C C There are a total of 12 entries in the algebraic variable array. C There are a total of 5 entries in each of the rate and state variable arrays. C There are a total of 32 entries in the constant variable array. C C C VOI is time in component environment (millisecond). C STATES(1) is V in component membrane (millivolt). C CONSTS(1) is Cm in component membrane (femtofarad). C ALGBRC(6) is Ica in component Ica (femtoampere). C ALGBRC(8) is Is1 in component Is1 (femtoampere). C ALGBRC(12) is Is2 in component Is2 (femtoampere). C ALGBRC(11) is Il in component Il (femtoampere). C ALGBRC(9) is Ik in component Ik (femtoampere). C CONSTS(2) is gCa in component Ica (picosiemens). C CONSTS(3) is VCa in component Ica (millivolt). C ALGBRC(1) is m_infinity in component m (dimensionless). C CONSTS(4) is vm in component m (millivolt). C CONSTS(5) is sm in component m (millivolt). C CONSTS(6) is gs1 in component Is1 (picosiemens). C CONSTS(7) is VK in component Ik (millivolt). C STATES(2) is s1 in component s1 (dimensionless). C ALGBRC(2) is s1_infinity in component s1 (dimensionless). C CONSTS(8) is autos1 in component s1 (dimensionless). C CONSTS(9) is s1knot in component s1 (dimensionless). C CONSTS(10) is tau_s1 in component s1 (millisecond). C CONSTS(11) is vs1 in component s1 (millivolt). C CONSTS(12) is ss1 in component s1 (millivolt). C CONSTS(13) is gK in component Ik (picosiemens). C STATES(3) is n in component n (dimensionless). C ALGBRC(3) is n_infinity in component n (dimensionless). C CONSTS(14) is tau_n_bar in component n (millisecond). C ALGBRC(7) is tau_n in component n (millisecond). C CONSTS(15) is vn in component n (millivolt). C CONSTS(16) is sn in component n (millivolt). C CONSTS(17) is gl in component Il (picosiemens). C CONSTS(18) is Vl in component Il (millivolt). C ALGBRC(10) is q in component Il (dimensionless). C STATES(4) is p in component Il (dimensionless). C CONSTS(19) is alpha_p in component Il (dimensionless). C CONSTS(20) is tau_p in component Il (millisecond). C CONSTS(31) is beta_p in component Il (dimensionless). C CONSTS(21) is p0 in component Il (dimensionless). C CONSTS(22) is noise in component Il (dimensionless). C ALGBRC(4) is sigma in component Il (dimensionless). C CONSTS(23) is w in component Il (dimensionless). C CONSTS(32) is nstoc in component Il (dimensionless). C CONSTS(24) is delNoise in component Il (dimensionless). C CONSTS(25) is gs2 in component Is2 (picosiemens). C STATES(5) is s2 in component s2 (dimensionless). C ALGBRC(5) is s2_infinity in component s2 (dimensionless). C CONSTS(26) is autos2 in component s2 (dimensionless). C CONSTS(27) is s2knot in component s2 (dimensionless). C CONSTS(28) is tau_s2 in component s2 (millisecond). C CONSTS(29) is vs2 in component s2 (millivolt). C CONSTS(30) is ss2 in component s2 (millivolt). C RATES(1) is d/dt V in component membrane (millivolt). C RATES(2) is d/dt s1 in component s1 (dimensionless). C RATES(3) is d/dt n in component n (dimensionless). C RATES(4) is d/dt p in component Il (dimensionless). C RATES(5) is d/dt s2 in component s2 (dimensionless). