Generated Code
The following is c code generated by the CellML API from this CellML file. (Back to language selection)
The raw code is available.
/*
There are a total of 79 entries in the algebraic variable array.
There are a total of 11 entries in each of the rate and state variable arrays.
There are a total of 75 entries in the constant variable array.
*/
/*
* VOI is time in component environment (millisecond).
* STATES[0] is Vm in component membrane (millivolt).
* CONSTANTS[0] is cm in component membrane (femtofarad).
* ALGEBRAIC[3] is Ica in component Ica (femtoampere).
* ALGEBRAIC[1] is Ik in component Ik (femtoampere).
* ALGEBRAIC[4] is Ikca in component Ikca (femtoampere).
* ALGEBRAIC[43] is Ikatp in component Ikatp (femtoampere).
* CONSTANTS[1] is gK in component Ik (picosiemens).
* CONSTANTS[2] is VK in component model_parameters (millivolt).
* STATES[1] is n in component n (dimensionless).
* ALGEBRAIC[0] is n_infinity in component n (dimensionless).
* CONSTANTS[3] is tau_n in component n (millisecond).
* CONSTANTS[4] is vn in component n (millivolt).
* CONSTANTS[5] is sn in component n (millivolt).
* CONSTANTS[6] is gCa in component Ica (picosiemens).
* CONSTANTS[7] is VCa in component model_parameters (millivolt).
* ALGEBRAIC[2] is m_infinity in component m (dimensionless).
* CONSTANTS[8] is v in component m (millivolt).
* CONSTANTS[9] is sm in component m (millivolt).
* CONSTANTS[10] is gkCa in component Ikca (picosiemens).
* CONSTANTS[11] is kd in component Ikca (micromolar).
* STATES[2] is c in component c (micromolar).
* CONSTANTS[12] is gkATP_ in component Ikatp (picosiemens).
* ALGEBRAIC[41] is katpo in component Ikatp (dimensionless).
* ALGEBRAIC[6] is topo in component Ikatp (dimensionless).
* ALGEBRAIC[39] is bottomo in component Ikatp (dimensionless).
* ALGEBRAIC[5] is mgadp in component Ikatp (micromolar).
* ALGEBRAIC[7] is adp3m in component Ikatp (micromolar).
* ALGEBRAIC[36] is atp4m in component Ikatp (micromolar).
* ALGEBRAIC[35] is atp in component atp (micromolar).
* STATES[3] is adp in component adp (micromolar).
* ALGEBRAIC[8] is JGPDH in component JGPDH (micromolar_millisecond).
* CONSTANTS[13] is kGPDH in component JGPDH (micromolar_millisecond).
* STATES[4] is FBP in component FBP (micromolar).
* STATES[5] is G6P in component G6P (micromolar).
* CONSTANTS[74] is JGK_ms in component JGK (micromolar_millisecond).
* ALGEBRAIC[78] is JPFK_ms in component JPFK (micromolar_millisecond).
* ALGEBRAIC[9] is F6P in component F6P (micromolar).
* ALGEBRAIC[77] is JPFK in component JPFK (micromolar_second).
* CONSTANTS[14] is bottom1 in component JPFK (dimensionless).
* CONSTANTS[15] is topa1 in component JPFK (dimensionless).
* CONSTANTS[16] is k1 in component JPFK (micromolar).
* CONSTANTS[17] is k2 in component JPFK (micromolar).
* CONSTANTS[18] is k3 in component JPFK (micromolar).
* CONSTANTS[19] is k4 in component JPFK (micromolar).
* CONSTANTS[20] is VmaxPFK in component JPFK (micromolar_millisecond).
* ALGEBRAIC[37] is weight2 in component JPFK (dimensionless).
* CONSTANTS[71] is topa2 in component JPFK (dimensionless).
* ALGEBRAIC[40] is bottom2 in component JPFK (dimensionless).
* ALGEBRAIC[13] is topa3 in component JPFK (dimensionless).
* ALGEBRAIC[11] is weight3 in component JPFK (dimensionless).
* ALGEBRAIC[42] is bottom3 in component JPFK (dimensionless).
* CONSTANTS[21] is f13 in component JPFK (dimensionless).
* CONSTANTS[22] is f43 in component JPFK (dimensionless).
* CONSTANTS[23] is f23 in component JPFK (dimensionless).
* CONSTANTS[24] is f42 in component JPFK (dimensionless).
* CONSTANTS[25] is f41 in component JPFK (dimensionless).
* ALGEBRAIC[44] is weight4 in component JPFK (dimensionless).
* ALGEBRAIC[45] is topa4 in component JPFK (dimensionless).
* ALGEBRAIC[46] is bottom4 in component JPFK (dimensionless).
