Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 29 entries in the algebraic variable array.
There are a total of 15 entries in each of the rate and state variable arrays.
There are a total of 46 entries in the constant variable array.
*/
/*
* VOI is time in component environment (minute).
* CONSTANTS[0] is k1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[1] is kn1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[2] is k2 in component rate_constants (first_order_rate_constant).
* CONSTANTS[3] is kn2 in component rate_constants (first_order_rate_constant).
* CONSTANTS[4] is k2_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[5] is k3_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[6] is kn3_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[7] is k4 in component rate_constants (first_order_rate_constant).
* CONSTANTS[8] is k5 in component rate_constants (first_order_rate_constant).
* CONSTANTS[9] is k6 in component rate_constants (first_order_rate_constant).
* CONSTANTS[10] is k7 in component rate_constants (first_order_rate_constant).
* CONSTANTS[11] is kn7 in component rate_constants (first_order_rate_constant).
* CONSTANTS[12] is k8 in component rate_constants (first_order_rate_constant).
* CONSTANTS[13] is kn8 in component rate_constants (first_order_rate_constant).
* CONSTANTS[14] is k8_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[15] is k9 in component rate_constants (first_order_rate_constant).
* CONSTANTS[16] is kn9 in component rate_constants (first_order_rate_constant).
* CONSTANTS[17] is k9_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[18] is k10 in component rate_constants (first_order_rate_constant).
* CONSTANTS[19] is k11 in component rate_constants (first_order_rate_constant).
* CONSTANTS[20] is k12 in component rate_constants (first_order_rate_constant).
* CONSTANTS[21] is k13 in component rate_constants (first_order_rate_constant).
* CONSTANTS[22] is k14 in component rate_constants (first_order_rate_constant).
* CONSTANTS[23] is k14_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[24] is k15 in component rate_constants (first_order_rate_constant).
* CONSTANTS[25] is k16 in component rate_constants (first_order_rate_constant).
* CONSTANTS[26] is k17 in component rate_constants (first_order_rate_constant).
* CONSTANTS[27] is k18 in component rate_constants (first_order_rate_constant).
* CONSTANTS[28] is kn18 in component rate_constants (first_order_rate_constant).
* CONSTANTS[29] is k20 in component rate_constants (first_order_rate_constant).
* CONSTANTS[30] is k21 in component rate_constants (first_order_rate_constant).
* CONSTANTS[31] is k22 in component rate_constants (first_order_rate_constant).
* CONSTANTS[32] is k23 in component rate_constants (first_order_rate_constant).
* CONSTANTS[33] is kn23 in component rate_constants (first_order_rate_constant).
* CONSTANTS[34] is kPlk1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[35] is kPlk1_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[36] is kctak1 in component rate_constants (first_order_rate_constant).
* CONSTANTS[37] is kctak1_ in component rate_constants (first_order_rate_constant).
* CONSTANTS[38] is kex in component rate_constants (first_order_rate_constant).
* STATES[0] is Chk1P in component Chk1P (dimensionless).
* ALGEBRAIC[11] is V_n1 in component V_n1 (first_order_rate_constant).
* ALGEBRAIC[7] is V_1 in component V_1 (first_order_rate_constant).
* STATES[1] is Rad3 in component Rad3 (dimensionless).
* CONSTANTS[41] is V_4 in component V_4 (first_order_rate_constant).
* ALGEBRAIC[1] is V_5 in component V_5 (first_order_rate_constant).
* STATES[2] is p53 in component p53 (dimensionless).
* CONSTANTS[42] is V_10 in component V_10 (first_order_rate_constant).
* ALGEBRAIC[2] is V_11 in component V_11 (first_order_rate_constant).
* STATES[3] is preMPF in component preMPF (dimensionless).
* ALGEBRAIC[12] is V_14 in component V_14 (first_order_rate_constant).
* ALGEBRAIC[8] is V_n9 in component V_n9 (first_order_rate_constant).
* ALGEBRAIC[3] is V_9 in component V_9 (first_order_rate_constant).
* STATES[4] is MPF in component MPF (dimensionless).
* ALGEBRAIC[26] is V_n23 in component V_n23 (first_order_rate_constant).
* ALGEBRAIC[21] is V_23 in component V_23 (first_order_rate_constant).
* ALGEBRAIC[13] is V_15 in component V_15 (first_order_rate_constant).
* STATES[5] is p21 in component p21 (dimensionless).
* CONSTANTS[43] is V_21 in component V_21 (first_order_rate_constant).
* ALGEBRAIC[16] is V_20 in component V_20 (first_order_rate_constant).
* ALGEBRAIC[18] is V_22 in component V_22 (first_order_rate_constant).
