/* There are a total of 1 entries in the algebraic variable array. There are a total of 17 entries in each of the rate and state variable arrays. There are a total of 16 entries in the constant variable array. */ /* * VOI is time in component environment (second). * STATES[0] is Py in component Py (nanomolar). * CONSTANTS[0] is Zn in component model_parameters (nanomolar). * STATES[1] is Py1 in component Py1 (nanomolar). * CONSTANTS[1] is r3 in component model_parameters (third_order_rate_constant). * CONSTANTS[2] is r4 in component model_parameters (first_order_rate_constant). * STATES[2] is Dw in component Dw (nanomolar). * STATES[3] is Qw2 in component Qw2 (nanomolar). * CONSTANTS[3] is k_1 in component model_parameters (first_order_rate_constant). * CONSTANTS[4] is k1a in component model_parameters (second_order_rate_constant). * STATES[4] is Qw1 in component Qw1 (nanomolar). * STATES[5] is Rw in component Rw (nanomolar). * CONSTANTS[5] is k2 in component model_parameters (second_order_rate_constant). * CONSTANTS[6] is k_2 in component model_parameters (first_order_rate_constant). * ALGEBRAIC[0] is k3 in component model_parameters (first_order_rate_constant). * STATES[6] is Mw in component Mw (nanomolar). * STATES[7] is Px in component Px (nanomolar). * STATES[8] is Px1 in component Px1 (nanomolar). * STATES[9] is Dz in component Dz (nanomolar). * STATES[10] is Qz4 in component Qz4 (nanomolar). * CONSTANTS[7] is r1 in component model_parameters (second_order_rate_constant). * CONSTANTS[8] is r2 in component model_parameters (first_order_rate_constant). * CONSTANTS[9] is k1b in component model_parameters (second_order_rate_constant). * STATES[11] is Qz2 in component Qz2 (nanomolar). * CONSTANTS[10] is k1 in component model_parameters (second_order_rate_constant). * STATES[12] is Qz1 in component Qz1 (nanomolar). * STATES[13] is Rz in component Rz (nanomolar). * CONSTANTS[11] is k2a in component model_parameters (second_order_rate_constant). * STATES[14] is Qz3 in component Qz3 (nanomolar). * STATES[15] is Qz5 in component Qz5 (nanomolar). * CONSTANTS[12] is k2b in component model_parameters (second_order_rate_constant). * CONSTANTS[13] is k2c in component model_parameters (second_order_rate_constant). * STATES[16] is Mz in component Mz (nanomolar). * CONSTANTS[14] is td0 in component model_parameters (second). * CONSTANTS[15] is td in component model_parameters (second). * RATES[0] is d/dt Py in component Py (nanomolar). * RATES[1] is d/dt Py1 in component Py1 (nanomolar). * RATES[2] is d/dt Dw in component Dw (nanomolar). * RATES[5] is d/dt Rw in component Rw (nanomolar). * RATES[4] is d/dt Qw1 in component Qw1 (nanomolar). * RATES[3] is d/dt Qw2 in component Qw2 (nanomolar). * RATES[6] is d/dt Mw in component Mw (nanomolar). * RATES[7] is d/dt Px in component Px (nanomolar). * RATES[8] is d/dt Px1 in component Px1 (nanomolar). * RATES[9] is d/dt Dz in component Dz (nanomolar). * RATES[13] is d/dt Rz in component Rz (nanomolar). * RATES[12] is d/dt Qz1 in component Qz1 (nanomolar). * RATES[11] is d/dt Qz2 in component Qz2 (nanomolar). * RATES[14] is d/dt Qz3 in component Qz3 (nanomolar). * RATES[10] is d/dt Qz4 in component Qz4 (nanomolar). * RATES[15] is d/dt Qz5 in component Qz5 (nanomolar). * RATES[16] is d/dt Mz in component Mz (nanomolar). * There are a total of 4 condition variables. */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { STATES[0] = 25.0; CONSTANTS[0] = 1E-5; STATES[1] = 0.0; CONSTANTS[1] = 4.41E10; CONSTANTS[2] = 9E-3; STATES[2] = 4.0; STATES[3] = 0.0; CONSTANTS[3] = 0.9; CONSTANTS[4] = 1.0; STATES[4] = 0.0; STATES[5] = 50.0; CONSTANTS[5] = 0.02; CONSTANTS[6] = 0.3; STATES[6] = 0.0; STATES[7] = 25.0; STATES[8] = 0.0; STATES[9] = 4.0; STATES[10] = 0.0; CONSTANTS[7] = 2.73E2; CONSTANTS[8] = 3.437E-4; CONSTANTS[9] = 1.253E-2; STATES[11] = 