* ALGEBRAIC[15] is weight5 in component JPFK (dimensionless).
* ALGEBRAIC[47] is topa5 in component JPFK (dimensionless).
* ALGEBRAIC[48] is bottom5 in component JPFK (dimensionless).
* ALGEBRAIC[49] is weight6 in component JPFK (dimensionless).
* ALGEBRAIC[50] is topa6 in component JPFK (dimensionless).
* ALGEBRAIC[51] is bottom6 in component JPFK (dimensionless).
* ALGEBRAIC[16] is weight7 in component JPFK (dimensionless).
* ALGEBRAIC[52] is topa7 in component JPFK (dimensionless).
* ALGEBRAIC[53] is bottom7 in component JPFK (dimensionless).
* ALGEBRAIC[54] is weight8 in component JPFK (dimensionless).
* ALGEBRAIC[55] is topa8 in component JPFK (dimensionless).
* ALGEBRAIC[56] is bottom8 in component JPFK (dimensionless).
* CONSTANTS[73] is weight9 in component JPFK (dimensionless).
* ALGEBRAIC[57] is topa9 in component JPFK (dimensionless).
* ALGEBRAIC[58] is bottom9 in component JPFK (dimensionless).
* ALGEBRAIC[59] is weight10 in component JPFK (dimensionless).
* ALGEBRAIC[60] is topa10 in component JPFK (dimensionless).
* ALGEBRAIC[61] is bottom10 in component JPFK (dimensionless).
* ALGEBRAIC[17] is weight11 in component JPFK (dimensionless).
* ALGEBRAIC[62] is topa11 in component JPFK (dimensionless).
* ALGEBRAIC[63] is bottom11 in component JPFK (dimensionless).
* ALGEBRAIC[64] is weight12 in component JPFK (dimensionless).
* ALGEBRAIC[65] is topa12 in component JPFK (dimensionless).
* ALGEBRAIC[66] is bottom12 in component JPFK (dimensionless).
* ALGEBRAIC[18] is weight13 in component JPFK (dimensionless).
* ALGEBRAIC[67] is topa13 in component JPFK (dimensionless).
* ALGEBRAIC[68] is bottom13 in component JPFK (dimensionless).
* ALGEBRAIC[69] is weight14 in component JPFK (dimensionless).
* ALGEBRAIC[70] is topa14 in component JPFK (dimensionless).
* ALGEBRAIC[71] is bottom14 in component JPFK (dimensionless).
* ALGEBRAIC[19] is weight15 in component JPFK (dimensionless).
* ALGEBRAIC[72] is topa15 in component JPFK (dimensionless).
* ALGEBRAIC[73] is bottom15 in component JPFK (dimensionless).
* ALGEBRAIC[74] is weight16 in component JPFK (dimensionless).
* ALGEBRAIC[75] is topa16 in component JPFK (dimensionless).
* ALGEBRAIC[76] is bottom16 in component JPFK (dimensionless).
* ALGEBRAIC[20] is topb in component JPFK (dimensionless).
* CONSTANTS[26] is AMP in component model_parameters (micromolar).
* CONSTANTS[27] is lambda in component JPFK (dimensionless).
* CONSTANTS[28] is kappa in component model_parameters (dimensionless).
* ALGEBRAIC[14] is JPDH in component JPDH (micromolar_millisecond).
* CONSTANTS[29] is p1 in component JPDH (dimensionless).
* CONSTANTS[30] is p2 in component JPDH (dimensionless).
* CONSTANTS[31] is p3 in component JPDH (micromolar).
* CONSTANTS[32] is JGPDHbas in component JPDH (micromolar_millisecond).
* ALGEBRAIC[12] is NADm in component NADm (millimolar).
* STATES[6] is Cam in component Cam (micromolar).
* STATES[7] is NADHm in component NADHm (millimolar).
* CONSTANTS[33] is gamma in component model_parameters (dimensionless).
* ALGEBRAIC[10] is JO in component JO (micromolar_millisecond).
* CONSTANTS[34] is p4 in component JO (micromolar_millisecond).
* CONSTANTS[35] is p5 in component JO (millimolar).
* CONSTANTS[36] is p6 in component JO (millivolt).
* CONSTANTS[37] is p7 in component JO (millivolt).
* STATES[8] is delta_psi in component delta_psi (millivolt).
* CONSTANTS[38] is NADmtot in component NADm (millimolar).
* CONSTANTS[39] is Cmito in component delta_psi (micromolar_millivolt).
* ALGEBRAIC[21] is JHres in component JHres (micromolar_millisecond).
* ALGEBRAIC[29] is JHatp in component JHatp (micromolar_millisecond).