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) STATES(1) = -40.0 CONSTS(1) = 4525.0 CONSTS(2) = 280.0 CONSTS(3) = 100.0 CONSTS(4) = -22.0 CONSTS(5) = 7.5 CONSTS(6) = 22.0 CONSTS(7) = -80.0 STATES(2) = 0.9 CONSTS(8) = 1 CONSTS(9) = 1 CONSTS(10) = 1000.0 CONSTS(11) = -50.0 CONSTS(12) = 5 CONSTS(13) = 1300.0 STATES(3) = 0.0 CONSTS(14) = 8.25 CONSTS(15) = -9.0 CONSTS(16) = 10.0 CONSTS(17) = 41.0 CONSTS(18) = -40.0 STATES(4) = 0.14 CONSTS(19) = 1.0 CONSTS(20) = 100.0 CONSTS(21) = 0.2 CONSTS(22) = 1 CONSTS(23) = 1 CONSTS(24) = 3 CONSTS(25) = 16 STATES(5) = 0.5 CONSTS(26) = 1 CONSTS(27) = 0.47 CONSTS(28) = 30000.0 CONSTS(29) = -40.0 CONSTS(30) = 15 CONSTS(31) = CONSTS(19)*(1.00000/CONSTS(21) - 1.00000) CONSTS(32) = 1000.00/CONSTS(24) ** 2.00000 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 1.00000/(1.00000+EXP((CONSTS(11) - STATES(1))/CONSTS(12))) RATES(2) = CONSTS(8)*((ALGBRC(2) - STATES(2))/CONSTS(10))+ (1.00000 - CONSTS(8))*(CONSTS(9) - STATES(2)) ALGBRC(4) = (( CONSTS(19)*(1.00000 - STATES(4))+ CONSTS(31)*STATES(4))/( CONSTS(20)*CONSTS(32))) ** (1.0 / 2) RATES(4) = ( CONSTS(19)*(1.00000 - STATES(4)) - CONSTS(31)*STATES(4))/CONSTS(20)+ CONSTS(22)*CONSTS(23)*ALGBRC(4) ALGBRC(5) = 1.00000/(1.00000+EXP((CONSTS(29) - STATES(1))/CONSTS(30))) RATES(5) = CONSTS(26)*((ALGBRC(5) - STATES(5))/CONSTS(28))+ (1.00000 - CONSTS(26))*(CONSTS(27) - STATES(5)) ALGBRC(3) = 1.00000/(1.00000+EXP((CONSTS(15) - STATES(1))/CONSTS(16))) ALGBRC(7) = CONSTS(14)/(1.00000+EXP((STATES(1) - CONSTS(15))/CONSTS(16))) RATES(3) = (ALGBRC(3) - STATES(3))/ALGBRC(7) ALGBRC(1) = 1.00000/(1.00000+EXP((CONSTS(4) - STATES(1))/CONSTS(5))) ALGBRC(6) = CONSTS(2)*ALGBRC(1)*(STATES(1) - CONSTS(3)) ALGBRC(8) = CONSTS(6)*STATES(2)*(STATES(1) - CONSTS(7)) ALGBRC(12) = CONSTS(25)*STATES(5)*(STATES(1) - CONSTS(7)) ALGBRC(10) = (1.00000+STATES(4))/2.00000 ALGBRC(11) = CONSTS(17)*ALGBRC(10)*(STATES(1) - CONSTS(18)) ALGBRC(9) = CONSTS(13)*STATES(3)*(STATES(1) - CONSTS(7)) RATES(1) = - (ALGBRC(6)+ALGBRC(8)+ALGBRC(12)+ALGBRC(11)+ALGBRC(9))/CONSTS(1) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = 1.00000/(1.00000+EXP((CONSTS(11) - STATES(1))/CONSTS(12))) ALGBRC(4) = (( CONSTS(19)*(1.00000 - STATES(4))+ CONSTS(31)*STATES(4))/( CONSTS(20)*CONSTS(32))) ** (1.0 / 2) ALGBRC(5) = 1.00000/(1.00000+EXP((CONSTS(29) - STATES(1))/CONSTS(30))) ALGBRC(3) = 1.00000/(1.00000+EXP((CONSTS(15) - STATES(1))/CONSTS(16))) ALGBRC(7) = CONSTS(14)/(1.00000+EXP((STATES(1) - CONSTS(15))/CONSTS(16))) ALGBRC(1) = 1.00000/(1.00000+EXP((CONSTS(4) - STATES(1))/CONSTS(5))) ALGBRC(6) = CONSTS(2)*ALGBRC(1)*(STATES(1) - CONSTS(3)) ALGBRC(8) = CONSTS(6)*STATES(2)*(STATES(1) - CONSTS(7)) ALGBRC(12) = CONSTS(25)*STATES(5)*(STATES(1) - CONSTS(7)) ALGBRC(10) = (1.00000+STATES(4))/2.00000 ALGBRC(11) = CONSTS(17)*ALGBRC(10)*(STATES(1) - CONSTS(18)) ALGBRC(9) = CONSTS(13)*STATES(3)*(STATES(1) - CONSTS(7)) RETURN END