* STATES[6] is p21_MPF in component p21_MPF (dimensionless).
* STATES[7] is iCdc25 in component iCdc25 (dimensionless).
* ALGEBRAIC[27] is V_n7 in component V_n7 (first_order_rate_constant).
* ALGEBRAIC[19] is V_n3_ in component V_n3_ (first_order_rate_constant).
* ALGEBRAIC[22] is V_7 in component V_7 (first_order_rate_constant).
* ALGEBRAIC[14] is V_2_ in component V_2_ (first_order_rate_constant).
* CONSTANTS[39] is V_in in component V_in (first_order_rate_constant).
* STATES[8] is iCdc25Ps216 in component iCdc25Ps216 (dimensionless).
* ALGEBRAIC[23] is V_n18 in component V_n18 (first_order_rate_constant).
* ALGEBRAIC[20] is V_18 in component V_18 (first_order_rate_constant).
* ALGEBRAIC[17] is V_3_ in component V_3_ (first_order_rate_constant).
* STATES[9] is iCdc25Ps216_protein1433 in component iCdc25Ps216_protein1433 (dimensionless).
* ALGEBRAIC[24] is V_ex in component V_ex (first_order_rate_constant).
* STATES[10] is aCdc25 in component aCdc25 (dimensionless).
* ALGEBRAIC[9] is V_n2 in component V_n2 (first_order_rate_constant).
* ALGEBRAIC[4] is V_2 in component V_2 (first_order_rate_constant).
* STATES[11] is aCdc25Ps216 in component aCdc25Ps216 (dimensionless).
* STATES[12] is protein1433 in component protein1433 (dimensionless).
* ALGEBRAIC[25] is V_6 in component V_6 (first_order_rate_constant).
* CONSTANTS[44] is V_13 in component V_13 (first_order_rate_constant).
* ALGEBRAIC[28] is V_12 in component V_12 (first_order_rate_constant).
* STATES[13] is Wee1 in component Wee1 (dimensionless).
* CONSTANTS[45] is V_16 in component V_16 (first_order_rate_constant).
* ALGEBRAIC[10] is V_n8 in component V_n8 (first_order_rate_constant).
* ALGEBRAIC[5] is V_8 in component V_8 (first_order_rate_constant).
* STATES[14] is Wee1P in component Wee1P (dimensionless).
* ALGEBRAIC[15] is V_17 in component V_17 (first_order_rate_constant).
* ALGEBRAIC[6] is aCdc25_T in component aCdc25_T (dimensionless).
* ALGEBRAIC[0] is Chk1 in component V_1 (dimensionless).
* CONSTANTS[40] is Chk1_T in component V_1 (dimensionless).
* RATES[0] is d/dt Chk1P in component Chk1P (dimensionless).
* RATES[1] is d/dt Rad3 in component Rad3 (dimensionless).
* RATES[2] is d/dt p53 in component p53 (dimensionless).
* RATES[3] is d/dt preMPF in component preMPF (dimensionless).
* RATES[4] is d/dt MPF in component MPF (dimensionless).
* RATES[5] is d/dt p21 in component p21 (dimensionless).
* RATES[6] is d/dt p21_MPF in component p21_MPF (dimensionless).
* RATES[7] is d/dt iCdc25 in component iCdc25 (dimensionless).
* RATES[8] is d/dt iCdc25Ps216 in component iCdc25Ps216 (dimensionless).
* RATES[9] is d/dt iCdc25Ps216_protein1433 in component iCdc25Ps216_protein1433 (dimensionless).
* RATES[10] is d/dt aCdc25 in component aCdc25 (dimensionless).
* RATES[11] is d/dt aCdc25Ps216 in component aCdc25Ps216 (dimensionless).
* RATES[12] is d/dt protein1433 in component protein1433 (dimensionless).
* RATES[13] is d/dt Wee1 in component Wee1 (dimensionless).