* ALGEBRAIC[33] is JANT in component JANT (micromolar_millisecond).
* ALGEBRAIC[22] is JHleak in component JHleak (micromolar_millisecond).
* ALGEBRAIC[24] is JNaCa in component JNaCa (micromolar_millisecond).
* ALGEBRAIC[23] is Juni in component Juni (micromolar_millisecond).
* CONSTANTS[40] is p8 in component JHres (micromolar_millisecond).
* CONSTANTS[41] is p9 in component JHres (millimolar).
* CONSTANTS[42] is p10 in component JHres (millivolt).
* CONSTANTS[43] is p11 in component JHres (millivolt).
* ALGEBRAIC[27] is JF1F0 in component JF1F0 (micromolar_millisecond).
* CONSTANTS[44] is p13 in component JF1F0 (millimolar).
* CONSTANTS[45] is p14 in component JF1F0 (millivolt).
* CONSTANTS[46] is p15 in component JF1F0 (millivolt).
* CONSTANTS[47] is p16 in component JF1F0 (micromolar_millisecond).
* ALGEBRAIC[25] is ATPm in component ATPm (millimolar).
* CONSTANTS[48] is JGK in component JGK (micromolar_second).
* CONSTANTS[49] is p17 in component JHleak (micromolar_millisecond_millivolt).
* CONSTANTS[50] is p18 in component JHleak (micromolar_millisecond).
* CONSTANTS[51] is p19 in component JANT (micromolar_millisecond).
* CONSTANTS[52] is p20 in component JANT (dimensionless).
* CONSTANTS[53] is FRT in component JANT (per_millivolt).
* ALGEBRAIC[31] is RATm in component RATm (dimensionless).
* STATES[9] is ADPm in component ADPm (millimolar).
* CONSTANTS[54] is p21 in component Juni (per_micromolar_millisecond_millivolt).
* CONSTANTS[55] is p22 in component Juni (second_order_rate_constant).
* CONSTANTS[56] is p23 in component JNaCa (micromolar_millisecond).
* CONSTANTS[57] is p24 in component JNaCa (per_millivolt).
* CONSTANTS[58] is fmito in component Cam (dimensionless).
* ALGEBRAIC[26] is Jmito in component Jmito (micromolar_millisecond).
* CONSTANTS[59] is Amtot in component ATPm (millimolar).
* CONSTANTS[72] is delta in component model_parameters (dimensionless).
* ALGEBRAIC[38] is Jhyd in component Jhyd (micromolar_millisecond).
* CONSTANTS[60] is khyd in component Jhyd (second_order_rate_constant).
* CONSTANTS[61] is khydbas in component Jhyd (first_order_rate_constant).
* CONSTANTS[62] is atot in component atp (micromolar).
* CONSTANTS[63] is fcyt in component c (dimensionless).
* ALGEBRAIC[34] is Jer in component Jer (micromolar_millisecond).
* ALGEBRAIC[28] is Jmem in component Jmem (micromolar_millisecond).
* CONSTANTS[64] is kPMCA in component Jmem (first_order_rate_constant).
* CONSTANTS[65] is alpha in component Jmem (micromolar_millisecond_femtoampere).
* CONSTANTS[66] is Cbas in component Jmem (micromolar).
* ALGEBRAIC[30] is Jleak in component Jleak (micromolar_millisecond).
* CONSTANTS[67] is pleak in component Jleak (first_order_rate_constant).
* STATES[10] is Caer in component Caer (micromolar).
* ALGEBRAIC[32] is JSERCA in component JSERCA (micromolar_millisecond).
* CONSTANTS[68] is kSERCA in component JSERCA (first_order_rate_constant).
* CONSTANTS[69] is fer in component Caer (dimensionless).
* CONSTANTS[70] is Vc_Ver in component Caer (dimensionless).
* RATES[0] is d/dt Vm in component membrane (millivolt).
* RATES[1] is d/dt n in component n (dimensionless).
* RATES[5] is d/dt G6P in component G6P (micromolar).
* RATES[4] is d/dt FBP in component FBP (micromolar).
* RATES[7] is d/dt NADHm in component NADHm (millimolar).
* RATES[8] is d/dt delta_psi in component delta_psi (millivolt).
* RATES[6] is d/dt Cam in component Cam (micromolar).
* RATES[9] is d/dt ADPm in component ADPm (millimolar).
* RATES[3] is d/dt adp in component adp (micromolar).
* RATES[2] is d/dt c in component c (micromolar).
* RATES[10] is d/dt Caer in component Caer (micromolar).
