C C There are a total of 14 entries in the algebraic variable array. C There are a total of 4 entries in each of the rate and state variable arrays. C There are a total of 46 entries in the constant variable array. C C C VOI is time in component environment (msec). C ALGBRC(1) is t_modulo in component environment (msec). C CONSTS(1) is Acap in component general_parameters (cm2). C CONSTS(2) is V_myo in component general_parameters (uL). C CONSTS(3) is C_m in component general_parameters (uF_per_cm2). C CONSTS(4) is F in component general_parameters (C_per_mmole). C CONSTS(5) is T in component general_parameters (kelvin). C CONSTS(6) is R in component general_parameters (J_per_K_per_mol). C CONSTS(7) is CaM_tot in component general_parameters (uM). C CONSTS(8) is Km_CaM in component general_parameters (uM). C CONSTS(9) is Ca_o in component general_parameters (uM). C CONSTS(10) is Na_o in component general_parameters (uM). C CONSTS(11) is Ca_NSR in component general_parameters (uM). C CONSTS(12) is J_leak in component general_parameters (uM_per_msec). C ALGBRC(2) is V in component action_potential (mV). C CONSTS(13) is t1 in component action_potential (msec). C CONSTS(14) is t2 in component action_potential (msec). C CONSTS(15) is p in component action_potential (dimensionless). C CONSTS(16) is A in component action_potential (mV). C CONSTS(17) is A1 in component action_potential (msec). C CONSTS(18) is rest in component action_potential (mV). C ALGBRC(4) is Ca_input in component calcium_input (uM_per_msec). C ALGBRC(3) is tcalcium in component calcium_input (msec). C CONSTS(19) is Ca_tau1 in component calcium_input (msec). C CONSTS(20) is Ca_tau2 in component calcium_input (msec). C CONSTS(21) is Ca_pow in component calcium_input (dimensionless). C CONSTS(22) is Ca_amp in component calcium_input (uM_per_msec). C ALGBRC(5) is INaCa in component NCX_current (uA_per_uF). C CONSTS(23) is Na_i in component NCX_current (uM). C CONSTS(24) is KmNa in component NCX_current (uM). C CONSTS(25) is KmCa in component NCX_current (uM). C CONSTS(26) is ksat in component NCX_current (dimensionless). C CONSTS(27) is eta in component NCX_current (dimensionless). C CONSTS(28) is kNaCa in component NCX_current (uA_per_uF). C STATES(1) is Ca_cyt in component differential_equations (uM). C CONSTS(29) is SERCA_TOT in component serca_parameters (uM). C CONSTS(30) is CaMKII_reg in component serca_parameters (dimensionless). C CONSTS(31) is PKA_reg in component serca_parameters (dimensionless). C CONSTS(32) is PSR in component serca_parameters (dimensionless). C CONSTS(33) is Kmf_PLBKO in component serca_parameters (uM). C CONSTS(34) is Kmf_PLB in component serca_parameters (uM). C CONSTS(35) is Kmr_PLBKO in component serca_parameters (uM). C CONSTS(36) is Kmr_PLB in component serca_parameters (uM). C CONSTS(37) is PLB_tot in component serca_parameters (uM). C CONSTS(38) is kplb_pos in component serca_parameters (per_msec). C CONSTS(39) is kplb_neg in component serca_parameters (per_msec). C