* RATES[14] is d/dt Wee1P in component Wee1P (dimensionless).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
CONSTANTS[0] = 1;
CONSTANTS[1] = 10;
CONSTANTS[2] = 0.1;
CONSTANTS[3] = 0.01;
CONSTANTS[4] = 0.1;
CONSTANTS[5] = 100;
CONSTANTS[6] = 0;
CONSTANTS[7] = 0;
CONSTANTS[8] = 1;
CONSTANTS[9] = 0.01;
CONSTANTS[10] = 1;
CONSTANTS[11] = 0.01;
CONSTANTS[12] = 0.1;
CONSTANTS[13] = 0.01;
CONSTANTS[14] = 0;
CONSTANTS[15] = 1;
CONSTANTS[16] = 1;
CONSTANTS[17] = 0;
CONSTANTS[18] = 0;
CONSTANTS[19] = 1;
CONSTANTS[20] = 0.1;
CONSTANTS[21] = 1;
CONSTANTS[22] = 0.0005;
CONSTANTS[23] = 1;
CONSTANTS[24] = 0.01;
CONSTANTS[25] = 0.0002;
CONSTANTS[26] = 0.1;
CONSTANTS[27] = 1;
CONSTANTS[28] = 0.01;
CONSTANTS[29] = 0.1;
CONSTANTS[30] = 0.01;
CONSTANTS[31] = 0.1;
CONSTANTS[32] = 0.1;
CONSTANTS[33] = 1;
CONSTANTS[34] = 0;
CONSTANTS[35] = 0;
CONSTANTS[36] = 0;
CONSTANTS[37] = 0;
CONSTANTS[38] = 1;
STATES[0] = 0.000001;
STATES[1] = 0;
STATES[2] = 0;
STATES[3] = 0.000001;
STATES[4] = 0.00000001;
STATES[5] = 0;
STATES[6] = 0;
STATES[7] = 0.000001;
CONSTANTS[39] = 0.00001;
STATES[8] = 0.00002;
STATES[9] = 0.03;
STATES[10] = 0.000001;
STATES[11] = 0;
STATES[12] = 2;
STATES[13] = 0.001;
STATES[14] = 0;
CONSTANTS[40] = 1;
CONSTANTS[41] = CONSTANTS[7];
CONSTANTS[42] = CONSTANTS[18];
CONSTANTS[43] = CONSTANTS[30];
CONSTANTS[44] = CONSTANTS[21];
CONSTANTS[45] = CONSTANTS[25];
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[1] = CONSTANTS[8]*STATES[1];
RATES[1] = CONSTANTS[41] - ALGEBRAIC[1];
ALGEBRAIC[2] = CONSTANTS[19]*STATES[2];
RATES[2] = CONSTANTS[42] - ALGEBRAIC[2];
ALGEBRAIC[10] = CONSTANTS[13]*STATES[14];
ALGEBRAIC[5] = CONSTANTS[12]*STATES[4]*STATES[13]+ CONSTANTS[14]*STATES[13];
RATES[13] = (CONSTANTS[45]+ALGEBRAIC[10]) - ALGEBRAIC[5];
ALGEBRAIC[11] = CONSTANTS[1]*STATES[0];
ALGEBRAIC[0] = CONSTANTS[40] - STATES[0];
ALGEBRAIC[7] = CONSTANTS[0]*ALGEBRAIC[0]*STATES[1];
RATES[0] = ALGEBRAIC[7] - ALGEBRAIC[11];
ALGEBRAIC[12] = (CONSTANTS[22]/(1.00000+ CONSTANTS[23]*STATES[2]))*1.00000;
ALGEBRAIC[8] = CONSTANTS[16]*STATES[4]*STATES[13];
ALGEBRAIC[3] = CONSTANTS[15]*(STATES[10]+STATES[11])*STATES[3]+ CONSTANTS[17]*STATES[3];
RATES[3] = (ALGEBRAIC[12]+ALGEBRAIC[8]) - ALGEBRAIC[3];
ALGEBRAIC[15] = CONSTANTS[26]*STATES[14];
RATES[14] = ALGEBRAIC[5] - (ALGEBRAIC[10]+ALGEBRAIC[15]);
ALGEBRAIC[14] = CONSTANTS[4]*STATES[0]*STATES[7]+ CONSTANTS[37]*STATES[7];
ALGEBRAIC[23] = CONSTANTS[28]*STATES[11];
ALGEBRAIC[20] = CONSTANTS[27]*STATES[4]*STATES[8]+ CONSTANTS[35]*STATES[8];
ALGEBRAIC[17] = CONSTANTS[5]*STATES[8]*STATES[12];
RATES[8] = (ALGEBRAIC[14]+ALGEBRAIC[23]) - (ALGEBRAIC[20]+ALGEBRAIC[17]);
ALGEBRAIC[19] = CONSTANTS[6]*STATES[9];
ALGEBRAIC[24] = CONSTANTS[38]*STATES[9];