*/
void
initConsts(double* CONSTANTS, double* RATES, double *STATES)
{
STATES[0] = -60.0;
CONSTANTS[0] = 5300.0;
CONSTANTS[1] = 2700.0;
CONSTANTS[2] = -75.0;
STATES[1] = 0.0;
CONSTANTS[3] = 20.0;
CONSTANTS[4] = -16.0;
CONSTANTS[5] = 5.0;
CONSTANTS[6] = 1000.0;
CONSTANTS[7] = 25.0;
CONSTANTS[8] = -20.0;
CONSTANTS[9] = 12.0;
CONSTANTS[10] = 300.0;
CONSTANTS[11] = 0.5;
STATES[2] = 0.17;
CONSTANTS[12] = 16000.0;
STATES[3] = 1137.0;
CONSTANTS[13] = 0.0005;
STATES[4] = 2.16;
STATES[5] = 301.0;
CONSTANTS[14] = 1;
CONSTANTS[15] = 0;
CONSTANTS[16] = 30;
CONSTANTS[17] = 1;
CONSTANTS[18] = 50000;
CONSTANTS[19] = 1000;
CONSTANTS[20] = 5.0;
CONSTANTS[21] = 0.02;
CONSTANTS[22] = 20;
CONSTANTS[23] = 0.2;
CONSTANTS[24] = 20;
CONSTANTS[25] = 20;
CONSTANTS[26] = 500.0;
CONSTANTS[27] = 0.06;
CONSTANTS[28] = 0.001;
CONSTANTS[29] = 400.0;
CONSTANTS[30] = 1.0;
CONSTANTS[31] = 0.01;
CONSTANTS[32] = 0.0005;
STATES[6] = 0.2;
STATES[7] = 0.4;
CONSTANTS[33] = 0.001;
CONSTANTS[34] = 0.6;
CONSTANTS[35] = 0.1;
CONSTANTS[36] = 177.0;
CONSTANTS[37] = 5.0;
STATES[8] = 164.0;
CONSTANTS[38] = 10.0;
CONSTANTS[39] = 1.8;
CONSTANTS[40] = 7.0;
CONSTANTS[41] = 0.1;
CONSTANTS[42] = 177.0;
CONSTANTS[43] = 5.0;
CONSTANTS[44] = 10.0;
CONSTANTS[45] = 190.0;
CONSTANTS[46] = 8.5;
CONSTANTS[47] = 35.0;
CONSTANTS[48] = 0.4;
CONSTANTS[49] = 0.002;
CONSTANTS[50] = -0.03;
CONSTANTS[51] = 0.35;
CONSTANTS[52] = 2.0;
CONSTANTS[53] = 0.037410133;
STATES[9] = 11.1;
CONSTANTS[54] = 0.04;
CONSTANTS[55] = 1.1;
CONSTANTS[56] = 0.01;
CONSTANTS[57] = 0.016;
CONSTANTS[58] = 0.01;
CONSTANTS[59] = 15.0;
CONSTANTS[60] = 0.00005;
CONSTANTS[61] = 0.00005;
CONSTANTS[62] = 2500.0;
CONSTANTS[63] = 0.01;
CONSTANTS[64] = 0.1;
CONSTANTS[65] = 4.5E-6;
CONSTANTS[66] = 0.05;
CONSTANTS[67] = 0.0002;
STATES[10] = 345.0;
CONSTANTS[68] = 0.4;
CONSTANTS[69] = 0.01;
CONSTANTS[70] = 31.0;
CONSTANTS[71] = CONSTANTS[15];
CONSTANTS[72] = 3.90000/53.2000;
CONSTANTS[73] = CONSTANTS[26]/CONSTANTS[16];
CONSTANTS[74] = CONSTANTS[28]*CONSTANTS[48];
}
void
computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[4] - STATES[0])/CONSTANTS[5]));
RATES[1] = (ALGEBRAIC[0] - STATES[1])/CONSTANTS[3];
ALGEBRAIC[8] = CONSTANTS[13]* pow(fabs(STATES[4]/1.00000), 1.0 / 2);
ALGEBRAIC[12] = CONSTANTS[38] - STATES[7];
ALGEBRAIC[14] = (CONSTANTS[29]/(CONSTANTS[30]+STATES[7]/ALGEBRAIC[12]))*(STATES[6]/(CONSTANTS[31]+STATES[6]))*(ALGEBRAIC[8]+CONSTANTS[32]);
ALGEBRAIC[10] = ( CONSTANTS[34]*(STATES[7]/(CONSTANTS[35]+STATES[7])))/(1.00000+exp((STATES[8] - CONSTANTS[36])/CONSTANTS[37]));
RATES[7] = CONSTANTS[33]*(ALGEBRAIC[14] - ALGEBRAIC[10]);
ALGEBRAIC[24] = (CONSTANTS[56]/STATES[2])*STATES[6]*exp( CONSTANTS[57]*STATES[8]);
ALGEBRAIC[23] = ( CONSTANTS[54]*STATES[8] - CONSTANTS[55])*pow(STATES[2], 2.00000);
