C
C There are a total of 12 entries in the algebraic variable array.
C There are a total of 4 entries in each of the rate and state variable arrays.
C There are a total of 44 entries in the constant variable array.
C
C
C VOI is time in component environment (day).
C STATES(1) is OB_p in component OB_p (dimensionless).
C CONSTS(1) is D_OB_u in component OB_p (first_order_rate_constant).
C CONSTS(2) is K_D1_TGF_beta in component OB_p (pM).
C CONSTS(3) is K_D2_TGF_beta in component model_parameters (pM).
C CONSTS(4) is D_OB_p in component model_parameters (first_order_rate_constant).
C ALGBRC(2) is TGF_beta in component TGF_beta (pM).
C STATES(2) is OB_a in component OB_a (dimensionless).
C CONSTS(5) is A_OB_a in component OB_a (first_order_rate_constant).
C STATES(3) is OC_a in component OC_a (dimensionless).
C CONSTS(6) is D_OC_p in component OC_a (first_order_rate_constant).
C CONSTS(7) is A_OC_a in component OC_a (first_order_rate_constant).
C CONSTS(8) is K_D3_TGF_beta in component OC_a (pM).
C CONSTS(9) is OC_p in component OC_a (dimensionless).
C ALGBRC(7) is RANKL in component RANKL (pM).
C ALGBRC(8) is pi_RANKL_act_OC_p in component RANKL (dimensionless).
C STATES(4) is BV in component BV (dimensionless).
C ALGBRC(1) is OC_a_tilde in component BV (dimensionless).
C ALGBRC(3) is OB_a_tilde in component BV (dimensionless).
C CONSTS(10) is OC_a_initial in component BV (dimensionless).
C CONSTS(11) is OB_a_initial in component BV (dimensionless).
C CONSTS(12) is k_form in component BV (first_order_rate_constant).
C CONSTS(13) is k_res in component model_parameters (first_order_rate_constant).
C CONSTS(14) is alpha in component TGF_beta (pM).
C CONSTS(15) is D_TGF_beta_tilde in component TGF_beta (first_order_rate_constant).
C CONSTS(16) is S_TGF_beta in component TGF_beta (flux).
C CONSTS(38) is PTH in component PTH (pM).
C CONSTS(39) is pi_PTH_rep_OB_p in component PTH (dimensionless).
C CONSTS(40) is pi_PTH_act_OB_p in component PTH (dimensionless).
C CONSTS(17) is beta_PTH in component PTH (flux).
C CONSTS(18) is D_PTH_tilde in component PTH (first_order_rate_constant).
C CONSTS(19) is P_PTH_d in component PTH (flux).
C CONSTS(20) is K_D4_PTH in component PTH (pM).
C CONSTS(21) is K_D5_PTH in component PTH (pM).
C CONSTS(22) is K_D6_PTH in component PTH (pM).
C CONSTS(23) is K_D7_PTH in component PTH (pM).
C CONSTS(41) is pi_PTH_act_OB_a in component PTH (dimensionless).
C CONSTS(42) is pi_PTH_rep_OB_a in component PTH (dimensionless).
C ALGBRC(4) is OPG in component OPG (pM).
C CONSTS(24) is beta1_OPG in component OPG (flux).
C CONSTS(25) is beta2_OPG in component OPG (flux).
C CONSTS(26) is OPG_max in component OPG (pM).
C ALGBRC(5) is P_OPG_e in component OPG (flux).
C CONSTS(27) is P_OPG_d in component OPG (flux).
C CONSTS(28) is D_OPG_tilde in component OPG (first_order_rate_constant).
C CONSTS(43) is pi_PTH_rep_OB in component OPG (dimensionless).
C CONSTS(29) is K_A2_RANKL in component RANKL (per_pM).
C CONSTS(30) is K_A1_RANKL in component RANKL (per_pM).
C CONSTS(31) is RANK in component RANKL (pM).
C ALGBRC(6) is RANKL_eff in component RANKL (pM).
C ALGBRC(9) is RANKL_tot in component RANKL (pM).
C ALGBRC(12) is P_RANKL in component RANKL (flux).
C ALGBRC(10) is P_RANKL_e in component RANKL (flux).
C CONSTS(32) is P_RANKL_d in component RANKL (flux).
C CONSTS(33) is R1_RANKL in component RANKL (pM).
C CONSTS(34) is R2_RANKL in component RANKL (pM).
C CONSTS(35) is beta_RANKL in component RANKL (flux).
C ALGBRC(11) is D_RANKL in component RANKL (flux).
C CONSTS(36) is D_RANKL_tilde in component RANKL (first_order_rate_constant).
C CONSTS(44) is pi_PTH_act_OB in component RANKL (dimensionless).
C CONSTS(37) is K_D8_RANKL in component RANKL (pM).
C RATES(1) is d/dt OB_p in component OB_p (dimensionless).
C RATES(2) is d/dt OB_a in component OB_a (dimensionless).
C RATES(3) is d/dt OC_a in component OC_a (dimensionless).
C RATES(4) is d/dt BV in component BV (dimensionless).