ALGBRC(6) is EC_50_fwd in component serca_parameters (uM). C ALGBRC(7) is EC_50_rev in component serca_parameters (uM). C STATES(2) is PLB_dephosph in component differential_equations (uM). C CONSTS(46) is k_cyt_serca in component transition_parameters (per_uM2_per_msec). C ALGBRC(8) is k_serca_cyt in component transition_parameters (per_msec). C CONSTS(44) is k_serca_sr in component transition_parameters (per_msec). C ALGBRC(9) is k_sr_serca in component transition_parameters (per_uM2_per_msec). C CONSTS(45) is br_cyt_serca in component transition_parameters (per_uM2_per_msec). C CONSTS(40) is br_serca_sr in component transition_parameters (per_msec). C ALGBRC(13) is J_up in component calcium_fluxes (uM_per_msec). C ALGBRC(10) is J_cyt_serca in component calcium_fluxes (uM_per_msec). C ALGBRC(11) is J_serca_sr in component calcium_fluxes (uM_per_msec). C STATES(3) is Ca_serca in component differential_equations (uM). C CONSTS(41) is LTRPN_tot in component calcium_buffering (uM). C CONSTS(42) is kltrpn_pos in component calcium_buffering (per_uM_per_msec). C CONSTS(43) is kltrpn_neg in component calcium_buffering (per_msec). C ALGBRC(14) is J_LTRPN in component calcium_buffering (uM_per_msec). C ALGBRC(12) is B_i in component calcium_buffering (dimensionless). C STATES(4) is LTRPN in component differential_equations (uM). C RATES(1) is d/dt Ca_cyt in component differential_equations (uM). C RATES(4) is d/dt LTRPN in component differential_equations (uM). C RATES(2) is d/dt PLB_dephosph in component differential_equations (uM). C RATES(3) is d/dt Ca_serca in component differential_equations (uM). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 1.534e-4 CONSTS(2) = 25.84e-6 CONSTS(3) = 1 CONSTS(4) = 96.5 CONSTS(5) = 298 CONSTS(6) = 8.314 CONSTS(7) = 24 CONSTS(8) = 2.38 CONSTS(9) = 1000 CONSTS(10) = 140000 CONSTS(11) = 760 CONSTS(12) = 0.0003 CONSTS(13) = 0.5 CONSTS(14) = 200 CONSTS(15) = 2 CONSTS(16) = 135 CONSTS(17) = 110 CONSTS(18) = -90 CONSTS(19) = 1.5 CONSTS(20) = 7.5 CONSTS(21) = 2 CONSTS(22) = 10 CONSTS(23) = 10000 CONSTS(24) = 87500 CONSTS(25) = 1380 CONSTS(26) = 0.1 CONSTS(27) = 0.35 CONSTS(28) = 950 STATES(1) = 0.1 CONSTS(29) = 20 CONSTS(30) = 0.1 CONSTS(31) = 0.1 CONSTS(32) = 1 CONSTS(33) = 0.15 CONSTS(34) = 0.15 CONSTS(35) = 2500 CONSTS(36) = 1110 CONSTS(37) = 1 CONSTS(38) = 1 CONSTS(39) = 6.8 STATES(2) = 0.1 CONSTS(40) = 0.00625 STATES(3) = 5 CONSTS(41) = 70 CONSTS(42) = 0.1 CONSTS(43) = 0.06 STATES(4) = 11 CONSTS(44) = CONSTS(40)*(1.00000+ 0.700000*CONSTS(30)) CONSTS(45) = 1000.00*CONSTS(40) CONSTS(46) = CONSTS(45)*(1.00000+ 0.700000*CONSTS(30)) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) RATES(4) = CONSTS(42)*STATES(1)*(CONSTS(41) - STATES(4)) - CONSTS(43)*STATES(4) RATES(2) = CONSTS(38)*(CONSTS(37) - STATES(2)) - CONSTS(39)*CONSTS(30)+CONSTS(31) ** 2.00000*STATES(2) ALGBRC(6) = (CONSTS(33)+( CONSTS(34)*CONSTS(32)*STATES(2))/1.00000)*(1.00000+ 0.270000*CONSTS(30)) ALGBRC(8) = ALGBRC(6) ** 2.00000*CONSTS(45) ALGBRC(10) = CONSTS(46)*STATES(1) ** 