Antidiuretic Hormone and its control functions.
This section calculates the control of antidiuretic hormone secretion and also
calculates multiplier factors for control of other aspects of circulatory function
by antidiuretic hormone. The major factors that are considered to affect the rate
of antidiuretic hormone secretion are (1) a feedback effect of osmotic concentration
in the extracellular fluids as determined from the concentration of sodium (CNA),
and (2) a feedback effect of arterial pressure (PA).
AD15:
Block 15 sets a lower limit for ADHMV equal to ADHVLL, and the upper limit is ADHVUL.
1000
100
Antidiuretic Hormone
AD14:
Calculation from the instantaneous concentration of ADH in the plasma (ADHC)
of a multiplier factor (ADHMV) to describe the effect of antidiuretic hormone
in causing contraction of many of the blood vessels of the body.
Antidiuretic Hormone
Description of Guyton antidiuretic hormone module
cardiovascular circulation
Guyton
physiology
antidiuretic hormone
organ systems
AD10, AD11, AD12, and AD13:
Calculation of instantaneous antidiuretic hormone concentration in the blood (ADHC)
by integrating in Block 12 the rate of hormone entry into the fluids (ADH) with
respect to time. A time constant for the integration (Block 11) is equal to ADHTC.
Block 13 damps the response of this integration to prevent oscillation when very
long iteration intervals are used in providing long-term solutions for the model.
Description of Guyton antidiuretic hormone module
AD10, AD11, AD12, and AD13:
Calculation of instantaneous antidiuretic hormone concentration in the blood (ADHC)
by integrating in Block 12 the rate of hormone entry into the fluids (ADH) with
respect to time. A time constant for the integration (Block 11) is equal to ADHTC.
Block 13 damps the response of this integration to prevent oscillation when very
long iteration intervals are used in providing long-term solutions for the model.
organ systems
Guyton
cardiovascular circulation
antidiuretic hormone
physiology
AD14 and AD15:
Calculation from the instantaneous concentration of ADH in the plasma (ADHC)
of a multiplier factor (ADHMV) to describe the effect of antidiuretic hormone
in causing contraction of many of the blood vessels of the body. Block 15 sets
a lower limit for ADHMV equal to ADHVLL, and the upper limit is ADHVUL.
2008-00-00 00:00
This is the CellML 1.1 "parent" file to test the Anti-diuretic Hormone Model.
AD9:
Calculation of the net rate of ADH entry into the body fluids (ADH) by adding
the partial effect of ADHNA for osmotic control of ADH secretion plus the partial
effect ADHPR for pressure control of secretion, plus ADHINF for any rate of
infusion of ADH.
keyword
Component to set all input values to 1.0 or a prescribed value.
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
AD9:
Calculation of the net rate of ADH entry into the body fluids (ADH) by adding
the partial effect of ADHNA for osmotic control of ADH secretion plus the partial
effect ADHPR for pressure control of secretion, plus ADHINF for any rate of
infusion of ADH.
Guyton
2008-00-00 00:00
AD1, AD2, and AD3:
Calculation of a multiplier factor (ADHNA) that determines the effect of the
concentration of sodium in the extracellular fluid (CNA) on the secretion of ADH.
The lower limit of CNA at which the normal stimulating effect of changes in CNA
will affect antidiuretic hormone secretion is equal to CNR. The mathematical
steps in Blocks AD1, AD2, and AD3 provide curve shaping effects for the relationship
between CNA and ADHNA.
Encapsulation grouping component containing all the components in the Anti-Diuretic Hormone Model.
The inputs and outputs of the Anti-Diuretic Hormone Model must be passed by this component.
AD16:
Calculation from the plasma concentration of ADH (ADHC) of a multiplier factor (ADHMK)
to describe the effect of the ADH in affecting the kidney.
Guyton
AD1, AD2, and AD3:
Calculation of a multiplier factor (ADHNA) that determines the effect of the
concentration of sodium in the extracellular fluid (CNA) on the secretion of ADH.
The lower limit of CNA at which the normal stimulating effect of changes in CNA
will affect antidiuretic hormone secretion is equal to CNR. The mathematical
steps in Blocks AD1, AD2, and AD3 provide curve shaping effects for the relationship
between CNA and ADHNA.
AD8:
The effect of sodium concentration on ADH secretion (ADHNA) is not allowed
to go below zero.
AD8:
The effect of sodium concentration on ADH secretion (ADHNA) is not allowed
to go below zero.
keyword
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
AD17:
Block 17 gives a lower limit to ADHMK equal to ADHKLL, and Block 16 gives an upper limit equal to AMKUL.
AD4, AD5, AD6, and AD7:
Calculation of the effect of low levels of arterial pressure to cause secretion
of antidiuretic hormone. The mathematical steps in these blocks provide appropriate
curve shaping. Zero effect of pressure on ADH secretion occurs whenever the arterial
pressure is greater than 85 mm Hg. The factor ADHPAM is the sensitivity control for
the overall effect. The output of this set of blocks is ADHPR.
AD16 and AD17:
Calculation from the plasma concentration of ADH (ADHC) of a multiplier factor (ADHMK)
to describe the effect of the ADH in affecting the kidney. Block 17 gives a lower limit
to ADHMK equal to ADHKLL, and Block 16 gives an upper limit equal to AMKUL.