/* There are a total of 5 entries in the algebraic variable array. There are a total of 3 entries in each of the rate and state variable arrays. There are a total of 14 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is V in component membrane (millivolt). * CONSTANTS[0] is Cm in component membrane (picoF). * ALGEBRAIC[0] is i_s in component calcium_channel (femtoA). * ALGEBRAIC[2] is i_K in component potassium_channel (femtoA). * ALGEBRAIC[3] is i_K_ACh in component acetyl_choline_activated_potassium_channel (femtoA). * ALGEBRAIC[4] is i_j in component coupling_current (femtoA). * CONSTANTS[1] is g_s in component calcium_channel (picoS). * CONSTANTS[2] is V_s in component calcium_channel (millivolt). * CONSTANTS[3] is V_1 in component calcium_channel (millivolt). * CONSTANTS[4] is V_2 in component calcium_channel (millivolt). * CONSTANTS[5] is g_K in component potassium_channel (picoS). * CONSTANTS[6] is V_K in component potassium_channel (millivolt). * STATES[1] is w in component potassium_channel_w_gate (dimensionless). * CONSTANTS[7] is lambda_w in component potassium_channel_w_gate (per_second). * CONSTANTS[8] is V_3 in component potassium_channel_w_gate (millivolt). * CONSTANTS[9] is V_4 in component potassium_channel_w_gate (millivolt). * STATES[2] is u in component acetyl_choline_activated_potassium_channel_u_gate (dimensionless). * CONSTANTS[13] is alpha in component acetyl_choline_activated_potassium_channel_u_gate (per_second). * ALGEBRAIC[1] is beta in component acetyl_choline_activated_potassium_channel_u_gate (per_second). * CONSTANTS[10] is ACh in component acetyl_choline_activated_potassium_channel_u_gate (molar). * CONSTANTS[11] is g_j in component coupling_current (picoS). * CONSTANTS[12] is V_B in component coupling_current (millivolt). * RATES[0] is d/dt V in component membrane (millivolt). * RATES[1] is d/dt w in component potassium_channel_w_gate (dimensionless). * RATES[2] is d/dt u in component acetyl_choline_activated_potassium_channel_u_gate (dimensionless). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = -52.07606; CONSTANTS[0] = 60; CONSTANTS[1] = 382.9118; CONSTANTS[2] = 214.1429; CONSTANTS[3] = -35.9358; CONSTANTS[4] = 7.8589; CONSTANTS[5] = 536.1093; CONSTANTS[6] = -259.0783; STATES[1] = 0.0008971; CONSTANTS[7] = 20.7796; CONSTANTS[8] = -27.9375; CONSTANTS[9] = 6.321; STATES[2] = 0.2344555; CONSTANTS[10] = 1e-6; CONSTANTS[11] = 0; CONSTANTS[12] = -50; CONSTANTS[13] = 0.0123320/(1.00000+4.20000e-06/CONSTANTS[10]); } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { RATES[1] = CONSTANTS[7]*cosh((STATES[0] - CONSTANTS[8])/( 2.00000*CONSTANTS[9]))*( (1.00000/2.00000)*(1.00000+ tanh((STATES[0] - CONSTANTS[8])/CONSTANTS[9])) - STATES[1]); ALGEBRAIC[1] = 0.0100000*exp( 0.0133000*(STATES[0]+40.0000)); RATES[2] = CONSTANTS[13]*(1.00000 - STATES[2]) - ALGEBRAIC[1]*STATES[2]; ALGEBRAIC[0] = (1.00000/2.00000)*CONSTANTS[1]*(1.00000+ tanh((STATES[0] - CONSTANTS[3])/CONSTANTS[4]))*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[2] = CONSTANTS[5]*STATES[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[3] = 1.00000*0.270000*STATES[2]*(STATES[0]+90.0000); ALGEBRAIC[4] = CONSTANTS[11]*(STATES[0] - CONSTANTS[12]); RATES[0] = - (ALGEBRAIC[0]+ALGEBRAIC[2]+ALGEBRAIC[3]+ALGEBRAIC[4])/CONSTANTS[0]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[1] = 0.0100000*exp( 0.0133000*(STATES[0]+40.0000)); ALGEBRAIC[0] = (1.00000/2.00000)*CONSTANTS[1]*(1.00000+ tanh((STATES[0] - CONSTANTS[3])/CONSTANTS[4]))*(STATES[0] - CONSTANTS[2]); ALGEBRAIC[2] = CONSTANTS[5]*STATES[1]*(STATES[0] - CONSTANTS[6]); ALGEBRAIC[3] = 1.00000*0.270000*STATES[2]*(STATES[0]+90.0000); ALGEBRAIC[4] = CONSTANTS[11]*(STATES[0] - CONSTANTS[12]); }