2.00000*(CONSTS(29) - STATES(3)) - ALGBRC(8)*STATES(3) ALGBRC(7) = CONSTS(35) - ( CONSTS(36)*CONSTS(32)*STATES(2))/1.00000 ALGBRC(9) = CONSTS(40)/ALGBRC(7) ** 2.00000 ALGBRC(11) = CONSTS(44)*STATES(3) - ALGBRC(9)*CONSTS(11) ** 2.00000*(CONSTS(29) - STATES(3)) RATES(3) = ALGBRC(10) - ALGBRC(11) ALGBRC(1) = INT(MOD(VOI, 1000.00)) ALGBRC(3) = TERNRY(ALGBRC(1) - 1.20000.LE.0.00000, 0.00000, ALGBRC(1) - 1.20000) ALGBRC(4) = CONSTS(22)*1.00000 - EXP(- ALGBRC(3)/CONSTS(19)) ** CONSTS(21)*EXP(- ALGBRC(3)/CONSTS(20)) ALGBRC(2) = CONSTS(18)+ CONSTS(16)*1.00000 - EXP(- ALGBRC(1)/CONSTS(13)) ** CONSTS(15)*EXP(- ALGBRC(1)/CONSTS(14))*(1.00000 - ALGBRC(1) ** 10.0000/(CONSTS(17) ** 10.0000+ALGBRC(1) ** 10.0000)) ALGBRC(5) = (CONSTS(28)/( (CONSTS(24) ** 3.00000+CONSTS(10) ** 3.00000)*(CONSTS(25)+CONSTS(9))*(1.00000+ CONSTS(26)*EXP(( (CONSTS(27) - 1.00000)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5))))))*( EXP(( CONSTS(27)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5)))*CONSTS(23) ** 3.00000*CONSTS(9) - EXP(( (CONSTS(27) - 1.00000)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5)))*CONSTS(10) ** 3.00000*STATES(1)) ALGBRC(14) = CONSTS(42)*STATES(1)*(CONSTS(41) - STATES(4)) - CONSTS(43)*STATES(4) ALGBRC(12) = 1.00000+( CONSTS(7)*CONSTS(8))/CONSTS(8)+STATES(1) ** 2.00000 ** - 1.00000 RATES(1) = ALGBRC(12)*(((( ALGBRC(5)*CONSTS(1)*CONSTS(3))/( 2.00000*CONSTS(2)*CONSTS(4)) - ALGBRC(10))+CONSTS(12)+ALGBRC(4)) - ALGBRC(14)) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(6) = (CONSTS(33)+( CONSTS(34)*CONSTS(32)*STATES(2))/1.00000)*(1.00000+ 0.270000*CONSTS(30)) ALGBRC(8) = ALGBRC(6) ** 2.00000*CONSTS(45) ALGBRC(10) = CONSTS(46)*STATES(1) ** 2.00000*(CONSTS(29) - STATES(3)) - ALGBRC(8)*STATES(3) ALGBRC(7) = CONSTS(35) - ( CONSTS(36)*CONSTS(32)*STATES(2))/1.00000 ALGBRC(9) = CONSTS(40)/ALGBRC(7) ** 2.00000 ALGBRC(11) = CONSTS(44)*STATES(3) - ALGBRC(9)*CONSTS(11) ** 2.00000*(CONSTS(29) - STATES(3)) ALGBRC(1) = INT(MOD(VOI, 1000.00)) ALGBRC(3) = TERNRY(ALGBRC(1) - 1.20000.LE.0.00000, 0.00000, ALGBRC(1) - 1.20000) ALGBRC(4) = CONSTS(22)*1.00000 - EXP(- ALGBRC(3)/CONSTS(19)) ** CONSTS(21)*EXP(- ALGBRC(3)/CONSTS(20)) ALGBRC(2) = CONSTS(18)+ CONSTS(16)*1.00000 - EXP(- ALGBRC(1)/CONSTS(13)) ** CONSTS(15)*EXP(- ALGBRC(1)/CONSTS(14))*(1.00000 - ALGBRC(1) ** 10.0000/(CONSTS(17) ** 10.0000+ALGBRC(1) ** 10.0000)) ALGBRC(5) = (CONSTS(28)/( (CONSTS(24) ** 3.00000+CONSTS(10) ** 3.00000)*(CONSTS(25)+CONSTS(9))*(1.00000+ CONSTS(26)*EXP(( (CONSTS(27) - 1.00000)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5))))))*( EXP(( CONSTS(27)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5)))*CONSTS(23) ** 3.00000*CONSTS(9) - EXP(( (CONSTS(27) - 1.00000)*ALGBRC(2)*CONSTS(4))/( CONSTS(6)*CONSTS(5)))*CONSTS(10) ** 3.00000*STATES(1)) ALGBRC(14) = CONSTS(42)*STATES(1)*(CONSTS(41) - STATES(4)) - CONSTS(43)*STATES(4) ALGBRC(12) = 1.00000+( CONSTS(7)*CONSTS(8))/CONSTS(8)+STATES(1) ** 2.00000 ** - 1.00000 ALGBRC(13) = ALGBRC(10) - ALGBRC(11) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END