C
      SUBROUTINE initConsts(CONSTS, RATES, STATES)
      REAL CONSTS(*), RATES(*), STATES(*)
      STATES(1) = 1.0
      CONSTS(1) = 7.000e-4
      CONSTS(2) = 4.545e-3
      CONSTS(3) = 1.416e-3
      CONSTS(4) = 5.348e-0
      STATES(2) = 1.0
      CONSTS(5) = 1.890e-1
      STATES(3) = 1.0
      CONSTS(6) = 2.100e-3
      CONSTS(7) = 7.000e-1
      CONSTS(8) = 1.416e-3
      CONSTS(9) = 1.0
      STATES(4) = 100.0
      CONSTS(10) = 1.0
      CONSTS(11) = 1.0
      CONSTS(12) = 1.571e0
      CONSTS(13) = 1.000e0
      CONSTS(14) = 1.000e0
      CONSTS(15) = 1.000e0
      CONSTS(16) = 0.0
      CONSTS(17) = 2.500e2
      CONSTS(18) = 8.600e1
      CONSTS(19) = 0.0
      CONSTS(20) = 1.5e2
      CONSTS(21) = 1.5e2
      CONSTS(22) = 2.226e-1
      CONSTS(23) = 2.226e-1
      CONSTS(24) = 1.464e8
      CONSTS(25) = 1.464e8
      CONSTS(26) = 2.000e8
      CONSTS(27) = 0.0
      CONSTS(28) = 3.500e-1
      CONSTS(29) = 3.412e-2
      CONSTS(30) = 1.000e-3
      CONSTS(31) = 1.000e1
      CONSTS(32) = 0.0
      CONSTS(33) = 3.000e6
      CONSTS(34) = 3.000e6
      CONSTS(35) = 1.684e4
      CONSTS(36) = 1.013e1
      CONSTS(37) = 1.306e1
      CONSTS(38) = (CONSTS(17)+CONSTS(19))/CONSTS(18)
      CONSTS(39) = 1.00000/(1.00000+CONSTS(38)/CONSTS(22))
      CONSTS(40) = CONSTS(38)/(CONSTS(20)+CONSTS(38))
      CONSTS(41) = CONSTS(38)/(CONSTS(21)+CONSTS(38))
      CONSTS(42) = 1.00000/(1.00000+CONSTS(38)/CONSTS(23))
      CONSTS(43) = CONSTS(39)
      CONSTS(44) = CONSTS(40)
      RETURN
      END
      SUBROUTINE computeRates(VOI, CONSTS,  RATES, STATES, ALGBRC)
      REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
      ALGBRC(2) = ( CONSTS(14)*CONSTS(13)*STATES(3)+CONSTS(16))/CONSTS(15)
      RATES(1) =  CONSTS(1)*(ALGBRC(2)/(CONSTS(2)+ALGBRC(2))) -  CONSTS(4)*STATES(1)*(1.00000/(1.00000+ALGBRC(2)/CONSTS(3)))
      RATES(2) =  CONSTS(4)*STATES(1)*(1.00000/(1.00000+ALGBRC(2)/CONSTS(3))) -  CONSTS(5)*STATES(2)
      ALGBRC(1) = STATES(3) - CONSTS(10)
      ALGBRC(3) = STATES(2) - CONSTS(11)
      RATES(4) =  CONSTS(12)*ALGBRC(3) -  CONSTS(13)*ALGBRC(1)
      ALGBRC(4) = ( ( CONSTS(24)*STATES(1)+ CONSTS(25)*STATES(2))*CONSTS(43)+CONSTS(27))/(( ( CONSTS(24)*STATES(1)+ CONSTS(25)*STATES(2))*CONSTS(43))/CONSTS(26)+CONSTS(28))
      ALGBRC(6) =  ( CONSTS(33)*STATES(1)+ CONSTS(34)*STATES(2))*CONSTS(44)
      ALGBRC(7) =  (ALGBRC(6)/(1.00000+ CONSTS(30)*ALGBRC(4)+ CONSTS(29)*CONSTS(31)))*((CONSTS(35)+CONSTS(32))/(CONSTS(35)+ CONSTS(36)*ALGBRC(6)))
      ALGBRC(8) = ALGBRC(7)/(CONSTS(37)+ALGBRC(7))
      RATES(3) =  CONSTS(6)*CONSTS(9)*ALGBRC(8) -  CONSTS(7)*STATES(3)*(ALGBRC(2)/(CONSTS(8)+ALGBRC(2)))
      RETURN
      END
      SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC)
      REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*)
      ALGBRC(2) = ( CONSTS(14)*CONSTS(13)*STATES(3)+CONSTS(16))/CONSTS(15)
      ALGBRC(1) = STATES(3) - CONSTS(10)
      ALGBRC(3) = STATES(2) - CONSTS(11)
      ALGBRC(4) = ( ( CONSTS(24)*STATES(1)+ CONSTS(25)*STATES(2))*CONSTS(43)+CONSTS(27))/(( ( CONSTS(24)*STATES(1)+ CONSTS(25)*STATES(2))*CONSTS(43))/CONSTS(26)+CONSTS(28))
      ALGBRC(6) =  ( CONSTS(33)*STATES(1)+ CONSTS(34)*STATES(2))*CONSTS(44)
      ALGBRC(7) =  (ALGBRC(6)/(1.00000+ CONSTS(30)*ALGBRC(4)+ CONSTS(29)*CONSTS(31)))*((CONSTS(35)+CONSTS(32))/(CONSTS(35)+ CONSTS(36)*ALGBRC(6)))
      ALGBRC(8) = ALGBRC(7)/(CONSTS(37)+ALGBRC(7))
      ALGBRC(5) =  ( CONSTS(24)*STATES(1)+ CONSTS(25)*STATES(2))*CONSTS(43)*(1.00000 - ALGBRC(4)/CONSTS(26))
      ALGBRC(9) =  ALGBRC(7)*(1.00000+ CONSTS(30)*ALGBRC(4)+ CONSTS(29)*CONSTS(31))
      ALGBRC(10) =  CONSTS(35)*(1.00000 - ALGBRC(9)/ALGBRC(6))
      ALGBRC(11) =  - CONSTS(36)*ALGBRC(9)
      ALGBRC(12) = ALGBRC(10)+CONSTS(32)
      RETURN
      END