0.0; CONSTANTS[10] = 0.025; STATES[12] = 0.0; STATES[13] = 50.0; CONSTANTS[11] = 0.00005; STATES[14] = 0.0; STATES[15] = 0.0; CONSTANTS[12] = 0.0002; CONSTANTS[13] = 0.0037; STATES[16] = 0.0; CONSTANTS[14] = 1800.0; CONSTANTS[15] = 2700; RATES[0] = 0.1001; RATES[1] = 0.1001; RATES[2] = 0.1001; RATES[5] = 0.1001; RATES[4] = 0.1001; RATES[3] = 0.1001; RATES[6] = 0.1001; RATES[7] = 0.1001; RATES[8] = 0.1001; RATES[9] = 0.1001; RATES[13] = 0.1001; RATES[12] = 0.1001; RATES[11] = 0.1001; RATES[14] = 0.1001; RATES[10] = 0.1001; RATES[15] = 0.1001; RATES[16] = 0.1001; } void computeResiduals(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { resid[0] = RATES[0] - CONSTANTS[2]*STATES[1] - CONSTANTS[1]*pow(CONSTANTS[0], 2.00000)*STATES[0]; resid[1] = RATES[1] - ( CONSTANTS[1]*pow(CONSTANTS[0], 2.00000)*STATES[0]+ CONSTANTS[3]*STATES[3]) - ( CONSTANTS[2]*STATES[1]+ CONSTANTS[4]*STATES[2]*STATES[1]); resid[2] = RATES[2] - ( CONSTANTS[3]*STATES[3]+ ALGEBRAIC[0]*STATES[4]+ CONSTANTS[6]*STATES[4]) - ( CONSTANTS[4]*STATES[2]*STATES[1]+ CONSTANTS[5]*STATES[2]*STATES[5]); resid[3] = RATES[5] - ( ALGEBRAIC[0]*STATES[4]+ CONSTANTS[6]*STATES[4]) - CONSTANTS[5]*STATES[2]*STATES[5]; resid[4] = RATES[4] - CONSTANTS[5]*STATES[2]*STATES[5] - ( ALGEBRAIC[0]*STATES[4]+ CONSTANTS[6]*STATES[4]); resid[5] = RATES[3] - CONSTANTS[4]*STATES[2]*STATES[1] - CONSTANTS[3]*STATES[3]; resid[6] = RATES[6] - ALGEBRAIC[0]*STATES[4]; resid[7] = RATES[7] - ( CONSTANTS[8]*STATES[8]+ CONSTANTS[3]*STATES[10]) - ( CONSTANTS[7]*CONSTANTS[0]*STATES[7]+ CONSTANTS[9]*STATES[9]*STATES[7]); resid[8] = RATES[8] - ( CONSTANTS[7]*CONSTANTS[0]*STATES[7]+ CONSTANTS[3]*STATES[11]) - ( CONSTANTS[8]*STATES[8]+ CONSTANTS[10]*STATES[9]*STATES[8]); resid[9] = RATES[9] - ( CONSTANTS[3]*STATES[11]+ ALGEBRAIC[0]*STATES[12]+ CONSTANTS[6]*STATES[12]+ CONSTANTS[3]*STATES[10]) - ( CONSTANTS[9]*STATES[9]*STATES[7]+ CONSTANTS[10]*STATES[9]*STATES[8]+ CONSTANTS[11]*STATES[9]*STATES[13]); resid[10] = RATES[13] - ( ALGEBRAIC[0]*STATES[12]+ CONSTANTS[6]*STATES[12]+ ALGEBRAIC[0]*STATES[14]+ CONSTANTS[6]*STATES[14]+ ALGEBRAIC[0]*STATES[15]+ CONSTANTS[6]*STATES[15]) - ( CONSTANTS[11]*STATES[9]*STATES[13]+ CONSTANTS[12]*STATES[10]*STATES[13]+ CONSTANTS[13]*STATES[11]*STATES[13]); resid[11] = RATES[12] - CONSTANTS[11]*STATES[9]*STATES[13] - ( ALGEBRAIC[0]*STATES[12]+ CONSTANTS[6]*STATES[12]); resid[12] = RATES[11] - ( CONSTANTS[10]*STATES[9]*STATES[8]+ ALGEBRAIC[0]*STATES[14]+ CONSTANTS[6]*STATES[14]) - ( CONSTANTS[3]*STATES[11]+ CONSTANTS[13]*STATES[11]*STATES[13]); resid[13] = RATES[14] - CONSTANTS[13]*STATES[11]*STATES[13] - ( ALGEBRAIC[0]*STATES[14]+ CONSTANTS[6]*STATES[14]); resid[14] = RATES[10] - ( CONSTANTS[9]*STATES[9]*STATES[7]+ ALGEBRAIC[0]*STATES[15]+ CONSTANTS[6]*STATES[15]) - ( CONSTANTS[3]*STATES[10]+ CONSTANTS[12]*STATES[10]*STATES[13]); resid[15] = RATES[15] - CONSTANTS[12]*STATES[10]*STATES[13] - ( ALGEBRAIC[0]*STATES[15]+ CONSTANTS[6]*STATES[15]); resid[16] = RATES[16] - ALGEBRAIC[0]*STATES[12]+ ALGEBRAIC[0]*STATES[14]+ ALGEBRAIC[0]*STATES[15]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { } void computeEssentialVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = (CONDVAR[0]>=0.00000&&CONDVAR[1]<0.00000 ? 0.00000 : CONDVAR[2]>=0.00000&&CONDVAR[3]<0.00000 ? 0.0110000 : 0.0/0.0); } void getStateInformation(double* SI) { SI[0] = 1.0; SI[1] = 1.0; SI[2] = 1.0; SI[3] = 1.0; SI[4] = 1.0; SI[5] = 1.0; SI[6] = 1.0; SI[7] = 1.0; SI[8] = 1.0; SI[9] = 1.0; SI[10] = 1.0; SI[11] = 1.0; SI[12] = 1.0; SI[13] = 1.0; SI[14] = 1.0; SI[15] = 1.0; SI[16] = 1.0; } void computeRoots(double VOI, double* CONSTANTS, double* RATES, double* OLDRATES, double* STATES, double* OLDSTATES, double* ALGEBRAIC, double* CONDVARS) { CONDVAR[0] = VOI - 0.00000; CONDVAR[1] = VOI - CONSTANTS[14]; CONDVAR[2] = VOI - CONSTANTS[14]; CONDVAR[3] = VOI - CONSTANTS[15]; }