C C There are a total of 2 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 13 entries in the constant variable array. C C C VOI is time in component environment (minute). C STATES(1) is C in component C (nanomolar). C CONSTS(1) is kf1 in component model_parameters (second_order_rate_constant). C CONSTS(12) is kr1 in component model_parameters (first_order_rate_constant). C CONSTS(2) is kx2 in component model_parameters (second_order_rate_constant). C CONSTS(3) is k_x2 in component model_parameters (first_order_rate_constant). C CONSTS(4) is kt in component model_parameters (first_order_rate_constant). C STATES(2) is D in component D (nanomolar). C CONSTS(5) is L in component model_parameters (nanomolar). C STATES(3) is R in component R (nanomolar). C CONSTS(13) is k_x1 in component model_parameters (first_order_rate_constant). C CONSTS(6) is ke in component model_parameters (first_order_rate_constant). C CONSTS(7) is krec in component model_parameters (first_order_rate_constant). C STATES(4) is Ri in component Ri (nanomolar). C CONSTS(8) is Vs in component model_parameters (flux). C CONSTS(9) is kdeg in component model_parameters (first_order_rate_constant). C ALGBRC(1) is R0 in component R0 (nanomolar). C ALGBRC(2) is signal in component signal (dimensionless). C CONSTS(10) is kappaE in component model_parameters (dimensionless). C CONSTS(11) is KD in component model_parameters (nanomolar). C RATES(1) is d/dt C in component C (nanomolar). C RATES(2) is d/dt D in component D (nanomolar). C RATES(3) is d/dt R in component R (nanomolar). C RATES(4) is d/dt Ri in component Ri (nanomolar). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = 0.0 CONSTS(1) = 0.1 CONSTS(2) = 4.83 CONSTS(3) = 0.016 CONSTS(4) = 0.005 STATES(2) = 0.0 CONSTS(5) = 0.01 STATES(3) = 0.0 CONSTS(6) = 0.10 CONSTS(7) = 0.0 STATES(4) = 0.0 CONSTS(8) = 10.0 CONSTS(9) = 0.05 CONSTS(10) = 0.20 CONSTS(11) = 1.0 CONSTS(12) = CONSTS(11)*CONSTS(1) CONSTS(13) = 0.0100000*CONSTS(12) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(1) = ( CONSTS(1)*CONSTS(5)*STATES(3)+ CONSTS(3)*STATES(2)) - (CONSTS(12)+ CONSTS(2)*STATES(3)+CONSTS(4))*STATES(1) RATES(2) = CONSTS(2)*STATES(3)*STATES(1) - (CONSTS(3)+CONSTS(13)+CONSTS(6))*STATES(2) RATES(3) = (CONSTS(8)+ CONSTS(12)*STATES(1)+ (CONSTS(3)+ 2.00000*CONSTS(13))*STATES(2)+ CONSTS(7)*STATES(4)) - ( CONSTS(1)*CONSTS(5)+ CONSTS(2)*STATES(1)+CONSTS(4))*STATES(3) RATES(4) = CONSTS(4)*(STATES(3)+STATES(1)) - (CONSTS(7)+CONSTS(9))*STATES(4) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = STATES(3)+STATES(1)+STATES(3)+ 2.00000*(CONSTS(6)/CONSTS(4))*(1.00000+CONSTS(7)/CONSTS(9))*STATES(2) ALGBRC(2) = (( 2.00000*STATES(2))/ALGBRC(1))/(CONSTS(10)+( 2.00000*STATES(2))/ALGBRC(1)) RETURN END