ALGEBRAIC[26] = ALGEBRAIC[24] - ALGEBRAIC[23];
RATES[6] = - CONSTANTS[58]*ALGEBRAIC[26];
ALGEBRAIC[21] = ( CONSTANTS[40]*(STATES[7]/(CONSTANTS[41]+STATES[7])))/(1.00000+exp((STATES[8] - CONSTANTS[42])/CONSTANTS[43]));
ALGEBRAIC[25] = CONSTANTS[59] - STATES[9];
ALGEBRAIC[27] = (( CONSTANTS[47]*CONSTANTS[44])/(CONSTANTS[44]+ALGEBRAIC[25]))/(1.00000+exp((CONSTANTS[45] - STATES[8])/CONSTANTS[46]));
ALGEBRAIC[29] = 3.00000*ALGEBRAIC[27];
ALGEBRAIC[31] = ALGEBRAIC[25]/STATES[9];
ALGEBRAIC[33] = CONSTANTS[51]*((ALGEBRAIC[31]/(ALGEBRAIC[31]+CONSTANTS[52]))/exp( -0.500000*CONSTANTS[53]*STATES[8]));
ALGEBRAIC[22] = CONSTANTS[49]*STATES[8]+CONSTANTS[50];
RATES[8] = (ALGEBRAIC[21] - (ALGEBRAIC[29]+ALGEBRAIC[33]+ALGEBRAIC[22]+ALGEBRAIC[24]+ 2.00000*ALGEBRAIC[23]))/CONSTANTS[39];
RATES[9] = CONSTANTS[33]*(ALGEBRAIC[33] - ALGEBRAIC[27]);
ALGEBRAIC[30] = CONSTANTS[67]*(STATES[10] - STATES[2]);
ALGEBRAIC[32] = CONSTANTS[68]*STATES[2];
ALGEBRAIC[34] = ALGEBRAIC[30] - ALGEBRAIC[32];
ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[8] - STATES[0])/CONSTANTS[9]));
ALGEBRAIC[3] = CONSTANTS[6]*ALGEBRAIC[2]*(STATES[0] - CONSTANTS[7]);
ALGEBRAIC[28] = - ( CONSTANTS[65]*ALGEBRAIC[3]+ CONSTANTS[64]*(STATES[2] - CONSTANTS[66]));
RATES[2] = CONSTANTS[63]*(ALGEBRAIC[28]+ALGEBRAIC[34]+ CONSTANTS[72]*ALGEBRAIC[26]);
RATES[10] = - CONSTANTS[69]*CONSTANTS[70]*ALGEBRAIC[34];
ALGEBRAIC[35] = CONSTANTS[62] - STATES[3];
ALGEBRAIC[38] = ( CONSTANTS[60]*STATES[2]+CONSTANTS[61])*ALGEBRAIC[35];
RATES[3] = - CONSTANTS[72]*ALGEBRAIC[33]+ALGEBRAIC[38];
ALGEBRAIC[1] = CONSTANTS[1]*STATES[1]*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[4] = (CONSTANTS[10]/(1.00000+pow(CONSTANTS[11]/STATES[2], 2.00000)))*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[5] = 0.165000*STATES[3];
ALGEBRAIC[6] = 0.0800000*(1.00000+( 2.00000*ALGEBRAIC[5])/17.0000)+ 0.890000*pow(ALGEBRAIC[5]/17.0000, 2.00000);
ALGEBRAIC[7] = 0.135000*STATES[3];
ALGEBRAIC[36] = 0.0500000*ALGEBRAIC[35];
ALGEBRAIC[39] = pow(1.00000+ALGEBRAIC[5]/17.0000, 2.00000)*(1.00000+ALGEBRAIC[7]/26.0000+ALGEBRAIC[36]/1.00000);
ALGEBRAIC[41] = ALGEBRAIC[6]/ALGEBRAIC[39];
ALGEBRAIC[43] = CONSTANTS[12]*ALGEBRAIC[41]*(STATES[0] - CONSTANTS[2]);
RATES[0] = - (ALGEBRAIC[1]+ALGEBRAIC[3]+ALGEBRAIC[4]+ALGEBRAIC[43])/CONSTANTS[0];
ALGEBRAIC[9] = 0.300000*STATES[5];
ALGEBRAIC[11] = pow(ALGEBRAIC[9], 2.00000)/( CONSTANTS[18]*1.00000);
ALGEBRAIC[13] = CONSTANTS[71]+ALGEBRAIC[11];
ALGEBRAIC[44] = pow( ALGEBRAIC[9]*ALGEBRAIC[35], 2.00000)/( CONSTANTS[22]*CONSTANTS[18]*CONSTANTS[19]*pow(1.00000, 2.00000));
ALGEBRAIC[45] = ALGEBRAIC[13]+ALGEBRAIC[44];
ALGEBRAIC[47] = ALGEBRAIC[45];
ALGEBRAIC[50] = ALGEBRAIC[47];
