C C There are a total of 2 entries in the algebraic variable array. C There are a total of 1 entries in each of the rate and state variable arrays. C There are a total of 17 entries in the constant variable array. C C C VOI is time in component environment (msec). C CONSTS(1) is Ca_cyt in component general_parameters (uM). C CONSTS(2) is Ca_NSR in component general_parameters (uM). C CONSTS(3) is CaMKII_reg in component general_parameters (dimensionless). C CONSTS(4) is SERCA_TOT in component serca_parameters (uM). C CONSTS(5) is PSR in component serca_parameters (dimensionless). C CONSTS(6) is Kmf_PLBKO in component serca_parameters (uM). C CONSTS(7) is Kmf_PLB in component serca_parameters (uM). C CONSTS(8) is Kmr_PLBKO in component serca_parameters (uM). C CONSTS(9) is Kmr_PLB in component serca_parameters (uM). C CONSTS(13) is EC_50_fwd in component serca_parameters (uM). C CONSTS(11) is EC_50_rev in component serca_parameters (uM). C CONSTS(16) is k_cyt_serca in component transition_parameters (per_msec_per_uM2). C CONSTS(17) is k_serca_cyt in component transition_parameters (per_msec). C CONSTS(12) is k_serca_sr in component transition_parameters (per_msec). C CONSTS(14) is k_sr_serca in component transition_parameters (per_msec_per_uM2). C CONSTS(15) is br_cyt_serca in component transition_parameters (per_msec_per_uM2). C CONSTS(10) is br_serca_sr in component transition_parameters (per_msec). C ALGBRC(1) is J_cyt_serca in component calcium_fluxes (uM_per_msec). C ALGBRC(2) is J_serca_sr in component calcium_fluxes (uM_per_msec). C STATES(1) is Ca_serca in component calcium_bound_serca (uM). C RATES(1) is d/dt Ca_serca in component calcium_bound_serca (uM). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 0.25 CONSTS(2) = 760 CONSTS(3) = 0 CONSTS(4) = 47 CONSTS(5) = 1 CONSTS(6) = 0.15 CONSTS(7) = 0.15 CONSTS(8) = 2500 CONSTS(9) = 1110 CONSTS(10) = 0.00625 STATES(1) = 12 CONSTS(11) = CONSTS(8) - CONSTS(9)*CONSTS(5) CONSTS(12) = CONSTS(10)*(1.00000+ 0.700000*CONSTS(3)) CONSTS(13) = (CONSTS(6)+ CONSTS(7)*CONSTS(5))*(1.00000+ 0.270000*CONSTS(3)) CONSTS(14) = CONSTS(10)/CONSTS(11) ** 2.00000 CONSTS(15) = 1000.00*CONSTS(10) CONSTS(16) = CONSTS(15)*(1.00000+ 0.700000*CONSTS(3)) CONSTS(17) = CONSTS(13) ** 2.00000*CONSTS(15) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(16)*CONSTS(1) ** 2.00000*(CONSTS(4) - STATES(1)) - CONSTS(17)*STATES(1) ALGBRC(2) = CONSTS(12)*STATES(1) - CONSTS(14)*CONSTS(2) ** 2.00000*(CONSTS(4) - STATES(1)) RATES(1) = ALGBRC(1) - ALGBRC(2) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(16)*CONSTS(1) ** 2.00000*(CONSTS(4) - STATES(1)) - CONSTS(17)*STATES(1) ALGBRC(2) = CONSTS(12)*STATES(1) - CONSTS(14)*CONSTS(2) ** 2.00000*(CONSTS(4) - STATES(1)) RETURN END