RATES[9] = ALGEBRAIC[17] - (ALGEBRAIC[19]+ALGEBRAIC[24]);
ALGEBRAIC[9] = CONSTANTS[3]*STATES[11];
ALGEBRAIC[4] = CONSTANTS[2]*STATES[0]*STATES[10]+ CONSTANTS[36]*STATES[10];
RATES[11] = (ALGEBRAIC[4]+ALGEBRAIC[20]) - (ALGEBRAIC[9]+ALGEBRAIC[23]);
ALGEBRAIC[26] = CONSTANTS[33]*STATES[6];
ALGEBRAIC[21] = CONSTANTS[32]*STATES[4]*STATES[5];
ALGEBRAIC[13] = CONSTANTS[24]*pow(STATES[4], 2.00000);
RATES[4] = (ALGEBRAIC[3]+ALGEBRAIC[26]) - (ALGEBRAIC[8]+ALGEBRAIC[21]+ALGEBRAIC[13]);
ALGEBRAIC[16] = CONSTANTS[29]*STATES[2];
ALGEBRAIC[18] = CONSTANTS[31]*STATES[5];
RATES[5] = (ALGEBRAIC[16]+CONSTANTS[43]+ALGEBRAIC[26]) - (ALGEBRAIC[18]+ALGEBRAIC[21]);
RATES[6] = ALGEBRAIC[21] - ALGEBRAIC[26];
ALGEBRAIC[27] = CONSTANTS[11]*STATES[10];
ALGEBRAIC[22] = CONSTANTS[10]*STATES[4]*STATES[7]+ CONSTANTS[34]*STATES[7];
RATES[7] = (ALGEBRAIC[27]+ALGEBRAIC[19]+CONSTANTS[39]) - (ALGEBRAIC[22]+ALGEBRAIC[14]);
RATES[10] = (ALGEBRAIC[22]+ALGEBRAIC[9]) - (ALGEBRAIC[27]+ALGEBRAIC[4]);
ALGEBRAIC[25] = CONSTANTS[9]*STATES[2];
ALGEBRAIC[28] = CONSTANTS[20]*STATES[12];
RATES[12] = (ALGEBRAIC[25]+CONSTANTS[44]+ALGEBRAIC[19]) - (ALGEBRAIC[17]+ALGEBRAIC[28]);
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[1] = CONSTANTS[8]*STATES[1];
ALGEBRAIC[2] = CONSTANTS[19]*STATES[2];
ALGEBRAIC[10] = CONSTANTS[13]*STATES[14];
ALGEBRAIC[5] = CONSTANTS[12]*STATES[4]*STATES[13]+ CONSTANTS[14]*STATES[13];
ALGEBRAIC[11] = CONSTANTS[1]*STATES[0];
ALGEBRAIC[0] = CONSTANTS[40] - STATES[0];
ALGEBRAIC[7] = CONSTANTS[0]*ALGEBRAIC[0]*STATES[1];
ALGEBRAIC[12] = (CONSTANTS[22]/(1.00000+ CONSTANTS[23]*STATES[2]))*1.00000;
ALGEBRAIC[8] = CONSTANTS[16]*STATES[4]*STATES[13];
ALGEBRAIC[3] = CONSTANTS[15]*(STATES[10]+STATES[11])*STATES[3]+ CONSTANTS[17]*STATES[3];
ALGEBRAIC[15] = CONSTANTS[26]*STATES[14];
ALGEBRAIC[14] = CONSTANTS[4]*STATES[0]*STATES[7]+ CONSTANTS[37]*STATES[7];
ALGEBRAIC[23] = CONSTANTS[28]*STATES[11];
ALGEBRAIC[20] = CONSTANTS[27]*STATES[4]*STATES[8]+ CONSTANTS[35]*STATES[8];
ALGEBRAIC[17] = CONSTANTS[5]*STATES[8]*STATES[12];
ALGEBRAIC[19] = CONSTANTS[6]*STATES[9];
ALGEBRAIC[24] = CONSTANTS[38]*STATES[9];
ALGEBRAIC[9] = CONSTANTS[3]*STATES[11];
ALGEBRAIC[4] = CONSTANTS[2]*STATES[0]*STATES[10]+ CONSTANTS[36]*STATES[10];
ALGEBRAIC[26] = CONSTANTS[33]*STATES[6];
ALGEBRAIC[21] = CONSTANTS[32]*STATES[4]*STATES[5];
ALGEBRAIC[13] = CONSTANTS[24]*pow(STATES[4], 2.00000);
ALGEBRAIC[16] = CONSTANTS[29]*STATES[2];
ALGEBRAIC[18] = CONSTANTS[31]*STATES[5];
ALGEBRAIC[27] = CONSTANTS[11]*STATES[10];
ALGEBRAIC[22] = CONSTANTS[10]*STATES[4]*STATES[7]+ CONSTANTS[34]*STATES[7];
ALGEBRAIC[25] = CONSTANTS[9]*STATES[2];
ALGEBRAIC[28] = CONSTANTS[20]*STATES[12];
ALGEBRAIC[6] = STATES[10]+STATES[11];
}