ALGEBRAIC[16] = ( STATES[4]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[23]*1.00000);
ALGEBRAIC[52] = ALGEBRAIC[50]+ALGEBRAIC[16];
ALGEBRAIC[54] = ( STATES[4]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[23]*CONSTANTS[24]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[55] = ALGEBRAIC[52]+ALGEBRAIC[54];
ALGEBRAIC[57] = ALGEBRAIC[55];
ALGEBRAIC[60] = ALGEBRAIC[57];
ALGEBRAIC[17] = ( CONSTANTS[26]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[16]*CONSTANTS[18]*CONSTANTS[21]*1.00000);
ALGEBRAIC[62] = ALGEBRAIC[60]+ALGEBRAIC[17];
ALGEBRAIC[64] = ( CONSTANTS[26]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[21]*CONSTANTS[25]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[65] = ALGEBRAIC[62]+ALGEBRAIC[64];
ALGEBRAIC[67] = ALGEBRAIC[65];
ALGEBRAIC[70] = ALGEBRAIC[67];
ALGEBRAIC[72] = ALGEBRAIC[70];
ALGEBRAIC[74] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[23]*CONSTANTS[21]*CONSTANTS[24]*CONSTANTS[25]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[75] = ALGEBRAIC[72]+ALGEBRAIC[74];
ALGEBRAIC[37] = pow(ALGEBRAIC[35], 2.00000)/( CONSTANTS[19]*1.00000);
ALGEBRAIC[40] = CONSTANTS[14]+ALGEBRAIC[37];
ALGEBRAIC[42] = ALGEBRAIC[40]+ALGEBRAIC[11];
ALGEBRAIC[46] = ALGEBRAIC[42]+ALGEBRAIC[44];
ALGEBRAIC[15] = STATES[4]/CONSTANTS[17];
ALGEBRAIC[48] = ALGEBRAIC[46]+ALGEBRAIC[15];
ALGEBRAIC[49] = ( STATES[4]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[17]*CONSTANTS[19]*CONSTANTS[24]*1.00000);
ALGEBRAIC[51] = ALGEBRAIC[48]+ALGEBRAIC[49];
ALGEBRAIC[53] = ALGEBRAIC[51]+ALGEBRAIC[16];
ALGEBRAIC[56] = ALGEBRAIC[53]+ALGEBRAIC[54];
ALGEBRAIC[58] = ALGEBRAIC[56]+CONSTANTS[73];
ALGEBRAIC[59] = ( CONSTANTS[26]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[19]*CONSTANTS[25]*1.00000);
ALGEBRAIC[61] = ALGEBRAIC[58]+ALGEBRAIC[59];
ALGEBRAIC[63] = ALGEBRAIC[61]+ALGEBRAIC[17];
ALGEBRAIC[66] = ALGEBRAIC[63]+ALGEBRAIC[64];
ALGEBRAIC[18] = ( CONSTANTS[26]*STATES[4])/( CONSTANTS[16]*CONSTANTS[17]);
ALGEBRAIC[68] = ALGEBRAIC[66]+ALGEBRAIC[18];
ALGEBRAIC[69] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[19]*CONSTANTS[24]*CONSTANTS[25]*1.00000);
ALGEBRAIC[71] = ALGEBRAIC[68]+ALGEBRAIC[69];
ALGEBRAIC[19] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[23]*CONSTANTS[21]*1.00000);
ALGEBRAIC[73] = ALGEBRAIC[71]+ALGEBRAIC[19];
ALGEBRAIC[76] = ALGEBRAIC[73]+ALGEBRAIC[74];
ALGEBRAIC[20] = ALGEBRAIC[19];
ALGEBRAIC[77] = ( CONSTANTS[27]*CONSTANTS[20]*ALGEBRAIC[75]+ CONSTANTS[20]*ALGEBRAIC[20])/ALGEBRAIC[76];
ALGEBRAIC[78] = CONSTANTS[28]*ALGEBRAIC[77];
RATES[5] = CONSTANTS[74] - ALGEBRAIC[78];
RATES[4] = ALGEBRAIC[78] - 0.500000*ALGEBRAIC[8];
}
void
computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC)
{
ALGEBRAIC[0] = 1.00000/(1.00000+exp((CONSTANTS[4] - STATES[0])/CONSTANTS[5]));
