSTANTS[4] = 0.1; CONSTANTS[5] = 100000; CONSTANTS[6] = 1; CONSTANTS[7] = 0.002; CONSTANTS[8] = -1.3; CONSTANTS[9] = 0.5; CONSTANTS[10] = 140; STATES[1] = 6.48; CONSTANTS[11] = 4; STATES[2] = 140; STATES[3] = 0.076; STATES[4] = 0.015; CONSTANTS[12] = 1e-5; CONSTANTS[13] = 0.01; CONSTANTS[14] = 0; STATES[5] = 0; STATES[6] = 1; CONSTANTS[15] = 0.14; CONSTANTS[16] = 1; CONSTANTS[17] = 40; CONSTANTS[18] = 0.00012; CONSTANTS[19] = 5e-5; CONSTANTS[20] = 2; STATES[7] = 1e-5; CONSTANTS[21] = 0.0001; CONSTANTS[22] = 3; CONSTANTS[23] = 0.0001; CONSTANTS[24] = 0.5; CONSTANTS[25] = 0.0017; CONSTANTS[26] = 0.017; CONSTANTS[27] = 10; CONSTANTS[28] = 0.05; STATES[8] = 0.0011; STATES[9] = 0.785; CONSTANTS[29] = 0.0003; CONSTANTS[30] = 0.4; CONSTANTS[31] = 0.5; CONSTANTS[32] = 3; CONSTANTS[33] = 0.23; STATES[10] = 0.3; CONSTANTS[34] = 0; CONSTANTS[35] = 250; STATES[11] = 0; STATES[12] = 0; CONSTANTS[36] = 1; STATES[13] = 0.3; CONSTANTS[37] = 50; STATES[14] = 0.0005; STATES[15] = 0.0015; CONSTANTS[38] = 0.02; CONSTANTS[39] = 0.15; CONSTANTS[40] = 100000; CONSTANTS[41] = 50; CONSTANTS[42] = 100000; CONSTANTS[43] = 200; CONSTANTS[44] = 0.01; CONSTANTS[45] = 0.08; CONSTANTS[46] = 0.1; CONSTANTS[47] = 0.4; CONSTANTS[48] = 0.01; CONSTANTS[49] = ( CONSTANTS[0]*CONSTANTS[1])/CONSTANTS[2]; CONSTANTS[50] = 3.14159*pow(CONSTANTS[44], 2.00000)*CONSTANTS[45]; CONSTANTS[51] = ( CONSTANTS[29]*CONSTANTS[30])/CONSTANTS[31]; CONSTANTS[52] = ((1.00000 - CONSTANTS[47]) - CONSTANTS[48]) - CONSTANTS[46]; CONSTANTS[53] = CONSTANTS[50]*CONSTANTS[52]; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[5] = 333.000*(1.00000/(1.00000+exp(- (STATES[0]+4.00000)/5.00000)) - STATES[5]); ALGEBRAIC[1] = 20.0000*exp( - 0.125000*(STATES[0]+75.0000)); ALGEBRAIC[7] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*(STATES[0]+75.0000))); RATES[4] = ALGEBRAIC[1]*(1.00000 - STATES[4]) - ALGEBRAIC[7]*STATES[4]; ALGEBRAIC[2] = 0.0330000*exp(- STATES[0]/17.0000); ALGEBRAIC[8] = 33.0000/(1.00000+exp( - 0.125000*(STATES[0]+10.0000))); RATES[6] = ALGEBRAIC[2]*(1.00000 - STATES[6]) - ALGEBRAIC[8]*STATES[6]; ALGEBRAIC[0] = STATES[0]+41.0000; ALGEBRAIC[6] = (fabs(ALGEBRAIC[0])=CONSTANTS[4]&&VOI<=CONSTANTS[5]&&(VOI - CONSTANTS[4]) - floor((VOI - CONSTANTS[4])/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[7] ? CONSTANTS[8] : 0.00000); RATES[0] = (- 1.00000/CONSTANTS[3])*(ALGEBRAIC[4]+ALGEBRAIC[26]+ALGEBRAIC[27]+ALGEBRAIC[18]+ALGEBRAIC[22]+ALGEBRAIC[24]+ALGEBRAIC[20]+ALGEBRAIC[25]+ALGEBRAIC[14]+ALGEBRAIC[38]); RATES[14] = CONSTANTS[40]*STATES[7]*(CONSTANTS[38] - STATES[14]) - CONSTANTS[41]*STATES[14]; RATES[15] = CONSTANTS[42]*STATES[7]*(CONSTANTS[39] - STATES[15]) - CONSTANTS[43]*STATES[15]; ALGEBRAIC[35] = STATES[7]+ STATES[10]*CONSTANTS[51]+ CONSTANTS[29]*CONSTANTS[30]+CONSTANTS[29]; ALGEBRAIC[37] = (STATES[7]/ALGEBRAIC[35])*CONSTANTS[32] - (( STATES[10]*CONSTANTS[51])/ALGEBRAIC[35])*CONSTANTS[33]; ALGEBRAIC[40] = (STATES[10] - STATES[13])*CONSTANTS[37]; RATES[10] = (CONSTANTS[52]/CONSTANTS[48])*ALGEBRAIC[37] - ALGEBRAIC[40]; ALGEBRAIC[39] = ( pow(STATES[11]/(STATES[11]+0.250000), 2.00000)*CONSTANTS[35]+CONSTANTS[34])*STATES[13]; RATES[13] = (CONSTANTS[48]/CONSTANTS[46])*ALGEBRAIC[40] - ALGEBRAIC[39]; RATES[7] = ((( (- 1.00000/( 2.00000*1.00000*CONSTANTS[53]*CONSTANTS[2]))*((ALGEBRAIC[33]+ALGEBRAIC[24]) - 2.00000*ALGEBRAIC[25])+( ALGEBRAIC[39]*CONSTANTS[46])/CONSTANTS[52]) - RATES[14]) - RATES[15]) - ALGEBRAIC[37]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 20.0000*exp( - 0.125000*(STATES[0]+75.0000)); ALGEBRAIC[7] = 2000.00/(1.00000+ 320.000*exp( - 0.100000*(STATES[0]+75.0000))); ALGEBRAIC[2] = 0.0330000*exp(- STATES[0]/17.0000); ALGEBRAIC[8] = 33.0000/(1.00000+exp( - 0.125000*(STATES[0]+10.0000))); ALGEBRAIC[0] = STATES[0]+41.0000; ALGEBRAIC[6] = (fabs(ALGEBRAIC[0])=CONSTANTS[4]&&VOI<=CONSTANTS[5]&&(VOI - CONSTANTS[4]) - floor((VOI - CONSTANTS[4])/CONSTANTS[6])*CONSTANTS[6]<=CONSTANTS[7] ? CONSTANTS[8] : 0.00000); ALGEBRAIC[35] = STATES[7]+ STATES[10]*CONSTANTS[51]+ CONSTANTS[29]*CONSTANTS[30]+CONSTANTS[29]; ALGEBRAIC[37] = (STATES[7]/ALGEBRAIC[35])*CONSTANTS[32] - (( STATES[10]*CONSTANTS[51])/ALGEBRAIC[35])*CONSTANTS[33]; ALGEBRAIC[40] = (STATES[10] - STATES[13])*CONSTANTS[37]; ALGEBRAIC[39] = ( pow(STATES[11]/(STATES[11]+0.250000), 2.00000)*CONSTANTS[35]+CONSTANTS[34])*STATES[13]; }