ALGEBRAIC[8] = CONSTANTS[13]* pow(fabs(STATES[4]/1.00000), 1.0 / 2);
ALGEBRAIC[12] = CONSTANTS[38] - STATES[7];
ALGEBRAIC[14] = (CONSTANTS[29]/(CONSTANTS[30]+STATES[7]/ALGEBRAIC[12]))*(STATES[6]/(CONSTANTS[31]+STATES[6]))*(ALGEBRAIC[8]+CONSTANTS[32]);
ALGEBRAIC[10] = ( CONSTANTS[34]*(STATES[7]/(CONSTANTS[35]+STATES[7])))/(1.00000+exp((STATES[8] - CONSTANTS[36])/CONSTANTS[37]));
ALGEBRAIC[24] = (CONSTANTS[56]/STATES[2])*STATES[6]*exp( CONSTANTS[57]*STATES[8]);
ALGEBRAIC[23] = ( CONSTANTS[54]*STATES[8] - CONSTANTS[55])*pow(STATES[2], 2.00000);
ALGEBRAIC[26] = ALGEBRAIC[24] - ALGEBRAIC[23];
ALGEBRAIC[21] = ( CONSTANTS[40]*(STATES[7]/(CONSTANTS[41]+STATES[7])))/(1.00000+exp((STATES[8] - CONSTANTS[42])/CONSTANTS[43]));
ALGEBRAIC[25] = CONSTANTS[59] - STATES[9];
ALGEBRAIC[27] = (( CONSTANTS[47]*CONSTANTS[44])/(CONSTANTS[44]+ALGEBRAIC[25]))/(1.00000+exp((CONSTANTS[45] - STATES[8])/CONSTANTS[46]));
ALGEBRAIC[29] = 3.00000*ALGEBRAIC[27];
ALGEBRAIC[31] = ALGEBRAIC[25]/STATES[9];
ALGEBRAIC[33] = CONSTANTS[51]*((ALGEBRAIC[31]/(ALGEBRAIC[31]+CONSTANTS[52]))/exp( -0.500000*CONSTANTS[53]*STATES[8]));
ALGEBRAIC[22] = CONSTANTS[49]*STATES[8]+CONSTANTS[50];
ALGEBRAIC[30] = CONSTANTS[67]*(STATES[10] - STATES[2]);
ALGEBRAIC[32] = CONSTANTS[68]*STATES[2];
ALGEBRAIC[34] = ALGEBRAIC[30] - ALGEBRAIC[32];
ALGEBRAIC[2] = 1.00000/(1.00000+exp((CONSTANTS[8] - STATES[0])/CONSTANTS[9]));
ALGEBRAIC[3] = CONSTANTS[6]*ALGEBRAIC[2]*(STATES[0] - CONSTANTS[7]);
ALGEBRAIC[28] = - ( CONSTANTS[65]*ALGEBRAIC[3]+ CONSTANTS[64]*(STATES[2] - CONSTANTS[66]));
ALGEBRAIC[35] = CONSTANTS[62] - STATES[3];
ALGEBRAIC[38] = ( CONSTANTS[60]*STATES[2]+CONSTANTS[61])*ALGEBRAIC[35];
ALGEBRAIC[1] = CONSTANTS[1]*STATES[1]*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[4] = (CONSTANTS[10]/(1.00000+pow(CONSTANTS[11]/STATES[2], 2.00000)))*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[5] = 0.165000*STATES[3];
ALGEBRAIC[6] = 0.0800000*(1.00000+( 2.00000*ALGEBRAIC[5])/17.0000)+ 0.890000*pow(ALGEBRAIC[5]/17.0000, 2.00000);
ALGEBRAIC[7] = 0.135000*STATES[3];
ALGEBRAIC[36] = 0.0500000*ALGEBRAIC[35];
ALGEBRAIC[39] = pow(1.00000+ALGEBRAIC[5]/17.0000, 2.00000)*(1.00000+ALGEBRAIC[7]/26.0000+ALGEBRAIC[36]/1.00000);
ALGEBRAIC[41] = ALGEBRAIC[6]/ALGEBRAIC[39];
ALGEBRAIC[43] = CONSTANTS[12]*ALGEBRAIC[41]*(STATES[0] - CONSTANTS[2]);
ALGEBRAIC[9] = 0.300000*STATES[5];
ALGEBRAIC[11] = pow(ALGEBRAIC[9], 2.00000)/( CONSTANTS[18]*1.00000);
ALGEBRAIC[13] = CONSTANTS[71]+ALGEBRAIC[11];
ALGEBRAIC[44] = pow( ALGEBRAIC[9]*ALGEBRAIC[35], 2.00000)/( CONSTANTS[22]*CONSTANTS[18]*CONSTANTS[19]*pow(1.00000, 2.00000));
ALGEBRAIC[45] = ALGEBRAIC[13]+ALGEBRAIC[44];
ALGEBRAIC[47] = ALGEBRAIC[45];
ALGEBRAIC[50] = ALGEBRAIC[47];
ALGEBRAIC[16] = ( STATES[4]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[23]*1.00000);
ALGEBRAIC[52] = ALGEBRAIC[50]+ALGEBRAIC[16];
ALGEBRAIC[54] = ( STATES[4]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[23]*CONSTANTS[24]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[55] = ALGEBRAIC[52]+ALGEBRAIC[54];
ALGEBRAIC[57] = ALGEBRAIC[55];
ALGEBRAIC[60] = ALGEBRAIC[57];
ALGEBRAIC[17] = ( CONSTANTS[26]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[16]*CONSTANTS[18]*CONSTANTS[21]*1.00000);
ALGEBRAIC[62] = ALGEBRAIC[60]+ALGEBRAIC[17];
ALGEBRAIC[64] = ( CONSTANTS[26]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[21]*CONSTANTS[25]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[65] = ALGEBRAIC[62]+ALGEBRAIC[64];
ALGEBRAIC[67] = ALGEBRAIC[65];
ALGEBRAIC[70] = ALGEBRAIC[67];
ALGEBRAIC[72] = ALGEBRAIC[70];
ALGEBRAIC[74] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[9], 2.00000)*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[19]*CONSTANTS[23]*CONSTANTS[21]*CONSTANTS[24]*CONSTANTS[25]*CONSTANTS[22]*pow(1.00000, 2.00000));
ALGEBRAIC[75] = ALGEBRAIC[72]+ALGEBRAIC[74];
ALGEBRAIC[37] = pow(ALGEBRAIC[35], 2.00000)/( CONSTANTS[19]*1.00000);
ALGEBRAIC[40] = CONSTANTS[14]+ALGEBRAIC[37];
ALGEBRAIC[42] = ALGEBRAIC[40]+ALGEBRAIC[11];
ALGEBRAIC[46] = ALGEBRAIC[42]+ALGEBRAIC[44];
ALGEBRAIC[15] = STATES[4]/CONSTANTS[17];
ALGEBRAIC[48] = ALGEBRAIC[46]+ALGEBRAIC[15];
ALGEBRAIC[49] = ( STATES[4]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[17]*CONSTANTS[19]*CONSTANTS[24]*1.00000);
ALGEBRAIC[51] = ALGEBRAIC[48]+ALGEBRAIC[49];
ALGEBRAIC[53] = ALGEBRAIC[51]+ALGEBRAIC[16];
ALGEBRAIC[56] = ALGEBRAIC[53]+ALGEBRAIC[54];
ALGEBRAIC[58] = ALGEBRAIC[56]+CONSTANTS[73];
ALGEBRAIC[59] = ( CONSTANTS[26]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[19]*CONSTANTS[25]*1.00000);
ALGEBRAIC[61] = ALGEBRAIC[58]+ALGEBRAIC[59];
ALGEBRAIC[63] = ALGEBRAIC[61]+ALGEBRAIC[17];
ALGEBRAIC[66] = ALGEBRAIC[63]+ALGEBRAIC[64];
ALGEBRAIC[18] = ( CONSTANTS[26]*STATES[4])/( CONSTANTS[16]*CONSTANTS[17]);
ALGEBRAIC[68] = ALGEBRAIC[66]+ALGEBRAIC[18];
ALGEBRAIC[69] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[35], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[19]*CONSTANTS[24]*CONSTANTS[25]*1.00000);
ALGEBRAIC[71] = ALGEBRAIC[68]+ALGEBRAIC[69];
ALGEBRAIC[19] = ( CONSTANTS[26]*STATES[4]*pow(ALGEBRAIC[9], 2.00000))/( CONSTANTS[16]*CONSTANTS[17]*CONSTANTS[18]*CONSTANTS[23]*CONSTANTS[21]*1.00000);
ALGEBRAIC[73] = ALGEBRAIC[71]+ALGEBRAIC[19];
ALGEBRAIC[76] = ALGEBRAIC[73]+ALGEBRAIC[74];
ALGEBRAIC[20] = ALGEBRAIC[19];
ALGEBRAIC[77] = ( CONSTANTS[27]*CONSTANTS[20]*ALGEBRAIC[75]+ CONSTANTS[20]*ALGEBRAIC[20])/ALGEBRAIC[76];
ALGEBRAIC[78] = CONSTANTS[28]*ALGEBRAIC[77];
}